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                <text>Phillipa Hay, Stephen Touyz, Hubert Lacey</text>
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                <text>DOI: 10.1186/s40337-020-00295-3</text>
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                <text>Aspects environnementaux du Livre vert de la Commission sur les mers et océans et de la communication sur la gestion intégrée des zones côtières</text>
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                <text>Phillippe Billet</text>
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                <text>coastal zone, environment, ENVIRONNEMENT, Governance, integrated coastal management, Integrated management</text>
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                <text>DOI: 10.4000/vertigo.8348</text>
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                <text>ACE2 Receptor in the skin and Cutaneous Manifestations of SARS-Cov-2: A Review of the Literature</text>
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                <text>Pho, Denita  Meiliani</text>
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                <text>A B S T R A C T Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is a newly discovered coronavirus that causes Coronavirus Disease 2019 (COVID-19). The interaction of SARS-CoV-2 transmembrane spike (S) glycoprotein with the human angiotensin-converting enzyme-2 (hACE2) is the primary method of virus entry to the cell. ACE2 is a transmembrane enzyme involved in the renin-angiotensin- aldosterone system. This enzyme plays pivotal roles in blood pressure regulations and also electrolyte homeostasis. The expression of ACE2 in various skin cells has been demonstrated in previous studies. Keratinocytes in the epidermis show an exceptionally high expression of ACE2. In addition to human skin, ACE2 is also found in animals’ tissues and were exceptionally high in cats and dogs’ skin and eyes. This finding suggests their obscure role in COVID-19 transmission. Cutaneous symptoms of COVID-19 in humans exist as the consequence of ACE2 presence in the skin. The possible mechanisms of COVID-19 clinical manifestations in the skin are upregulated innate immune human response, hypercoagulable state, and non- structural proteins in SARS-CoV-2. These processes are presented as different dermatologic manifestations, which are maculopapular rash, papulovesicular rash, and livedo reticularis. This review aims to link the theoretical framework and published findings to establish the connection between ACE2 expression in skin and cutaneous manifestations of COVID-19.</text>
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                <text>covid-19, SARS-CoV-2, ACE2, hace2</text>
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                <text>Korean Society of Epidemiology</text>
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                <text>Therapeutics. Pharmacology, Neurology. Diseases of the nervous system</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Treatment with Exogenous Trypsin Expands In Vitro Cellular Tropism of the Avian Coronavirus Infectious Bronchitis Virus</text>
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                <text>Phoebe Stevenson-Leggett, Sarah Keep, Erica Bickerton</text>
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                <text>The Gammacoronavirus infectious bronchitis virus (IBV) causes a highly contagious and economically important respiratory disease in poultry. In the laboratory, most IBV strains are restricted to replication in ex vivo organ cultures or in ovo and do not replicate in cell culture, making the study of their basic virology difficult. Entry of IBV into cells is facilitated by the large glycoprotein on the surface of the virion, the spike (S) protein, comprised of S1 and S2 subunits. Previous research showed that the S2′ cleavage site is responsible for the extended tropism of the IBV Beaudette strain. This study aims to investigate whether protease treatment can extend the tropism of other IBV strains. Here we demonstrate that the addition of exogenous trypsin during IBV propagation in cell culture results in significantly increased viral titres. Using a panel of IBV strains, exhibiting varied tropisms, the effects of spike cleavage on entry and replication were assessed by serial passage cell culture in the presence of trypsin. Replication could be maintained over serial passages, indicating that the addition of exogenous protease is sufficient to overcome the barrier to infection. Mutations were identified in both S1 and S2 subunits following serial passage in cell culture. This work provides a proof of concept that exogenous proteases can remove the barrier to IBV replication in otherwise non-permissive cells, providing a platform for further study of elusive field strains and enabling sustainable vaccine production in vitro.</text>
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                <text>coronavirus, spike protein, cleavage, glycoprotein, animal coronavirus, tropism</text>
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                <text>10.3390/v12101102</text>
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                <text>Epidemiology and Health</text>
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                <text>Korean Society of Epidemiology</text>
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                <text>Microbiology</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>How COVID-19 impacts Vietnam’s banking stocks: An event study method</text>
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                <text>Phuong Lai Cao Mai</text>
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                <text>The banking industry is one of the major industries in the Vietnamese stock market, so understanding how the industry index reacts to unusual events such as COVID-19’s impact is very important for the development of the Vietnamese stock market. This study examines the response of the banking sector index to three lockdown/blockage announcements to prevent the COVID-19 epidemic in Vietnam in 2020. Three times of lockdown/blockage: On February 13, 2020, blockade of Son Loi commune, Vinh Phuc province; on March 30, 2020, Vietnam announced the nationwide epidemic of COVID-19 and then nationwide lockdown, and on July 28, 2020, blockade in Da Nang. In the first case, the abnormal returns changed the sign around the notification date indicating that the stock price deviated from its fair value, but accumulating abnormal returns CAR (0;3] and CAR (0; 2] are both positive and statistically significant, which means that investors are more secure when the epidemic area is tightly controlled. The nationwide lockdown was the event that had the strongest impact on the stock price when both AR and CAR were negative and statistically significant before and after the date of the event’s announcement. Nationwide lockdown was the event that had the strongest impact on stock prices as both AR and CAR were negative in the days before and days after the event. This result supports the theory of imperfect substitution. Only AR [2] was positive and statistically significant, showing that the blockade event in Da Nang had a slight impact on the banking sector’s stock price.</text>
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                <text>2021</text>
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                <text>In Myanmar, two expatriates have started infected by COVID-19 pandemic on 23 March in 2020 and COVID-19 period was divided into the two periods by the data of patients, from starting July 29, no more infected people found till August 19. Myanmar citizen think that there will be no more new COVID-19 cases, they started running their daily work, not following precaution methods. Unfortunately, the number of patients increased more and more, starting from 20th August. The period between 23rd March and 19th August was regarded as COVID-19 first wave and the period starting from 10th August was COVID-19 second wave by Government. In Myanmar, numbers of developed city are fewer than rural townships. Infrastructures of townships are same and most people, living in rural townships are not rich and they didn’t have saving money in Banks and they are depending on their monthly salaries. During pandemic period, general workers faced with unemployment problem and difficulty in daily expenses. Some volunteers helped daily expenses to poor people in COVID-19 first wave. In second COVID-19 wave, volunteers cannot help many families. This paper focused on COVID-19 pandemic impact on Public psychological consequences, Economy, Educational dimension and the prospects after pandemic.</text>
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                <text>A potential therapeutic combination for treatment of COVID-19: Synergistic effect of DPP4 and RAAS suppression.</text>
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                <text>COVID-19, caused by the novel coronavirus SARS-CoV-2, is an abbreviated name for coronavirus disease 2019. COVID-19 became a global pandemic in early 2020. It predominantly affects not only the upper and lower respiratory tract, but also multiple organs, including the kidney, heart, and brain. The mortality of COVID-19 patients is high in men and in elderly patients with age-related diseases such as hypertension and diabetes. The angiotensin converting enzyme-2 (ACE-2), a component in the renin-angiotensin-aldosterone system (RAAS), plays as cell surface receptors for SARS-CoV-2. A recent study proved that coronavirus SARS-CoV-2 also uses dipeptidyl peptidase-4 (DPP4, also known as adenosine deaminase complexing protein 2, CD26) as a co-receptor when entering cells. In addition, DPP4 is also implicated in the regulation of the immune response. Thus, the combination of DPP4 inhibition and suppression of ACE-2/RAAS may be a novel therapeutic strategy for combating this pandemic.</text>
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                <text>The COVID-19 pandemic has taken the mental health system by surprise, with the state of lockdown forcing businesses to close their doors, including many mental health services. This has driven many psychotherapists and other mental health professionals towards telepsychotherapy, relying on online consultations to provide continuity of care. However, the adoption of telepsychotherapy required major adaptations from both mental health professionals and patients. This study set out to explore the predictors of the use of online consultations and the perceived level of comfort using telepsychotherapy in a sample of 73 Lebanese mental health professionals. Data was collected via online dissemination of a survey. Results show that 82% of participants made use of online consultations in the past few days, reflecting the adaptation of Lebanese mental health professionals to the atypical newly imposed situation triggered by the COVID-19 pandemic and its consequent lockdown. Having previous experience in the use of online consultations and perceived level of telepresence were significant predictors of the level of comfort of mental health professionals in the execution online consultations. We suggest that more awareness and trainings are required around the practice of telepsychotherapy outside the context of the COVID-19 pandemic.</text>
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                <text>Abstract Background The world is facing a massive burden from the coronavirus disease 2019 (COVID-19) pandemic. Governments took the extraordinary step of locking down their own countries to curb the spread of the coronavirus. After weeks of severe restrictions, countries have begun to relax their strict lockdown measures. However, reopening will not be back to normal. Simulation facilities (SF) are training spaces that enable health professionals and students to learn skills and procedures in a safe and protected environment. Today’s clinicians and students have an expectation that simulation laboratories are part of lifelong healthcare education. There is great uncertainty about how COVID-19 will impact future training in SF. In particular, the delivery of training activities will benefit of adequate safety measures implemented for all individuals involved. This paper discusses how to safely reopen SF in the post-lockdown phase. Main body The paper outlines 10 focus points and provides operational tips and recommendations consistent with current international guidelines to reopen SF safely in the post-lockdown phase. Considering a variety of national advices and regulations which describe initial measures for the reopening of workplaces as well as international public health recommendations, we provide points of reflection that can guide decision-makers and SF leaders on how to develop local approaches to specific challenges. The tips have been laid out taking also into account two main factors: (a) the SF audience, mainly consisting of undergraduate and postgraduate healthcare professionals, who might face exposure to COVID-19 infection, and (b) for many simulation-based activities, such as teamwork training, adequate physical distancing cannot be maintained. Conclusions The planning of future activities will have to be based not only on safety but also on flexibility principles. Sharing common methods consistent with national and international health guidelines, while taking into account the specific characteristics of the different contexts and centres, will ultimately foster dissemination of good practices. This article seeks to further the conversation. It is our hope that this manuscript will prompt research about the impact of such mitigation procedures and measures in different countries.</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="40">
            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="86009">
                <text>2020</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="86010">
                <text>coronavirus, covid-19, SARS-CoV-2, simulation, lockdown, simulation centre</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="43">
            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
            <elementTextContainer>
              <elementText elementTextId="86011">
                <text>10.1186/s41077-020-00131-3</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="86012">
                <text>Epidemiology and Health</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="86013">
                <text>Korean Society of Epidemiology</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="86014">
                <text>Computer applications to medicine. Medical informatics</text>
              </elementText>
            </elementTextContainer>
          </element>
        </elementContainer>
      </elementSet>
    </elementSetContainer>
  </item>
</itemContainer>
