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                <text>Repurposing Antiviral Protease Inhibitors Using Extracellular Vesicles for Potential Therapy of COVID-19</text>
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                <text>Kelli Gerth, Santosh Kumar, Kaining Zhi, Ahona Mukherji</text>
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                <text>In January 2020, Chinese health agencies reported an outbreak of a novel coronavirus-2 (CoV-2) which can lead to severe acute respiratory syndrome (SARS). The virus, which belongs to the coronavirus family (SARS-CoV-2), was named coronavirus disease 2019 (COVID-19) and declared a pandemic by the World Health Organization (WHO). Full-length genome sequences of SARS-CoV-2 showed 79.6% sequence identity to SARS-CoV, with 96% identity to a bat coronavirus at the whole-genome level. COVID-19 has caused over 133,000 deaths and there are over 2 million total confirmed cases as of April 15th, 2020. Current treatment plans are still under investigation due to a lack of understanding of COVID-19. One potential mechanism to slow disease progression is the use of antiviral drugs to either block the entry of the virus or interfere with viral replication and maturation. Currently, antiviral drugs, including chloroquine/hydroxychloroquine, remdesivir, and lopinavir/ritonavir, have shown effective inhibition of SARS-CoV-2 in vitro. Due to the high dose needed and narrow therapeutic window, many patients are experiencing severe side effects with the above drugs. Hence, repurposing these drugs with a proper formulation is needed to improve the safety and efficacy for COVID-19 treatment. Extracellular vesicles (EVs) are a family of natural carriers in the human body. They play a critical role in cell-to-cell communications. EVs can be used as unique drug carriers to deliver protease inhibitors to treat COVID-19. EVs may provide targeted delivery of protease inhibitors, with fewer systemic side effects. More importantly, EVs are eligible for major aseptic processing and can be upscaled for mass production. Currently, the FDA is facilitating applications to treat COVID-19, which provides a very good chance to use EVs to contribute in this combat.</text>
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                <text>Coronaviruses, HIV, covid-19, Extracellular vesicles, antiviral drugs, Protease Inhibitors</text>
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                <text>Epidemiology and Health</text>
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                <text>Korean Society of Epidemiology</text>
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                  <text>Agricultura sostenible</text>
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                  <text>Dominio científico: Agricultura sostenible</text>
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                <text>Uso de las ciencias ómicas para el mejoramiento genético de cultivos</text>
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                <text>Kelly Botero O., Tatiana Arias</text>
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                <text>El crecimiento de la población, el cambio climático y la pérdida de los servicios ecosistémicos, son algunos de los desafíos que enfrenta el sector agrícola en las últimas décadas para garantizar la seguridad alimentaria a largo plazo. Los programas de mejoramiento genético son un frente de acción que puede contribuir al desarrollo de materiales genéticos adaptados a nuevas condiciones ambientales. El desarrollo y la implementación de tecnologías de secuenciación de alto rendimiento han permitido acelerar dichos programas en cultivos que alimentan a la mayoría de la población mundial. El propósito de este artículo es revisar algunos de los desarrollos tecnológicos de las ciencias ómicas para el estudio de mejoramiento genético de cultivos. En este trabajo se discuten cuatro enfoques de las ciencias ómicas y sus aplicaciones en la agricultura: la filogenómica, la genómica comparativa, la transcriptómica comparativa y la selección asistida por marcadores moleculares. Estos enfoques permiten comprender la historia evolutiva de cultivos y sus parientes silvestres, identificar la estructura y función de los genes de interés en la agricultura, revelar la expresión de los genes importantes en el proceso de domesticación y caracterizar molecularmente individuos de especies agrícolas, con el fin de evidenciar variaciones genéticas que permitan agilizar procesos de selección. Es necesario implementar programas de mejoramiento genético que incluya el uso de algunas, o todas estas tecnologías con el propósito de acelerar los resultados de dichos procesos y contribuir a los desafíos del sector agrícola.</text>
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                <text>2018</text>
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                <text>SAM, filogenética, genómica, transcriptómica</text>
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            <name>Identifier</name>
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                <text>10.22267/rcia.183502.92</text>
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                <text>Revista de Ciencias Agrícolas</text>
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                <text>Universidad de Nariño</text>
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                <text>Agriculture (General), Agriculture</text>
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                <text>&lt;a href="http://revistas.udenar.edu.co/index.php/rfacia/article/view/4276" target="_blank" rel="noreferrer noopener"&gt;http://revistas.udenar.edu.co/index.php/rfacia/article/view/4276&lt;/a&gt;</text>
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                <text>Food for People in Place: Reimagining Resilient Food Systems for Economic Recovery</text>
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            <description>An entity primarily responsible for making the resource</description>
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                <text>Kelly Dombroski, Gradon Diprose, Emma Sharp, Rebekah Graham, Louise Lee, Matthew Scobie, Sophie Richardson, Alison Watkins, Rosemarie Martin-Neuninger</text>
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                <text>The COVID-19 pandemic and associated response have brought food security into sharp focus for many New Zealanders. The requirement to “shelter in place” for eight weeks nationwide, with only “essential services” operating, affected all parts of the New Zealand food system. The nationwide full lockdown highlighted existing inequities and created new challenges to food access, availability, affordability, distribution, transportation, and waste management. While Aotearoa New Zealand is a food producer, there remains uncertainty surrounding the future of local food systems, particularly as the long-term effects of the pandemic emerge. In this article we draw on interviews with food rescue groups, urban farms, community organisations, supermarket management, and local and central government staff to highlight the diverse, rapid, community-based responses to the COVID-19 pandemic. Our findings reveal shifts at both the local scale, where existing relationships and short supply chains have been leveraged quickly, and national scale, where funding has been mobilised towards a different food strategy. We use these findings to re-imagine where and how responsibility might be taken up differently to enhance resilience and care in diverse food systems in New Zealand.</text>
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                <text>2020</text>
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                <text>governance, covid-19, food security, responsibility, New Zealand, food justice</text>
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                <text>10.3390/su12229369</text>
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                <text>Biotemas</text>
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                <text>Universidade Federal de Santa Catarina</text>
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                <text>Environmental effects of industries and plants, Renewable energy sources, Environmental sciences</text>
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                  <text>Agricultura sostenible</text>
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                  <text>Dominio científico: Agricultura sostenible</text>
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                <text>Projeto Esperança/Cooesperança, Santa Maria, RS: o caso dos agricultores associados PROJECT ESPERANÇA/COOESPERANÇA, SANTA MARIA, RS: THE CASE OF ASSOCIATED FAMILY FARMERS.</text>
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                <text>Kelly Perlin Cassol, Carmen Rejane Flores Wizniewsky</text>
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            <description>An account of the resource</description>
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                <text>A busca de alternativas para a manutenção de famílias no campo é um tema que vem sendo fortemente trabalho na região central do estado do Rio Grande do Sul. O Projeto Esperança/Cooesperança é uma das entidades de destaque em relação ao tema na perspectiva da economia solidária. O caso dos agricultores familiares associados ao Projeto Esperança/Cooesperança, e sua relação com a economia solidária é o centro de interesse do presente trabalho, que objetiva compreender como as famílias de agricultores de Santa Maria, associados à Cooperativa desenvolvem suas atividades produtivas e como estas se inserem na perspectiva da economia solidária, suas relações com a produção e comercialização e suas condições de vida, são os pontos a serem analisados nesta pesquisa. Palavras-chave: agricultura familiar – cooperação – economia solidária – inclusão social.The search for alternatives for the maintenance of rural families is a theme that has been strongly worked on the central region of Rio Grande do Sul. The project Esperança/Cooesperança is one of the prominent entities regarding to the subject in perspective of the solidarity economy. The case of farming families associated with the Esperança /Cooesperança Project, and their relation to the social economy is the focus of this study, which aims to understand how these families of Santa Maria, develop their productive activities and how they fall in view of the solidarity economy. Their relationship with the production and marketing and their conditions of life are points to be analyzed in this research. &amp;#13; Keywords: family farming - cooperation - solidarity economy - social inclusion.</text>
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                <text>2013</text>
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                <text>10.5902/223649948737</text>
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                <text>Geografia Ensino &amp; Pesquisa</text>
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                <text>Universidade Federal de Santa Maria - UFSM</text>
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                <text>Geography (General)</text>
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                <text>&lt;a href="http://cascavel.ufsm.br/revistas/ojs-2.2.2/index.php/geografia/article/view/8737" target="_blank" rel="noreferrer noopener"&gt;http://cascavel.ufsm.br/revistas/ojs-2.2.2/index.php/geografia/article/view/8737&lt;/a&gt;</text>
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                <text>La agricultura orgánica es la medida agroambiental y alternativa agroecológica que resulta en una agricultura de valor agregado. Este estudio determinó a través de la interpolación del mapeo de análisis geoestadístico si las medidas orgánicas utilizadas fueron biointensivas, y se modificó el suelo para cumplir con los requisitos para el cultivar de arándano. El área de estudio fue un huerto de arándanos de 0.88 hectáreas, en el municipio de Cusihuriachi, Chihuahua, México, que había sido sometido a 3 tratamientos distintos de enmienda orgánica del suelo para camas elevadas: (t1) yeso y azufre, (t2) yeso, azufre y compost y (t3) yeso, azufre, compost y polvo de aserrín de pino. Veinticuatro muestras de suelo se tomaron de 0 a 30 centímetros en todo el huerto de las camas elevadas, 75 días después de la aplicación de los 3 tratamientos del suelo. Las técnicas de análisis de suelo se usaron para determinar el porcentaje de arcilla en el suelo, el pH del suelo, la cantidad de nitratos mg.kg-1 de suelo y el porcentaje de materia orgánica en el suelo. El análisis geoestadístico se determinó a través de grupos de similitud y diferencia con el agrupamiento Ward. Con los resultados del análisis del clúster Ward se generó un mapa interpolado para cada parámetro al utilizar ArcMap y la interpolación de ponderación de distancia inversa. La conclusión de este estudio fue que el mapeo de interpolación era una herramienta de visualización útil para determinar que no había diferencia ponderada entre los 3 tratamientos de enmienda y que ninguno de los tratamientos fue lo suficientemente efectivo como para emendar el suelo a las condiciones deseadas por el cultivar de arándano en los parámetros observados. Los mapas también fueron útiles para determinar las condiciones específicas del suelo, fuera del área de tratamiento, que podrían ser utilizadas por el productor para determinar un plan de gestión de agricultura de precisión, que podría considerarse como una medida agroambiental adicional.</text>
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                <text>Agronomía Costarricense</text>
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                <text>Universidad de Costa Rica</text>
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                <text>Agriculture (General), Agriculture</text>
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                <text>&lt;a href="http://www.redalyc.org/articulo.oa?id=43656391008" target="_blank" rel="noreferrer noopener"&gt;http://www.redalyc.org/articulo.oa?id=43656391008&lt;/a&gt;</text>
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                <text>Halochromic Polystyrene Nanofibers Obtained by Solution Blow Spinning for Wine pH Sensing</text>
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                <text>Kelvi  W.E. Miranda, Caio  V. L. Natarelli, Adriana  C. Thomazi, Guilherme  M. D. Ferreira, Maryana  M. Frota, Maria  do Socorro R. Bastos, Luiz  H. C. Mattoso, Juliano  E. Oliveira</text>
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                <text>Colorimetric sensors developed by the solution blow spinning (SBS) technique have a rapid response to a variation in different physicochemical properties. In this study, polystyrene nanofibrous (PSNF) mats containing the bromothymol blue (BTB) indicator were obtained by SBS for the pH sensing of wine sample. The incorporation of the indicator did not promote changes in fiber diameter but led to the appearance of beads, allowing for the encapsulation of BTB. The halochromic property of BTB was retained in the PSNF material, and the migration tests showed that the indicator mats presented values below the maximum acceptable limit (10 mg dm&amp;#8722;2) established by EU Commission Regulation No. 10/2011 for foods with an alcohol content up to 20%. The present study opens the possibility of applying nanostructured materials to innovative food packaging which, through nanosensory zones, change color as a function of the food pH.</text>
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                <text>Sensor, nanofiber, smart packaging</text>
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                <text>10.3390/s20020417</text>
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            <description>A related resource from which the described resource is derived</description>
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                <text>Sensors</text>
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                <text>MDPI AG</text>
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                <text>Chemical technology</text>
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                <text>&lt;a href="https://www.mdpi.com/1424-8220/20/2/417" target="_blank" rel="noreferrer noopener"&gt;https://www.mdpi.com/1424-8220/20/2/417&lt;/a&gt;</text>
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                <text>COVID-19 was declared a pandemic by the World Health Organisation (WHO) on March 11th, 2020. With half of the world's countries in lockdown as of April due to this pandemic, monitoring and understanding the spread of the virus and infection rates and how these factors relate to behavioural and societal parameters is crucial for developing control strategies. This paper aims to investigate the effectiveness of masks, social distancing, lockdown and self-isolation for reducing the spread of SARS-CoV-2 infections. Our findings from an agent-based simulation modelling showed that whilst requiring a lockdown is widely believed to be the most efficient method to quickly reduce infection numbers, the practice of social distancing and the usage of surgical masks can potentially be more effective than requiring a lockdown. Our multivariate analysis of simulation results using the Morris Elementary Effects Method suggests that if a sufficient proportion of the population uses surgical masks and follows social distancing regulations, then SARS-CoV-2 infections can be controlled without requiring a lockdown.</text>
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                <text>epidemiology, coronavirus, infectious diseases, isolation, virus, covid-19, SARS-CoV-2, simulation, social distancing, survival, lockdown, Masks, agent-based modelling, NetLogo, stochastic processes, Python, Stochasticity</text>
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                <text>Broad-Spectrum Host-Based Antivirals Targeting the Interferon and Lipogenesis Pathways as Potential Treatment Options for the Pandemic Coronavirus Disease 2019 (COVID-19).</text>
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                <text>The ongoing Coronavirus Disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) signals an urgent need for an expansion in treatment options. In this study, we investigated the anti-SARS-CoV-2 activities of 22 antiviral agents with known broad-spectrum antiviral activities against coronaviruses and/or other viruses. They were first evaluated in our primary screening in VeroE6 cells and then the most potent anti-SARS-CoV-2 antiviral agents were further evaluated using viral antigen expression, viral load reduction, and plaque reduction assays. In addition to remdesivir, lopinavir, and chloroquine, our primary screening additionally identified types I and II recombinant interferons, 25-hydroxycholesterol, and AM580 as the most potent anti-SARS-CoV-2 agents among the 22 antiviral agents. Betaferon (interferon-β1b) exhibited the most potent anti-SARS-CoV-2 activity in viral antigen expression, viral load reduction, and plaque reduction assays among the recombinant interferons. The lipogenesis modulators 25-hydroxycholesterol and AM580 exhibited EC50 at low micromolar levels and selectivity indices of &gt;10.0. Combinational use of these host-based antiviral agents with virus-based antivirals to target different processes of the SARS-CoV-2 replication cycle should be evaluated in animal models and/or clinical trials.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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              <elementText elementTextId="32936">
                <text>2020</text>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
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                <text>treatment, coronavirus, interferon, 25-hydroxycholesterol, COVID-19, AM580</text>
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            <name>Identifier</name>
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              <elementText elementTextId="32938">
                <text>DOI: 10.3390/v12060628</text>
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            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="32939">
                <text>Viruses</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="32940">
                <text>MDPI AG</text>
              </elementText>
            </elementTextContainer>
          </element>
        </elementContainer>
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        <src>http://socictopen.socict.org/files/original/3937fb0642448415a4fd300ede0f7536.pdf</src>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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          <element elementId="50">
            <name>Title</name>
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                <text>The Impact of COVID-19 on HIV Treatment and Research: A Call to Action</text>
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          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="38417">
                <text>Kemesha Gabbidon, Tiffany Chenneville, Patricia Hanson, Cashea Holyfield</text>
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          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
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                <text>The impact of the COVID-19 pandemic is far reaching, with devastating effects on individuals, communities, and societies across the world. People with chronic health conditions may be at greater risk of contracting or experiencing complications from COVID-19. In addition to illness or death for those who contract the virus, the physical distancing required to flatten the curve of new cases is having a negative impact on the economy, the effects of which intersect with mental health and other existing health concerns, thus affecting marginalized communities. Given that HIV also has a disproportionate impact on marginalized communities, COVID-19 is affecting people with HIV (PWH) in unique ways and will continue to have an impact on HIV research and treatment after the COVID-19 crisis passes. Using the biopsychosocial framework to contextualize the impact of COVID-19 on PWH, the purpose of this review article is to: (1) outline the similarities and differences between the COVID-19 and HIV pandemics; (2) describe the current and future impact of COVID-19 on PWH; and (3) outline a call to action for scientists and practitioners to respond to the impact of COVID-19 on HIV prevention and treatment.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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                <text>2020</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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                <text>HIV, health disparities, Aids, coronavirus, COVID-19</text>
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                <text>DOI: 10.3390/ijerph17124548</text>
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            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="38422">
                <text>International Journal of Environmental Research and Public Health</text>
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          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="38423">
                <text>MDPI AG</text>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Medicine</text>
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