http://socictopen.socict.org/files/original/41639014614d0e4c0eee05d15802ab63.pdf 07d2357d84091956d790765440e93b26 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Perspectives on anti-IL-1 inhibitors as potential therapeutic interventions for severe COVID-19. Creator An entity primarily responsible for making the resource Jie Geng, Feng Wang, Zhiwei Huang, Xiaobo Chen, Yuliang Wang Description An account of the resource The overproduction of proinflammatory cytokines, resulting in what has been described as a cytokine storm or cytokine release syndrome (CRS), may be the key factor in the pathology of severe coronavirus disease 2019 (COVID-19) and is also a crucial cause of death from COVID-19. With the purpose of finding effective and low-toxicity drugs to mitigate CRS, IL-1 blockade agents, which are one of the safest ways to stop this overwhelming innate immune response, are already available in several preliminary reports or are under observational trials and may offer an important treatment option in hyperinflammatory COVID-19. In this review, we described the key information in both case reports and clinical studies on the potential beneficial features of IL-1 inhibitors in COVID-19 patients. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource covid-19, SARS-CoV-2, Cytokine release syndrome, anakinra, Interleukin-1 blockade Identifier An unambiguous reference to the resource within a given context 10.1016/j.cyto.2021.155544 Source A related resource from which the described resource is derived Cytokine