1736 10 20655 http://socictopen.socict.org/files/original/2426b1389f9acb958b6fa568ab39a891.pdf 17d3cd9c3eb9ac3ff42cf2e1cbcea840 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Selective Packaging in Murine Coronavirus Promotes Virulence by Limiting Type I Interferon Responses Creator An entity primarily responsible for making the resource Jeremiah Athmer, Anthony R. Fehr, Matthew E Grunewald, Wen Qu, D. Lori Wheeler, Kevin W. Graepel, Rudragouda Channappanavar, Aimee Sekine, Dana Saud Aldabeeb, Michael Gale, Mark R. Denison, Stanley Perlman Description An account of the resource Selective packaging is a mechanism used by multiple virus families to specifically incorporate genomic RNA (gRNA) into virions and exclude other types of RNA. Lineage A betacoronaviruses incorporate a 95-bp stem-loop structure, the packaging signal (PS), into the nsp15 locus of ORF1b that is both necessary and sufficient for the packaging of RNAs. However, unlike other viral PSs, where mutations generally resulted in viral replication defects, mutation of the coronavirus (CoV) PS results in large increases in subgenomic RNA packaging with minimal effects on gRNA packaging in vitro and on viral titers. Here, we show that selective packaging is also required for viral evasion of the innate immune response and optimal pathogenicity. We engineered two distinct PS mutants in two different strains of murine hepatitis virus (MHV) that packaged increased levels of subgenomic RNAs, negative-sense genomic RNA, and even cellular RNAs. All PS mutant viruses replicated normally in vitro but caused dramatically reduced lethality and weight loss in vivo. PS mutant virus infection of bone marrow-derived macrophages resulted in increased interferon (IFN) production, indicating that the innate immune system limited the replication and/or pathogenesis of PS mutant viruses in vivo. PS mutant viruses remained attenuated in MAVS−/− and Toll-like receptor 7-knockout (TLR7−/−) mice, two well-known RNA sensors for CoVs, but virulence was restored in interferon alpha/beta receptor-knockout (IFNAR−/−) mice or in MAVS−/− mice treated with IFNAR-blocking antibodies. Together, these data indicate that coronaviruses promote virulence by utilizing selective packaging to avoid innate immune detection.Coronaviruses (CoVs) produce many types of RNA molecules during their replication cycle, including both positive- and negative-sense genomic and subgenomic RNAs. Despite this, coronaviruses selectively package only positive-sense genomic RNA into their virions. Why CoVs selectively package their genomic RNA is not clear, as disruption of the packaging signal in MHV, which leads to loss of selective packaging, does not affect genomic RNA packaging or virus replication in cultured cells. This contrasts with other viruses, where disruption of selective packaging generally leads to altered replication. Here, we demonstrate that in the absence of selective packaging, the virulence of MHV was significantly reduced. Importantly, virulence was restored in the absence of interferon signaling, indicating that selective packaging is a mechanism used by CoVs to escape innate immune detection. Date A point or period of time associated with an event in the lifecycle of the resource 2018 Subject The topic of the resource coronavirus, interferon response, murine hepatitis virus, RNA packaging, packaging signal, selective packaging Identifier An unambiguous reference to the resource within a given context DOI: 10.1128/mBio.00272-18 Source A related resource from which the described resource is derived mBio Publisher An entity responsible for making the resource available American Society for Microbiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Microbiology Language A language of the resource EN http://socictopen.socict.org/files/original/22827db6d0a0a021330c3e46d80984a1.pdf 9bfb3fddc2d106dcc787e5b800528ec8 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Selective Recording of Tectonic Forcings in an Oligocene/Miocene Submarine Channel System: Insights From New Age Constraints and Sediment Volumes From the Austrian Northern Alpine Foreland Basin Creator An entity primarily responsible for making the resource Julian Hülscher, Gero Fischer, Patrick Grunert, Gerald Auer, Anne Bernhardt Description An account of the resource Detailed characterization of variations in sediment architecture, flux, and transport processes in peri-orogenic basins offers insights into external climatic or tectonic forcings. We tested how four well-known tectonic/erosional events in the Oligocene/Miocene Alpine source area are recorded in the sediment-accumulation rates (SARs) of the deep marine sink in the Northern Alpine Foreland Basin (NAFB): exhumation of the Lepontine Dome (starting at 30 Ma) and the Tauern Window (23-21 Ma), erosion of the Augenstein Formation (∼21 Ma), and the visco-elastic relaxation of the European Plate. The Upper Austrian NAFB offers a unique opportunity to investigate external forcings on sedimentary infill due to the large amount of data on the Alpine hinterland and foreland. Deep-marine sedimentation, forming the Puchkirchen Group and the basal Hall Formation, was controlled by a basin-axial submarine channel (3–5 km wide, &gt;100 km length). Two basin-wide unconformities were recognized in seismic-reflection data: the Northern Slope Unconformity (NSU) and the Base Hall Unconformity (BHU). We combine biostratigraphic and chemostratigraphic analyses of 316 drill-cutting samples from three wells with a large 3D-seismic-reflection data set (3300 km2, &gt;5 km depth) to determine age and duration of the unconformities and to calculate spatially averaged SARs for the submarine channel and its overbanks, separately. Deepening of the basin, recorded by the NSU, occurred between 28.1 and 26.9 Ma. The Puchkirchen Group (26.9–19.6 Ma) is characterized by constant SARs (within standard deviation) in the channel [432–623 (t/m2/Ma)] and on the overbanks [240–340 (t/m2/Ma)]. The visco-elastic relaxation of the European Plate results in low SARs on the overbanks [186 (t/m2/Ma)], a decrease in sediment grain size in channel deposits and a decrease in sea level at the BHU (19.6–19.0 Ma). In the upper Hall Formation (19.0–18.1 Ma), clinoforms prograding from the south filled up the basin [1497 (t/m2/Ma)] within 1 Myrs. We conclude that only two of the tectonic signals are recorded in this part of the deep-marine sink, erosion of Augenstein Formation and visco-elastic relaxation of the European Plate; the exhumation of the Tauern Window and Lepontine Dome remain unrecorded. Date A point or period of time associated with an event in the lifecycle of the resource 2019 Subject The topic of the resource foraminiferal analysis, calcareous nannoplankton analysis, chemostratigraphy, submarine channel, Molasse Basin, environmental signal propagation Identifier An unambiguous reference to the resource within a given context DOI: 10.3389/feart.2019.00302 Source A related resource from which the described resource is derived Frontiers in Earth Science Publisher An entity responsible for making the resource available Frontiers Media S.A. Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Science Language A language of the resource EN http://socictopen.socict.org/files/original/a498da0e3a88962d29ae816f5992444a.pdf fe3d208812628eb00397e2e8a5bcf71e Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Selective Vagus Nerve Stimulation as a Therapeutic Approach for the Treatment of ARDS: A Rationale for Neuro-Immunomodulation in COVID-19 Disease Creator An entity primarily responsible for making the resource Svetlana Mastitskaya, Nicole Thompson, David Holder Description An account of the resource Acute respiratory distress syndrome (ARDS) is the most severe form of acute lung injury. It is induced by sepsis, aspiration, and pneumonia, including that caused by SARS coronavirus and human influenza viruses. The main pathophysiological mechanism of ARDS is a systemic inflammatory response. Vagus nerve stimulation (VNS) can limit cytokine production in the spleen and thereby dampen any systemic inflammation and inflammation-induced tissue damage in the lungs and other organs. However, the effects of increased parasympathetic outflow to the lungs when non-selective VNS is applied may result in bronchoconstriction, increased mucus secretion and enhance local pulmonary inflammatory activity; this may outweigh the beneficial systemic anti-inflammatory action of VNS. Organ/function-specific therapy can be achieved by imaging of localized fascicle activity within the vagus nerve and selective stimulation of identified organ-specific fascicles. This may be able to provide selective neuromodulation of different pathways within the vagus nerve and offer a novel means to improve outcome in ARDS. This has motivated this review in which we discuss the mechanisms of anti-inflammatory effects of VNS, progress in selective VNS techniques, and a possible application for ARDS. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource inflammation, covid-19, ARDS, cytokine storm, vagus nerve, Neuromodulation Identifier An unambiguous reference to the resource within a given context 10.3389/fnins.2021.667036 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Neurosciences. Biological psychiatry. Neuropsychiatry http://socictopen.socict.org/files/original/d737fb23ccb58786341489b28bf28a9a.pdf 6fd9ff099f3a74190e6329927717578a Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Selenium Deficiency Is Associated with Mortality Risk from COVID-19 Creator An entity primarily responsible for making the resource Arash Moghaddam, Raban Arved Heller, Qian Sun, Julian Seelig, Asan Cherkezov, Linda Seibert, Julian Hackler, Petra Seemann, Joachim Diegmann, Maximilian Pilz, Manuel Bachmann, Waldemar B. Minich, Lutz Schomburg Description An account of the resource SARS-CoV-2 infections underlie the current coronavirus disease (COVID-19) pandemic and are causative for a high death toll particularly among elderly subjects and those with comorbidities. Selenium (Se) is an essential trace element of high importance for human health and particularly for a well-balanced immune response. The mortality risk from a severe disease like sepsis or polytrauma is inversely related to Se status. We hypothesized that this relation also applies to COVID-19. Serum samples (n = 166) from COVID-19 patients (n = 33) were collected consecutively and analyzed for total Se by X-ray fluorescence and selenoprotein P (SELENOP) by a validated ELISA. Both biomarkers showed the expected strong correlation (r = 0.7758, p < 0.001), pointing to an insufficient Se availability for optimal selenoprotein expression. In comparison with reference data from a European cross-sectional analysis (EPIC, n = 1915), the patients showed a pronounced deficit in total serum Se (mean ± SD, 50.8 ± 15.7 vs. 84.4 ± 23.4 µg/L) and SELENOP (3.0 ± 1.4 vs. 4.3 ± 1.0 mg/L) concentrations. A Se status below the 2.5th percentile of the reference population, i.e., [Se] < 45.7 µg/L and [SELENOP] < 2.56 mg/L, was present in 43.4% and 39.2% of COVID samples, respectively. The Se status was significantly higher in samples from surviving COVID patients as compared with non-survivors (Se; 53.3 ± 16.2 vs. 40.8 ± 8.1 µg/L, SELENOP; 3.3 ± 1.3 vs. 2.1 ± 0.9 mg/L), recovering with time in survivors while remaining low or even declining in non-survivors. We conclude that Se status analysis in COVID patients provides diagnostic information. However, causality remains unknown due to the observational nature of this study. Nevertheless, the findings strengthen the notion of a relevant role of Se for COVID convalescence and support the discussion on adjuvant Se supplementation in severely diseased and Se-deficient patients. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource inflammation, covid-19, Micronutrient, trace element, Selenoprotein P Identifier An unambiguous reference to the resource within a given context 10.3390/nu12072098 Source A related resource from which the described resource is derived Biotemas Publisher An entity responsible for making the resource available Universidade Federal de Santa Catarina Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Nutrition. Foods and food supply http://socictopen.socict.org/files/original/b5eb80b3b2eb5fe839ec48b6b3e90f13.pdf 945bffffc6308c0345741c7e60f58d1c Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Self-Collected versus Healthcare Worker-Collected Swabs in the Diagnosis of Severe Acute Respiratory Syndrome Coronavirus 2 Creator An entity primarily responsible for making the resource Johan H. Therchilsen, Christian von Buchwald, Anders Koch, Susanne Dam Nielsen, Daniel B. Rasmussen, Rebekka Faber Thudium, Nikolai S. Kirkby, Daniel E. T. Raaschou-Pedersen, Johan S. Bundgaard, Kasper Iversen, Henning Bundgaard, Tobias Todsen Description An account of the resource The aim of this study was to compare the sensitivity of self-collected versus healthcare worker (HCW)-collected swabs for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) testing. Symptomatic individuals referred for SARS-CoV-2 testing were invited to provide mobile-phone video-instructed self-collected oropharyngeal and nasal samples followed by a HCW-collected oropharyngeal sample. All samples were sent for analysis to the same microbiology laboratory, and the number of SARS-CoV-2-positive participants in the two tests was compared. A total of 109 participants were included, and 19 participants had SARS-CoV-2-positive results. The diagnostic sensitivity of the self-collected and HCW-collected swabs was 84.2% and 89.5%, respectively, with an acceptable agreement, Cohens kappa 0.82, p < 0.001. Further, results from a questionnaire answered by the participants found that loss of smell as a self-reported symptom was a strong predictor for a SARS-CoV-2-positive test. In conclusion, we found that self-collected oropharyngeal and nasal swabs for SARS-CoV-2 testing can be reliable compared to HCW-collected oropharyngeal samples. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource covid-19, severe acute respiratory syndrome coronavirus 2, covid-19 diagnostic testing Identifier An unambiguous reference to the resource within a given context 10.3390/diagnostics10090678 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine (General) http://socictopen.socict.org/files/original/8ab67e4b6bde89a5a9adbc00d09ee1cc.pdf f44f4006376146723319ccfe4b81c7a0 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Self-help in times of COVID-19 Creator An entity primarily responsible for making the resource Annia Esther Vizcaino Escobar, Idania María Otero-Ramos, Evelyn Fernández-Castillo, Diana Rosa Rodríguez-González Description An account of the resource Introduction: In the presence of SARS-CoV-2, the new coronavirus and causative agent of COVID-19, a pandemic has been triggered worldwide, resulting in millions of patients and high fatality rates. This crisis presents challenges at all levels, hence Psychology as a behavioral science, has the function not only of predicting how it will affect people, but also how to help reduce their emotional impact. Objective: Propose self-help bulletins as psychological support tools to promote coping strategies in the face of the crisis generated by COVID-19. Methods: A qualitative study was conducted through an action-research design, this was structured as a process of diffusion of innovations and followed three stages of work: knowledge of innovation, persuasion for adoption of innovation and decision to adopt innovation Results: Until the closing of this report, an average of 23930 visits were reached for the totality of the 10 published bulletins. The predominance of visualizations in females was manifested, however, men and women between the ages of 25-34 years coincide. Issues related to care and self-care; family; behavioral alterations and older adults were favorably evaluated. Conclusions: The comments made by the beneficiaries of the proposed self-help actions show the relevance for the current crisis situation. A favorable dynamic of change was identified at the reflective-experiential and behavioral level. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource covid-19, investigación acción, autoayuda, recursos de autoayuda Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine, Medicine (General) http://socictopen.socict.org/files/original/06794bd66b60db94276327bd92ea05d5.pdf 412574d469078c79aa69f51b2a069b09 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Self-Illusion and Medical Expertise in the Era of COVID-19. Creator An entity primarily responsible for making the resource Arthur Claessens, Olivia Keita-Perse, Frédéric Berthier, Jocelyn Raude, Gilles Chironi, Marc Faraggi, Gildas Rousseau, Sylvie Chaillou-Opitz, Hervé Renard, Valérie Aubin, Bertrand Mercier, Atul Pathak, Christophe Perrin, Yann-Erick Claessens Description An account of the resource The Dunning-Kruger premise assumes that unqualified people are unaware of their limited skills. We tested this hypothesis in the context of the coronavirus disease 2019 (COVID-19) pandemic. In this cross-sectional study, 2487 participants had to self-estimate their knowledge about COVID-19 in a questionnaire on the topic. Poor performers were more likely to use mass media and social networks as sources of information and had lower levels of education. The mean self-assessment (SD) was 6.88 (2.06) and was not linked to actual level of knowledge. This observation should prompt regulatory agencies and media to apply rules that limit dissemination of infodemics" during global health crises." Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource covid-19, Perception, Cross-sectional survey, cognitive bias, agnotology Identifier An unambiguous reference to the resource within a given context 10.1093/ofid/ofab058 Source A related resource from which the described resource is derived Open forum infectious diseases http://socictopen.socict.org/files/original/997820583a88606160e1227247f34614.pdf 418324565372ca641d9d8b6878ebe33e Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Agricultura sostenible Description An account of the resource Dominio científico: Agricultura sostenible Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Self-Inhibitory Activity of Trichoderma Soluble Metabolites and Their Antifungal Effects on <i>Fusarium oxysporum</i> Creator An entity primarily responsible for making the resource Sara Mayo-Prieto, Santiago Gutiérrez, Samuel Álvarez-García, Pedro Antonio Casquero Description An account of the resource Self-inhibitory processes are a common feature shared by different organisms. One of the main mechanisms involved in these interactions regarding microorganisms is the release of toxic diffusible substances into the environment. These metabolites can exert both antimicrobial effects against other organisms as well as self-inhibitory ones. The in vitro evaluation of these effects against other organisms has been widely used to identify potential biocontrol agents against phytopathogenic microorganisms. In the present study, we performed membrane assays to compare the self-inhibitory effects of soluble metabolites produced by several Trichoderma isolates and their antifungal activity against a phytopathogenic strain of Fusarium oxysporum. The results demonstrated that Trichoderma spp. present a high self-inhibitory activity in vitro, being affected in both their growth rate and the macroscopic structure of their colonies. These effects were highly similar to those exerted against F. oxysporum in the same conditions, showing no significant differences in most cases. Consequently, membrane assays may not be very informative by themselves to assess putative biocontrol capabilities. Therefore, different methods, or a combination of antifungal and self-inhibitory experiments, could be a better approach to evaluate the potential biocontrol activity of microbial strains in order to pre-select them for further in vivo trials. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource auto-toxicity, autoinhibition, diffusible metabolites, membrane assay, secondary metabolites, self inhibition Identifier An unambiguous reference to the resource within a given context 10.3390/jof6030176 Source A related resource from which the described resource is derived Journal of Fungi Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Biology (General) Relation A related resource <a href="https://www.mdpi.com/2309-608X/6/3/176" target="_blank" rel="noreferrer noopener">https://www.mdpi.com/2309-608X/6/3/176</a> http://socictopen.socict.org/files/original/73f18c35becd4283632ea58dccccba19.pdf 3d54f1ed85ecfdf5470fb8bab4e36e8c Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Self-interest versus group-interest in antiviral control. Creator An entity primarily responsible for making the resource Michiel van Boven, Don Klinkenberg, Ido Pen, Franz J. Weissing, Hans Heesterbeek Description An account of the resource Antiviral agents have been hailed to hold considerable promise for the treatment and prevention of emerging viral diseases like H5N1 avian influenza and SARS. However, antiviral drugs are not completely harmless, and the conditions under which individuals are willing to participate in a large-scale antiviral drug treatment program are as yet unknown. We provide population dynamical and game theoretical analyses of large-scale prophylactic antiviral treatment programs. Throughout we compare the antiviral control strategy that is optimal from the public health perspective with the control strategy that would evolve if individuals make their own, rational decisions. To this end we investigate the conditions under which a large-scale antiviral control program can prevent an epidemic, and we analyze at what point in an unfolding epidemic the risk of infection starts to outweigh the cost of antiviral treatment. This enables investigation of how the optimal control strategy is moulded by the efficacy of antiviral drugs, the risk of mortality by antiviral prophylaxis, and the transmissibility of the pathogen. Our analyses show that there can be a strong incentive for an individual to take less antiviral drugs than is optimal from the public health perspective. In particular, when public health asks for early and aggressive control to prevent or curb an emerging pathogen, for the individual antiviral drug treatment is attractive only when the risk of infection has become non-negligible. It is even possible that from a public health perspective a situation in which everybody takes antiviral drugs is optimal, while the process of individual choice leads to a situation where nobody is willing to take antiviral drugs. Date A point or period of time associated with an event in the lifecycle of the resource 2008 Identifier An unambiguous reference to the resource within a given context DOI: 10.1371/journal.pone.0001558 Source A related resource from which the described resource is derived PLoS ONE Publisher An entity responsible for making the resource available Public Library of Science (PLoS) Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Science, Medicine Language A language of the resource EN http://socictopen.socict.org/files/original/d408f001c9bb4c67395ce9961ee80285.pdf f7a967ef25826ea708edb087fbe7a7cd Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Self-Leadership and Psychological Capital as Key Cognitive Resources for Shaping Health-Protective Behaviors during the COVID-19 Pandemic Creator An entity primarily responsible for making the resource Sherry A. Maykrantz, Luke A. Langlinais, Jeffery D. Houghton, Christopher P. Neck Description An account of the resource As COVID-19 has become a global pandemic, health researchers and practitioners have focused attention on identifying the factors that may help to shape health-protective behaviors, protecting individual health and well-being, and helping to mitigate the spread of COVID-19. This study explores the potential role of self-leadership and psychological capital (PsyCap) as key cognitive resources for shaping health-protective behaviors. Using multiple theoretical frameworks (social cognitive theory, psychological resources theory, and the health belief model), this paper develops and tests a hypothesized serial mediation model in which PsyCap and coping self-efficacy mediate the relationship between self-leadership and health-protective behaviors including hand washing, wearing face masks, and social distancing. Results suggest that PsyCap and coping self-efficacy mediate the positive relationship between self-leadership and health-protective behaviors. These results yield valuable insights regarding the usefulness of self-leadership and PsyCap as cognitive resources for shaping health-protective behaviors and for possible self-leadership and PsyCap interventions, potentially tailored to at-risk populations, which should have practical benefits for both the current and future pandemics and health crises. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource covid-19, self-leadership, Coping Self-efficacy, psychological capital (PsyCap), health protective behaviors Identifier An unambiguous reference to the resource within a given context 10.3390/admsci11020041 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Political institutions and public administration (General)