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              <name>Title</name>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Efficacy and safety of convalescent plasma therapy in patients with COVID-19: arapid review of case series</text>
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                <text>David Dwi Putera, Mardiah Suci Hardianti</text>
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                <text>Coronavirus disease 2019 (COVID-19) has become a world pandemic since early 2020.Currently, there is no established treatment to combat this potentially fatal disease. Convalescent plasma (CP) therapy has a strong scientific basis and historical perspective to treat previous viral infections such as Ebola, Middle East respiratory syndrome (MERS) and severe acute respiratory syndrome (SARS). The aim of this review was to evaluate the efficacy and safety of convalescent plasma CP therapy in patients with COVID-19.We searched for every available study from major databases (CENTRAL, MEDLINE via Ovid, EMBASE) through 20th April 2020. We independently screened, extracted, assessed the risk of bias, analyzed the data using SPSS version 26, and narratively summarized the data. For the outcomes, we wanted to evaluate the changes of clinical parameters, radiological appearance, pulmonary function, the titer of neutralizing antibody, viral load, the disappearance of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) RNA, and adverse events.We found five case series from our literature searching. The overall methodological quality of the case series was moderate. We included 27 patients, and all patients received CP transfusion. All patients experienced improvement of clinical symptoms and pulmonary lesions after receiving 200 to 2400 mL (median 200 mL) of CP transfusion. All patients in reported studies had negative results of reverse transcriptase-polymerase chain reaction(RT-PCR) after 1 to 26 days of transfusion (median 3 days). There was one non-life threatening adverse event reported after CP transfusion (facial red spot). In conclusion, CP therapy in COVID-19 patients showed promising results as it improved clinical symptoms and parameters, and it is well-tolerated based on our included studies. However, further expanded clinical trials with better designs are still required to evaluate the efficacy of this treatment although suchidea will be quite challenging to be conducted in the era of an epidemic.</text>
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                <text>2020</text>
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                <text>covid-19, Therapy, systematic review, side effect, onvalescent plasma</text>
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                <text>10.19106/JMedSciSI005203202012</text>
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                <text>Journal of the Medical Sciences</text>
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                <text>Universitas Gadjah Mada</text>
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                <text>Medicine, Medicine (General)</text>
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                  <text>Agricultura sostenible</text>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Agricultura sostenible</text>
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                <text>SENSIBILIDAD IN VITRO DE PHYTOPHTHORA INFESTANS AL EXTRACTO DE FIQUE (Furcraea gigantea vent.) Y FUNGICIDAS SISTEMICOS SENSIBILIDADE IN VITRO DE PHYTOPHTHORA INFESTANS AO EXTRATO DA CULTURA DO FIQUE (Furcraea Gigantea Vent.) E FUNGICIDAS SISTEMICOS IN VITRO SENSITIVITY OF PHYTOPHTHORA INFESTANS TO FIQUE EXTRACT (Furcraea gigantea vent.) AND SYSTEMIC FUNGICIDES</text>
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            <description>An entity primarily responsible for making the resource</description>
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                <text>DAVID E ALVAREZ S, CLAUDIA E SALAZAR G, ANDRES M HURTADO B, DERIAN M DELGADO B, OSCAR ARANGO B</text>
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            <description>An account of the resource</description>
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                <text>Con el objeto de evaluar tratamientos alternativos para el manejo de tizón tardío de la papa causada por Phytophthora infestans, se estudió la respuesta de sensibilidad in vitro del patógeno al bioinsumo de fique (Furcraea gigantea Vent), comparándolo con los productos comerciales Ridomil-Gold® y Curzate®. Para esto, se utilizó un diseño irrestrictamente al azar con arreglo factorial, en donde el factor A correspondió a los tratamientos antes nombrados y el factor B a las concentraciones: 10, 100, 1.000, 10.000, 100.000 µg.mL-1 adicionadas al medio de cultivo. La sensibilidad del aislamiento se evaluó mediante la escala de Shattock y se calculó la concentración efectiva cincuenta (EC50). Los resultados mostraron diferencias significativas (P</text>
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            <name>Date</name>
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                <text>2011</text>
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                <text>Extract plant, Tizón tardío, extracto vegetal, extrato de planta, late blight, papa (Solanum tuberosum L), potato (Solanum tuberosum L.), requeima da batata</text>
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            <description>A related resource from which the described resource is derived</description>
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                <text>Biotecnología en el Sector Agropecuario y Agroindustrial</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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                <text>Universidad del Cauca</text>
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                <text>Agriculture (General), Biotechnology</text>
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                <text>&lt;a href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;amp;pid=S1692-35612011000200011" target="_blank" rel="noreferrer noopener"&gt;http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;amp;pid=S1692-35612011000200011&lt;/a&gt;</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Infectious Disease Threats in the Twenty-First Century: Strengthening the Global Response</text>
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              <elementText elementTextId="10693">
                <text>David E Bloom, Daniel Cadarette</text>
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                <text>The world has developed an elaborate global health system as a bulwark against known and unknown infectious disease threats. The system consists of various formal and informal networks of organizations that serve different stakeholders; have varying goals, modalities, resources, and accountability; operate at different regional levels (i.e., local, national, regional, or global); and cut across the public, private-for-profit, and private-not-for-profit sectors. The evolving global health system has done much to protect and promote human health. However, the world continues to be confronted by longstanding, emerging, and reemerging infectious disease threats. These threats differ widely in terms of severity and probability. They also have varying consequences for morbidity and mortality, as well as for a complex set of social and economic outcomes. To various degrees, they are also amenable to alternative responses, ranging from clean water provision to regulation to biomedical countermeasures. Whether the global health system as currently constituted can provide effective protection against a dynamic array of infectious disease threats has been called into question by recent outbreaks of Ebola, Zika, dengue, Middle East respiratory syndrome, severe acute respiratory syndrome, and influenza and by the looming threat of rising antimicrobial resistance. The concern is magnified by rapid population growth in areas with weak health systems, urbanization, globalization, climate change, civil conflict, and the changing nature of pathogen transmission between human and animal populations. There is also potential for human-originated outbreaks emanating from laboratory accidents or intentional biological attacks. This paper discusses these issues, along with the need for a (possibly self-standing) multi-disciplinary Global Technical Council on Infectious Disease Threats to address emerging global challenges with regard to infectious disease and associated social and economic risks. This Council would strengthen the global health system by improving collaboration and coordination across organizations (e.g., the WHO, Gavi, CEPI, national centers for disease control, pharmaceutical manufacturers, etc.); filling in knowledge gaps with respect to (for example) infectious disease surveillance, research and development needs, financing models, supply chain logistics, and the social and economic impacts of potential threats; and making high-level, evidence-based recommendations for managing global risks associated with infectious disease.</text>
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                <text>2019</text>
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                <text>global health, global health systems, infectious disease, Outbreak, epidemic, Pandemic</text>
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                <text>DOI: 10.3389/fimmu.2019.00549</text>
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                <text>Frontiers in Immunology</text>
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                <text>Frontiers Media S.A.</text>
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                <text>Immunologic diseases. Allergy</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Domestic Poultry and SARS Coronavirus, Southern China</text>
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                <text>David E. Swayne, David L. Suarez, Erica Spackman, Terrence M Tumpey, Joan R. Beck, Dean D. Erdman, Pierre E Rollin, Thomas G. Ksiazek</text>
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                <text>SARS coronavirus injected intratracheally into chickens, turkeys, geese, ducks, and quail, or into the allantoic sac of their embryonating eggs, failed to cause disease or replicate. This finding suggests that domestic poultry were unlikely to have been the reservoir, or associated with dissemination, of SARS coronavirus in the animal markets of southern China.</text>
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                <text>2004</text>
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                <text>disease, pathogenesis, poultry, reservoir, SARS-coronavirus, China</text>
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                <text>DOI: 10.3201/eid1005.030827</text>
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                <text>Emerging Infectious Diseases</text>
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                <text>Centers for Disease Control and Prevention</text>
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                <text>Infectious and parasitic diseases, Medicine</text>
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              <name>Title</name>
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                  <text>Dominio científico: Coronavirus</text>
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            <description>A name given to the resource</description>
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                <text>Mice Susceptible to SARS Coronavirus</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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                <text>David E. Wentworth, Laura Gillim-Ross, Noel Espina, Kristen A. Bernard</text>
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          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
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                <text>Murine models of severe acute respiratory syndrome–associated coronavirus (SARS-CoV) will greatly advance research on this emerging virus. When BALB/c mice were simultaneously inoculated intranasally and orally, replication of SARS-CoV was found in both lung and intestinal tissue.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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              <elementText elementTextId="18456">
                <text>2004</text>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
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                <text>SARS-CoV, coronavirus, SARS virus, Mice, model, Multiplex</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="18458">
                <text>DOI: 10.3201/eid1007.031119</text>
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          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="18459">
                <text>Emerging Infectious Diseases</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="18460">
                <text>Centers for Disease Control and Prevention</text>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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              <elementText elementTextId="18461">
                <text>Infectious and parasitic diseases, Medicine</text>
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          </element>
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            <name>Language</name>
            <description>A language of the resource</description>
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                <text>EN</text>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
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                <elementText elementTextId="1">
                  <text>Coronavirus</text>
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              </elementTextContainer>
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            <element elementId="41">
              <name>Description</name>
              <description>An account of the resource</description>
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                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>A case series of patients, including a consultant rhinologist,  who all experienced a loss of smell associated with  confirmed or suspected COVID-19</text>
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          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="55370">
                <text>David E.J. Whitehead, Christine Kelly, N. Ahmad</text>
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          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
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              <elementText elementTextId="55371">
                <text>Background: Non-invasive detection of carriers of COVID-19 virus remains elusive. A decrease in sense of smell appears to be a potential marker of the disease. However, it is not the most frequently reported complaint and there may be more novel early markers of disease.Methodology: We present a case series of patients, including a consultant rhinologist who all experienced a loss of smell associated with confirmed or suspected COVID-19.Results: A consultant rhinologist presented with a delayed sudden onset anosmia, four days after testing positive for coronavirus whilst also exhibiting evidence of autonomic dysfunction prior to rRT-PCR diagnosis and during the time period during which smell suddenly deteriorated. Sudden loss of smell can occur within a 3-hour window and a transient increase in SNOT-22 score was also noted at the time of loss.Conclusions: Transient hyposmia or anosmia appear to be an early warning sign or marker symptom associated with COVID-19. Smell can be lost rapidly but appears to recover for many. For others a variety of novel treatments exist. There may be more sensitive or specific signs associated with the disease.</text>
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          <element elementId="40">
            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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              <elementText elementTextId="55372">
                <text>2020</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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              <elementText elementTextId="55373">
                <text>coronavirus, covid-19, anosmia, hyposmia, Autonomic nervous system, heart rate variability, autonomic dysfunction, SNOT-22, olfactory loss, smell training</text>
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            </elementTextContainer>
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          <element elementId="43">
            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="55374">
                <text>10.4193/RHINOL/20.027</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="55375">
                <text>Epidemiology and Health</text>
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          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="55376">
                <text>Korean Society of Epidemiology</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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              <elementText elementTextId="55377">
                <text>Otorhinolaryngology</text>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Agricultura sostenible</text>
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              </elementTextContainer>
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            <element elementId="41">
              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Agricultura sostenible</text>
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              </elementTextContainer>
            </element>
          </elementContainer>
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      </elementSetContainer>
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    <itemType itemTypeId="1">
      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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              <elementText elementTextId="150225">
                <text>Migración y renovación generacional en la agricultura familiar indígena: estudio de caso Otavalo-Ecuador</text>
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          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="150226">
                <text>David Eche</text>
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          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
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              <elementText elementTextId="150227">
                <text>El presente proyecto analiza la migración y la renovación generacional en la agricultura familiar indígena como parte del proceso de la desagrarización, desde los enfoques de la agricultura familiar indígena y la juventud rural en el cantón indígena kichwa de Otavalo. Mediante análisis cuantitativos y cualitativos de los datos obtenidos con encuestas estructuradas, se determinó que este tipo de agricultura adolece de severos problemas de productividad que afectan negativamente sobre la generación de ingresos económicos, los cuales fomentan la emigración rural. Particularmente, la disminución de la productividad de la agricultura familiar se debe a factores ambientales como la escasez de agua y la degradación de suelos. El abandono de la actividad agrícola esta principalmente relacionada con la falta de apoyos económicos y técnicos gubernamentales a la agricultura familiar, forzando a los agricultores a la búsqueda de empleo fuera de la finca, lo que conlleva a una disminución de la mano de obra agrícola local, y al inicio de micro emprendimientos familiares de textiles y artesanías. La juventud rural, consciente de estas limitantes agrícolas, no se siente atraída para continuar con la actividad agrícola, ni tampoco considera estudiar esta ciencia en la formación profesional. La combinación de las problemáticas estudiadas como la migración, el cambio de actividad económica, y de la escasa renovación generacional demuestran la existencia de un proceso de desagrarización de la agricultura familiar indígena, que conllevan a cambios demográficos, económicos y laborales de este grupo de estudio</text>
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          <element elementId="40">
            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="150228">
                <text>2020</text>
              </elementText>
            </elementTextContainer>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="150229">
                <text>agricultura de subsistencia, desagrarización, desarrollo rural, juventud rural, migración laboral</text>
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            </elementTextContainer>
          </element>
          <element elementId="43">
            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
            <elementTextContainer>
              <elementText elementTextId="150230">
                <text>10.29166/siembra.v5i1.1423</text>
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            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="150231">
                <text>Siembra</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="150232">
                <text>Universidad Central del Ecuador</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="150233">
                <text>Agriculture</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="46">
            <name>Relation</name>
            <description>A related resource</description>
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              <elementText elementTextId="150234">
                <text>&lt;a href="http://revistadigital.uce.edu.ec/index.php/SIEMBRA/article/view/1423" target="_blank" rel="noreferrer noopener"&gt;http://revistadigital.uce.edu.ec/index.php/SIEMBRA/article/view/1423&lt;/a&gt;</text>
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          <name>Dublin Core</name>
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          <elementContainer>
            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
              <elementTextContainer>
                <elementText elementTextId="88121">
                  <text>Agricultura sostenible</text>
                </elementText>
              </elementTextContainer>
            </element>
            <element elementId="41">
              <name>Description</name>
              <description>An account of the resource</description>
              <elementTextContainer>
                <elementText elementTextId="88122">
                  <text>Dominio científico: Agricultura sostenible</text>
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            </element>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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              <elementText elementTextId="157249">
                <text>EVALUACIÓN DEL BIOINSUMO DE FIQUE (Furcraea gigantea) EN EL CONTROL DEL TIZÓN TARDÍO DE LA PAPA</text>
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          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="157250">
                <text>DAVID EDUARDO ÁLVAREZ S, ANDRÉS MAURICIO HURTADO B, CLAUDIA ELIZABETH SALAZAR G, OSCAR ARANGO B, JULIÁN MARCELO ACOSTA M</text>
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          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="157251">
                <text>Se evaluó el efecto de un bioinsumo elaborado a partir de jugo de fique (Furcraea gigantea Vent.) en el manejo de la enfermedad del tizón tardío causada por el patógeno Phytophthora infestans en dos cultivos experimentales de papa (Solanum tuberosum L.).e utilizóun diseño de bloques completos al azar con arreglo factorial, en donde el factor A correspondió a las concentraciones: 5, 10 y 15 L.ha-1 y el factor B al tiempo de fermentación: 2, 4 y 6 días (a 33ºC)comparados con un testigo absoluto (agua) y un testigo comercial (Cymoxanil 8% + Mancozeb 64%).Los valores de severidad, incidencia y rendimiento determinaron que la aplicación de 15 L.ha-1 bajo un tiempo de fermentación de 4 días fue el único tratamiento que mostró diferencias estadísticas (P</text>
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          <element elementId="40">
            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="157252">
                <text>2013</text>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="157253">
                <text>Phytophthora infestans, Solanum tuberosum L, extracto vegetal</text>
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          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="157254">
                <text>Biotecnología en el Sector Agropecuario y Agroindustrial</text>
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          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="157255">
                <text>Universidad del Cauca</text>
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            </elementTextContainer>
          </element>
          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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              <elementText elementTextId="157256">
                <text>Agriculture (General), Biotechnology</text>
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          <element elementId="46">
            <name>Relation</name>
            <description>A related resource</description>
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              <elementText elementTextId="157257">
                <text>&lt;a href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;amp;pid=S1692-35612013000200004&amp;amp;lng=en&amp;amp;tlng=en" target="_blank" rel="noreferrer noopener"&gt;http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;amp;pid=S1692-35612013000200004&amp;amp;lng=en&amp;amp;tlng=en&lt;/a&gt;</text>
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                <text>David Enoc Villalobos Betancourt</text>
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                <text>Revista Nuevo Humanismo</text>
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                <text>Universidad Nacional, Costa Rica</text>
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                <text>History of scholarship and learning. The humanities</text>
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                <text>&lt;a href="https://www.revistas.una.ac.cr/index.php/nuevohumanismo/article/view/9164" target="_blank" rel="noreferrer noopener"&gt;https://www.revistas.una.ac.cr/index.php/nuevohumanismo/article/view/9164&lt;/a&gt;</text>
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