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                <text>Covid-19 discloses unequal geographies</text>
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                <text>Kirsi Pauliina Kallio, Marcelo Lopes de Sousa, Katharyne Mitchell, Jouni Häkli, Simone Tulumello, Isabel Meier, Anna  Carastathis, Aila Spathopoulou, Myrto Tsilimpounidi, Gemma Bird, Amanda Russell Beattie, Jelena Obradovic-Wochnik, Patrycja Rozbicka, James Riding</text>
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                <text>The collective editorial discusses inequalities that scholars in Europe and the Americas world have paid attention to during 2020 when the Covid-19 pandemic has unevenly and unpredictably impacted on societies. The critical reflections reveal that the continuing ramifications of the pandemic can only be understood in place; like other large-scale phenomena, this exceptional global crisis concretizes very differently in distinct national, regional and local contexts. The pandemic intertwines with ongoing challenges in societies, for example those related to poverty, armed conflicts, migration, racism, natural hazards, corruption and precarious labor. Through collective contextual understanding, the editorial invites further attention to the unequal geographies made visible and intensified by the current pandemic.</text>
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                <text>Fennia: International Journal of Geography</text>
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                <text>Kirsi S. Honkavuori, Thomas Briese, Scott Krauss, Maria D Sanchez, Komal Jain, Stephen K. Hutchison, Robert G. Webster, W. Ian Lipkin</text>
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                <text>Wild birds are an important but to some extent under-studied reservoir for emerging pathogens. We used unbiased sequencing methods for virus discovery in shorebird samples from the Delaware Bay, USA; an important feeding ground for thousands of migratory birds.Analysis of shorebird fecal samples indicated the presence of a novel astrovirus and coronavirus. A sanderling sample yielded sequences with distant homology to avian nephritis virus 1, an astrovirus associated with acute nephritis in poultry. A ruddy turnstone sample yielded sequences with homology to deltacoronaviruses.Our findings highlight shorebirds as a virus reservoir and the need to closely monitor wild bird populations for the emergence of novel virus variants.</text>
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                <text>DOI: 10.1371/journal.pone.0093395</text>
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                <text>Kirsten Bentley, María Armesto, Paul Britton</text>
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                <text>The avian coronavirus infectious bronchitis virus (IBV) is the causative agent of the respiratory disease infectious bronchitis of domestic fowl, and is controlled by routine vaccination. To explore the potential use of IBV as a vaccine vector a reverse genetics system was utilised to generate infectious recombinant IBVs (rIBVs) expressing the reporter genes enhanced green fluorescent protein (eGFP) or humanised Renilla luciferase (hRluc). Infectious rIBVs were obtained following the replacement of Gene 5 or the intergenic region (IR) with eGFP or hRluc, or the replacement of ORFs 3a and 3b with hRluc. The replacement of Gene 5 with an IBV codon-optimised version of the hRluc gene also resulted in successful rescue of infectious rIBV. Reporter gene expression was confirmed by fluorescence microscopy, or luciferase activity assays, for all successfully rescued rIBVs following infection of primary chick kidney (CK) cells. The genetic stability of rIBVs was analysed by serial passage on CK cells. Recombinant IBV stability varied depending on the genome region being replaced, with the reporter genes maintained up to at least passage 8 (P8) following replacement of Gene 5, P7 for replacement of the IR and P5 for replacement of ORFs 3a and 3b. Codon-optimisation of the hRluc gene, when replacing Gene 5, resulted in an increase in genome stability, with hRluc expression stable up to P10 compared to P8 for standard hRluc. Repeated passaging of rIBVs expressing hRluc at an MOI of 0.01 demonstrated an increase in stability, with hRluc expression stable up to at least P12 following the replacement of Gene 5. This study has demonstrated that heterologous genes can be incorporated into, and expressed from a range of IBV genome locations and that replacement of accessory Gene 5 offers a promising target for realising the potential of IBV as a vaccine vector for other avian pathogens.</text>
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                <text>DOI: 10.1371/journal.pone.0067875</text>
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                <text>Angiotensin-converting enzyme 2 (ACE2) is the receptor for COVID-19 (SARs-CoV-2). ACE2 protects the lung and heart from acute respiratory distress syndrome (ARDS) and acute myocarditis and arrhythmias, because it breaks down Angiotensin II, which has inflammatory effects in the lung and heart as well as in the kidney. When SARS-CoV-2 binds to ACE2, it suppresses it, so this protective action of ACE2 is lost. Death from COVID-19 is due to ARDS and also heart failure and acute cardiac injury. Drugs that prevent the inflammatory actions of Angiotensin II (i.e., Angiotensin receptor blockers, ARBs) prevent acute lung injury caused by SARS-CoV. Clinical trials are underway to test the risks and benefits of ARBs and angiotensin-converting enzyme inhibitors (ACEIs) in COVID-19 patients requiring hospitalization. Other potential treatments are also discussed.</text>
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                <text>DOI: 10.3389/fmed.2020.00248</text>
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                <text>A criação de aves em sistemas de base agroecológica é considerada uma opção viável para a diversificação da renda na agricultura familiar, com a venda de carne e ovos de qualidade, contribuindo para a segurança alimentar e nutricional do mercado consumidor. Entretanto, apresenta certa complexidade, necessitando-se conhecer as técnicas de manejo recomendadas para obter o sucesso da criação. Diante disso, o objetivo deste trabalho foi mostrar, através de uma pesquisa bibliográfica, as exigências e recomendações inerentes à criação de aves em sistemas de produção de base agroecológica de acordo com a legislação vigente.</text>
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        <name>Dublin Core</name>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Algunas perspectivas sociológicas generales sobre problemas fundamentales de intervención en la Naturaleza y la sociedad de cara a la globalización</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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                <text>Klaus Kuhnekath</text>
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          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
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                <text>El trabajo empieza preguntándose acerca del concepto de sostenibilidad; posteriormente, enumera y analiza las características estructurales más profundas y, por ello, menos evidentes de la sociedad actual; luego, plantea los problemas que se generan como consecuencia de dichas características; continúa presentando los cambios cualitativos producidos por la globalización; y termina planteando algunas posibles estrategias para enfrentar los aspectos más negativos que vaticinan los diferentes ámbitos señalados. Todo ello, manteniendo como leit motiv la sostenibilidad y la ecología, en su sentido más amplio.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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              <elementText elementTextId="165332">
                <text>2001</text>
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          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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                <text>Encuentro</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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                <text>Universidad Centroamericana de Managua</text>
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          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Social Sciences, Science</text>
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          <element elementId="46">
            <name>Relation</name>
            <description>A related resource</description>
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              <elementText elementTextId="165336">
                <text>&lt;a href="http://www.uca.edu.ni/2/images/Revista-Encuentro/Revistas/e59/art-7.pdf" target="_blank" rel="noreferrer noopener"&gt;http://www.uca.edu.ni/2/images/Revista-Encuentro/Revistas/e59/art-7.pdf&lt;/a&gt;</text>
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