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                  <text>Dominio científico: Coronavirus</text>
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                <text>Innovation and Challenges in Funding Rapid Research Responses to Emerging Infectious Diseases: Lessons Learned from the Outbreak of Severe Acute Respiratory Syndrome</text>
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                <text>Bhagirath Singh</text>
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                <text>Although the local public health response to the severe acute respiratory syndrome outbreak in Canada was critical to the diagnosis, management and treatment of patients, such a rapid research response required a national effort to engage the research and stakeholder communities. The Canadian research effort, coordinated through the Institute of Infection and Immunity of the Canadian Institutes of Health Research and the Michael Smith Foundation for Health Research, has provided insight into the mechanisms required to ensure the rapid development of strategical initiatives in response to emerging infectious diseases. It has also provided a rational basis to set up a national network to be engaged if needed in the future.</text>
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                <text>2004</text>
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                <text>DOI: 10.1155/2004/925872</text>
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                <text>Canadian Journal of Infectious Diseases and Medical Microbiology</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="27227">
                <text>Hindawi Limited</text>
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                <text>Infectious and parasitic diseases, Microbiology</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Viral aetiology of wheezing in children under five</text>
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                <text>Bhagirathi Dwibedi, Prithi Sureka Mummidi, Radha Tripathy, Amarendra Mahapatra, Suryakanta Baraha</text>
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                <text>Background &amp; objectives: Wheezing is a common problem in children under five with acute respiratory infections (ARIs). Viruses are known to be responsible for a considerable proportion of ARIs in children. This study was undertaken to know the viral aetiology of wheezing among the children less than five years of age, admitted to a tertiary care hospital in eastern India. Methods: Seventy five children, under the age of five years admitted with wheezing, were included in the study. Throat and nasal swabs were collected, and real-time multiplex polymerase chain reaction (PCR) assay was used to screen for influenza 1 and 2, respiratory syncytial virus (RSV), parainfluenza virus (PIV) 1, 2, 3 and 4, rhinovirus, human meta-pneumovirus, bocavirus (HBoV), Coronavirus, adenovirus, Enterovirus and Parechovirus. Results: The total viral detection rate was 28.57 per cent. Viral RNA markers were detected from children diagnosed to be having pneumonia (3 cases), bronchiolitis (9 cases), episodic wheeze (2 cases) and multitrigger wheeze (6 cases). RSV was the most common virus (35%) followed by PIV1, 2 and 3 (20%), HBoV (10%) and rhinovirus (5%). However, mixed infection was observed in 30 per cent of cases. Interpretation &amp; conclusions: The study reported the presence of respiratory viral agents in 28.57 per cent of children with wheezing; RSV and PIV were most common, accounting to 55 per cent of the total cases. Mixed infection was reported in 30 per cent of cases. Seasonal variation in the occurrence of these viruses was also noted. Further studies need to be done with a large sample and longer follow up period to verify these findings.</text>
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                <text>2017</text>
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                <text>Asthma - bronchiolitis - child - incidence - India - multiplex polymerase chain reaction</text>
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                <text>DOI: 10.4103/ijmr.IJMR_840_15</text>
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              <elementText elementTextId="27184">
                <text>Indian Journal of Medical Research</text>
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                <text>Wolters Kluwer Medknow Publications</text>
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                <text>Medicine</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>COVID-19 Pandemic and Child Neurology Training: A Bumpy Road Ahead.</text>
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                <text>Bhanudeep Singanamalla, Priyanka Madaan, Lokesh Saini</text>
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                <text>10.1016/j.pediatrneurol.2020.10.004</text>
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                <text>Pediatric neurology</text>
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                  <text>Dominio científico: Coronavirus</text>
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      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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                <text>Innovative application of ultraviolet rays and hydrogen peroxide vapor for decontamination of respirators during COVID-19 pandemic- An experience from a tertiary eye care hospital</text>
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                <text>Bharat Gurnani, Rengaraj Venkatesh, Kirandeep Kaur, Rajesh Vedachalam, Joseph Gubert</text>
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                <text>10.4103/ijo.IJO_2160_20</text>
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                <text>Biotemas</text>
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                <text>Universidade Federal de Santa Catarina</text>
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                <text>Ophthalmology</text>
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                <text>The Impact of COVID-19 on Price Volatility of Crude Oil and Natural Gas Listed on Multi Commodity Exchange of India</text>
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          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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                <text>Bharat Kumar Meher, Iqbal Thonse Hawaldar, Latasha Mohapatra, Adel M. Sarea</text>
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            <description>An account of the resource</description>
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                <text>The impact of COVID-19, due to the wide-spread demand and supply destruction and downward movement of crude oil prices is of concern for all those connected with the oil and gas industry. In this study, an attempt has been made to estimate the price volatility of crude oil and natural gas listed on Multi Commodity Exchange of India (MCX). We measured the leverage effect of COVID-19 on price volatility of crude oil and natural gas by using the daily prices of crude oil and natural gas from 1st May 2017 to 30th April 2020. The findings of the study reveal that there is a presence of leverage effect of COVID-19 on the price volatility of crude oil. However, this leverage effect is not present on the price volatility of natural gas. The findings of the study will help investors to develop investment strategies and to the policymakers to formulate appropriate policies to overcome or minimise the impact of COVID-19. The forecasting graphs of crude oil prices indicate that there is a possibility that price volatility will be higher in the future. However, it is difficult to forecast the expected price volatility of natural gas for the future because the price volatility graph is extremely fluctuating.Keywords: COVID-19, Asymmetric Volatility, Leverage Effect, Crude Oil, Natural Gas, MCX Limited. JEL Classifications: G15; G20; G21; G22; G23DOI: https://doi.org/10.32479/ijeep.10047</text>
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                <text>2020</text>
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                <text>Biotemas</text>
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                <text>Universidade Federal de Santa Catarina</text>
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                <text>Environmental sciences, Energy industries. Energy policy. Fuel trade</text>
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                <text>Bharat Rekhi, Ram Nawal Rao, Indranil Chakrabarti, Prabal Deb, Madhusmita Jena, Nalini Gupta, Madhu Mati Goel, Arvind Rajwanshi, Radhika Srinivasan, Sandeep Mathur, Parikshaa Gupta, R. G. W. Pinto, Dev Prasoon, Vijay S Nijhawan, Venkat Iyer, Meherbano Kamal, Siddaraju Raju, Surendra Verma</text>
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                <text>COVID-19, caused by the SARS-CoV-2 virus, has been declared a pandemic by the World Health Organization. This scenario has impacted the way we practice cytopathology. Cytology laboratories receive fresh and potentially infectious biological samples including those from the respiratory tract, from COVID-19 positive or suspected patients. Hence, the Indian Academy of Cytologists thought it necessary and fit to bring forth appropriate guidelines starting from transportation, receipt, processing, and reporting of samples in the COVID-19 era. The guidelines are prepared with the aim of safeguarding and protecting the health care personnel including laboratory staff, trainees and cytopathologists by minimizing exposure to COVID-19 so that they remain safe, in order to able to provide a continuous service. We hope that these national guidelines will be implemented across all cytopathology laboratories effectively.</text>
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                <text>DOI: 10.4103/JOC.JOC_44_20</text>
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                <text>DOI: 10.1055/s-0040-1713342</text>
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                <text>Journal of Neurosciences in Rural Practice</text>
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                <text>Thieme Publishers</text>
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                <text>Neurosciences. Biological psychiatry. Neuropsychiatry</text>
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                <text>Electronic health record derived-impact of COVID-19 on myasthenia gravis.</text>
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                <text>Bhaskar Roy, Sukanthi Kovvuru, Krishna Nalleballe, Sanjeeva Reddy Onteddu, Richard J Nowak</text>
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                <text>covid-19, Hospitalization, Vaccination, Outcomes, myasthenia gravis</text>
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            <name>Identifier</name>
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                <text>10.1016/j.jns.2021.117362</text>
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              <elementText elementTextId="42462">
                <text>Journal of the neurological sciences</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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                <text>Recording COVID-19 consultations: review of symptoms, risk factors, and proposed SNOMED CT terms</text>
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                <text>Bhautesh Dinesh Jani, Jill P Pell, Dylan McGagh, Harshana Liyanage, Dave Kelly, Simon de Lusignan, Christopher J Weatherburn, Ronnie Burns, Frank M Sullivan, Frances S Mair</text>
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            <name>Description</name>
            <description>An account of the resource</description>
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              <elementText elementTextId="46285">
                <text>Background: There is an urgent need for epidemiological research in primary care to develop risk assessment processes for patients presenting with COVID-19, but lack of a standardised approach to data collection is a significant barrier to implementation. Aim: To collate a list of relevant symptoms, assessment items, demographics, and lifestyle and health conditions associated with COVID-19, and match these data items with corresponding SNOMED CT clinical terms to support the development and implementation of consultation templates. Design &amp; setting: Published and preprint literature for systematic reviews, meta-analyses, and clinical guidelines describing the symptoms, assessment items, demographics, and/or lifestyle and health conditions associated with COVID-19 and its complications were reviewed. Corresponding clinical concepts from SNOMED CT, a widely used structured clinical vocabulary for electronic primary care health records, were identified. Method: Guidelines and published and unpublished reviews (N = 61) were utilised to collate a list of relevant data items for COVID-19 consultations. The NHS Digital SNOMED CT Browser was used to identify concept and descriptive identifiers. Key implementation challenges were conceptualised through a Normalisation Process Theory (NPT) lens. Results: In total, 32 symptoms, eight demographic and lifestyle features, 25 health conditions, and 20 assessment items relevant to COVID-19 were identified, with proposed corresponding SNOMED CT concepts. These data items can be adapted into a consultation template for COVID-19. Key implementation challenges include: 1) engaging with key stakeholders to achieve ’buy in’; and 2) ensuring any template is usable within practice settings. Conclusion: Consultation templates for COVID-19 are needed to standardise data collection, facilitate research and learning, and potentially improve quality of care for COVID-19.</text>
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                <text>2020</text>
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                <text>covid-19, PRIMARY HEALTH CARE, General practice, Medical records systems, computerised, systematised nomenclature of medicine</text>
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                <text>10.3399/bjgpopen20X101125</text>
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                <text>Epidemiology and Health</text>
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                <text>Korean Society of Epidemiology</text>
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                <text>Medicine (General)</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>SARS coronavirus 3b accessory protein modulates transcriptional activity of RUNX1b.</text>
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                <text>Bhavna Varshney, Sudhakar Agnihothram, Yee-Joo Tan, Ralph Baric, Sunil K. Lal</text>
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                <text>BACKGROUND: The causative agent of severe acute respiratory syndrome, SARS coronavirus (SARS-CoV) genome encodes several unique group specific accessory proteins with unknown functions. Among them, accessory protein 3b (also known as ORF4) was lately identified as one of the viral interferon antagonist. Recently our lab uncovered a new role for 3b in upregulation of AP-1 transcriptional activity and its downstream genes. Thus, we believe that 3b might play an important role in SARS-CoV pathogenesis and therefore is of considerable interest. The current study aims at identifying novel host cellular interactors of the 3b protein. METHODOLOGY/PRINCIPAL FINDINGS: In this study, using yeast two-hybrid and co-immunoprecipitation techniques, we have identified a host transcription factor RUNX1b (Runt related transcription factor, isoform b) as a novel interacting partner for SARS-CoV 3b protein. Chromatin immunoprecipitaion (ChIP) and reporter gene assays in 3b expressing jurkat cells showed recruitment of 3b on the RUNX1 binding element that led to an increase in RUNX1b transactivation potential on the IL2 promoter. Kinase assay and pharmacological inhibitor treatment implied that 3b also affect RUNX1b transcriptional activity by regulating its ERK dependent phosphorylation levels. Additionally, mRNA levels of MIP-1α, a RUNX1b target gene upregulated in SARS-CoV infected monocyte-derived dendritic cells, were found to be elevated in 3b expressing U937 monocyte cells. CONCLUSIONS/SIGNIFICANCE: These results unveil a novel interaction of SARS-CoV 3b with the host factor, RUNX1b, and speculate its physiological relevance in upregulating cytokines and chemokine levels in state of SARS virus infection.</text>
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                <text>DOI: 10.1371/journal.pone.0029542</text>
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                <text>PLoS ONE</text>
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