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                <text>Coronavirus</text>
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                <text>Dominio científico: Coronavirus</text>
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              <text>Gerbil: a fast and memory-efficient k-mer counter with GPU-support</text>
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          <name>Creator</name>
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              <text>Marius Erbert, Steffen Rechner, Matthias Müller-Hannemann</text>
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          <name>Description</name>
          <description>An account of the resource</description>
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              <text>Abstract Background A basic task in bioinformatics is the counting of k-mers in genome sequences. Existing k-mer counting tools are most often optimized for small k &lt; 32 and suffer from excessive memory resource consumption or degrading performance for large k. However, given the technology trend towards long reads of next-generation sequencers, support for large k becomes increasingly important. Results We present the open source k-mer counting software Gerbil that has been designed for the efficient counting of k-mers for k ≥ 32. Our software is the result of an intensive process of algorithm engineering. It implements a two-step approach. In the first step, genome reads are loaded from disk and redistributed to temporary files. In a second step, the k-mers of each temporary file are counted via a hash table approach. In addition to its basic functionality, Gerbil can optionally use GPUs to accelerate the counting step. In a set of experiments with real-world genome data sets, we show that Gerbil is able to efficiently support both small and large k. Conclusions While Gerbil’s performance is comparable to existing state-of-the-art open source k-mer counting tools for small k &lt; 32, it vastly outperforms its competitors for large k, thereby enabling new applications which require large values of k.</text>
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              <text>2017</text>
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          <name>Subject</name>
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              <text>k-mer counting, de novo assembly, Genome sequences, GPU computing, algorithm engineering</text>
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              <text>DOI: 10.1186/s13015-017-0097-9</text>
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          <name>Source</name>
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              <text>Algorithms for Molecular Biology</text>
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          <name>Publisher</name>
          <description>An entity responsible for making the resource available</description>
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            <elementText elementTextId="21661">
              <text>BMC</text>
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          <name>Coverage</name>
          <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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              <text>Biology (General), Genetics</text>
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          <name>Language</name>
          <description>A language of the resource</description>
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              <text>EN</text>
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