http://socictopen.socict.org/files/original/747c2f6caa749ecb497155d278afa1ff.pdf d3849d1724547a16969c79da5988349e Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Intractable COVID-19 and Prolonged SARS-CoV-2 Replication in a CAR-T-cell Therapy Recipient: A Case Study. Creator An entity primarily responsible for making the resource Matthew K Hensley, William G Bain, Jana Jacobs, Sham Nambulli, Urvi Parikh, Anthony Cillo, Brittany Staines, Amy Heaps, Michele D Sobolewski, Linda J Rennick, Bernard J C Macatangay, Cynthia Klamar-Blain, Georgios D Kitsios, Barbara Methé, Ashwin Somasundaram, Tullia Bruno, Carly Cardello, Feng Shan, Creg Workman, Prabir Ray, Anuradha Ray, Janet Lee, Rahil Sethi, William E Schwarzmann, Mark S Ladinsky, Pamela J Bjorkman, Dario A Vignali, W Paul Duprex, Mounzer E Agha, John W Mellors, Kevin D McCormick, Alison Morris, Ghady Haidar Description An account of the resource A CAR-T-cell recipient developed severe COVID-19, intractable RNAemia, and viral replication lasting >2 months. Pre-mortem endotracheal aspirate contained 2x10 10 SARS-CoV-2 RNA copies/mL and infectious virus. Deep sequencing revealed multiple sequence variants consistent with intra-host virus evolution. SARS-CoV-2 humoral and cell-mediated immunity were minimal. Prolonged transmission from immunosuppressed patients is possible. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource covid-19, severe acute respiratory syndrome coronavirus 2, SARS-CoV-2 infectivity, SARS-CoV-2 RNAemia, SARS-CoV-2 immune responses, SARS-CoV-2 intra-host variation Identifier An unambiguous reference to the resource within a given context 10.1093/cid/ciab072 Source A related resource from which the described resource is derived Clinical infectious diseases : an official publication of the Infectious Diseases Society of America