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                <text>Effectiveness of lopinavir/ritonavir on COVID-19-related pneumonia in a child with COVID-19-associated Kawasaki disease.</text>
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                <text>The large outbreak of coronavirus disease 2019 (COVID-19) is spreading all over the world rapidly. There have recently been publications in the literature regarding the relationship between COVID-19 and Kawasaki disease, but there is no sufficient knowledge about the treatment and follow-up.</text>
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                <text>2021</text>
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                <text>10.1017/S1047951120004291</text>
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                <text>Cardiology in the young</text>
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                <text>Silent War to Emerging or Re-emerging Respiratory Infection Diseases Badly Kept in Mind</text>
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                <text>Zhancheng Gao, Yali Zheng</text>
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                <text>DOI: 10.4103/0366-6999.162492</text>
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                <text>Chinese Medical Journal</text>
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                <text>Wolters Kluwer</text>
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                <text>Investor Attention and Stock Market under the Outbreak of the COVID-19-Based on the Data of Mask Concept Stocks</text>
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                <text>Zhang Bokai, Wang Xuan, Rao Meng</text>
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                <text>With the outbreak of the COVID-19 epidemic, masks have become an important medical material widely concerned by society, which also affects investor sentiment and mask concept stock prices. This article focuses on the impact of investor attention on the rate of return of mask concept stocks. Through the establishment of a panel fixed effect model, it is found that during the epidemic, investor attention to masks has a significant positive impact on the rate of return on mask concept stocks. Then, this article takes the epidemic-related indicators as instrumental variables and uses a two-stage least squares method to carry out the endogenous test, which further verifies the above conclusions and finally puts forward reasonable suggestions.</text>
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              <elementText elementTextId="52016">
                <text>10.1051/e3sconf/202021402024</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="52017">
                <text>Epidemiology and Health</text>
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            <name>Publisher</name>
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              <elementText elementTextId="52018">
                <text>Korean Society of Epidemiology</text>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Environmental sciences</text>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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              </elementTextContainer>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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          <element elementId="50">
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                <text>Individual Perceived Stress Mediates Psychological Distress in Medical Workers During COVID-19 Epidemic Outbreak in Wuhan</text>
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            <name>Creator</name>
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              <elementText elementTextId="45259">
                <text>Zhang C, Peng D, Lv L, Zhuo K, Yu K, Shen T, Xu Y, Wang Z</text>
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            <description>An account of the resource</description>
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                <text>Chen Zhang,1&amp;ndash; 3 Daihui Peng,1&amp;ndash; 3 Lu Lv,4 Kaiming Zhuo,1,3 Kai Yu,5 Tian Shen,4 Yifeng Xu,1,2 Zhen Wang1&amp;ndash; 3 1Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, People&amp;rsquo;s Republic of China; 2Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, People&amp;rsquo;s Republic of China; 3Shanghai Psychological Medical Team Supporting Hubei, Shanghai, People&amp;rsquo;s Republic of China; 4School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, People&amp;rsquo;s Republic of China; 5MoE Key Laboratory of Artificial Intelligence, AI Institute Shanghai Jiao Tong University, Shanghai, People&amp;rsquo;s Republic of ChinaCorrespondence: Zhen Wang Email wangzhen@smhc.org.cnYifeng Xu Email xuyifeng@smhc.org.cnBackground: Since the novel coronavirus disease (COVID-19) outbreak in Wuhan, thousands of medical workers have been dispatched to support Wuhan against the virus. The purpose of this study was to identify the independent risk factors for psychological distress in order to develop a more effective strategy and precise evidence-based psychological intervention for medical workers.Methods: This multisite cross-sectional survey recruited doctors and nurses from local and nonlocal medical teams working at 16 hospitals in Wuhan to complete this online survey from February to March, 2020. Psychological status was evaluated through Perceived Stress Scales (PSS), Patient Health Questionnaire-9 (PHQ-9), General Anxiety Disorder Scale (GAD-7) and Acute Stress Disorder Scale (ASDS).Results: Of 966 participants, the prevalence of stress (95.9%), depression (46.0%) and anxiety (39.3%) were high. Local medical workers exhibited even higher scores of PSS, PHQ-9, GAD-7 and ASDS than those from outside Hubei (P&amp;lt; 0.001). Females had more severe perceived stress, depression and anxiety than males (P&amp;lt; 0.001). Multiple logistic regression showed that perceived stress is associated with increased odds of depression (OR=1.413; 95% CI: 1.338&amp;ndash; 1.493; P&amp;lt; 0.001) and anxiety (OR=1.515; 95% CI: 1.407&amp;ndash; 1.631; P&amp;lt; 0.001).Conclusion: Our findings demonstrated a high prevalence of stress, depression, anxiety and acute distress among medical workers on the front-line during the COVID-19 outbreak in Wuhan. The level of psychological impact may be mediated by individual perceptions of stressful events.Keywords: COVID-19, stress, anxiety, depression, Wuhan</text>
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                <text>2020</text>
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            <name>Subject</name>
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                <text>Anxiety, covid-19, Wuhan, Stress, Depression</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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                <text>Biotemas</text>
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            <name>Publisher</name>
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              <elementText elementTextId="45264">
                <text>Universidade Federal de Santa Catarina</text>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Neurology. Diseases of the nervous system, Neurosciences. Biological psychiatry. Neuropsychiatry</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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                <text>ZCURVE_V: a new self-training system for recognizing protein-coding genes in viral and phage genomes</text>
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              <elementText elementTextId="6695">
                <text>Zhang Chun-Ting, Guo Feng-Biao</text>
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                <text>Abstract Background It necessary to use highly accurate and statistics-based systems for viral and phage genome annotations. The GeneMark systems for gene-finding in virus and phage genomes suffer from some basic drawbacks. This paper puts forward an alternative approach for viral and phage gene-finding to improve the quality of annotations, particularly for newly sequenced genomes. Results The new system ZCURVE_V has been run for 979 viral and 212 phage genomes, respectively, and satisfactory results are obtained. To have a fair comparison with the currently available software of similar function, GeneMark, a total of 30 viral genomes that have not been annotated by GeneMark are selected to be tested. Consequently, the average specificity of both systems is well matched, however the average sensitivity of ZCURVE_V for smaller viral genomes (&lt; 100 kb), which constitute the main parts of viral genomes sequenced so far, is higher than that of GeneMark. Additionally, for the genome of Amsacta moorei entomopoxvirus, probably with the lowest genomic GC content among the sequenced organisms, the accuracy of ZCURVE_V is much better than that of GeneMark, because the later predicts hundreds of false-positive genes. ZCURVE_V is also used to analyze well-studied genomes, such as HIV-1, HBV and SARS-CoV. Accordingly, the performance of ZCURVE_V is generally better than that of GeneMark. Finally, ZCURVE_V may be downloaded and run locally, particularly facilitating its utilization, whereas GeneMark is not downloadable. Based on the above comparison, it is suggested that ZCURVE_V may serve as a preferred gene-finding tool for viral and phage genomes newly sequenced. However, it is also shown that the joint application of both systems, ZCURVE_V and GeneMark, leads to better gene-finding results. The system ZCURVE_V is freely available at: http://tubic.tju.edu.cn/Zcurve_V/. Conclusion ZCURVE_V may serve as a preferred gene-finding tool used for viral and phage genomes, especially for anonymous viral and phage genomes newly sequenced.</text>
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                <text>2006</text>
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                <text>DOI: 10.1186/1471-2105-7-9</text>
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                <text>BMC Bioinformatics</text>
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                <text>Biology (General), Computer applications to medicine. Medical informatics</text>
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            <description>A language of the resource</description>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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              </elementTextContainer>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Explaining Organizational Citizenship Behavior Among Chinese Nurses Combating COVID-19</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="67845">
                <text>Zhang H, Zhao Y, Zou P, Lin S, Mu S, Deng Q, Du C, Zhou G, Wu J, Gan L</text>
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          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
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              <elementText elementTextId="67846">
                <text>Hui Zhang,1,* Yi Zhao,2,* Ping Zou,3 Shuanghong Lin,2 Shaoyu Mu,4 Qiansu Deng,5 Chunxue Du,1 Guanglan Zhou,1 Jiang Wu,2 Lu Gan2 1Department of Cardiology, Guizhou Provincial People&amp;rsquo;s Hospital, Guiyang, 550002, Guizhou, People&amp;rsquo;s Republic of China; 2Department of Nursing, Hubei NO.3 People&amp;rsquo;s Hospital of Jianghan University, Wuhan, People&amp;rsquo;s Republic of China; 3Department of Scholar Practitioner Program, School of Nursing, Nipissing University, Toronto, M6J 3S3, Ontario, Canada; 4Department of Nursing, Nursing College of Chongqing Medical University, Chongqing, 400016, People&amp;rsquo;s Republic of China; 5Department of Nursing, Chongqing Traditional Chinese Medicine Hospital, Chongqing, 400011, People&amp;rsquo;s Republic of China*These authors contributed equally to this workCorrespondence: Shuanghong LinDepartment of Nursing, Hubei NO.3 People&amp;rsquo;s Hospital of Jianghan University, Wuhan, People&amp;rsquo;s Republic of ChinaTel +8618771059373Email 18771059373@163.comBackground: Little is known about the associated factors with organizational citizenship behavior among Chinese nurses combating COVID-19. The aim of the present study was to investigate the relationships between autonomy, optimism, role conflict, work engagement, and organizational citizenship behavior based on moderated mediation models among Chinese nurses combating COVID-19.Methods: This cross-sectional study was performed on a sample of 368 nurses supporting the COVID-19 epidemic in Wuhan Leishenshan Hospital, China. According to the Job Demands-Resources model, two moderated mediation models were tested, in which autonomy/optimism was associated with organizational citizenship behavior through work engagement, when role conflict served as a moderator.Results: This current study found the mediating effect of work engagement and the moderating effect of role conflict on the relationship between autonomy/optimism and organizational citizenship behavior among nurses. Of note, nurses working in the COVID-19 epidemic viewed role conflict as challenge job demands rather than hindrance job demands.Conclusion: Based on the findings, organizational citizenship behavior can be affected by work engagement and role conflict. Nursing management is suggested to put emphasis on work engagement and role conflict among nurses supporting the COVID-19 epidemic.Keywords: the job demands-resources model, autonomy, optimism, organizational citizenship behavior, nurses, COVID-19</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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                <text>2021</text>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
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              <elementText elementTextId="67848">
                <text>covid-19, nurses, optimism, autonomy, Organizational Citizenship Behavior, the Job Demands-Resources model</text>
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          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="67849">
                <text>Biotemas</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="67850">
                <text>Universidade Federal de Santa Catarina</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="67851">
                <text>Public aspects of medicine</text>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
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                <elementText elementTextId="1">
                  <text>Coronavirus</text>
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              </elementTextContainer>
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            <element elementId="41">
              <name>Description</name>
              <description>An account of the resource</description>
              <elementTextContainer>
                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
                </elementText>
              </elementTextContainer>
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    <itemType itemTypeId="1">
      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
    </itemType>
    <elementSetContainer>
      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
        <elementContainer>
          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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              <elementText elementTextId="20799">
                <text>Moderate mutation rate in the SARS coronavirus genome and its implications</text>
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          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="20800">
                <text>Zhang Keqin, Zhong Yixi, Wu Xiaozhuang, Li Haipeng, Zhao Zhongming, Zhang Ya-ping, Boerwinkle Eric, Fu Yunxin</text>
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          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
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              <elementText elementTextId="20801">
                <text>Abstract Background The outbreak of severe acute respiratory syndrome (SARS) caused a severe global epidemic in 2003 which led to hundreds of deaths and many thousands of hospitalizations. The virus causing SARS was identified as a novel coronavirus (SARS-CoV) and multiple genomic sequences have been revealed since mid-April, 2003. After a quiet summer and fall in 2003, the newly emerged SARS cases in Asia, particularly the latest cases in China, are reinforcing a wide-spread belief that the SARS epidemic would strike back. With the understanding that SARS-CoV might be with humans for years to come, knowledge of the evolutionary mechanism of the SARS-CoV, including its mutation rate and emergence time, is fundamental to battle this deadly pathogen. To date, the speed at which the deadly virus evolved in nature and the elapsed time before it was transmitted to humans remains poorly understood. Results Sixteen complete genomic sequences with available clinical histories during the SARS outbreak were analyzed. After careful examination of multiple-sequence alignment, 114 single nucleotide variations were identified. To minimize the effects of sequencing errors and additional mutations during the cell culture, three strategies were applied to estimate the mutation rate by 1) using the closely related sequences as background controls; 2) adjusting the divergence time for cell culture; or 3) using the common variants only. The mutation rate in the SARS-CoV genome was estimated to be 0.80 – 2.38 × 10-3 nucleotide substitution per site per year which is in the same order of magnitude as other RNA viruses. The non-synonymous and synonymous substitution rates were estimated to be 1.16 – 3.30 × 10-3 and 1.67 – 4.67 × 10-3 per site per year, respectively. The most recent common ancestor of the 16 sequences was inferred to be present as early as the spring of 2002. Conclusions The estimated mutation rates in the SARS-CoV using multiple strategies were not unusual among coronaviruses and moderate compared to those in other RNA viruses. All estimates of mutation rates led to the inference that the SARS-CoV could have been with humans in the spring of 2002 without causing a severe epidemic.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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              <elementText elementTextId="20802">
                <text>2004</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
            <elementTextContainer>
              <elementText elementTextId="20803">
                <text>DOI: 10.1186/1471-2148-4-21</text>
              </elementText>
            </elementTextContainer>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="20804">
                <text>BMC Evolutionary Biology</text>
              </elementText>
            </elementTextContainer>
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          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="20805">
                <text>BMC</text>
              </elementText>
            </elementTextContainer>
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          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="20806">
                <text>Evolution</text>
              </elementText>
            </elementTextContainer>
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          <element elementId="44">
            <name>Language</name>
            <description>A language of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="20807">
                <text>EN</text>
              </elementText>
            </elementTextContainer>
          </element>
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        <src>http://socictopen.socict.org/files/original/9dc9a534e976dc17d5fc9b5db99a051e.pdf</src>
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          <name>Dublin Core</name>
          <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
              <elementTextContainer>
                <elementText elementTextId="1">
                  <text>Coronavirus</text>
                </elementText>
              </elementTextContainer>
            </element>
            <element elementId="41">
              <name>Description</name>
              <description>An account of the resource</description>
              <elementTextContainer>
                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
                </elementText>
              </elementTextContainer>
            </element>
          </elementContainer>
        </elementSet>
      </elementSetContainer>
    </collection>
    <itemType itemTypeId="1">
      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
    </itemType>
    <elementSetContainer>
      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
        <elementContainer>
          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="39922">
                <text>Analysis of the Public Health Functions of the Chinese Government in the Prevention and Control of COVID-19</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="39923">
                <text>Zhang P</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="39924">
                <text>Pengfei Zhang School of Labor and Human Resources, Renmin University of China, Beijing, People&amp;rsquo;s Republic of ChinaCorrespondence: Pengfei ZhangSchool of Labor and Human Resources, No. 59, Zhongguancun Street, Beijing 100872, People&amp;rsquo;s Republic of ChinaEmail pfzoffice@ruc.edu.cnBackground: The focus of the study is to assess the defects of the public health functions of the Chinese government in the prevention and control of COVID-19 and to explore ways to improve the public health functions of the Chinese government.Methods: This study adopted a qualitative design. A logical framework based on the theoretical underpinning of public health functions of the government in the prevention and control of a major public health crisis was constructed. We compared the public health functions of the Chinese government and the effectiveness of these functions for COVID-19.Results: The defects of the public health functions of the Chinese government in the prevention and control of COVID-19 include a lack of crisis prediction, initiative and timeliness in crisis early warning functions; weak crisis security functions; and a lack of functions for handling the aftermath. The Chinese government should improve its crisis early warning functions, strengthen its crisis security functions, and establish functions for handling the aftermath.Conclusion: The defects of the public health functions of the Chinese government in the prevention and control of COVID-19 can provide referential value for other countries. Especially, by continuously improving the construction of standard pandemic early warning procedures and regulations, optimizing the pandemic treatment system, and strengthening the fairness and accessibility of medical services, countries with severe pandemic situations may be able to reduce the impact of COVID-19 on public health more efficiently.Keywords: COVID-19, public health functions, prevention and control, defects</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="39925">
                <text>2021</text>
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            </elementTextContainer>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="39926">
                <text>covid-19, Prevention and control, defects, public health functions</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="39927">
                <text>Biotemas</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="39928">
                <text>Universidade Federal de Santa Catarina</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="39929">
                <text>Public aspects of medicine</text>
              </elementText>
            </elementTextContainer>
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          <name>Dublin Core</name>
          <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
          <elementContainer>
            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
              <elementTextContainer>
                <elementText elementTextId="1">
                  <text>Coronavirus</text>
                </elementText>
              </elementTextContainer>
            </element>
            <element elementId="41">
              <name>Description</name>
              <description>An account of the resource</description>
              <elementTextContainer>
                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
                </elementText>
              </elementTextContainer>
            </element>
          </elementContainer>
        </elementSet>
      </elementSetContainer>
    </collection>
    <itemType itemTypeId="1">
      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
    </itemType>
    <elementSetContainer>
      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
        <elementContainer>
          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="67245">
                <text>Beware of Steroid-Induced Avascular Necrosis of the Femoral Head in the Treatment of COVID-19&amp;mdash;Experience and Lessons from the SARS Epidemic</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="67246">
                <text>Zhang S, Wang C, Shi L, Xue Q</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="67247">
                <text>Shenqi Zhang,1&amp;ndash; 3 Chengbin Wang,3 Lei Shi,1 Qingyun Xue1,2 1Department of Orthopedics, Beijing Hospital, National Center of Gerontology, Beijing, People&amp;rsquo;s Republic of China; 2Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, People&amp;rsquo;s Republic of China; 3Department of Joint and Sports Medicine, Zaozhuang Municipal Hospital Affiliated to Jining Medical University, Shandong, People&amp;rsquo;s Republic of ChinaCorrespondence: Qingyun XueBeijing Hospital, National Center of Gerontology, No. 1 Dongdan Dahua Road, Dongcheng District, Beijing, 100730, People&amp;rsquo;s Republic of ChinaTel +8613188929900Email bjyyxqy@163.comSummary: The recent outbreak of coronavirus disease 2019 (COVID-19) has become a global epidemic. Corticosteroids have been widely used in the treatment of severe acute respiratory syndrome (SARS), and the pathological findings seen in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are very similar to those observed in severe acute respiratory syndrome-related coronavirus (SARS-CoV) infection. However, the long-term use of corticosteroids (especially at high doses) is associated with potentially serious adverse events, particularly steroid-induced avascular necrosis of the femoral head (SANFH). In today&amp;rsquo;s global outbreak, whether corticosteroid therapy should be used, the dosage and duration of treatment, and ways for the prevention, early detection, and timely intervention of SANFH are some important issues that need to be addressed. This review aims to provide a reference for health care providers in COVID-19 endemic countries and regions.Article Focus: Hormones are a double-edged sword. This review aims to provide a reference for health care providers in coronavirus disease 2019 (COVID-19) endemic countries and regions, especially with respect to the pros and cons of corticosteroid use in the treatment of patients with COVID-19.Key Messages: In today&amp;rsquo;s global outbreak, whether corticosteroid therapy should be used, the dosage and duration of treatment, and ways for the prevention, early detection, and timely intervention of SANFH are some important issues that need to be addressed.Strengths and Limitations: Since SARS was mainly prevalent in China at that time, many evidences in this paper came from the reports of Chinese scholars. There is a bias in the selection of data, which may ignore the differences in environment, race, living habits, medical level and so on. SANFH may be the result of multiple factors. Whether the virus itself is an independent risk factor for SANFH has not been confirmed. In this paper, through literature retrieval, some reference opinions on glucocorticoid usage, diagnosis and treatment of SANFH are given. However, due to the lack of large-scale research data support, it can not be used as the gold standard for the above problems.Keywords: COVID-19, steroid, necrosis of the femoral head, SARS</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="67248">
                <text>2021</text>
              </elementText>
            </elementTextContainer>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="67249">
                <text>SARS, covid-19, steroid, necrosis of the femoral head</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="67250">
                <text>Biotemas</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Virtual Reality Exposure Therapy (VRET) for Anxiety Due to Fear of COVID-19 Infection: A Case Series</text>
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                <text>Zhang W, Paudel D, Shi R, Liang J, Liu J, Zeng X, Zhou Y, Zhang B</text>
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                <text>Wanling Zhang,1,2,* Dhirendra Paudel,2,3,* Rui Shi,1 Jie Liang,1 Jingwen Liu,1 Xiansheng Zeng,1 Yunfei Zhou,1 Bin Zhang2,4 1Shenzhen Mental Health Center, Shenzhen Kangning Hospital, Shenzhen 518118, People&amp;rsquo;s Republic of China; 2Center for Brain Science and Brain-Inspired Intelligence, Guangdong-Hong Kong-Macao Greater Bay Area, Southern Medical University, Guangzhou, 510515, People&amp;rsquo;s Republic of China; 3Department of Psychiatry, Dhaulagiri Hospital, Baglung 33300, Gandaki, Nepal; 4Department of Psychiatry, Nanfang Hospital, Southern Medical University, Guangzhou 510515, People&amp;rsquo;s Republic of China*These authors contributed equally to this workCorrespondence: Bin ZhangDepartment of Psychiatry, Nanfang Hospital, Southern Medical University, Guangzhou 510515, People&amp;rsquo;s Republic of ChinaTel +86-20-62786731Email zhang73bin@hotmail.comYunfei ZhouShenzhen Mental Health Center, Shenzhen Kangning Hospital, Shenzhen 518118, People&amp;rsquo;s Republic of ChinaTel +86-755-25615965Email drzyf2007@163.comAbstract: Virtual reality exposure therapy (VRET) is becoming popular for treating phobia and anxiety disorder. The recent pandemic of COVID-19 not only causes infection per se but also has an impact on mental health. This case series aimed to explore the role of VRET in the intervention of psychiatric illnesses with chief complaints of fear of COVID-19 infection. In vivo exposure therapy for fear of COVID-19 infection is not possible due to the risk of virus infection; in this scenario, the VRET provides an immersive experience and can act as adjunctive therapy for treating phobias and anxiety disorders arising due to novel coronavirus pandemic. Clinical presentation and findings as well as management and procedures of VRET are discussed. Medical record of three patients (two male and one female) at the Shenzhen Mental Health Center (Shenzhen Kangning Hospital), China, was included in the present case series. Patients were assessed with the Hamilton Anxiety Rating Scale and Fear of COVID-19 Scale to measure anxiety and fear, respectively. Throughout VRET sessions, we gradually and systematically exposed the patient to virtual COVID-19 scenarios (for example, touching stained door handle which may have viruses, watching pandemic news, watching frontline health care workers, etc.). In our study, VRET intervention significantly reduced the related symptoms caused by fear of COVID-19 infection. Furthermore, virtual reality can provide relevant theoretical and practical support for exploring the remote psychological counseling of patients in isolation wards.Keywords: VRET, COVID-19, phobia, telemedicine, telehealth, exposure therapy</text>
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                <text>2020</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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                <text>covid-19, telemedicine, telehealth, exposure therapy, Phobia, VRET</text>
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            <name>Source</name>
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                <text>Biotemas</text>
              </elementText>
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          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="62293">
                <text>Universidade Federal de Santa Catarina</text>
              </elementText>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Neurology. Diseases of the nervous system, Neurosciences. Biological psychiatry. Neuropsychiatry</text>
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