1076 10 20655 http://socictopen.socict.org/files/original/3d2d08a5919b8a31e0d46f4ccc92b56d.pdf 523a2ff2fc1b8250ddde57041140a3b1 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource The role of myeloid cell activation and arginine metabolism in the pathogenesis of virus-induced diseases Creator An entity primarily responsible for making the resource Kristina S. Burrack, Thomas E. Morrison Description An account of the resource When an antiviral immune response is generated, a balance must be reached between two opposing pathways: the production of proinflammatory and cytotoxic effectors that drive a robust antiviral immune response to control the infection and regulators that function to limit or blunt an excessive immune response to minimize immune-mediated pathology and repair tissue damage. Myeloid cells, including monocytes and macrophages, play an important role in this balance, particularly through the activities of the arginine-hydrolyzing enzymes nitric oxide synthase 2 (Nos2; iNOS) and arginase 1 (Arg1). Nitric oxide (NO) production by iNOS is an important proinflammatory mediator, whereas Arg1-expressing macrophages contribute to the resolution of inflammation and wound repair. In the context of viral infections, expression of these enzymes can result in a variety of outcomes for the host. NO has direct antiviral properties against some viruses, whereas during other virus infections NO can mediate immunopathology and/or inhibit the antiviral immune response to promote chronic infection. Arg1 activity has important wound healing functions but can also inhibit the antiviral immune response during some viral infections. Thus, depending on the specific virus and the tissue(s) involved, the activity of both of these arginine-hydrolyzing enzymes can either exacerbate or limit the severity of virus-induced disease. In this review, we will discuss a variety of viral infections, including HIV, SARS-CoV, LCMV, HCV, RSV, and others, where myeloid cells influence the control and clearance of the virus from the host, as well as the severity and resolution of tissue damage, via the activities of iNOS and/or Arg1. Clearly, monocyte/macrophage activation and arginine metabolism will continue to be important areas of investigation in the context of viral infections. Date A point or period of time associated with an event in the lifecycle of the resource 2014 Subject The topic of the resource Arginase, Immunity, Cellular, macrophages, iNOS, Viral pathogenicity Identifier An unambiguous reference to the resource within a given context DOI: 10.3389/fimmu.2014.00428 Source A related resource from which the described resource is derived Frontiers in Immunology Publisher An entity responsible for making the resource available Frontiers Media S.A. Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Immunologic diseases. Allergy Language A language of the resource EN http://socictopen.socict.org/files/original/30315a502887b171bdd791768a4061a5.pdf 83212dc09b2dc515d6400812258f59f6 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource A Parsimonious Description and Cross-Country Analysis of COVID-19 Epidemic Curves Creator An entity primarily responsible for making the resource Kristoffer Rypdal, Martin Rypdal Description An account of the resource In a given country, the cumulative death toll of the first wave of the COVID-19 epidemic follows a sigmoid curve as a function of time. In most cases, the curve is well described by the Gompertz function, which is characterized by two essential parameters, the initial growth rate and the decay rate as the first epidemic wave subsides. These parameters are determined by socioeconomic factors and the countermeasures to halt the epidemic. The Gompertz model implies that the total death toll depends exponentially, and hence very sensitively, on the ratio between these rates. The remarkably different epidemic curves for the first epidemic wave in Sweden and Norway and many other countries are classified and discussed in this framework, and their usefulness for the planning of mitigation strategies is discussed. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource covid-19, Epidemic Curve, death toll, Gompertz model, logistic curve Identifier An unambiguous reference to the resource within a given context 10.3390/ijerph17186487 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine http://socictopen.socict.org/files/original/27f32c6f6d662a0c08ba00cf20a9e5e5.pdf 6630b76698df125e494a2b9bbc2672c4 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Genetic variation in the Staphylococcus aureus 8325 strain lineage revealed by whole-genome sequencing. Creator An entity primarily responsible for making the resource Kristoffer T. Bæk, Dorte Frees, Adriana Renzoni, Christine Barras, Natalia Rodríguez, Caroline Manzano, William L Kelley Description An account of the resource Staphylococcus aureus strains of the 8325 lineage, especially 8325-4 and derivatives lacking prophage, have been used extensively for decades of research. We report herein the results of our deep sequence analysis of strain 8325-4. Assignment of sequence variants compared with the reference strain 8325 (NRS77/PS47) required correction of errors in the 8325 reference genome, and reassessment of variation previously attributed to chemical mutagenesis of the restriction-defective RN4220. Using an extensive strain pedigree analysis, we discovered that 8325-4 contains 16 single nucleotide polymorphisms (SNP) arising prior to the construction of RN4220. We identified 5 indels in 8325-4 compared with 8325. Three indels correspond to expected Φ11, 12, 13 excisions, one indel is explained by a sequence assembly artifact, and the final indel (Δ63bp) in the spa-sarS intergenic region is common to only a sub-lineage of 8325-4 strains including SH1000. This deletion was found to significantly decrease (75%) steady state sarS but not spa transcript levels in post-exponential phase. The sub-lineage 8325-4 was also found to harbor 4 additional SNPs. We also found large sequence variation between 8325, 8325-4 and RN4220 in a cluster of repetitive hypothetical proteins (SA0282 homologs) near the Ess secretion cluster. The overall 8325-4 SNP set results in 17 alterations within coding sequences. Remarkably, we discovered that all tested strains of the 8325-4 lineage lack phenol soluble modulin α3 (PSMα3), a virulence determinant implicated in neutrophil chemotaxis, biofilm architecture and surface spreading. Collectively, our results clarify and define the 8325-4 pedigree and reveal clear evidence that mutations existing throughout all branches of this lineage, including the widely used RN6390 and SH1000 strains, could conceivably impact virulence regulation. Date A point or period of time associated with an event in the lifecycle of the resource 2013 Identifier An unambiguous reference to the resource within a given context DOI: 10.1371/journal.pone.0077122 Source A related resource from which the described resource is derived PLoS ONE Publisher An entity responsible for making the resource available Public Library of Science (PLoS) Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Science, Medicine Language A language of the resource EN http://socictopen.socict.org/files/original/364302af1321e7a81551f0474aa561f2.pdf dad81848c1219c4fbb91ddbeb11c1e4f Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Reflections on Virtual Care for Chronic Conditions During the COVID-19 Pandemic. Creator An entity primarily responsible for making the resource Kristy D M Wittmeier, Jennifer L P Protudjer, Brandy A Wicklow Date A point or period of time associated with an event in the lifecycle of the resource 2021 Identifier An unambiguous reference to the resource within a given context 10.1016/j.jcjd.2020.11.013 Source A related resource from which the described resource is derived Canadian journal of diabetes http://socictopen.socict.org/files/original/33e354efba2eebf74e22b276bfcac8fa.pdf 6024ca09b52d66a38fc814754145f0c1 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource 2'-O methylation of the viral mRNA cap by West Nile virus evades ifit1-dependent and -independent mechanisms of host restriction in vivo. Creator An entity primarily responsible for making the resource Kristy J Szretter, Brian P. Daniels, Hyelim Cho, Maria D Gainey, Wayne M. Yokoyama, Michael Gale, Herbert W. Virgin, Robyn S. Klein, Ganes C Sen, Michael S. Diamond Description An account of the resource Prior studies have shown that 2'-O methyltransferase activity of flaviviruses, coronaviruses, and poxviruses promotes viral evasion of Ifit1, an interferon-stimulated innate immune effector protein. Viruses lacking 2'-O methyltransferase activity exhibited attenuation in primary macrophages that was rescued in cells lacking Ifit1 gene expression. Here, we examined the role of Ifit1 in restricting pathogenesis in vivo of wild type WNV (WNV-WT) and a mutant in the NS5 gene (WNV-E218A) lacking 2'-O methylation of the 5' viral RNA cap. While deletion of Ifit1 had marginal effects on WNV-WT pathogenesis, WNV-E218A showed increased replication in peripheral tissues of Ifit1⁻/⁻ mice after subcutaneous infection, yet this failed to correlate with enhanced infection in the brain or lethality. In comparison, WNV-E218A was virulent after intracranial infection as judged by increased infection in different regions of the central nervous system (CNS) and a greater than 16,000-fold decrease in LD(50) values in Ifit1⁻/⁻ compared to wild type mice. Ex vivo infection experiments revealed cell-type specific differences in the ability of an Ifit1 deficiency to complement the replication defect of WNV-E218A. In particular, WNV-E218A infection was impaired in both wild type and Ifit1⁻/⁻ brain microvascular endothelial cells, which are believed to participate in blood-brain barrier (BBB) regulation of virus entry into the CNS. A deficiency of Ifit1 also was associated with increased neuronal death in vivo, which was both cell-intrinsic and mediated by immunopathogenic CD8⁺ T cells. Our results suggest that virulent strains of WNV have largely evaded the antiviral effects of Ifit1, and viral mutants lacking 2'-O methylation are controlled in vivo by Ifit1-dependent and -independent mechanisms in different cell types. Date A point or period of time associated with an event in the lifecycle of the resource 2012 Identifier An unambiguous reference to the resource within a given context DOI: 10.1371/journal.ppat.1002698 Source A related resource from which the described resource is derived PLoS Pathogens Publisher An entity responsible for making the resource available Public Library of Science (PLoS) Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Biology (General), Immunologic diseases. Allergy Language A language of the resource EN http://socictopen.socict.org/files/original/14232919ce2abb49eff2696c861c4189.pdf c82eb7dcca1872b76e17f2f3558035fc Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Clinical Characteristics of Patients Hospitalized with Coronavirus Disease, Thailand. Creator An entity primarily responsible for making the resource Krit Pongpirul, Tawee Chotpitayasunondh, Timothy M. Uyeki, Joshua A. Mott, John R. MacArthur, Sumonmal Uttayamakul, Wisit Prasithsirikul, Supamit Chunsuttiwat, Wannarat A Pongpirul, Apichart Vachiraphan, Joseph V Woodring, Pawita Suwanvattana Description An account of the resource Among 11 patients in Thailand infected with severe acute respiratory syndrome coronavirus 2, we detected viral RNA in upper respiratory specimens a median of 14 days after illness onset and 9 days after fever resolution. We identified viral co-infections and an asymptomatic person with detectable virus RNA in serial tests. We describe implications for surveillance. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource Viruses, Zoonoses, coronavirus, reverse transcription PCR, Thailand, SARS, SARS-CoV-2, COVID-19, Severe Acute Respiratory Syndrome Coronavirus 2, 2019 novel coronavirus disease, Coronavirus disease Identifier An unambiguous reference to the resource within a given context DOI: 10.3201/eid2607.200598 Source A related resource from which the described resource is derived Emerging Infectious Diseases Publisher An entity responsible for making the resource available Centers for Disease Control and Prevention http://socictopen.socict.org/files/original/71bc7e4995b2a4624f35afa95fc00047.pdf bff30d4c14ef2dfe7952fd9e605377cf Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Short-term cytotoxic effects and long-term instability of RNAi delivered using lentiviral vectors Creator An entity primarily responsible for making the resource Kruithof Egbert KO, Fish Richard J Description An account of the resource Abstract Background RNA interference (RNAi) can potently reduce target gene expression in mammalian cells and is in wide use for loss-of-function studies. Several recent reports have demonstrated that short double-stranded RNAs (dsRNAs), used to mediate RNAi, can also induce an interferon-based response resulting in changes in the expression of many interferon-responsive genes. Off-target gene silencing has also been described, bringing into question the validity of certain RNAi-based approaches for studying gene function. We have targeted the plasminogen activator inhibitor-2 (PAI-2 or SERPINB2) mRNA using lentiviral vectors for delivery of U6 promoter-driven PAI-2-targeted short hairpin RNA (shRNA) expression. PAI-2 is reported to have anti-apoptotic activity, thus reduction of endogenous expression may be expected to make cells more sensitive to programmed cell death. Results As expected, we encountered a cytotoxic phenotype when targeting the PAI-2 mRNA with vector-derived shRNA. However, this predicted phenotype was a potent non-specific effect of shRNA expression, as functional overexpression of the target protein failed to rescue the phenotype. By decreasing the shRNA length or modifying its sequence we maintained PAI-2 silencing and reduced, but did not eliminate, cytotoxicity. ShRNA of 21 complementary nucleotides (21 mers) or more increased expression of the oligoadenylate synthase-1 (OAS1) interferon-responsive gene. 19 mer shRNA had no effect on OAS1 expression but long-term selective pressure on cell growth was observed. By lowering lentiviral vector titre we were able to reduce both expression of shRNA and induction of OAS1, without a major impact on the efficacy of gene silencing. Conclusions Our data demonstrate a rapid cytotoxic effect of shRNAs expressed in human tumor cell lines. There appears to be a cut-off of 21 complementary nucleotides below which there is no interferon response while target gene silencing is maintained. Cytotoxicity or OAS1 induction could be reduced by changing shRNA sequence or vector titre, but stable gene silencing could not be maintained in extended cell culture despite persistent marker gene expression from the RNAi-inducing transgene cassette. These results underscore the necessity of careful controls for immediate and long-term RNAi use in mammalian cell systems. Date A point or period of time associated with an event in the lifecycle of the resource 2004 Identifier An unambiguous reference to the resource within a given context DOI: 10.1186/1471-2199-5-9 Source A related resource from which the described resource is derived BMC Molecular Biology Publisher An entity responsible for making the resource available BMC Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Genetics, Cytology Language A language of the resource EN http://socictopen.socict.org/files/original/c7e0eed97bbcfaa22735d53f424b15ce.pdf 573591ac38de3e6b8acf2e6c56edb7c3 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Agricultura sostenible Description An account of the resource Dominio científico: Agricultura sostenible Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Efectos del cambio climático sobre la producción de papa en el municipio de Villapinzón (Cundinamarca-Colombia) a partir del Enfoque Ricardiano Creator An entity primarily responsible for making the resource Krystle Danitza González Velandia, Katia Cecilia Galera Gelvez Description An account of the resource La agricultura es uno de los sectores más vulnerables al cambio climático debido a su directa dependencia de las condiciones climáticas. Para medir los efectos del cambio climático sobre la agricultura se han desarrollado diferentes metodologías, dentro de éstas aparece el enfoque Ricardiano, el cual permite cuantificar los efectos del cambio climático asumiendo que el valor del suelo va a depender de su productividad, y de la capacidad de adaptación de los productores. La presente investigación, muestra los efectos del cambio climático sobre la producción de papa en el municipio de Villapinzón (Cundinamarca-Colombia) a partir del enfoque Ricardiano, en búsqueda de pronósticos que reflejen efectos exclusivos a nivel local. En este caso se encontró que los efectos están ligados a la disponibilidad de agua, acceso a servicios básicos, al casco urbano, y además se encontró que los efectos asociados a aumentos de temperatura en la producción de papa van a ser positivos, ya que el precio de la tierra tenderá a incrementarse para el 2040, 2070 y 2100. Date A point or period of time associated with an event in the lifecycle of the resource 2014 Subject The topic of the resource Agricultura, Cambio climático, Colombia - Villapinzón, Papa, enfoque Ricardiano Identifier An unambiguous reference to the resource within a given context 10.22490/21456453.958 Source A related resource from which the described resource is derived Revista de Investigación Agraria y Ambiental Publisher An entity responsible for making the resource available UNAD Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Agriculture, Environmental sciences Relation A related resource <a href="https://hemeroteca.unad.edu.co/index.php/riaa/article/view/958" target="_blank" rel="noreferrer noopener">https://hemeroteca.unad.edu.co/index.php/riaa/article/view/958</a> http://socictopen.socict.org/files/original/faae1a7ab7e15202486b6378ff82e6c7.pdf c870471cd0d604495bc51b625dc68a3d Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Agricultura sostenible Description An account of the resource Dominio científico: Agricultura sostenible Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Evaluación de impactos ambientales en la cadena de producción de huevos agroecológicos con un enfoque de ciclo de vida Creator An entity primarily responsible for making the resource Krystle Danitza González-Velandia, Andrés Landázury-Correa, Adriana María Chaparro Description An account of the resource [Introducción]: Análisis de impactos ambientales en la producción de huevos, muestran diferencias significativas entre sistemas convencionales y orgánicos, relacionados con la alimentación, la eficiencia energética, la distribución y la gestión de residuos; sin embargo, se desconocen los impactos ambientales en sistemas agroecológicos para la producción de huevo. [Objetivo]: Evaluar los impactos ambientales de la producción agroecológica de huevos empleando un análisis de ciclo de vida. [Metodología]: La evaluación se realizó para 350 gallinas de raza Hy Line Brow de granjas agroecológicas en Cundinamarca, Colombia, contemplando toda la cadena de producción de 1 kg de huevos, es decir, desde la cuna hasta la tumba, siguiendo los lineamientos de la ISO 14040. La información se recolectó durante un año contemplando la elaboración de alimentos, la producción, la distribución, consumo y disposición final. Se consideraron cantidades de materiales, energía y residuos, para posteriormente, evaluar los impactos con la metodología CML-2001. [Resultados]: Los impactos ambientales de un huevo agroecológico son menores hasta en un 30 %, comparado con los de un huevo convencional, principalmente, por la alimentación, que en este caso es producida de forma agroecológica en la misma finca, al aprovechamiento de todos los residuos, el uso de energías alternativas y a que se reducen intermediarios en la cadena de comercialización. [Conclusiones]: Aunque, la producción de huevos agroecológicos tiene menores impactos, es necesario lograr una mayor eficiencia en la gestión del nitrógeno, buscar desinfectantes con menores impactos en el suelo, implementar sistemas de distribución más cortos y menos contaminantes y además propiciar una reutilización de los empaques. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource agroecología; análisis de ciclo de vida; gases de invernadero; huevo agroecológico; producción avícola Identifier An unambiguous reference to the resource within a given context 10.15359/rca.54-2.9 Source A related resource from which the described resource is derived Ciencias Ambientales Publisher An entity responsible for making the resource available Universidad Nacional, Costa Rica Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Human ecology. Anthropogeography, Natural history (General) Relation A related resource <a href="https://www.revistas.una.ac.cr/index.php/ambientales/article/view/14037" target="_blank" rel="noreferrer noopener">https://www.revistas.una.ac.cr/index.php/ambientales/article/view/14037</a> http://socictopen.socict.org/files/original/ac26cd52cf5cda9f8239c4e16b1fc8ae.pdf 43df9096b90634de52e70a682d64db4e Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Stress and Coping in a Self-Isolated Family during COVID-19 Pandemic Creator An entity primarily responsible for making the resource Kryukova T.L., Ekimchik O.A., Opekina T.P., Shipova N.S. Description An account of the resource Objective. To find out the level of stressfulness of inside family isolation in Russia; coping with the negative effects of a pandemic, fear and isolation.Background. The situation of a health threat causes unexpected stress enhancing the fear of get- ting infected, uncertainty, anxiety. The coronavirus disease outbreak has introduced special demands: to lockdown not to get infected. But it also “triggers” adaptive coping behavior. It`s suggested that situa- tion-adequate coping, as well as close relationships based on support, reduce the effects of coronavirus threat. Domestic violence and its effects (physical abuse, mental illness, PTSD) negatively affect family relationships, maybe as deadly as the coronavirus, require immediate prevention.Study design. A mini-longitudinal empirical study was conducted online at the beginning (27.03.2020—12.04.2020) (N1=248) and in the second half of lockdown (28.04.2020—03.05.2020) (N2=310). The role of stressors in changing family relationships has been correlated with the impact of catching COVID-19 threat and self-isolation on the psychological state of family members.Participants. 558 volunteers aged 18—87, including 425 women and 117 men; the majority of them (66%) have their own family — 369 are married/in a relationship; work.Measurements. A questionnaire created by the authors on the basis of international projects as- sessing impact of stress and self-isolation on family relationships, standardized anxiety and depression scales; coping scales.Results. Negative outcomes of the threat of infection and isolation are reduced if coping is ad- equate, emotional support from family members, and their views on the necessary daily changes are con- sistent. Stress levels are higher in single people. Having a partner is important for ways of coping choice.Conclusions. Stress generating from the threat of catching virus/COVID-19 experienced by people during lockdown in close/family relationships is normative as long as they use coping strategies, ade- quate to the situation (acceptance, positive reappraisal) with a low frequency of choosing less adequate strategies. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource Stress, Family, Coping strategies, close relationships, Emotional support, Anxiety/depression, threat of catching coronavirus Identifier An unambiguous reference to the resource within a given context 10.17759/sps.2020110409 Source A related resource from which the described resource is derived Социальная психология и общество Publisher An entity responsible for making the resource available Moscow State University of Psychology and Education Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Psychology