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            <name>Title</name>
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                <text>Coronavirus</text>
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                <text>Dominio científico: Coronavirus</text>
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              <text>Identification and Characterization of a Novel Alpaca Respiratory Coronavirus Most Closely Related to the Human Coronavirus 229E</text>
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              <text>Sharon K. Hietala, Richard E. Mock, Scott A. Callison, Beate M. Crossley</text>
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              <text>In 2007, a novel coronavirus associated with an acute respiratory disease in alpacas (Alpaca Coronavirus, ACoV) was isolated. Full-length genomic sequencing of the ACoV demonstrated the genome to be consistent with other Alphacoronaviruses. A putative additional open-reading frame was identified between the nucleocapsid gene and 3&amp;#039;UTR. The ACoV was genetically most similar to the common human coronavirus (HCoV) 229E with 92.2% nucleotide identity over the entire genome. A comparison of spike gene sequences from ACoV and from HCoV-229E isolates recovered over a span of five decades showed the ACoV to be most similar to viruses isolated in the 1960&amp;amp;#8217;s to early 1980&amp;amp;#8217;s. The true origin of the ACoV is unknown, however a common ancestor between the&amp;amp;#160;ACoV and HCoV-229E appears to have existed prior to the 1960&amp;amp;#8217;s, suggesting virus&amp;amp;#160;transmission, either as a zoonosis or anthroponosis, has occurred between alpacas and humans.</text>
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              <text>2012</text>
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              <text>alpaca, human, coronavirus, reverse zoonosis, anthroponosis, respiratory, molecular evolution</text>
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          <name>Identifier</name>
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              <text>DOI: 10.3390/v4123689</text>
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              <text>Viruses</text>
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          <name>Publisher</name>
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              <text>MDPI AG</text>
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          <name>Coverage</name>
          <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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              <text>Microbiology</text>
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          <name>Language</name>
          <description>A language of the resource</description>
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              <text>EN</text>
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