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                  <text>Dominio científico: Coronavirus</text>
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                <text>What the Web Has Wrought</text>
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                <text>Antony Bryant</text>
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                <text>In 1989, Sir Tim Berners-Lee proposed the development of ‘a large hypertext database with typed links’, which eventually became The World Wide Web. It was rightly heralded at the time as a significant development and a boon for one-and-all as the digital age flourished both in terms of universal accessibility and affordability. The general anticipation was that this could herald an era of universal friendship and knowledge-sharing, ushering in global cooperation and mutual regard. In November 2019, marking 30 years of the Web, Berners-Lee lamented that its initial promise was being largely undermined, and that we were in danger of heading towards a ‘digital dystopia’: What happened?</text>
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                <text>2020</text>
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                <text>Governance, Internet governance, COVID-19, Contract for the Web, Berners-Lee, Contractarianism and Contractualism</text>
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                <text>DOI: 10.3390/informatics7020015</text>
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                <text>Informatics</text>
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                <text>MDPI AG</text>
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                <text>Information technology</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Effect of COVID-19 Epidemic on Delay of Diagnosis and Treatment Path for Patients with Nasopharyngeal Carcinoma</text>
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                <text>Hu C, Yang Y, Shen C</text>
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                <text>Youqi Yang, Chunying Shen, Chaosu Hu Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Shanghai 200032, People&amp;rsquo;s Republic of ChinaCorrespondence: Chaosu Hu No. 270, Dong&amp;rsquo;an Road, Shanghai, People&amp;rsquo;s Republic of ChinaTel Fax + 8602164175590Email hucsu62@yahoo.comIntroduction: 2019 novel coronavirus disease (COVID-19) outbreaks have been occurring in China and other countries in the world. To prevent further spread of the disease, restrictions of population flow from the government and measures to reduce virus transmission from hospitals may lead to the delay of diagnosis and treatment in patients with nasopharyngeal carcinoma (NPC).Methods: All NPC patients with radiotherapy indications were included from 20 weekdays before (group A) and after (group B) January 31, 2020, when the institute began to take measures against COVID-19. The waiting intervals of each step and variation from the diagnosis and treatment path of NPC between two groups were compared.Results: Significant differences were found between the group A and group B in the median waiting days for pathological biopsy (5 vs 15, P=0.012), radiotherapy immobilization and simulation (3.5 vs 16.5, P&amp;lt; 0.001), validation of position and plan (20 vs 61, P&amp;lt; 0.001) and initiation of radiotherapy (28 vs 36, P=0.005). During the waiting period of radiotherapy, 32.4% of the NPC patients received an additional one cycle of chemotherapy to the original treatment strategy.Conclusion: The prevalence of COVID-19 caused delay in the diagnosis and treatment of NPC patients to a certain extent. Additional chemotherapy could be considered to counteract the effect of treatment delay. More specific measures should be taken to balance the risk of delayed diagnosis and treatment of NPC and infection of COVID-19.Keywords: COVID-19, nasopharyngeal carcinoma, radiotherapy &amp;nbsp;</text>
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                <text>Radiotherapy, Nasopharyngeal carcinoma, COVID-19</text>
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                <text>Cancer Management and Research</text>
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                <text>Dove Medical Press</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Neoplasms. Tumors. Oncology. Including cancer and carcinogens</text>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
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                <text>Understanding COVID-19 in children may provide clues to protect at-risk populations</text>
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                <text>Philip Sutton, Paul V Licciardi, Lien Anh Ha Do, Daniel G. Pellicci, Jeremy Anderson</text>
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                <text>2020</text>
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                <text>DOI: 10.1136/bmjpo-2020-000702</text>
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                <text>BMJ Paediatrics Open</text>
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                <text>BMJ Publishing Group</text>
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                <text>Pediatrics</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Development of Point-of-Care Biosensors for COVID-19</text>
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                <text>Jane Ru Choi</text>
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            <description>An account of the resource</description>
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                <text>Coronavirus disease 2019 (COVID-19) outbreak has become a global pandemic. The deleterious effects of coronavirus have prompted the development of diagnostic tools to manage the spread of disease. While conventional technologies such as quantitative real time polymerase chain reaction (qRT-PCR) have been broadly used to detect COVID-19, they are time-consuming, labor-intensive and are unavailable in remote settings. Point-of-care (POC) biosensors, including chip-based and paper-based biosensors are typically low-cost and user-friendly, which offer tremendous potential for rapid medical diagnosis. This mini review article discusses the recent advances in POC biosensors for COVID-19. First, the development of POC biosensors which are made of polydimethylsiloxane (PDMS), papers, and other flexible materials such as textile, film, and carbon nanosheets are reviewed. The advantages of each biosensors along with the commercially available COVID-19 biosensors are highlighted. Lastly, the existing challenges and future perspectives of developing robust POC biosensors to rapidly identify and manage the spread of COVID-19 are briefly discussed.</text>
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                <text>2020</text>
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                <text>Paper, PDMS, flexible materials, COVID-19, POC biosensors</text>
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                <text>DOI: 10.3389/fchem.2020.00517</text>
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                <text>Frontiers in Chemistry</text>
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              <elementText elementTextId="26771">
                <text>Frontiers Media S.A.</text>
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                <text>Chemistry</text>
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                <text>Value Shaping of Ecological Man: External Standard and Internal Idea</text>
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                <text>Bo Ma</text>
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            <description>An account of the resource</description>
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                <text>“Ecological man” is an important existing form of the “legal man” mode which generallyexperiences the rising of the “economic man” and the reflection on the “social man” in terms of itsevolution process and Spatio-temporal trajectory, and is now striding toward the “ecological man.” InChina, it is necessary to implant the core value that is depended on by the “ecological man” into thelegislation for the construction of ecology civilization, so as to give a response to the realistic demand onthe practice governed by law. After the outbreak of COVID-19, the Local People’s Congresses of Chinalaunches the revision of the laws and regulations in relation to the prohibition of eating wild animalscomprehensively and stresses that prohibition of eating wild animals by legislation is a necessaryrequirement to guarantee the life, the health and the safety, maintain biological security and ecologicalsafety, strengthen the construction of ecological civilization and promote the harmonious coexistencebetween human and nature.The Wild Animal Conservation Law that is revised by the Standing Committee of GuangdongProvincial People’s Congress stresses, on the one hand, the necessity of comprehensively prohibitingthe eating of terrestrial wildlife according to law, and on the other hand, attaches great importance tothe response to the social reality appeal and clarifies to make rational compensations to legal breedersfor their actual loss. The local legislation on the wild animal conservation adopted in Shenzhen Cityand Zhuhai City of Guangdong Province clarifies the scope of application for the prohibition of eatingterrestrial wildlife and the “white list” of edible animals, and thus stepping in the forefront for locallegislation. It can be said that those local legislations above lay a solid foundation for the revision or theformulation of the legislation in connection to the ecological, environmental protection, and public healthand safety at the state level and also builds a pleasant atmosphere for the rule of law. In considerationof the unexpected public health and safety issues, this paper stresses that it is essential to see both thesurface problem in inadequate legal system supply and the underlying problem in lacking the “ecologicalman” value idea in the design of legal systems.</text>
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                <text>2020</text>
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                <text>ecological civilization, COVID-19, external standard, wild animal conservation, legal man mode, ecological man, implication of value, internal idea</text>
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                <text>DOI: 10.29202/fhi/13/6</text>
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                <text>International Society of Philosophy and Cosmology</text>
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                <text>Education</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>COVID-19: A Relook at Healthcare Systems and Aged Populations</text>
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                <text>Quan-Hoang Vuong, Thanh-Long Giang, Dinh-Tri Vo</text>
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                <text>Using data from the WHO’s Situation Report on the COVID-19 pandemic from 21 January 2020 to 30 March 2020 along with other health, demographic, and macroeconomic indicators from the WHO’s Application Programming Interface and the World Bank’s Development Indicators, this paper explores the death rates of infected persons and their possible associated factors. Through the panel analysis, we found consistent results that healthcare system conditions, particularly the number of hospital beds and medical staff, have played extremely important roles in reducing death rates of COVID-19 infected persons. In addition, both the mortality rates due to different non-communicable diseases (NCDs) and rate of people aged 65 and over were significantly related to the death rates. We also found that controlling international and domestic travelling by air along with increasingly popular anti-COVID-19 actions (i.e., quarantine and social distancing) would help reduce the death rates in all countries. We conducted tests for robustness and found that the Driscoll and Kraay (1998) method was the most suitable estimator with a finite sample, which helped confirm the robustness of our estimations. Based on the findings, we suggest that preparedness of healthcare systems for aged populations need more attentions from the public and politicians, regardless of income level, when facing COVID-19-like pandemics.</text>
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                <text>2020</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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                <text>healthcare systems, COVID-19, aged populations</text>
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                <text>DOI: 10.3390/su12104200</text>
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            <description>A related resource from which the described resource is derived</description>
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                <text>Sustainability</text>
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            <description>An entity responsible for making the resource available</description>
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                <text>MDPI AG</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Environmental sciences, Renewable energy sources, Environmental effects of industries and plants</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Toward Sustainable Learning during School Suspension: Socioeconomic, Occupational Aspirations, and Learning Behavior of Vietnamese Students during COVID-19</text>
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            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="26792">
                <text>Trung Tran, Anh-Duc Hoang, Quynh Anh Le, Linh Chi Nguyen, Tien-Trung Nguyen, Viet-Hung Dinh, Yen-Chi Nguyen, Ngoc-Thuy Ta, Quang-Hong Pham, Chung-Xuan Pham</text>
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                <text>The overspread of the novel coronavirus—SARS-CoV-2—over the globe has caused significant damage to manufacturing and service businesses, regardless of whether they are commercial, public, or not-for-profit sectors. While both the short-term and long-term impacts of most companies can be approximately measured or estimated, it is challenging to address the enduring effects of COVID-19 on teaching and learning activities. The target of this research is to investigate students’ manners of studying at home during the school suspension time as a result of COVID-19. Through analyzing original survey data from 420 K6–12 students in Hanoi, Vietnam, this work demonstrates the different learning habits of students with different socioeconomic statuses and occupational aspirations during the disease’s outbreak. In particular, we featured the differences in students’ learning behaviors between private schools and public schools, as well as between students who plan to follow STEM-related careers and those who intend to engage in social science-related careers. The empirical evidence of this study can be used for the consideration of the local government to increase the sustainability of coming policies and regulations to boost students’ self-efficacy, as it will affect 1.4 million students in Hanoi, as well as the larger population of nearly 10 million Vietnamese students. These results can also be the foundation for future investigations on how to elevate students’ learning habits toward Sustainable Development Goal 4 (SDG4)—Quality Education—especially in fanciful situations in which the regular school operation has been disrupted, counting with limited observation and support from teachers and parents.</text>
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              <elementText elementTextId="26794">
                <text>2020</text>
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          <element elementId="49">
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            <description>The topic of the resource</description>
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                <text>Socioeconomic, sustainable education, School closure, occupational aspiration, COVID-19, Learning habit</text>
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            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="26796">
                <text>DOI: 10.3390/su12104195</text>
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            </elementTextContainer>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="26797">
                <text>Sustainability</text>
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            </elementTextContainer>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="26798">
                <text>MDPI AG</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="26799">
                <text>Environmental sciences, Renewable energy sources, Environmental effects of industries and plants</text>
              </elementText>
            </elementTextContainer>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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            <element elementId="41">
              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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              </elementTextContainer>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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      <elementSet elementSetId="1">
        <name>Dublin Core</name>
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                <text>MSC Therapies for COVID-19: Importance of Patient Coagulopathy, Thromboprophylaxis, Cell Product Quality and Mode of Delivery for Treatment Safety and Efficacy</text>
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            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="26801">
                <text>Sven Geissler, Petra Reinke, Julian Kamhieh-Milz, Hans-Dieter Volk, Guido Moll, Norman Drzeniek</text>
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            <description>An account of the resource</description>
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                <text>Numerous clinical trials of mesenchymal stromal/stem cells (MSCs) as a new treatment for coronavirus-induced disease (COVID-19) have been registered recently, most of them based on intravenous (IV) infusion. There is no approved effective therapy for COVID-19, but MSC therapies have shown first promise in the treatment of acute respiratory distress syndrome (ARDS) pneumonia, inflammation, and sepsis, which are among the leading causes of mortality in COVID-19 patients. Many of the critically ill COVID-19 patients are in a hypercoagulable procoagulant state and at high risk for disseminated intravascular coagulation, thromboembolism, and thrombotic multi-organ failure, another cause of high fatality. It is not yet clear whether IV infusion is a safe and effective route of MSC delivery in COVID-19, since MSC-based products express variable levels of highly procoagulant tissue factor (TF/CD142), compromising the cells' hemocompatibility and safety profile. Of concern, IV infusions of poorly characterized MSC products with unchecked (high) TF/CD142 expression could trigger blood clotting in COVID-19 and other vulnerable patient populations and further promote the risk for thromboembolism. In contrast, well-characterized products with robust manufacturing procedures and optimized modes of clinical delivery hold great promise for ameliorating COVID-19 by exerting their beneficial immunomodulatory effects, inducing tissue repair and organ protection. While the need for MSC therapy in COVID-19 is apparent, integrating both innate and adaptive immune compatibility testing into the current guidelines for cell, tissue, and organ transplantation is critical for safe and effective therapies. It is paramount to only use well-characterized, safe MSCs even in the most urgent and experimental treatments. We here propose three steps to mitigate the risk for these vulnerable patients: (1) updated clinical guidelines for cell and tissue transplantation, (2) updated minimal criteria for characterization of cellular therapeutics, and (3) updated cell therapy routines reflecting specific patient needs.</text>
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              <elementText elementTextId="26803">
                <text>2020</text>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
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                <text>intensive care unit (ICU), mesenchymal stromal cells (MSC), severe acute respiratory distress syndrome coronavirus-2 (SARS-CoV-2), coronavirus-induced disease 2019 (COVID19), intravascular and intravenous infusion, hemocompatibility testing</text>
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            <name>Identifier</name>
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              <elementText elementTextId="26805">
                <text>DOI: 10.3389/fimmu.2020.01091</text>
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            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="26806">
                <text>Frontiers in Immunology</text>
              </elementText>
            </elementTextContainer>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="26807">
                <text>Frontiers Media S.A.</text>
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            </elementTextContainer>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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              <elementText elementTextId="26808">
                <text>Immunologic diseases. Allergy</text>
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            <element elementId="50">
              <name>Title</name>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Coronavirus breathing: on the implementation of remote psychological assistance during a pandemic</text>
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            <name>Creator</name>
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              <elementText elementTextId="26810">
                <text>Dilyara N.  Efremova</text>
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            <name>Description</name>
            <description>An account of the resource</description>
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                <text>In the situation, associated with the introduction of the self-isolation regime during the COVID-19 pandemic, the remote form of psychological assistance has confirmed its relevance. Features of the development of anxiety reactions in people who seek psychological help have shown the need to introduce information hygiene rules. A sense of danger and an excessive flow of information about it accelerate the development of stressful reactions in people with different levels of perception of the situation. Continual information on the topic related to mortal danger is a trigger for the development of hysteria, panic attacks, conflicts and domestic violence, disorders of the depressive spectrum and, including paradoxical behavior, a complete denial of danger.These and other issues are covered in the interview with D. N. Efremova, the practicing psychologist. Questions were asked by N. S. Kramarenko, the deputy editor-in-chief of the electronic journal Bulletin of Moscow Region State University, Doctor of Psychological sciences.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="26812">
                <text>2020</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="26813">
                <text>Anxiety, panic attack, psychological assistance, social and psychological support, COVID-19 pandemic, remote psychological counseling</text>
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