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                <text>&lt;a href="https://revista.fecolsog.org/index.php/rcog/article/view/2932" target="_blank" rel="noreferrer noopener"&gt;https://revista.fecolsog.org/index.php/rcog/article/view/2932&lt;/a&gt;</text>
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                <text>Federica Alessandrini, Sara Caucci, Valerio Onofri, Filomena Melchionda, Adriano Tagliabracci, Patrizia Bagnarelli, Laura   Di Sante, Chiara Turchi, Stefano Menzo</text>
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                <text>Deep knowledge of the genetic features of SARS-CoV-2 is essential to track the ongoing pandemic through different geographical areas and to design and develop early diagnostic procedures, therapeutic strategies, public health interventions, and vaccines. We describe protocols and first results of the Ion AmpliSeq™ SARS-CoV-2 Research Panel by a massively parallel sequencing (MPS) assay. The panel allows for targeted sequencing by overlapping amplicons, thereby providing specific, accurate, and high throughput analysis. A modified reverse transcription reaction, which consists of the use of a SARS-CoV-2 specific primers pool from the Ion AmpliSeq SARS-CoV-2 Research Panel, was assessed in order to promote viral RNA specific reverse transcription. The aim of this study was to evaluate the effectiveness of the Ion AmpliSeq™ SARS-CoV-2 Research Panel in sequencing the entire viral genome in different samples. SARS-CoV-2 sequence data were obtained from ten viral isolates and one nasopharyngeal swab from different patients. The ten isolate samples amplified with 12 PCR cycles displayed high mean depth values compared to those of the two isolates amplified with 20 PCR cycles. High mean depth values were also obtained for the nasopharyngeal swab processed by use of a target-specific reverse transcription. The relative depth of coverage (rDoC) analysis showed that when 12 PCR cycles were used, all target regions were amplified with high sequencing coverage, while in libraries amplified at 20 cycles, a poor uniformity of amplification, with absent or low coverage of many target regions, was observed. Our results show that the Ion AmpliSeq SARS-CoV-2 Research Panel can achieve rapid and high throughput SARS-CoV-2 whole genome sequencing from 10 ng of DNA-free viral RNA from isolates and from 1 ng of DNA-free viral RNA from a nasopharyngeal swab using 12 PCR cycles for library amplification. The modified RT-PCR protocol yielded superior results on the nasopharyngeal swab compared to the reverse transcription reaction set up according to the manufacturer’s instructions.</text>
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                <text>SOMMARIO: 1. Premessa - 2. La democrazia in pericolo? - 3. La libertà religiosa tra Costituzione e Concordato - 4. Sulla libertas Ecclesiae e sulle regole del diritto internazionale - 5. Le trattative diplomatiche de facto tra la CEI e il Governo e il dibattito pubblico - 6. Il FEC e il (mancato) trasferimento della proprietà delle chiese con personalità giuridica in favore dell’autorità ecclesiastica: un case study.  Trifles for a pandemic  ABSTRACT: The emergency regulations for the containment of Covid-19 as well as affecting religious freedom (art. 19 of the Italian Constitution) can also be relevant from the point of view of the bilaterality of the pact between the Italian State and the Holy See by opening up to the principles of international law and the Vienna Convention the entrance to the list of instruments that can be applied for the solution of the problem, alongside the usual pragmatic instruments of realpolitik.</text>
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                <text>Stato, Chiese e Pluralismo Confessionale</text>
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                <text>Università degli Studi di Milano</text>
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                <text>The emergency at COVID-19 has changed the face of our cities, preventing most urban activities, limiting travel on large, medium and short distances and drastically reducing the number and intensity of social relationships. The organization of the built environment, combined with the characteristics of the pedestrian network, has taken on greater weight in relation to the restrictive measures that COVID-19 has imposed on entire populations.  Social distancing, the limitations of movements allowed almost exclusively for the achievement of the services identified as essential, together with the ban on carrying out certain activities, on the one hand have changed people's living habits and on the other have revealed the need to reorganize quickly the network of canals and open spaces to adapt them to the current emergency situation, but probably also to the conditions of a different normal". Local decision makers are faced with a new demand for mobility and accessibility by moving in completely unexplored waters."</text>
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                <text>This article analyzes some relevant questions as regards the impact of COVID-19-related social living conditions on spatial planning policies and practices. The proposed discussion aims at highlighting and discussing a number of outstanding topics of spatial planning which public administrative bodies, practitioners, entrepreneurs and organizations operating in the profit and non-profit sectors, and the local communities should carefully consider with reference to a new planning outset after the lockdown period. Innovative and creative approaches should be identified and implemented when dealing with collective public spaces, shopping malls, retail activities and related areas, urban and regional mobility-related infrastructure and services, food-supply changes and their implications in terms of development of local food-producing practices, spatial social control and privacy, mitigation of climate change-related negative impacts, and public awareness and commitment towards losers, especially urban losers. Each of these points presents important challenges for the future of spatial planning. Some of these challenges are synthetically described and discussed in this article.</text>
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                <text>2020</text>
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                <text>climate change, mobility, food self-sufficiency, COVID-19, post-lockdown planning</text>
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                <text>DOI: 10.6092/1970-9870/6846</text>
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                <text>Università di Napoli Federico II</text>
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                <text>Transportation engineering, Urbanization. City and country</text>
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                  <text>Agricultura sostenible</text>
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                  <text>Dominio científico: Agricultura sostenible</text>
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                <text>Análisis en la relación entre el fondo de maniobra y la rentabilidad: caso del sector oleícola español</text>
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                <text>Federico  Li Bonilla, Alberto López Pérez, Sara Fernández López, David Rodeiro Pazos</text>
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                <text>La estacionalidad de la actividad oleica, incide que los flujos de caja por ventas de contado y a crédito. Sus plazos y recuperación de efectivo, afectan el rendimiento financiero de las empresas involucradas en dicha actividad. En el entorno empresarial se rumora que dicha actividad oleica es de baja rentabilidad, lo cual motiva esta investigación, para poder anticipar o corregir la gestión del capital de maniobra y mejorar la rentabilidad.  Para llevar a cabo esta pesquisa, se utilizó una base de datos con 817 empresas del sector. Una vez depurada la muestra, esta quedó en 324 empresas para realizar el análisis entre la relación de fondo de maniobra y la rentabilidad y poder determinar si el fondo de maniobra o capital de trabajo incide en la baja rentabilidad o no.  El valor del aporte de esta investigación, a la academia y al mundo empresarial, es sobre la importancia del fondo de maniobra y su rentabilidad en la gestión de Pymes; en especial para las empresas que se dedican a la extracción, manipulación y envasado a granel así como al detal del aceite de oliva. Para ello, los análisis realizados rechazan las cuatro hipótesis de este trabajo. La contribución de esta investigación se da en que, en los hallazgos obtenidos, existe una relación positiva entre la gestión del fondo de maniobra y la rentabilidad. Se da una diferencia de rentabilidad entre cooperativas y no cooperativas. Estos hallazgos sugieren que las bajas tasas de interés en España y la flexibilidad en el plazo venta del aceite y de su cobro, no afectan su rentabilidad en forma negativa.</text>
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                <text>2018</text>
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                <text>COOPERATIVAS, Fondo de maniobra, Gestión, Pymes, agroindustria oleica, rentabilidad</text>
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                <text>10.22458/rna.v9i1.2102</text>
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            <description>A related resource from which the described resource is derived</description>
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                <text>Revista Nacional de Administración</text>
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            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="194646">
                <text>Universidad Nacional de Educación a Distancia (UNED)</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Business, Political institutions and public administration (General)</text>
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                <text>&lt;a href="https://revistas.uned.ac.cr/index.php/rna/article/view/2102" target="_blank" rel="noreferrer noopener"&gt;https://revistas.uned.ac.cr/index.php/rna/article/view/2102&lt;/a&gt;</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>COVID-19 and Dentistry: Prevention in Dental Practice, a Literature Review</text>
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                <text>Federico Alcide Villani, Riccardo Aiuto, Luigi Paglia, Dino Re</text>
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                <text>SARS-CoV-2 is a member of the family of coronaviruses. The first cases were recorded in Wuhan, China, between December 2019 and January 2020. Italy is one of the most affected countries in Europe. COVID-19 is a new challenge in modern dentistry. New guidelines are required in dental clinics to avoid contagion caused by cross-infections. A narrative review was performed using both primary sources, such as scientific articles and secondary ones, such as bibliographic indexes, web pages, and databases. The main search engines were PubMed, SciELO, and Google Scholar. Twelve articles were selected to develop the bibliographic review by applying pre-established inclusion and exclusion criteria. Precautionary measures should be applied to control COVID-19 in clinical practice. Several authors have highlighted the importance of telephone triage and/or clinic questionnaires, body temperature measurement, usage of personal protective equipment, surface disinfection with ethanol between 62% and 71%, high-speed instruments equipped with an anti- retraction system, four-handed work, and large-volume cannulas for aspiration. Clinically, the use of a rubber dam is essential. FFP2 (or N95) and FFP3 respirators, if compared to surgical masks, provide greater protection for health workers against viral respiratory infections. Further accurate studies are needed to confirm this.</text>
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                <text>2020</text>
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            <description>The topic of the resource</description>
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              <elementText elementTextId="47977">
                <text>covid-19, infection, hygiene, Dentistry, dental practice, PPE</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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                <text>10.3390/ijerph17124609</text>
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                <text>Epidemiology and Health</text>
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                <text>Korean Society of Epidemiology</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Medicine</text>
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                <text>Interleukin-6 receptor blockade in patients with COVID-19: placing clinical trials into context.</text>
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                <text>Federico Angriman, Bruno L Ferreyro, Lisa Burry, Eddy Fan, Niall D Ferguson, Shahid Husain, Shaf H Keshavjee, Enrico Lupia, Laveena Munshi, Samuele Renzi, Onion Gerald V Ubaldo, Bram Rochwerg, Lorenzo Del Sorbo</text>
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                <text>The pleiotropic cytokine interleukin-6 (IL-6) has been implicated in the pathogenesis of COVID-19, but uncertainty remains about the potential benefits and harms of targeting IL-6 signalling in patients with the disease. The efficacy and safety of tocilizumab and sarilumab, which block the binding of IL-6 to its receptor, have been tested in adults with COVID-19-related acute respiratory illness in randomised trials, with important differences in trial design, characteristics of included patients, use of co-interventions, and outcome measurement scales. In this Series paper, we review the clinical and methodological heterogeneity of studies of IL-6 receptor antagonists, and consider how this heterogeneity might have influenced reported treatment effects. Timing from clinical presentation to treatment, severity of illness, and concomitant use of corticosteroids are among the factors that might have contributed to apparently inconsistent results. With an understanding of the sources of variability in these trials, available evidence could be applied to guide clinical decision making and to inform the enrichment of future studies.</text>
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                <text>2021</text>
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                <text>10.1016/S2213-2600(21)00139-9</text>
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                <text>The Lancet. Respiratory medicine</text>
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                  <text>Agricultura sostenible</text>
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                  <text>Dominio científico: Agricultura sostenible</text>
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                <text>Primer registro de Najas marina (Hydrocharitaceae) y listado florístico de hidrófitas sumergidas en el Bajo Paraná (Argentina)</text>
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                <text>Federico Brumnich, Berenice Schneider</text>
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            <description>An account of the resource</description>
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                <text>Se comunica el registro de Najas marina L., una hidrófita completamente sumergida, en el Bajo Paraná (Argentina) como nueva cita para su flora y se revisan brevemente aspectos de su ecología (rasgos biológicos, hábitat y distribución). Además, se presen- ta un listado de las 24 especies de hidrófitas sumergidas (en 12 familias y 15 géneros) que han sido registradas para la extensa planicie de inundación del Bajo Paraná.</text>
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            <description>The topic of the resource</description>
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                <text>Nueva cita, Paraná Medio, delta del paraná, macrófitas acuáticas, planicie de inundación</text>
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                <text>10.30550/j.lil/2020.57.1/2</text>
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                <text>Lilloa</text>
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                <text>Fundación Miguel Lillo</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Plant culture, Botany</text>
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            <name>Relation</name>
            <description>A related resource</description>
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