http://socictopen.socict.org/files/original/538e40657b1d835ba7b34b323cb460c0.pdf 068ec5e1621c2f1bb4d3d37febb29c39 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource A multi-targeting drug design strategy for identifying potent anti-SARS-CoV-2 inhibitors. Creator An entity primarily responsible for making the resource Weijuan Shang, Leike Zhang, Peng-Xuan Ren, Wan-Chao Yin, Huan Ge, Lin Wang, Xiang-Lei Zhang, Bing-Qian Li, Hong-Lin Li, Ye-Chun Xu, Eric H Xu, Hua-Liang Jiang, Li-Li Zhu, Fang Bai Description An account of the resource The COVID-19, caused by SARS-CoV-2, is threatening public health, and there is no effective treatment. In this study, we have implemented a multi-targeted anti-viral drug design strategy to discover highly potent SARS-CoV-2 inhibitors, which simultaneously act on the host ribosome, viral RNA as well as RNA-dependent RNA polymerases, and nucleocapsid protein of the virus, to impair viral translation, frameshifting, replication, and assembly. Driven by this strategy, three alkaloids, including lycorine, emetine, and cephaeline, were discovered to inhibit SARS-CoV-2 with EC50 values of low nanomolar levels potently. The findings in this work demonstrate the feasibility of this multi-targeting drug design strategy and provide a rationale for designing more potent anti-virus drugs. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource RdRp, SARS-CoV-2 inhibitors, Virus RNA, host ribosome Identifier An unambiguous reference to the resource within a given context 10.1038/s41401-021-00668-7 Source A related resource from which the described resource is derived Acta pharmacologica Sinica