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                <text>A series of compounds based on the dipeptidyl nitrile scaffold were synthesized and assayed for their inhibitory activity against the T. cruzi cysteine protease cruzain. Structure activity relationships (SARs) were established using three, eleven and twelve variations respectively at the P1, P2 and P3 positions. A Ki value of 16 nM was observed for the most potent of these inhibitors which reflects a degree of non-additivity in the SAR. An X-ray crystal structure was determined for the ligand-protein complex for the structural prototype for the series. Twenty three inhibitors were also evaluated for their anti-trypanosomal effects and an EC50 value of 28 μM was observed for the most potent of these. Although there remains scope for further optimization, the knowledge gained from this study is also transferable to the design of cruzain inhibitors based on warheads other than nitrile as well as alternative scaffolds.</text>
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                <text>El derecho humano al abastecimiento y al saneamiento (DHAS) constituye hoy en España y en Europa la bandera de un movimiento que se articula en torno al concepto del agua como bien común y que se orienta al objetivo de construir un modelo de gestión pública participativa y transparente. La materialización efectiva del DHAS se relaciona discursivamente con la titularidad pública o privada de los operadores de los servicios urbanos de agua, lo que ha contribuido a la reactivación de los debates sobre la necesidad de conservar o recuperar el carácter público de estos servicios, y sobre la necesidad de generar marcos jurídicos que garanticen políticas de democracia local efectiva. A esta dimensión sociopolítica, se añade otra característica: el movimiento del DHAS en España sintoniza en discurso y articulación organizativa con las perspectivas socio-eco-integradoras de la gestión del agua como recurso natural, de los ecosistemas acuáticos. Ésta es una cualidad importante y en cierta manera distintiva de la experiencia española, que contrasta con los desencuentros y conflictos que frecuentemente caracterizan a las perspectivas social y ambiental en los movimientos de defensa del agua, y en general de los recursos naturales. Complementariamente a lo anterior, este artículo presenta un nuevo enfoque de la tipología de pobrezas hídricas. La reciente recepción del DHAS en los países europeos se ha focalizado especialmente en la asequibilidad (prohibición de cortes, garantía del mínimo vital, tarifas sociales) y en las implicaciones para la gobernanza (transparencia, rendición de cuentas) y el modelo de gestión (publico versus privado). No obstante, a lo largo de la investigación que se presenta, se ha constatado que la accesibilidad sigue siendo un problema significativo en ciertas regiones europeas, relacionado especialmente con la existencia de asentamientos marginales, chabolismo, personas sin hogar o trabajadores temporeros inmigrantes en áreas rurales. Finalmente, este artículo aborda la cuestión de la regulación legal del derecho humano al agua en España, analizando las claves de este proceso y presentando las últimas propuestas del movimiento del DHAS en el que sus autores conceptualmente se sitúan. Desde un punto de vista teórico (ecología política urbana) y metodológico (investigación-acción participativa transdisciplinar), el artículo se ha desarrollado en el doble marco en el que los autores se desenvuelven. Por una parte, el grupo de trabajo de ciclo urbano del agua de la Fundación Nueva Cultura de Agua (https://fnca.eu/oppa/ciclo-urbano-del-agua); y, por otra, la Red de Excelencia de la Agencia Estatal de Investigación sobre pobreza hídrica (WAPONET, CSO2017-90702-REDT, https://waponet.org/approach/).</text>
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                <text>Resumo: Ascia monuste orseis (Lepidoptera: Pieridae) é uma praga-chave de brassicáceas, cujo controle ainda carece de informações sobre ferramentas alternativas de manejo. Assim, este estudo avaliou, inicialmente em condições de laboratório, a atividade ovicida e larvicida de extratos aquosos de sete espécies vegetais e de um bioinseticida à base de limonoides (DalNeem®) diante dessa praga. Além disso, também foi avaliada a ação antialimentar dos tratamentos em testes com e sem chance de escolha. DalNeem® e extratos aquosos de pó de fumo (Nicotiana tabacum), de eucalipto (Eucalyptus tereticornis) e de timbó (Ateleia glazioveana) reduziram a viabilidade de ovos, sendo o extrato de pó de fumo o tratamento com maior atividade ovicida. Por sua vez, o extrato de pó de fumo e DalNeem® apresentaram a maior ação larvicida via ingestão. Todos os derivados botânicos testados causaram efeito antialimentar para o curuquerê-da-couve. Em teste no campo, o extrato aquoso de pó de fumo apresentou eficácia similar a um inseticida sintético à base de deltametrina (Decis® 25CE). Dessa forma, o extrato aquoso de pó de fumo e o inseticida botânico DalNeem® apresentam potencial para ser utilizados no manejo de A. monuste orseis.   </text>
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                <text>Ascia monuste orseis, Azadirachta indica, Nicotiana tabacum. Action of botanical insecticides on kale leafworm</text>
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          <element elementId="48">
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                <text>Revista Agropecuária Catarinense</text>
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          <element elementId="45">
            <name>Publisher</name>
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              <elementText elementTextId="225657">
                <text>Empresa de Pesquisa Agropecuária e Extensão Rural de Santa Catarina - Epagri</text>
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            </elementTextContainer>
          </element>
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                <text>Agriculture (General)</text>
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                <text>&lt;a href="https://publicacoes.epagri.sc.gov.br/RAC/article/view/74" target="_blank" rel="noreferrer noopener"&gt;https://publicacoes.epagri.sc.gov.br/RAC/article/view/74&lt;/a&gt;</text>
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                  <text>Coronavirus</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Unexpected diversity of cellular immune responses against Nef and Vif in HIV-1-infected patients who spontaneously control viral replication.</text>
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              <elementText elementTextId="3147">
                <text>Leandro F Tarosso, Mariana M. Sauer, Sabri Sanabani, Maria Teresa Giret, Helena I. Tomiyama, John Sidney, Shari M. Piaskowski, Ricardo S. Diaz, Ester C. Sabino, Alessandro Sette, Jorge Kalil Filho, David I. Watkins, Esper G Kallas</text>
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                <text>HIV-1-infected individuals who spontaneously control viral replication represent an example of successful containment of the AIDS virus. Understanding the anti-viral immune responses in these individuals may help in vaccine design. However, immune responses against HIV-1 are normally analyzed using HIV-1 consensus B 15-mers that overlap by 11 amino acids. Unfortunately, this method may underestimate the real breadth of the cellular immune responses against the autologous sequence of the infecting virus.Here we compared cellular immune responses against nef and vif-encoded consensus B 15-mer peptides to responses against HLA class I-predicted minimal optimal epitopes from consensus B and autologous sequences in six patients who have controlled HIV-1 replication. Interestingly, our analysis revealed that three of our patients had broader cellular immune responses against HLA class I-predicted minimal optimal epitopes from either autologous viruses or from the HIV-1 consensus B sequence, when compared to responses against the 15-mer HIV-1 type B consensus peptides.This suggests that the cellular immune responses against HIV-1 in controller patients may be broader than we had previously anticipated.</text>
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                <text>DOI: 10.1371/journal.pone.0011436</text>
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              <elementText elementTextId="3151">
                <text>PLoS ONE</text>
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                <text>Public Library of Science (PLoS)</text>
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                  <text>Agricultura sostenible</text>
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                  <text>Dominio científico: Agricultura sostenible</text>
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            <description>A name given to the resource</description>
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                <text>Análise de crescimento do girassol em função do suprimento de fósforo e boro</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="242102">
                <text>Leandro Gonçalves dos Santos, Ubiratan Oliveira Souza, Zuleide Silva de Carvalho, Dário Costa Primo, Anacleto Ranulfo dos Santos</text>
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            <description>An account of the resource</description>
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                <text>A cultura do girassol é de grande importância no cenário mundial por ser uma planta de múltiplas finalidades. No Brasil, o interesse do produtor por esta cultura vem crescendo a cada ano, pois além do destacado teor de óleo nos aquênios, a planta pode ser utilizada para alimentação animal na forma de silagem. Outro fator que merece destaque é que o Governo Federal em parceria com o Governo do Estado, a Petrobras S.A. e as prefeituras dos municípios envolvidos vem incentivando o plantio da oleaginosa através da agricultura familiar gerando renda aos pequenos agricultores e desenvolvimento para a região. O objetivo deste estudo foi analisar o crescimento do girassol (Helianthus annuus L.) híbrido 'Helio 358' em diferentes níveis de fósforo e boro no solo, cultivado em sistema convencional no município de Cruz das Almas, Bahia. O experimento foi conduzido no Campus da Universidade Federal do Recôncavo da Bahia, em Latossolo Amarelo coeso, no período de Julho a Novembro de 2008. O delineamento experimental utilizado foi em esquema fatorial 5x2, sendo cinco doses de fósforo (0; 40; 80; 120 e 200 kg ha-1 de P) e duas de boro (0 e 2 kg ha-1 de B), com os tratamentos distribuídos em blocos casualizados, com três repetições e amostragens na parcela a cada quinze dias. Em cada coleta avaliou-se o rendimento de matéria seca total da parte aérea, a área foliar, a altura das plantas e o diâmetro das hastes. Através da variação da matéria seca e da área foliar obteve-se a taxa de crescimento da cultura, a taxa de crescimento relativo e taxa assimilatória líquida. Verificou-se que não houve efeito significativo da interação entre fósforo e boro nas variáveis em estudo, contudo houve significância para a aplicação isolada de fósforo no crescimento do girassol. A aplicação de fósforo acelerou o desenvolvimento do girassol e o florescimento, antecipando a colheita e a obtenção do índice de área foliar ótimo.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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                <text>2014</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="242105">
                <text>Helianthus annuus L, adubação fosfatada, índices fisiológicos</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="242106">
                <text>10.14393/BJ-v31n2a2015-22316</text>
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            <name>Source</name>
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                <text>Bioscience Journal</text>
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                <text>Edufu</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Agriculture, Biology (General)</text>
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                <text>&lt;a href="http://www.seer.ufu.br/index.php/biosciencejournal/article/view/22316" target="_blank" rel="noreferrer noopener"&gt;http://www.seer.ufu.br/index.php/biosciencejournal/article/view/22316&lt;/a&gt;</text>
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                <text>Netflix, “más acá” de los contenidos : la interfaz y la plataforma</text>
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                <text>Leandro González</text>
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                <text>[es] El artículo analiza Netflix con prescindencia de sus contenidos. Desde el marco de la ecología de los medios, argumenta que las nociones de interfaz y plataforma constituyen herramientas propicias para comprender este tipo de fenómenos contemporáneos. El texto se organiza del siguiente modo: en primer lugar, se sitúa el objeto de estudio bajo la teoría de la no neutralidad del código, con referencias al origen y a la actualidad de la misma. En segundo lugar, se busca responder qué implica la aparición de Netflix en la historia de la mediatización audiovisual, con el objetivo de reponer el contexto mediático y dar cuenta de los múltiples vínculos que guarda con sus antecedentes históricos (en particular en lo que respecta a géneros y estilos). En tercer lugar, se despliega un análisis empírico y sincrónico de diversas interfaces de la plataforma: partiendo de la comparación en distintos dispositivos técnicos, se argumentará que no existe una única interfaz de Netflix, sino que ésta varía de acuerdo a los condicionamientos de software y hardware. El texto cierra con algunas reflexiones finales que, retomando los principales hallazgos, apuntan a mantener abierta la mirada analítica y reflexiva sobre el dinamismo de las plataformas mediáticas.[en] The article analyzes Netflix regardless of its contents. From the framework of the ecology of the media, it argues that the notions of inter face and plat form constitute propitious tools to understand this type of contemporary phenomena. The text is organized as follows: first, the object of study is placed under the theory of non-neutrality of the code, with references to its origin and actuality. Secondly, we seek to answer what the appearance of Netflix entails in the history of audiovisual mediatization, with the aim of replenishing the media context and giving account of the multiple links it maintains with its historical antecedents (in particular with regard to genres and styles). Thirdly, an empirical and synchronic analysis of various inter faces of the plat form is deployed: starting from the comparison in different technical devices, it will be argued that there is not a single Netflix interface, but that it varies according to soft ware and hardware constraints. The text closes with some final reflections that, taking up the main findings, aim to keep open the analytical and reflective view on the dynamism of media plat forms.</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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                <text>Media  Ecology, Netflix, apps, ecología de los medios, interface, interfaz, plataforma</text>
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                <text>10.35305/lt.v24i1.721</text>
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                <text>La Trama de la Comunicación</text>
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                <text>Universidad Nacional Rosario</text>
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                <text>Communication. Mass media, Language and Literature, Philology. Linguistics</text>
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                <text>&lt;a href="https://latrama.fcpolit.unr.edu.ar/index.php/trama/article/view/721/487" target="_blank" rel="noreferrer noopener"&gt;https://latrama.fcpolit.unr.edu.ar/index.php/trama/article/view/721/487&lt;/a&gt;</text>
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                <text>For a significant geography: readings on urban agriculture and the importance of fieldwork for research and teaching geography / Por uma Geografia significativa: leituras sobre a agricultura urbana e a importância do trabalho de campo para a pesquisa e o ensino de Geografia</text>
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                <text>Leandro Matias dos Santos, Michelle Emanuelle Silva, Cirlene Jeane Santos e Santos</text>
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            <description>An account of the resource</description>
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                <text>This article is based on the fieldwork carried out by researchers from NUAGRARIOtogether with the students of the 5th period of the subject Agrarian Geography, of the GeographyCourses (licenciatura and baccalaureate), Federal University of Alagoas on Urban Agriculture, in themunicipality of Maceió -AL. In order to verify if the selected areas virtually contained the practice ofurban agriculture. In this way, the main objective of the article is to demonstrate the importance of thework of campo no process of social formation through the understanding, observation and recognition ofreality, highlighting the geographic contents that can be approached through this methodology.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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                <text>2018</text>
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            <name>Subject</name>
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                <text>Fieldwork. Teaching Geography, urban agriculture</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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                <text>10.17648/diversitas-journal-v3i1.596</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="142688">
                <text>Diversitas Journal</text>
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            <name>Publisher</name>
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                <text>Universidade Estadual de Alagoas</text>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Social Sciences, Education, Science</text>
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                <text>&lt;a href="https://doi.org/10.17648/diversitas-journal-v3i1.596" target="_blank" rel="noreferrer noopener"&gt;https://doi.org/10.17648/diversitas-journal-v3i1.596&lt;/a&gt;</text>
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        <src>http://socictopen.socict.org/files/original/5b13bf1244d874d30f75702d2ee8cd64.pdf</src>
        <authentication>c892153754f1a5225a7a1423539c123b</authentication>
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            <element elementId="50">
              <name>Title</name>
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                  <text>Agricultura sostenible</text>
                </elementText>
              </elementTextContainer>
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            <element elementId="41">
              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Agricultura sostenible</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
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                <text>Identificação, bioecologia e estratégias de monitoramento da mosca-da-grama-bermuda: uma espécie-praga exótica invasora no Brasil</text>
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            </elementTextContainer>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="225580">
                <text>Leandro Prado Ribeiro, Alexandre Carlos Menezes Netto</text>
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          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
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                <text>A mosca-da-grama-bermuda, Atherigona (Atherigona) reversura Villeneuve (Diptera: Muscidae), espécie até então não documentada na América do Sul, foi identificada no início de 2015 em pastagens de Cynodon dactylon (L.) Pers. cv. Jiggs em municípios da mesorregião do Oeste Catarinense, Brasil. Em face do potencial impacto de espécies-praga exóticas na produtividade dos cultivos agrícolas e dos significativos danos causadas por A. reversura em outros países, nesse informativo são reunidas informações sobre a origem, as formas de detecção e identificação, aspectos da bioecologia da mosca-da-grama-bermuda, bem como são discutidas estratégias para o seu monitoramento em pastagens.</text>
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            <name>Date</name>
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                <text>2017</text>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
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                <text>Atherigona reversura, Cynodon dactylon, Diptera, manejo integrado de pragas</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="225584">
                <text>Revista Agropecuária Catarinense</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="225585">
                <text>Empresa de Pesquisa Agropecuária e Extensão Rural de Santa Catarina - Epagri</text>
              </elementText>
            </elementTextContainer>
          </element>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Agriculture (General)</text>
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                <text>&lt;a href="https://publicacoes.epagri.sc.gov.br/RAC/article/view/120" target="_blank" rel="noreferrer noopener"&gt;https://publicacoes.epagri.sc.gov.br/RAC/article/view/120&lt;/a&gt;</text>
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