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                  <text>Dominio científico: Coronavirus</text>
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                <text>Repurposing Drugs for COVID-19: Pharmacokinetics and Pharmacogenomics of Chloroquine and Hydroxychloroquine</text>
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                <text>Babayeva M, Loewy Z</text>
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                <text>Mariana Babayeva,1 Zvi Loewy1,2 1Touro College of Pharmacy, New York, NY, USA; 2New York Medical College, Valhalla, NY, USACorrespondence: Mariana BabayevaTouro College of Pharmacy, 230 West 125th Street, Room 433, New York, NY 10027, USATel + 1 646 981 4740Fax +1 212 678 1780Email mariana.babayeva@touro.eduBackground: A new coronavirus SARS-CoV-2 has been identified as the etiological agent of the severe acute respiratory syndrome, COVID-19, the source and cause of the 2019&amp;ndash; 20 coronavirus pandemic. Hydroxychloroquine and chloroquine have gathered extraordinary attention as therapeutic candidates against SARS-CoV-2 infections. While there is growing scientific data on the therapeutic effect, there is also concern for toxicity of the medications. The therapy of COVID-19 by hydroxychloroquine and chloroquine is off-label. Studies to analyze the personalized effect and safety are lacking.Methods: A review of the literature was performed using Medline/PubMed/Embase database. A variety of keywords were employed in keyword/title/abstract searches. The electronic search was followed by extensive hand searching using reference lists from the identified articles.Results: A total of 126 results were obtained after screening all sources. Mechanisms underlying variability in drug concentrations and therapeutic response with chloroquine and hydroxychloroquine in mediating beneficial and adverse effects of chloroquine and hydroxychloroquine were reviewed and analyzed. Pharmacogenomic studies from various disease states were evaluated to elucidate the role of genetic variation in drug response and toxicity.Conclusion: Knowledge of the pharmacokinetics and pharmacogenomics of chloroquine and hydroxychloroquine is necessary for effective and safe dosing and to avoid treatment failure and severe complications.Keywords: COVID-19, pharmacokinetics, pharmacogenomics, chloroquine, hydroxychloroquine</text>
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                <text>2020</text>
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                <text>Biotemas</text>
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                <text>Universidade Federal de Santa Catarina</text>
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                <text>Therapeutics. Pharmacology</text>
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                  <text>Agricultura sostenible</text>
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                <text>Efecto de la disponibilidad de agua de riego en el valor de las tierras agrícolas en Guanacaste, Costa Rica. Un enfoque de precios hedónicos.</text>
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                <text>Bach. Paulo Méndez Campos, M.Sc. Johanna Solorzano Thompson, M.Sc. Javier Paniagua Molina</text>
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                <text>La necesidad de agua y sus impactos en la agricultura y en la seguridad alimentaria son preocupaciones crecientes en todo el mundo y Costa Rica no es la excepción. En este contexto, la valoración de las tierras ante la disponibilidad de agua de riego y otras variables externas, ha sido utilizado por diferentes autores en todo el mundo. El objetivo de esta investigación fue el de estimar el cambio en el valor de la tierra asociado a la mejora en la calidad hidrológica en las fincas beneficiadas con los programas de riego en la región de Guanacaste. Para estimar este cambio, ese utilizó el método de precios hedónicos (HPM) aplicado a una muestra final de 90 referencias para la compraventa de inmuebles disponibles en el DRAT y su entorno, en el período 2018-2019. Los resultados del modelo ajustado indican que la disponibilidad de agua para producción y consumo en la zona de estudio pueden aumentar el valor de la tierra hasta en un 10%. Otras variables cumplen positivamente con las caracteristicas buscadas por empresas inmobiliarias y propietarios tales como, cercanía a centro poblacional, caminos accesibles, uso del suelo. Finalmente, el tamaño de la finca, tiene un comportamiento inverso al relacionar el precio por metro cuadrado. El modelo  utilizado resultó ser una herramienta viable para la identificación de las variables que determinan el valor de la tierra en áreas destinadas principalmente a la producción agrícola y pecuaria en la zona de estudio.</text>
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                <text>Econometría, precios hedónicos, transformación cochrane-orcutt, valoración de tierras</text>
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                <text>10.18845/ea.v7i1.5580</text>
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                <text>e-Agronegocios</text>
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                <text>Instituto Tecnológico de Costa Rica</text>
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                <text>Agriculture (General), Agriculture</text>
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                <text>&lt;a href="https://revistas.tec.ac.cr/index.php/eagronegocios/article/view/5580/5352" target="_blank" rel="noreferrer noopener"&gt;https://revistas.tec.ac.cr/index.php/eagronegocios/article/view/5580/5352&lt;/a&gt;</text>
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                <text>Medicinal Plants as Sources of Active Molecules Against COVID-19</text>
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                <text>Bachir Benarba, Atanasio Pandiella</text>
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                <text>The Severe Acute Respiratory Syndrome-related Coronavirus 2 (SARS-CoV-2) or novel coronavirus (COVID-19) infection has been declared world pandemic causing a worrisome number of deaths, especially among vulnerable citizens, in 209 countries around the world. Although several therapeutic molecules are being tested, no effective vaccines or specific treatments have been developed. Since the COVID-19 outbreak, different traditional herbal medicines with promising results have been used alone or in combination with conventional drugs to treat infected patients. Here, we review the recent findings regarding the use of natural products to prevent or treat COVID-19 infection. Furthermore, the mechanisms responsible for this preventive or therapeutic effect are discussed. We conducted literature research using PubMed, Google Scholar, Scopus, and WHO website. Dissertations and theses were not considered. Only the situation reports edited by the WHO were included. The different herbal products (extracts) and purified molecules may exert their anti-SARS-CoV-2 actions by direct inhibition of the virus replication or entry. Interestingly, some products may block the ACE-2 receptor or the serine protease TMPRRS2 required by SARS-CoV-2 to infect human cells. In addition, natural products were shown to inhibit the SARS-CoV-2 life-cycle related proteins such as papain-like or chymotrypsin-like proteases. In conclusion, we suggest that natural products could be used alone or in combination as alternative medicines to treat/prevent COVID-19 infection. Moreover, their structures may offer clues for the development of anti-SARS-CoV-2 drugs.</text>
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                <text>ACE2, coronavirus disease 2019 (covid-19), Natural products, plants, Severe Acute Respiratory Syndrome-related Coronavirus 2 (SARS-CoV-2)</text>
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                <text>Korean Society of Epidemiology</text>
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                <text>In this paper, we examine the impact of investors’ attention to Covid-19 on stock market returns and the moderating effect of national culture on this relationship. Using daily data from 34 countries over the period January 23 to June 12, 2020, and measuring investors’ attention with the Google search volume (GSV) of the word “coronavirus” for each country, we find that investors’ enhanced attention to the Covid-19 pandemic results in negative stock market returns. Further, measuring the national culture with the uncertainty avoidance index (the aspect of national culture which measures the cross-country differences in decision-making under stress and ambiguity), we find that the negative impact of investors’ attention on stock market returns is stronger in countries where investors possess higher uncertainty avoidance cultural values. Our findings imply that uncertainty avoidance cultural values of investors promote financial market instability amid the crisis.</text>
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                <text>2021</text>
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                <text>Alaa Badawi1,2 1Public Health Risk Sciences Division, Public Health Agency of Canada, Toronto, ON, Canada; 2Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, CanadaCorrespondence: Alaa BadawiPublic Health Risk Sciences Division, Public Health Agency of Canada, 180 Queen Street West, Toronto, ON M5V 3L7, CanadaEmail alaa.badawi@canada.caAbstract: Severe acute respiratory syndrome (SARS) coronavirus (CoV)-2 (SARS-CoV-2) is a novel coronavirus identified as the cause of coronavirus disease-2019 (COVID-19) that began in Wuhan, China in late 2019 and spread now in 210 countries and territories around the world. Many people are asymptomatic or with mild symptoms. However, in some cases (usually the elderly and those with comorbidities) the disease may progress to pneumonia, acute respiratory distress syndrome and multi-organ dysfunction that can lead to death. Such wide interindividual differences in response to SARS-CoV-2 infection may relate to several pathogen- and host-related factors. These include the different levels of the ubiquitously present human angiotensin I converting enzyme 2 (ACE2) receptors gene expression and its variant alleles, the different binding affinities of ACE2 to the virus spike (S) protein given its L- and S-subtypes and the subsequent extent of innate immunity-related hypercytokinemia. The extensive synthesis of cytokines and chemokines in coronavirus diseases was suggested as a major factor in exacerbating lung damage and other fatal complications. The polymorphisms in genes coding for pro-inflammatory cytokines and chemokines have been associated with mediating the response and susceptibility to a wide range of infections and their severe outcomes. Understanding the nature of pathogen&amp;ndash;host interaction in COVID-19 symptomatology together with the role of hypercytokinemia in disease severity may permit developing new avenues of approach for prevention and treatment and can delineate public health measures to control the spread of the disease.Keywords: SARS-CoV, MERS-CoV, SARS-CoV-2, COVID-19, hypercytokinemia</text>
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            <description>An account of the resource</description>
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                <text>Alaa Badawi1,2 1Public Health Risk Sciences Division, Public Health Agency of Canada, Toronto, ON, Canada; 2Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, CanadaCorrespondence: Alaa BadawiPublic Health Risk Sciences Division, Public Health Agency of Canada, 180 Queen Street West, Toronto, ON M5V 3L7, CanadaEmail alaa.badawi@canada.caAbstract: Severe acute respiratory syndrome (SARS) coronavirus (CoV)-2 (SARS-CoV-2) is a novel coronavirus identified as the cause of coronavirus disease-2019 (COVID-19) that began in Wuhan, China in late 2019 and spread now in 210 countries and territories around the world. Many people are asymptomatic or with mild symptoms. However, in some cases (usually the elderly and those with comorbidities) the disease may progress to pneumonia, acute respiratory distress syndrome and multi-organ dysfunction that can lead to death. Such wide interindividual differences in response to SARS-CoV-2 infection may relate to several pathogen- and host-related factors. These include the different levels of the ubiquitously present human angiotensin I converting enzyme 2 (ACE2) receptors gene expression and its variant alleles, the different binding affinities of ACE2 to the virus spike (S) protein given its L- and S-subtypes and the subsequent extent of innate immunity-related hypercytokinemia. The extensive synthesis of cytokines and chemokines in coronavirus diseases was suggested as a major factor in exacerbating lung damage and other fatal complications. The polymorphisms in genes coding for pro-inflammatory cytokines and chemokines have been associated with mediating the response and susceptibility to a wide range of infections and their severe outcomes. Understanding the nature of pathogen&amp;ndash;host interaction in COVID-19 symptomatology together with the role of hypercytokinemia in disease severity may permit developing new avenues of approach for prevention and treatment and can delineate public health measures to control the spread of the disease.Keywords: SARS-CoV, MERS-CoV, SARS-CoV-2, COVID-19, hypercytokinemia</text>
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                <text>Universidade Federal de Santa Catarina</text>
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                  <text>Coronavirus</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Badr  M. Al-Shomrani, Manee  M. Manee, Sultan  N. Alharbi, Mussad  A. Altammami, Manal  A. Alshehri, Majed  S. Nassar, Muhammed  A. Bakhrebah, Mohamed  B. Al-Fageeh</text>
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                <text>Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe respiratory illness in humans; the second-largest and most deadly outbreak to date occurred in Saudi Arabia. The dromedary camel is considered a possible host of the virus and also to act as a reservoir, transmitting the virus to humans. Here, we studied evolutionary relationships for 31 complete genomes of betacoronaviruses, including eight newly sequenced MERS-CoV genomes isolated from dromedary camels in Saudi Arabia. Through bioinformatics tools, we also used available sequences and 3D structure of MERS-CoV spike glycoprotein to predict MERS-CoV epitopes and assess antibody binding affinity. Phylogenetic analysis showed the eight new sequences have close relationships with existing strains detected in camels and humans in Arabian Gulf countries. The 2019-nCov strain appears to have higher homology to both bat coronavirus and SARS-CoV than to MERS-CoV strains. The spike protein tree exhibited clustering of MERS-CoV sequences similar to the complete genome tree, except for one sequence from Qatar (KF961222). B cell epitope analysis determined that the MERS-CoV spike protein has 24 total discontinuous regions from which just six epitopes were selected with score values of &gt;80%. Our results suggest that the virus circulates by way of camels crossing the borders of Arabian Gulf countries. This study contributes to finding more effective vaccines in order to provide long-term protection against MERS-CoV and identifying neutralizing antibodies.</text>
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                <text>2020</text>
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                <text>MERS-CoV, phylogenetic analysis, 2019ncov, Dromedary camel, vaccine design</text>
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                <text>Korean Society of Epidemiology</text>
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                <text>Microbiology</text>
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              </elementTextContainer>
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              <description>An account of the resource</description>
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                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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          <element elementId="50">
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            <description>A name given to the resource</description>
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                <text>Preliminary Design of a Smart Wristband Disinfectant to Help in Covid-19 Fight</text>
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                <text>Badre El Majid, Saad Motahhir, Aboubakr El Hammoumi, Ambar Lebbadi, Abdelaziz El Ghzizal</text>
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            <description>An account of the resource</description>
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              <elementText elementTextId="68803">
                <text>This concept paper describes a device consisting of a disinfectant wristband for the hands of the wearer and objects that the wearer intends to touch. This wristband can be powered automatically by the movement of the user’s hand or by solar cells or, if necessary, by a power outlet. It disinfects the surface of the hands and the objects in front of them using an ultraviolet (UV) lamp. Control and monitoring can be carried out automatically or manually, which guarantees complete and effective disinfection. The electronic control system, which is fully integrated into the UV emitter head, regulates the intensity and duration of the UV radiation and also manages the electrical energy. In addition, the wristband can be fitted with an optional watch to improve its decoration and ergonomics. The device in question has a compact, elegant, and practical shape. This hand sanitizing wristband can be an effective tool in the fight against the current COVID-19 pandemic and, in general, help to address the health challenges related to hygiene and disease prevention.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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                <text>2020</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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              <elementText elementTextId="68805">
                <text>Disinfectant, covid’19, bracelet</text>
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            </elementTextContainer>
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            <description>An unambiguous reference to the resource within a given context</description>
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                <text>10.3390/inventions5030032</text>
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            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="68807">
                <text>Epidemiology and Health</text>
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            <description>An entity responsible for making the resource available</description>
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