http://socictopen.socict.org/files/original/597375b5fc22e052b479b642b52a7c16.pdf c82b8ac6ecc9bc3b5f81a2577f47bbd2 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Agricultura sostenible Description An account of the resource Dominio científico: Agricultura sostenible Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Chemical Profiling and Cholinesterase Inhibitory Activity of Five <i>Phaedranassa</i> Herb. (Amaryllidaceae) Species from Ecuador Creator An entity primarily responsible for making the resource Luciana R. Tallini, Jaume Bastida, Raúl Moreno, Cristina Salazar, Edison H. Osorio, Evelin Montero, Nora H. Oleas, Karen Acosta León Description An account of the resource It is estimated that 50 million people in the world live with dementia, 60–70% of whom suffer from Alzheimer’s disease (AD). Different factors are involved in the development of AD, including a reduction in the cholinergic neurotransmission level. The Amaryllidaceae plant family contains an exclusive, large, and still understudied alkaloid group characterized by a singular skeleton arrangement and a broad spectrum of biological activities. The chemistry and biodiversity of Ecuadorian representatives of the Phaedranassa genus (Amaryllidaceae) have not been widely studied. In this work, five Ecuadorian Phaedranassa species were examined in vitro for their activity towards the enzymes acetyl- (AChE) and butyrylcholinesterase (BuChE), and the alkaloid profile of bulb extracts was analyzed by GC-MS. The species Phaedranassa cuencana and Phaedranassa dubia showed the most AChE and BuChE inhibitory activity, respectively. To obtain insight into the potential role of the identified alkaloids in these inhibitory effects, docking experiments were carried out, and cantabricine showed in silico inhibitory activity against both cholinesterase structures. Our results show that Amaryllidaceae species from Ecuador are a potential source of new drugs for the palliative treatment of AD. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource <i>Phaedranassa</i>, Amaryllidaceae, GC/MS, alkaloids, cholinesterases, molecular docking Identifier An unambiguous reference to the resource within a given context 10.3390/molecules25092092 Source A related resource from which the described resource is derived Molecules Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Organic chemistry Relation A related resource <a href="https://www.mdpi.com/1420-3049/25/9/2092" target="_blank" rel="noreferrer noopener">https://www.mdpi.com/1420-3049/25/9/2092</a>