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              <name>Title</name>
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                  <text>Coronavirus</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Traditional Chinese herbal medicine for treating novel coronavirus (COVID-19) pneumonia: protocol for a systematic review and meta-analysis</text>
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                <text>Yuxi Li, Xiao-bo Liu, Liuxue Guo, Juan Li, Dongling Zhong, Yonggang Zhang, Mike Clarke, Rong-jiang JIN</text>
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                <text>Abstract Background A new type of coronavirus, novel coronavirus (COVID-19), is causing an increasing number of cases of pneumonia and was declared a Public Health Emergency of International Concern by the World Health Organization on 30 January 2020. The virus first appeared in Wuhan, China, in late December 2019, and traditional Chinese herbal medicine is being used for its treatment. This systematic review and meta-analysis will assess studies of the effects of traditional Chinese herbal medicine in COVID-19 pneumonia. Methods We will search electronic databases including PubMed, Embase, the Cochrane Central Register of Controlled Trials (CENTRAL), Chinese Biomedical Literature Database (CBM), China National Knowledge Infrastructure (CNKI), Chinese Science and Technology Periodical Database (VIP), and Wanfang database using keywords related to COVID-19 and traditional Chinese herbal medicine. Reference lists of relevant trials and reviews will be searched. We will manually search gray literature, such as conference proceedings and academic degree dissertations, and trial registries. Two independent reviewers will screen studies (XL and DZ), extract data (YL and LG), and evaluate risk of bias (YL and DZ). Data analysis will be conducted using the Review Manager software (version 5.3.5) and R software (version 3.6.1). Statistical heterogeneity will be assessed using a standard chi-square test with a significance level of P &lt; 0.10. Biases associated with study size (e.g., publication bias) will be investigated using funnel plots, Egger’s test and Begg’s test, and Trim and Fill analysis. Discussion This study will provide a high-quality synthesis of the effects of traditional Chinese herbal medicine for COVID-19. The use of traditional Chinese herbal medicine for treatment or prevention of these novel viral infections affecting the pneumonia will be investigated. Systematic review registration PROSPERO registration number: CRD42020168004</text>
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                <text>2020</text>
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                <text>COVID-19, coronavirus, Pneumonia, Traditional Chinese herbal medicine emerging infectious diseases, systematic review, Meta-analysis</text>
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                <text>DOI: 10.1186/s13643-020-01343-4</text>
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                <text>Systematic Reviews</text>
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                <text>BMC</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>The First 75 Days of Novel Coronavirus (SARS-CoV-2) Outbreak: Recent Advances, Prevention, and Treatment</text>
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                <text>Yuxin Yan, Woo  In Shin, Yoong  Xin Pang, Yang Meng, Jianchen Lai, Chong You, Haitao Zhao, Edward Lester, Tao Wu, Cheng Heng Pang</text>
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                <text>The recent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, previously known as 2019-nCoV) outbreak has engulfed an unprepared world amidst a festive season. The zoonotic SARS-CoV-2, believed to have originated from infected bats, is the seventh member of enveloped RNA coronavirus. Specifically, the overall genome sequence of the SARS-CoV-2 is 96.2% identical to that of bat coronavirus termed BatCoV RaTG13. Although the current mortality rate of 2% is significantly lower than that of SARS (9.6%) and Middle East respiratory syndrome (MERS) (35%), SARS-CoV-2 is highly contagious and transmissible from human to human with an incubation period of up to 24 days. Some statistical studies have shown that, on average, one infected patient may lead to a subsequent 5.7 confirmed cases. Since the first reported case of coronavirus disease 2019 (COVID-19) caused by the SARS-CoV-2 on December 1, 2019, in Wuhan, China, there has been a total of 60,412 confirmed cases with 1370 fatalities reported in 25 different countries as of February 13, 2020. The outbreak has led to severe impacts on social health and the economy at various levels. This paper is a review of the significant, continuous global effort that was made to respond to the outbreak in the first 75 days. Although no vaccines have been discovered yet, a series of containment measures have been implemented by various governments, especially in China, in the effort to prevent further outbreak, whilst various medical treatment approaches have been used to successfully treat infected patients. On the basis of current studies, it would appear that the combined antiviral treatment has shown the highest success rate. This review aims to critically summarize the most recent advances in understanding the coronavirus, as well as the strategies in prevention and treatment.</text>
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                <text>coronavirus, SARS-CoV-2, COVID-19, coronavirus-infected pneumonia, novel coronavirus pneumonia, zoonotic pathogen</text>
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                <text>DOI: 10.3390/ijerph17072323</text>
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                <text>International Journal of Environmental Research and Public Health</text>
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                <text>MDPI AG</text>
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                <text>Digitalization of the Residential Mortgage Market in Crisis Conditions: Main Factors and Drivers of Development</text>
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                <text>Yuzvovich Larisa, Sharafieva Maria, Mokeeva Natalia, Nasyrova Gulmira</text>
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                <text>The industrialization of the residential mortgage market during the pandemic has undergone significant changes, like all sectors of the economy, including the banking system. During the transformation, a positive dynamics has been noted in the volume of loans, which contradicts the usual scenarios for the behavior of the mortgage market in the period of the unstable macroeconomic situation in recent years. The crises of 2008 and 2014 showed the vulnerability of the banking system and the market for residential mortgage market, the lack of timely measures to prevent drastic consequences for the banks and the state. At the moment, it is important to understand what drivers triggered the growth in the volume of residential mortgage. The research analyzed the reasons that had a key impact on the mortgage market and the banking sector during the covid-19 pandemic. As a result of the study, the main factors that help to draw up directions and digital algorithms for further development have been highlighted and classified.</text>
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                <text>2021</text>
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                <text>10.1051/shsconf/20219302004</text>
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                <text>Epidemiology and Health</text>
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                <text>Korean Society of Epidemiology</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>The Reign of the Ventilator: Acute Respiratory Distress Syndrome, COVID-19, and Technological Imperatives in Intensive Care.</text>
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                <text>In the early phase of the COVID-19 pandemic, a dispute arose as to whether the disease caused a typical or atypical version of acute respiratory distress syndrome (ARDS). This essay recounts the emergence of ARDS and places it in the context of the technological transformation of modern hospital care-particularly the emergence of intensive care after the 1952 Copenhagen polio epidemic. The polio epidemic seemed to show the value of manual positive-pressure ventilation, leading to the proliferation of mechanical ventilators and the expansion of intensive care units in the 1960s. This created the conditions of possibility for ARDS to be described and institutionalized within modern intensive care. Yet the centrality of the ventilator to descriptions and definitions of ARDS quickly made it difficult to conceive of the disorder outside the framework of mechanical ventilation and blood gas levels, or to acknowledge the degree to which the ventilator was a source of iatrogenic injury and complications. Moreover, the imperative to understand and treat ARDS with mechanical ventilation set the stage for the early confusion about whether patients with COVID-19 should receive mechanical ventilation. This history offers many crucial lessons about how new technologies can lead to new and valuable therapies but can also subtly shape and constrain medical thinking. Moreover, ventilators not only changed how respiratory disorders were conceived; they also brought new forms of respiratory illness into existence.</text>
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                <text>10.7326/M21-0270</text>
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                <text>Annals of internal medicine</text>
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                <text>Claude Martinaud, Frank Paris, Océans, mers et îles - Appuis de la mondialisation</text>
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                <text>Yvonne Xinyi Lim, Yan Ling Ng, James P Tam, Ding Xiang Liu</text>
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                <text>Human coronaviruses (HCoVs) are known respiratory pathogens associated with a range of respiratory outcomes. In the past 14 years, the onset of severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) have thrust HCoVs into spotlight of the research community due to their high pathogenicity in humans. The study of HCoV-host interactions has contributed extensively to our understanding of HCoV pathogenesis. In this review, we discuss some of the recent findings of host cell factors that might be exploited by HCoVs to facilitate their own replication cycle. We also discuss various cellular processes, such as apoptosis, innate immunity, ER stress response, mitogen-activated protein kinase (MAPK) pathway and nuclear factor kappa B (NF-κB) pathway that may be modulated by HCoVs.</text>
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                <text>DOI: 10.3390/diseases4030026</text>
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                <text>Diseases</text>
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            <description>An entity responsible for making the resource available</description>
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                <text>MDPI AG</text>
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                <text>Medicine</text>
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              <description>A name given to the resource</description>
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                  <text>Agricultura sostenible</text>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Agricultura sostenible</text>
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                <text>Temporal changes in fish species composition of headwater streams of the upper Paraguay and Paraná basins, Brazil = Alteração temporal na composição de espécies de peixes em riachos de cabeceira das bacias do alto Paraguai e Paraná, Brasil</text>
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            <description>An entity primarily responsible for making the resource</description>
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                <text>Yzel Rondon Súarez, Karina Keyla Tondato</text>
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            <description>An account of the resource</description>
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                <text>This study was carried out in headwater streams in the Paraguay and Paraná river basins, with bi-monthly samples from January to November 2004, aiming to quantify the influence of environmental factors on the temporal rate of turnover in species composition of the fish communities. The environmental variables explained 73.5% of the variation in beta diversity and 52.5% of the variation in mean dissimilarity. Altitude was the only environmental descriptor that significantly explained the variation in beta diversity and mean dissimilarity in both basins.O presente estudo foi realizado em riachos de cabeceira nas bacias dos rios Paraguai e Paraná, por amostragens bimestrais de janeiro a novembro de 2004, com o objetivo de se quantificar a influência dos fatores ambientais sobre a taxa de alteração temporal na composição de espécies nas comunidades de peixes. As variáveis ambientais utilizadas explicaram 73,5% da variação na taxa de alteração na composição de espécies, utilizando a diversidade beta e 52,5% da variação na taxa de alteração pelo coeficiente de Jaccard. A altitude dos locais amostrados foi o único preditor significativo da taxa de alteração temporal na composição de espécies para ambas as bacias.</text>
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                <text>Community ecology, Neotropical streams, ecología de comunidades, environmental variables, riachos neotropicais, variáveis ambientais</text>
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                <text>Acta Scientiarum : Biological Sciences</text>
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            <description>An entity responsible for making the resource available</description>
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                <text>Universidade Estadual de Maringá</text>
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                <text>Biology (General), Microbiology</text>
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                <text>&lt;a href="http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/6160/6160" target="_blank" rel="noreferrer noopener"&gt;http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/6160/6160&lt;/a&gt;</text>
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                  <text>Coronavirus</text>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Molecular detection of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in Tunisian dromedary camels (Camelus dromedarius)</text>
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                <text>Z. AZAOUZI, M.H. JEMLI, L. Messadi, I. ZAOUIA, M.A. BEN HADJ KACEM</text>
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                <text>Middle East Respiratory Syndrome Coronavirus (MERS-CoV) was identified in humans in 2012. Dromedary camels were considered as the major reservoir of the virus throw several studies. Tunisian dromedary camels were implicated in a serological survey and a seropositivity reaching 100% was observed among some of them. Therefore, more investigations are necessary to look for the current infection situation. In this study, we aimed to detect the MERS-CoV virus in our camels by molecular technics. Blood and nasal swabs samples from 64 dromedary camels from 4 Tunisian provinces were collected during June 2014 and April 2015. All the animals tested negative by real time reverse transcriptase–polymerase chain reaction assay (RT-PCR). These findings could not confirm the absence of MERS-CoV active shading among the Tunisian camel population and more researches should be carried on to survey dromedary camels in Tunisia and its neighboring countries.</text>
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                <text>2018</text>
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            <name>Subject</name>
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                <text>Middle East respiratory syndrome (MERS), camels, Tunisia, RT-PCR, animal surveillance, Coronavirus (CoVs), molecular detection</text>
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                <text>Revue Marocaine des Sciences Agronomiques et Vétérinaires</text>
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                <text>Institut Agronomique et Vétérinaire Hassan II</text>
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                <text>General Works</text>
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            <description>A language of the resource</description>
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                <text>ESTIMATING A JOINT PROBABILITY OF DEFAULT INDEX FOR INDONESIAN BANKS: A COPULA APPROACH</text>
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                <text>Zaafri Ananto Husodo, Sigit Sulistyo Wibowo, Muhammad Budi Prasetyo, Usman Arief, Maulana Harris Muhajir</text>
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                <text>We develop a joint default probability index to signal potential systemic risks in the highly concentrated Indonesian banking industry. To build the index, we estimate bank-level tail risks using monthly bank financial reports. We use the copula approach to derive the joint multivariate dependencies at the bank level, as reflected in the monthly financial reports. Our results, which are based on a sample of 104 banks from December 2003 to April 2020, show joint multivariate dependencies at the bank level suggesting that the standard univariate normal distribution is unsuitable for capturing tail risks of individual banks. Our index accurately captures the global financial crisis of 2007-2008 indicating that it is a valid joint default probability index. Further, our index also signaled a higher degree of joint default before the COVID-19 outbreak in 2020, suggesting that it is a good indicator of potential systemic risk in the economy.</text>
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                <text>systemic risk, financial system, Pair copula construction, copula</text>
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                <text>10.21098/bemp.v23i3.1358</text>
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                <text>Bulletin Ekonomi Moneter dan Perbankan</text>
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                <text>Bank Indonesia</text>
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                <text>Finance</text>
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              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Molecular mechanisms of severe acute respiratory syndrome (SARS)</text>
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                <text>Zabel Peter, Hilgenfeld Rolf, Groneberg David A</text>
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                <text>Abstract Severe acute respiratory syndrome (SARS) is a new infectious disease caused by a novel coronavirus that leads to deleterious pulmonary pathological features. Due to its high morbidity and mortality and widespread occurrence, SARS has evolved as an important respiratory disease which may be encountered everywhere in the world. The virus was identified as the causative agent of SARS due to the efforts of a WHO-led laboratory network. The potential mutability of the SARS-CoV genome may lead to new SARS outbreaks and several regions of the viral genomes open reading frames have been identified which may contribute to the severe virulence of the virus. With regard to the pathogenesis of SARS, several mechanisms involving both direct effects on target cells and indirect effects via the immune system may exist. Vaccination would offer the most attractive approach to prevent new epidemics of SARS, but the development of vaccines is difficult due to missing data on the role of immune system-virus interactions and the potential mutability of the virus. Even in a situation of no new infections, SARS remains a major health hazard, as new epidemics may arise. Therefore, further experimental and clinical research is required to control the disease.</text>
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                <text>2005</text>
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                <text>severe acute respiratory syndrome, SARS, coronavirus, molecular mechanisms, therapy, vaccination</text>
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                <text>DOI: 10.1186/1465-9921-6-8</text>
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                <text>Respiratory Research</text>
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                <text>BMC</text>
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                <text>Diseases of the respiratory system</text>
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                <text>EN</text>
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