SARS-CoV-2 Inflammatory Syndrome. Clinical Features and Rationale for Immunological Treatment
inflammation, anti-cytokine antibodies, acute respiratory syndrome, SARS-CoV-2, COVID-19, human immunoglobulin for intravenous use
The current pandemic coronavirus, SARS-CoV-2, is a global health emergency because of its highly contagious nature, the great number of patients requiring intensive care therapy, and the high fatality rate. In the absence of specific antiviral drugs, passive prophylaxis, or a vaccine, the treatment aim in these patients is to prevent the potent virus-induced inflammatory stimuli from leading to the acute respiratory distress syndrome (ARDS), which has a severe prognosis. Here, the mechanism of action and the rationale for employing immunological strategies, which range from traditional chemically synthesized drugs, anti-cytokine antibodies, human immunoglobulin for intravenous use, to vaccines, are reviewed.
Vito Racanelli, Marcella Prete, Elvira Favoino, Giacomo Catacchio, Federico Perosa
International Journal of Molecular Sciences