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                  <text>Dominio científico: Coronavirus</text>
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                <text>Coronaviruses and Central Nervous System Manifestations</text>
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                <text>Noam Bosak, Mohamed Khateb, Maryam Muqary</text>
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                <text>SARS-CoV-2 is a highly pathogenic coronavirus that has caused an ongoing worldwide pandemic. Emerging in Wuhan, China in December 2019, the virus has spread rapidly around the world. Corona virus disease 2019 (COVID-19), which is caused by SARS-CoV-2, has resulted in significant morbidity and mortality. The most prominent symptoms of SARS-CoV-2 infection are respiratory. However, accumulating evidence highlights involvement of the central nervous system (CNS). This includes headache, anosmia, meningoencephalitis, acute ischemic stroke, and several presumably post/para-infectious syndromes and altered mental status not explained by respiratory etiologies. Interestingly, previous studies in animal models emphasized the neurotropism of coronaviruses; thus, these CNS manifestations of COVID-19 are not surprising. This minireview scans the literature regarding the involvement of the CNS in coronavirus infections in general, and in regard to the recent SARS-CoV-2, specifically.</text>
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                <text>Brain Disorders, neurological infection and inflammation, SARS-CoV-2, COVID-19, coronaviral infections, neurological &amp; psychiatric symptoms</text>
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                <text>DOI: 10.3389/fneur.2020.00715</text>
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                <text>Frontiers in Neurology</text>
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                <text>Frontiers Media S.A.</text>
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                <text>Neurology. Diseases of the nervous system</text>
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                <text>MSW Management in Universities: Sharing Best Practices</text>
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                <text>Vincenzo Torretta, Elena Cristina Rada, Marco Schiavon, Elena  Romenovna Magaril, Anzhelika Karaeva, Maxim Chashchin</text>
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                <text>The optimization of municipal solid waste management requires the re-organization of niche sectors too. The sector of the university is not fully explored from the scientific point of view. The creation of networks among universities in order to face this issue allows an exchange of expertise also at an international level as demonstrated in this article, by three case studies: two Italian (University of Trento and University of Insubria) and one Russian (Ural Federal University) universities. This study highlights the pros and cons of each university in terms of waste management. Specifically, setting up communication campaigns, standard procedures, monitoring actions, pricing strategies that incentivize selective collection, and improving the collaboration within the university community are identified as crucial initiatives. The margins of improvement of the three universities analyzed are favored by the composition of the generated waste. The implementation of good practices can give economic advantages to the universities, besides improving their level of sustainability.</text>
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                <text>DOI: 10.3390/su12125084</text>
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                <text>MDPI AG</text>
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                <text>Environmental sciences, Renewable energy sources, Environmental effects of industries and plants</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Manifestation of Borderline Personality Symptomatology in Chronic Pain Patients Under Stress: An Understated and Exacerbated Consequence of the COVID-19 Crisis</text>
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                <text>Schatman ME, Kulich RJ, Shapiro H</text>
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                <text>Hannah Shapiro, 1 Ronald J Kulich, 2, 3 Michael E Schatman 3, 4  1Department of Biopsychology, Tufts University, Medford, MA, USA;  2Department of Anesthesia, Critical Care and Pain Medicine, Harvard Medical School/Massachusetts General Hospital, Boston, MA, USA;  3Department of Diagnostic Sciences, Tufts University School of Dental Medicine, Boston, MA, USA;  4Department of Public Health and Community Medicine, Tufts University School of Medicine, Boston, MA, USACorrespondence: Michael E Schatman Tel +1 425 647-4880Email Michael.Schatman@tufts.eduTo the best of our knowledge, no one has ever suggested that it is &amp;ldquo;easy&amp;rdquo; to suffer&amp;nbsp;from intractable chronic pain, with some subgroups impacted more than others.&amp;nbsp;This burden has had a particularly strong impact in the United States, where the&amp;nbsp;chronic pain treatment system has demonstrated failings with respect to access to&amp;nbsp;care1&amp;ndash;8 Because chronic pain is so poorly treated in the United States, patients have&amp;nbsp;struggled not only with their pain and its sequelae but also with mounting frustration&amp;nbsp;and downstream psychological consequences. Depression and suicidality have&amp;nbsp;been linked to poorly controlled pain,9,10 and the authors of a recent study11 noted&amp;nbsp;that these phenomena are a concern within the context of opioid tapering. Similarly,&amp;nbsp;Lembke has recently acknowledged that even mention of tapering can trigger&amp;nbsp;severe anxiety in chronic pain patients,12 with data supporting the relationship&amp;nbsp;between undertreated chronic pain and anxiety.13,14 Although myriad investigations&amp;nbsp;have supported the existence of a reciprocal relationship between chronic pain and&amp;nbsp;depression15&amp;ndash;17 as well as between chronic pain and anxiety,18&amp;ndash;20 detailed discussion&amp;nbsp;of causality is beyond the scope of this analysis.</text>
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                <text>n/a</text>
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                <text>Journal of Pain Research</text>
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                <text>Dove Medical Press</text>
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                <text>Medicine (General)</text>
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                <text>Psychological Care of Health Workers during the COVID-19 Outbreak in Italy: Preliminary Report of an Occupational Health Department (AOUP) Responsible for Monitoring Hospital Staff Condition</text>
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                <text>Sigrid Baldanzi, Liliana Dell’Osso, Martina Corsi, Claudia Carmassi, Alfonso Cristaudo, Rodolfo Buselli, Martina Chiumiento, Elena Del Lupo</text>
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                <text>The recent worldwide COVID-19 outbreak provided a timely demonstration of the mental health needs of health care workers on the front lines of the response to the pandemic. In addition to international guidelines, local institutions demand rapid and practical approaches easily replicable in different populations and contests. The principal aim of this paper is to highlight and share the experience of an Occupational Health Department responsible for monitoring hospital staff conditions during the SARS-COV-2 pandemic phase 1. The multidisciplinary team of the Occupational Health Department of a major university hospital in central Italy (AOUP) developed a specific protocol called PsicoCovid19 in order to provide targeted help, based on new psychosocial risk factors, to workers involved in the COVID-19 emergency to preserve hospital staff health. As of the date of this report, 106 workers (79 female, 27 male, mean age respectively, 51 ± 9.8, 45.7± 10.1) requested this service, reporting mild to moderate subjective distress. Approximately 81% of all the participants were already monitored before the outbreak of the pandemic. Among the total sample, 60% received a remodeling of a previous therapeutic program. Meanwhile, 7% passed from a psychiatric therapy to a combination therapy with the addition of a psychological treatment. The results demonstrate that those who asked for help were primarily female nurses who already presented with mental health vulnerabilities. A more gender-specific, clinical approach is needed.</text>
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                <text>psychological, health workers, Pandemic, multidisciplinary, COVID-19, occupational teams</text>
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                <text>DOI: 10.3390/su12125039</text>
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                <text>SARS-CoV-2 / COVID-19 and its Transmission, Prevention, Treatment and Control - An Update</text>
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                <text>Pooja Sharma, Kuldeep Dhama, Ram Chandra, Sonam Tripathi, Shailesh Kumar Patel</text>
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                <text>Coronavirus Disease 2019 (COVID-19), caused by Severe Acute Respiratory Syndrome Virus-2 (SARSCoV-2), pandemic has caused huge panic, havoc and global threats worldwide. The origin of this virushas been linked to animals, intermediate host is still to be identified, and studies are being carried outthat how it got transmitted to humans and acquired rapid human-to-human transmission. Within ashort time period of only 05 months, SARS-CoV-2 has spread to 213 countries, and till 28th May, 2020,nearly 5.8 million confirmed cases have been reported while taking lives of 0.36 million persons. Seeingthe current situation of rapid increase in COVID-19 cases daily in many countries, this seems to be thedeadliest pandemic after the 1918 Spanish Flu. There is currently no specific effective treatment forCOVID-19 and also in absence of vaccine the radical cure of the disease is far away. Researchers arepacing high to design and develop effective vaccines, drugs and therapeutics to counter COVID-19,however such efforts, clinical trials, necessary approvals and then to reach the level of bulk productionof many millions of doses may still take much time. Prevention and control of COVID-19 outbreaksrequires an evidence-based, multi-factorial and effective mitigation strategy to be adopted. The currentreview discusses on the research advancements, challenges and opportunities in COVID 19 managementwith a focus on its transmission, prevention, treatment and control.</text>
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                <text>prevention, treatment, control, Transmission, SARS-CoV-2, COVID-19</text>
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                <text>DOI: 10.22207/JPAM.14.SPL1.32</text>
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                <text>Journal of Pure and Applied Microbiology</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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                <text>Journal of Pure and Applied Microbiology</text>
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                <text>Microbiology</text>
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              <name>Title</name>
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                  <text>Dominio científico: Coronavirus</text>
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          <element elementId="50">
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            <description>A name given to the resource</description>
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                <text>Developing a Preliminary Causal Loop Diagram for Understanding the Wicked Complexity of the COVID-19 Pandemic</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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                <text>Rodney A. Stewart, Emiliya Suprun, Oz Sahin, Shannon Rutherford, Cara D. Beal, Hengky Salim, Russell Richards, Stefen MacAskill, Simone Heilgeist</text>
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            <description>An account of the resource</description>
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                <text>COVID-19 is a wicked problem for policy makers internationally as the complexity of the pandemic transcends health, environment, social and economic boundaries. Many countries are focusing on two key responses, namely virus containment and financial measures, but fail to recognise other aspects. The systems approach, however, enables policy makers to design the most effective strategies and reduce the unintended consequences. To achieve fundamental change, it is imperative to firstly identify the “right” interventions (leverage points) and implement additional measures to reduce negative consequences. To do so, a preliminary causal loop diagram of the COVID-19 pandemic was designed to explore its influence on socio-economic systems. In order to transcend the “wait and see” approach, and create an adaptive and resilient system, governments need to consider “deep” leverage points that can be realistically maintained over the long-term and cause a fundamental change, rather than focusing on “shallow” leverage points that are relatively easy to implement but do not result in significant systemic change.</text>
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                <text>2020</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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                <text>systems approach, Pandemic, wicked problem, Leverage points, COVID-19</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="37885">
                <text>DOI: 10.3390/systems8020020</text>
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            <name>Source</name>
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                <text>Systems</text>
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              <elementText elementTextId="37887">
                <text>MDPI AG</text>
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            <name>Coverage</name>
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                <text>Technology (General), Systems engineering</text>
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              <name>Title</name>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Why Italy First? Health, Geographical and Planning Aspects of the COVID-19 Outbreak</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="37890">
                <text>Beniamino Murgante, Giuseppe Borruso, Ginevra Balletto, Paolo Castiglia, Marco Dettori</text>
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                <text>COVID-19 hit Italy in February 2020 after its outbreak in China at the beginning of January. Why was Italy first among the Western countries? What are the conditions that made Italy more vulnerable and the first target of this disease? What characteristics and diffusion patterns could be highlighted and hypothesized from its outbreak to the end of March 2020, after containment measures, including a national lockdown, were introduced? In this paper, we try to provide some answers to these questions, analyzing the issue from medical, geographical and planning points of view. With reference to the Italian case, we observed the phenomenon in terms of the spatial diffusion process and by observing the relation between the epidemic and various environmental elements. In particular, we started from a hypothesis of the comparable economic, geographical, climatic and environmental conditions of the areas of Wuhan (in the Hubei Province in China, where the epidemic broke out) and the Po Valley area (in Italy) where most cases and deaths were registered. Via an ecological approach, we compared the spatial distribution and pattern of COVID-19-related mortality in Italy with several geographical, environmental and socio-economic variables at a Provincial level, analyzing them by means of spatial analytical techniques such as LISA (Local Indicators of Spatial Association). Possible evidence arose relating to COVID-19 cases and Nitrogen-related pollutants and land take, particularly in the Po Valley area.</text>
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            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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              <elementText elementTextId="37892">
                <text>2020</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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                <text>Italy, pollution, particles, Po Valley, NO&lt;sub&gt;x&lt;/sub&gt;, COVID-19</text>
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            <name>Identifier</name>
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              <elementText elementTextId="37894">
                <text>DOI: 10.3390/su12125064</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="37895">
                <text>Sustainability</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="37896">
                <text>MDPI AG</text>
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            </elementTextContainer>
          </element>
          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="37897">
                <text>Environmental sciences, Renewable energy sources, Environmental effects of industries and plants</text>
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  <item itemId="4146" public="1" featured="0">
    <fileContainer>
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        <src>http://socictopen.socict.org/files/original/f8ce0631efe264f7117ca8746e3371c5.pdf</src>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Vitamin D Supplementation: A Potential Approach for Coronavirus/COVID-19 Therapeutics?</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="37899">
                <text>Silvio Urcuqui Inchima, John F. Arboleda</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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                <text>2020</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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              <elementText elementTextId="37901">
                <text>anti-inflammatory, antiviral, vitamin D, SARS-CoV-2, COVID-19</text>
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            <name>Identifier</name>
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              <elementText elementTextId="37902">
                <text>DOI: 10.3389/fimmu.2020.01523</text>
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            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="37903">
                <text>Frontiers in Immunology</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="37904">
                <text>Frontiers Media S.A.</text>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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              <elementText elementTextId="37905">
                <text>Immunologic diseases. Allergy</text>
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  <item itemId="4147" public="1" featured="0">
    <fileContainer>
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              <name>Title</name>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Human Sialome and Coronavirus Disease-2019 (COVID-19) Pandemic: An Understated Correlation?</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="37907">
                <text>Carlo Pietrasanta, Fabio Mosca, Maria Lorella Giannì, Daniela Morniroli, Alessandra Consales</text>
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            <name>Date</name>
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              <elementText elementTextId="37908">
                <text>2020</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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              <elementText elementTextId="37909">
                <text>sialic acid, pathogen susceptibility, SARS-CoV-2, COVID-19, human sialome, sialoquake</text>
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              <elementText elementTextId="37910">
                <text>DOI: 10.3389/fimmu.2020.01480</text>
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            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="37911">
                <text>Frontiers in Immunology</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="37912">
                <text>Frontiers Media S.A.</text>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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              <elementText elementTextId="37913">
                <text>Immunologic diseases. Allergy</text>
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              <name>Title</name>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
        <elementContainer>
          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="37914">
                <text>Liver Injury in Critically Ill and Non-critically Ill COVID-19 Patients: A Multicenter, Retrospective, Observational Study</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="37915">
                <text>Rong-rong Wang, Ming-hua Xie, Lu Li, Na Chen, Yunzhen Hu, Jing Miao, Xiao-Yang Lu, Tingbo Liang, Yuefeng Rao, Xiuhua Wu, Yunqing Qiu, Sai-Ping Jiang, Ziqi Ye, Dongsheng Hong, Renping Ru, Minjuan Zuo</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="37916">
                <text>Background: Liver injury commonly occurs in patients with COVID-19. There is limited data describing the course of liver injury occurrence in patients with different disease severity, and the causes and risk factors are unknown. We aim to investigate the incidence, characteristics, risk factors, and clinical outcomes of liver injury in patients with COVID-19.Methods: This retrospective observational study was conducted in three hospitals (Zhejiang, China). From January 19, 2020 to February 20, 2020, patients confirmed with COVID-19 (≥18 years) and without liver injury were enrolled and divided into non-critically ill and critically ill groups. The incidence and characteristics of liver injury were compared between the two groups. Demographics, clinical characteristics, treatments, and treatment outcomes between patients with or without liver injury were compared within each group. The multivariable logistic regression model was used to explore the risk factors for liver injury.Results: The mean age of 131 enrolled patients was 51.2 years (standard deviation [SD]: 16.1 years), and 70 (53.4%) patients were male. A total of 76 patients developed liver injury (mild, 40.5%; moderate, 15.3%; severe, 2.3%) with a median occurrence time of 10.0 days. Critically ill patients had higher and earlier occurrence (81.5 vs. 51.9%, 12.0 vs. 5.0 days; p &amp;lt; 0.001), greater injury severity (p &amp;lt; 0.001), and slower recovery (50.0 vs. 61.1%) of liver function than non-critically ill patients. Multivariable regression showed that the number of concomitant medications (odds ratio [OR]: 1.12, 95% confidence interval [CI]: 1.05–1.21) and the combination treatment of lopinavir/ritonavir and arbidol (OR: 3.58, 95% CI: 1.44–9.52) were risk factors for liver injury in non-critically ill patients. The metabolism of arbidol can be significantly inhibited by lopinavir/ritonavir in vitro (p &amp;lt; 0.005), which may be the underlying cause of drug-related liver injury. Liver injury was related to increased length of hospital stay (mean difference [MD]: 3.2, 95% CI: 1.3–5.2) and viral shedding duration (MD: 3.0, 95% CI: 1.0–4.9).Conclusions: Critically ill patients with COVID-19 suffered earlier occurrence, greater injury severity, and slower recovery from liver injury than non-critically ill patients. Drug factors were related to liver injury in non-critically ill patients. Liver injury was related to prolonged hospital stay and viral shedding duration in patients with COVID-19.Clinical Trial Registration: World Health Organization International Clinical Trials Registry Platform, ChiCTR2000030593. Registered March 8, 2020.</text>
              </elementText>
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          <element elementId="40">
            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="37917">
                <text>2020</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="37918">
                <text>Risk factors, incidence, Disease severity, Liver injury, COVID-19</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="43">
            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
            <elementTextContainer>
              <elementText elementTextId="37919">
                <text>DOI: 10.3389/fmed.2020.00347</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="37920">
                <text>Frontiers in Medicine</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="37921">
                <text>Frontiers Media S.A.</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="37922">
                <text>Medicine (General)</text>
              </elementText>
            </elementTextContainer>
          </element>
        </elementContainer>
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    </elementSetContainer>
  </item>
</itemContainer>
