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                  <text>Dominio científico: Coronavirus</text>
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                <text>Infants Born to Mothers With a New Coronavirus (COVID-19)</text>
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                <text>Yan Chen, Hua Peng, Lin Wang, Yin Zhao, Lingkong Zeng, Hui Gao, Yalan Liu</text>
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                <text>A novel viral respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is responsible for an epidemic of the coronavirus disease 2019 (COVID-19) in cases in China and worldwide. Four full-term, singleton infants were born to pregnant women who tested positive for COVID-19 in the city of Wuhan, the capital of Hubei province, China, where the disease was first identified. Of the three infants, for who consent to be diagnostically tested was provided, none tested positive for the virus. None of the infants developed serious clinical symptoms such as fever, cough, diarrhea, or abnormal radiologic or hematologic evidence, and all four infants were alive at the time of hospital discharge. Two infants had rashes of unknown etiology at birth, and one had facial ulcerations. One infant had tachypnea and was supported by non-invasive mechanical ventilation for 3 days. One had rashes at birth but was discharged without parental consent for a diagnostic test. This case report describes the clinical course of four live born infants, born to pregnant women with the COVID-19 infection.</text>
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                <text>newborns, clinical course, China, COVID-19 infected mothers, vertical transmission</text>
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                <text>DOI: 10.3389/fped.2020.00104</text>
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                <text>Frontiers in Pediatrics</text>
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                <text>Frontiers Media S.A.</text>
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                <text>Research Progress of Chloroquine and Hydroxychloroquine on the COVID-19 and Their Potential Risks in Clinic Use</text>
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                <text>Yan Chen, TaiPeng Shen, LiJun Zhong, ZhiXi Liu, XinWei Dong, TingWenLi Huang, QiuJu Wang, HongTao Xiao, HongTao Xiao</text>
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                <text>In December 2019, a severe outbreak of a novel coronavirus (COVID-19) occurred in the whole world, posing a great threat to people’s health. With the outbreak and development of the epidemic, how to improve the cure rate, find effective drugs against this virus, has been the most urgent problem. Chloroquine (CQ) was verified effective against COVID-19 in vitro. As CQ’s analogue, hydroxychloroquine (HCQ) was also reminded as a potential candidate for treating COVID-19. This review summarizes the latest clinical trials of CQ and HCQ against COVID-19 and its therapeutic regimen in China aiming to share their current usage to the whole world and provide insight into its appropriate future use in the treatment of COVID-19. Through searching the CNKI and Wangfang databases in Chinese language and PubMed, EMBASE, and Ovid databases in English language to identify published reports with the keywords including “coronavirus/COVID, chloroquine, hyroxychloroquine” in alone or combined, we found out the potential preclinical or clinical evidence for using CQ and HCQ against COVID-19. Consequently, we also searched the website of Chinese Clinical Trial Registry (http://www.chictr.org.cn/) till the day on 27th, June, 2020. This review found that there are 23 programs aimed to treat the different phases under COVID-19 pipeline in clinic with CQ and HCQ, totally. The inclusion criteria, exclusion criteria and therapeutic regimen were all shared to consult. Among them, seven have been canceled due to lack of patients or other objective factors. There are two trials have completed, which the potential relationship between usage and adverse reactions was discussed emphatically. Through literature research, we suggested that paid close attention to retinal toxicity and ophthalmologic adverse symptom of CQ and HCQ. And the outcome of HCQ in clinic shows better than CQ especially in protective effect with low dosage.</text>
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                <text>10.3389/fphar.2020.01167</text>
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                <text>Epidemiology and Health</text>
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                <text>Korean Society of Epidemiology</text>
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                <text>Therapeutics. Pharmacology</text>
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                <text>Clinical Characteristics of 5 COVID-19 Cases With Non-respiratory Symptoms as the First Manifestation in Children</text>
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                <text>Yan Chen, Wenbin Li, Songbo Li, Xiao-Fang Cai, Zhihui Rong, Yaoling Ma</text>
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                <text>An outbreak of the novel coronavirus disease 2019 (COVID-19) occurred in Wuhan, China, in December 2019, which then rapidly spread to more than 80 countries. However, detailed information on the characteristics of COVID-19 in children is still scarce. Five patients with non-respiratory symptoms as the first manifestation were hospitalized from the emergency department, and were later confirmed to have COVID-19, between 23 January and 20 February 2020, at the Wuhan Children's Hospital. SARS-CoV-2 nucleic acid detection was positive for all the patients. Four of the patients were male and one was female, and their ages ranged from 2-months to 5.6 years. All lived in Wuhan. One patient had a clear history of exposure to SARS-CoV-2, one had a suspected history of exposure, while the others had no exposure history. For three of the five patients, the primary onset disease required an emergency operation or treatment, and included intussusception, acute suppurative appendicitis perforation with local peritonitis, and traumatic subdural hemorrhage with convulsion, while for the other two it was acute gastroenteritis (including one patient with hydronephrosis and a stone in his left kidney). During the course of the disease, four of the five patients had a fever, whereas one case had no fever or cough. Two patients had leukopenia, and one also had lymphopenia. In the two cases of severe COVID-19, the levels of CRP, PCT, serum ferritin, IL-6, and IL-10 were significantly increased, whereas the numbers of CD3+, CD4+, CD8+ T lymphocytes, and CD16 + CD56 natural killer cells were decreased. We also found impaired liver, kidney, and myocardial functions; the presence of hypoproteinemia, hyponatremia, and hypocalcemia; and, in one case, abnormal coagulation function. Except for one patient who had a rotavirus infection, all patients tested negative for common pathogens, including the influenza virus, parainfluenza virus, respiratory syncytial virus, adenovirus, enterovirus, mycoplasma, Chlamydia, and Legionella. Chest CT images of all the patients showed patches or ground-glass opacities in the lung periphery or near the pleura, even large consolidations. This case series is the first report to describe the clinical features of COVID-19 with non-respiratory symptoms as the first manifestation in children.</text>
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                <text>pediatrics, clinical characteristics, Nonrespiratory symptoms, first manifestation, novel coronavirus disease 2019</text>
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                <text>DOI: 10.3389/fped.2020.00258</text>
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                <text>Frontiers in Pediatrics</text>
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                <text>Frontiers Media S.A.</text>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Status and Challenges of Public Health Emergency Management in China Related to COVID-19</text>
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                <text>Yan Gao, Yulong Cao, Zhizhong Gong, Jiao Shan, Jiqiu Kuang</text>
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                <text>Objective: This study aimed at exploring the current development status and problems of health emergency management in China and provides a reference for improving, constructing, and implementing a public health emergency management system.Methods: Cases of major and severe public health emergencies in China were analyzed along with the relevant health emergency management literature from the last decade.Results: China's health emergency system gradually improved during the study period. Monitoring and early warning systems were significantly strengthened. Material reserves and transfer management systems were constantly improved. However, the operational efficiency of command and decision systems was low, versatile talent accounted for a relatively small proportion, and emergency fund investment was insufficient.Conclusion: Constructing a sound and scientific emergency management mechanism is a lengthy and challenging process. To establish an emergency management mode for public health emergencies that is appropriate for China, it is necessary to solve existing problems and learn from the models and experiences of developed foreign countries.</text>
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                <text>health policy, modernization, emergency management, public health emergency, COVID-19</text>
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                <text>DOI: 10.3389/fpubh.2020.00250</text>
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                <text>Frontiers in Public Health</text>
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                <text>Frontiers Media S.A.</text>
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                <text>Public aspects of medicine</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Administrative Mechanism of Joint Participation and Cooperation in the Early Stages of the COVID-19 Outbreak in Wuhan</text>
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                <text>Yan J, Zhao D</text>
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                <text>Jingjing Yan,1 Dahai Zhao1,2 1School of International and Public Affairs, Shanghai Jiao Tong University, Shanghai, People&amp;rsquo;s Republic of China; 2Shanghai Jiao Tong University-Yale University Joint Center for Health Policy, Shanghai, People&amp;rsquo;s Republic of ChinaCorrespondence: Dahai ZhaoSchool of International and Public Affairs, Shanghai Jiao Tong University, No. 1954 Huashan Road, Shanghai 200030, People&amp;rsquo;s Republic of ChinaTel +86 139-1896-8766Email dahaizhao@sjtu.edu.cnIntroduction: From December 2019 to January 2020, a novel coronavirus disease (officially COVID-19) was reported in Wuhan and continued to spread all China. This study describes the administrative mechanism of joint participation and cooperation during the early stages of the COVID-19 outbreak in Wuhan and the rest of the country by health practitioners and administrative authorities.Methods: This study adopted a qualitative design. An analytical framework based on the theory of policy participation that included stimulus, setting, and position of policy participation was constructed. Qualitative data of policy participation by health practitioners and administrative authorities consisted of publicly available data.Results: Early during the outbreak, from December 2019 to January 2020, three main stages occurred according to the containment situation. The first stage was characterized by limited knowledge of the transmission dynamics of the virus and a consequently weak response. In the second stage, the disease spreads rapidly because of travel during a national festival. In the third stage, particularly when top Chinese leaders delivered instructions to intensify containment efforts, diverse departments initiated joint prevention and control measures to combat COVID-19.Conclusion: The administrative mechanism of joint participation and cooperation was instrumental in avoiding a substantial increase in both cases and fatalities in the initial stage of the outbreak. This joint participation provides valuable experience and initiatives for major public health emergency preparedness, and the new empirical evidence further highlights the importance of policy participation theory in epidemic prevention in other countries.Keywords: joint administration, coronavirus disease 2019, public health emergency, policy participation</text>
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                <text>Coronavirus disease 2019, public health emergency, joint administration, policy participation</text>
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                <text>Biotemas</text>
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                <text>Universidade Federal de Santa Catarina</text>
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                <text>Minimized glycemic fluctuation decreases the risk of severe illness and death in patients with COVID-19.</text>
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                <text>Yan Leng, Mengyuan Dai, Zhongyuan Xia, Shaoqing Lei, Ming Chen, Yang Wu, Kuo Yan, Ning-Yi Shao, Miao Liu</text>
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                <text>Journal of medical virology</text>
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                <text>Research on the Network Teaching of Ideological and Political Theory Courses in Universities under the epidemic situation – Take Guangzhou Nanyang Polytechnic College as an example</text>
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                <text>Yan Li</text>
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                <text>The sudden outbreak of COVID-19 is unprecedented in its scope and impact. Under the epidemic situation, the special “classroom” under the completely virtual state brought by the implementation of network teaching brings challenges and tests to the ideological and political theory course teaching in colleges and universities, and also provides an opportunity for reform and innovation. Ideological and political theory course is a key course for the implementation of moral education. In the prevention and control of COVID-19 epidemic, it plays a role in the publicity and education of college students and the guidance of public opinion. For the further implementation of xi jinping, general secretary of COVID 19 epidemic prevention and control of a series of important speech and the important instructions instructions spirit, and the Ministry of Education “closed on teaching, not suspended” requirements, our hospital rapid response, positive response, to carry out the ideological and political theory course network teaching boost war “epidemic” confidence, to ensure the successful completion of the teaching task. In this process, the author realized the shortcomings of our school’s horse academy in information literacy, high-quality online course construction and other aspects, and made clear the direction of reform and innovation.</text>
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                <text>10.1051/e3sconf/202018903033</text>
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                <text>Epidemiology and Health</text>
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                <text>Korean Society of Epidemiology</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Environmental sciences</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Yan LI, Abdelmalik Ibrahim Khalafalla, Clinton R Paden, Mohammed F Yusof, Yassir M. Eltahir, Zulaikha M. Al Hammadi, Ying Tao, Krista Queen, Farida Al Hosani, Susan I. Gerber, Aron J. Hall, Salama Al Muhairi, Suxiang Tong</text>
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                <text>Camels are known carriers for many viral pathogens, including Middle East respiratory syndrome coronavirus (MERS-CoV). It is likely that there are additional, as yet unidentified viruses in camels with the potential to cause disease in humans. In this study, we performed metagenomic sequencing analysis on nasopharyngeal swab samples from 108 MERS-CoV-positive dromedary camels from a live animal market in Abu Dhabi, United Arab Emirates. We obtained a total of 846.72 million high-quality reads from these nasopharyngeal swab samples, of which 2.88 million (0.34%) were related to viral sequences while 512.63 million (60.5%) and 50.87 million (6%) matched bacterial and eukaryotic sequences, respectively. Among the viral reads, sequences related to mammalian viruses from 13 genera in 10 viral families were identified, including Coronaviridae, Nairoviridae, Paramyxoviridae, Parvoviridae, Polyomaviridae, Papillomaviridae, Astroviridae, Picornaviridae, Poxviridae, and Genomoviridae. Some viral sequences belong to known camel or human viruses and others are from potentially novel camel viruses with only limited sequence similarity to virus sequences in GenBank. A total of five potentially novel virus species or strains were identified. Co-infection of at least two recently identified camel coronaviruses was detected in 92.6% of the camels in the study. This study provides a comprehensive survey of viruses in the virome of upper respiratory samples in camels that have extensive contact with the human population.</text>
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                <text>DOI: 10.1371/journal.pone.0184718</text>
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                <text>Emerging infectious diseases (EIDs) are newly identified or known infectious diseases that have either expanded in geographic range or increased in infection prevalence over the previous two decades. During the last three decades, more than 30 EIDs have surfaced worldwide, including deadly diseases such as SARS, severe fever with thrombocytopenia syndrome (SFTS), Ebola, Marburg virus disease, Nipah virus disease, hepatitis C, and AIDS.EIDs can not only cause suffering and death in patients but also hinder commercial trade and travel, and create fear or even widespread panic in society. The challenge for the medical community is to effectively recognize and diagnose EIDs. The present study reports our experience in identification and diagnosis of EIDs.</text>
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                <text>emerging infectious diseases, pathogen, identification, diagnosis</text>
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                <text>DOI: 10.11979/idtm.201701005</text>
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                <text>Infectious Diseases and Translational Medicine</text>
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                <text>Infectious and parasitic diseases</text>
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              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Protective and Risk Factors for Medical and Nursing Staff Suffering From Psychological Symptoms During COVID-19</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="80548">
                <text>Yan Lv, Hailong Luo, Huiqi Yao, Yuandi Xi, Zhun Zhang, Jia Li, Jie Li, Xuewen Wang, Zhixiong Zhong</text>
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            <name>Description</name>
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                <text>Background: With the outbreak of the coronavirus disease 2019 (COVID-19) epidemic in China, the general public but also medical staff were confronted with psychological challenges, suffering from the highly infectious and unknown characteristics of COVID-19. In this study, we surveyed psychological symptoms including anxiety, depression, and sleep disorders in medical staff.Method: A questionnaire star/WeChat link-based survey assessing the Generalized Anxiety Disorder 7-item scale, Patient Health Questionnaire-9 depression, the Insomnia Severity Index, Social Support scales in addition to lifestyle, and income level was conducted and included 8,288 medical staff from 24 provinces in China. Pearson Chi-square and Mann-Whitney U-tests were used to evaluate single risk factors and significant differences in psychological symptoms before and during the outbreak of COVID-19. Binary logistic regression analyses were conducted for the risk factors of anxiety, depression, and sleep disorder symptoms.Results: Medical staff had a high incidence of psychological symptoms, which was more prominent during the COVID-19 epidemic. Comparatively, females, nurses, first-line department, never exercised, and low income were risk factors for psychological symptoms. Social support including objective support, subjective support, support utility, and regular sports over 3 times per week were protective and manageable elements that could protect from and manage the psychological symptoms of medical staff.Conclusion: The susceptibility of psychological symptoms among medical staff should be of concern to policymakers and the public in the long-term, and the aggravation of mental health problems of medical staff could be eased by providing adequate social support during and after the COVID-19 outbreak.</text>
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            <name>Date</name>
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                <text>2021</text>
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            <name>Subject</name>
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                <text>covid-19, Social support, Medical staff, psychological symptoms, protective elements</text>
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            <name>Identifier</name>
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                <text>10.3389/fpsyg.2021.603553</text>
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          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="80553">
                <text>Epidemiology and Health</text>
              </elementText>
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          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="80554">
                <text>Korean Society of Epidemiology</text>
              </elementText>
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          </element>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Psychology</text>
              </elementText>
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