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                  <text>Dominio científico: Coronavirus</text>
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                <text>COVID-19 and Cancer: Lessons Learnt from a Michigan Hotspot</text>
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                <text>Sunny  R. K. Singh, Kannan Thanikachalam, Hiba Jabbour-Aida, Laila  M. Poisson, Gazala Khan</text>
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                <text>(1) Background: Outcomes with coronavirus disease 2019 (COVID-19) have been worse in those with comorbidities and amongst minorities. In our study, we describe outcomes amongst cancer patients in Detroit, a major COVID-19 hotspot with a predominant inner-city population. (2) Methods: We retrospectively analyzed 85 patients with active invasive cancers who were infected with COVID-19. The primary outcome was death or transition to hospice. (3) Results: The majority were males (55.3%, n = 47), ≤70 years old (58.5%, n = 50), and African Americans (65.5%, n = 55). The most common primary site was prostate (18.8%, n = 16). Inpatient admission was documented in 85.5% (n = 73), ICU admission in 35.3% (n = 30), and primary outcome in 43.8% (n = 32) of hospitalized patients. On a multivariate analysis, factors associated with increased odds of a primary outcome included an age of &gt;70 years versus ≤70 years (OR 4.7, p = 0.012) and of male gender (OR 4.8, p = 0.008). Recent cancer-directed therapy was administered in 66.7% (n = 20) of ICU admissions versus 39.5% (n = 17) of general floor admissions (Chi-square p-value of 0.023). (4) Conclusions: High rates of mortality/transition to hospice and ICU utilization were noted amongst our patients with active invasive cancer, following a COVID-19 infection. Men and those of &gt;70 years of age had a greater than four-fold increase in odds of death or transition to hospice.</text>
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                <text>cancer, covid-19, SARS-CoV-2, Healthcare disparity</text>
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                <text>10.3390/cancers12092377</text>
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                <text>Epidemiology and Health</text>
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                <text>Korean Society of Epidemiology</text>
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                <text>Neoplasms. Tumors. Oncology. Including cancer and carcinogens</text>
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                <text>COVID-19 and Cardiac Surgery: Still Many Questions and Much Work to Do.</text>
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                <text>Carlo M Rosati, Chan Tran N Nguyen, Shinichi Fukuhara</text>
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                <text>The Annals of thoracic surgery</text>
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                <text>COVID-19 and cardiovascular disease in elderly patients: a challenge in the challenge</text>
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                <text>Raffaele Costa, Giovanni Ruotolo, Alberto Castagna, Carmen Ruberto, Carlo Torchia</text>
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                <text>On 11 March 2020, the World Health Organization declared a pandemic state, in relation to the spread of the severe acute respiratory syndrome-coronavirus disease-2, responsible for the coronavirus disease-2019 (COVID-19). The pandemical blast of COVID-19 uncovered well known weakness of financial chain and put our economic organizations facing off dramatic consequences if new strategies will not be developed to adapt health-care on detailed sub-groups of patients. Frail individual aged &gt;65 years affected by cardiovascular disease are an aged population that showed a particular attitude to contract infection and a higher mortality rate compared to general population. In this brief article, we will focus on the management of issues related to cardiovascular patients facing coronavirus infection, in particular in the most fragile groups of the population such as the elderly, increasingly numerous and affected by multimorbidity. Protecting aged populations will be a central question, probably primary in everyone's interest.</text>
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                <text>2020</text>
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                <text>elderly, Cardiovascular patients, COVID-19</text>
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                <text>DOI: 10.4081/gc.2020.9121</text>
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                <text>Geriatric Care</text>
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                <text>PAGEPress Publications</text>
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                <text>Geriatrics</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>COVID-19 and Cerebrovascular Diseases: A Systematic Review and Perspectives for Stroke Management</text>
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                <text>Pedro Fraiman, Clecio Godeiro Junior, Elena Moro, Francesco Cavallieri, Francesco Cavallieri, Marialuisa Zedde</text>
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                <text>Importance: Reported cerebrovascular events in patients with COVID-19 are mainly ischemic, but hemorrhagic strokes and cerebral venous sinus thrombosis (CSVT), especially in critically ill patients, have also been described. To date, it is still not clear whether cerebrovascular manifestations are caused by direct viral action or indirect action mediated by inflammatory hyperactivation, and in some cases, the association may be casual rather than causal.Objective: To conduct a systematic review on the cerebrovascular events in COVID-19 infection.Evidence review: A comprehensive literature search on PubMed was performed including articles published from January 1, 2020, to July 23, 2020, using a suitable keyword strategy. Additional sources were added by the authors by reviewing related references. The systematic review was conducted in accordance with the PRISMA guidelines. Only articles reporting individual data on stroke mechanism and etiology, sex, age, past cardiovascular risk factors, COVID symptoms, admission NIHSS, D-dimer levels, and acute stroke treatment were selected for the review. Articles that did not report the clinical description of the cases were excluded. A descriptive statistical analysis of the data collected was performed.Finding: From a total of 1,210 articles published from January 1, 2020, to July 23, 2020, 80 articles (275 patients), which satisfied the abovementioned criteria, were included in this review. A total of 226 cases of ischemic stroke (IS), 35 cases of intracranial bleeding, and 14 cases of CVST were found. Among patients with IS, the mean age was 64.16 ±14.73 years (range 27–92 years) and 53.5% were male. The mean NIHSS score reported at the onset of stroke was 15.23 ±9.72 (range 0–40). Primary endovascular thrombectomy (EVT) was performed in 24/168 patients (14.29%), intravenous thrombolysis (IVT) was performed in 17/168 patients (10.12%), and combined IVT+EVT was performed in 11/168 patients (6.55%). According to the reported presence of large vessel occlusion (LVO) (105 patients), 31 patients (29.52%) underwent primary EVT or bridging. Acute intracranial bleeding was reported in 35 patients: 24 patients (68.57%) had intracerebral hemorrhage (ICH), 4 patients (11.43%) had non-traumatic subarachnoid hemorrhage (SAH), and the remaining 7 patients (20%) had the simultaneous presence of SAH and ICH. Fourteen cases of CVST were reported in the literature (50% males), mean age 42.8 years ±15.47 (range 23–72). Treatment was reported only in nine patients; seven were treated with anticoagulant therapy; one with acetazolamide, and one underwent venous mechanical thrombectomy.Conclusion: Cerebrovascular events are relatively common findings in COVID-19 infection, and they could have a multifactorial etiology. More accurate and prospective data are needed to better understand the impact of cerebrovascular events in COVID-19 infection.</text>
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                <text>coronavirus, covid-19, SARS-CoV-2, Stroke, cerebrovascular, Intracranial hemorrhage</text>
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                <text>10.3389/fneur.2020.574694</text>
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                <text>Epidemiology and Health</text>
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                <text>Korean Society of Epidemiology</text>
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                <text>Neurology. Diseases of the nervous system</text>
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                <text>Terry R Bard</text>
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                <text>Richard Russell Respiratory Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, UKCorrespondence: Richard Russell Email richard.russell@ndm.ox.ac.ukAs China seems to be emerging from their COVID epidemic and the rest of the&amp;nbsp;world is plunged headlong into their own perhaps I can be forgiven by the readers&amp;nbsp;of this journal for a moment or two of reflection and even self-indulgence. It is&amp;nbsp;a huge privilege to be the editor of the International Journal of COPD and this&amp;nbsp;enables me to keep abreast of all current COPD research. Loyal readers will know&amp;nbsp;that we accept a catholic spread of research and are very much patient-focused. As&amp;nbsp;editor, I have maintained as a principle that the research we published must be&amp;nbsp;potentially translatable. I am also a committed front-line clinician and clinical&amp;nbsp;researcher. And so, with these three perspectives, I have been able to reflect on&amp;nbsp;the current COVID-19 crisis and what this means to our patients, our colleagues&amp;nbsp;and our families.</text>
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                <text>SARS-CoV-2 is a member of the family of coronaviruses. The first cases were recorded in Wuhan, China, between December 2019 and January 2020. Italy is one of the most affected countries in Europe. COVID-19 is a new challenge in modern dentistry. New guidelines are required in dental clinics to avoid contagion caused by cross-infections. A narrative review was performed using both primary sources, such as scientific articles and secondary ones, such as bibliographic indexes, web pages, and databases. The main search engines were PubMed, SciELO, and Google Scholar. Twelve articles were selected to develop the bibliographic review by applying pre-established inclusion and exclusion criteria. Precautionary measures should be applied to control COVID-19 in clinical practice. Several authors have highlighted the importance of telephone triage and/or clinic questionnaires, body temperature measurement, usage of personal protective equipment, surface disinfection with ethanol between 62% and 71%, high-speed instruments equipped with an anti- retraction system, four-handed work, and large-volume cannulas for aspiration. Clinically, the use of a rubber dam is essential. FFP2 (or N95) and FFP3 respirators, if compared to surgical masks, provide greater protection for health workers against viral respiratory infections. Further accurate studies are needed to confirm this.</text>
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          <element elementId="40">
            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="47976">
                <text>2020</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="47977">
                <text>covid-19, infection, hygiene, Dentistry, dental practice, PPE</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="43">
            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
            <elementTextContainer>
              <elementText elementTextId="47978">
                <text>10.3390/ijerph17124609</text>
              </elementText>
            </elementTextContainer>
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          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="47979">
                <text>Epidemiology and Health</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
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                <text>Korean Society of Epidemiology</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="47981">
                <text>Medicine</text>
              </elementText>
            </elementTextContainer>
          </element>
        </elementContainer>
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    </elementSetContainer>
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</itemContainer>
