https://socictopen.socict.org/files/original/d5c077e32a5494522d4612d4cd2ee7c7.pdf feb2fae9f25b45a5a2efa3975eb26625 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Elucidation on the Physicochemical Properties of Potential and Clinically Approved Antiviral Drugs: A Search for Effective Therapies against SARS-CoV-2 Infection Creator An entity primarily responsible for making the resource Derick Erl P. Sumalapao Description An account of the resource COVID-19 has been confirmed in millions of individuals worldwide, rendering it a global medicalemergency. In the absence of vaccines and the unavailability of effective drugs for the SARS-CoV-2infection, vaccine development is being continuously explored and several antiviral compoundsand immunotherapies are currently being investigated. Given the high similarity in genetic identitybetween SARS-CoV and SARS-CoV-2, the present investigation identified the interaction between thephysicochemical properties and the antiviral activity of different potential and clinically approvedantiviral drugs against SARS-CoV using hierarchically weighted principal component analysis.Representative drugs from the classes of neuraminidase inhibitors, reverse transcriptase inhibitors,protease inhibitors, nucleoside analogues, and other compounds with potential antiviral activity wereexamined. The pharmacologic classification and the biological activity of the different antiviral drugswere described using indices, namely, rotatable bond count, molecular weight, heavy atom count, andmolecular complexity (92.32% contribution rate). The physicochemical properties and inhibitory actionagainst SARS-CoV-2 of lopinavir, chloroquine, ivermectin, and ciclesonide validated the adequacy ofthe current computational approach. The findings of the present study provide additional information,although further investigation is warranted to identify potential targets and establish exact mechanisms,in the emergent search and design of antiviral drug candidates and their subsequent synthesis aseffective therapies for COVID-19. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource principal component analysis, Neuraminidase inhibitors, Protease inhibitors, Nucleoside analogues, reverse transcriptase inhibitors, COVID-19 Identifier An unambiguous reference to the resource within a given context DOI: 10.22207/JPAM.14.SPL1.41 Source A related resource from which the described resource is derived Journal of Pure and Applied Microbiology Publisher An entity responsible for making the resource available Journal of Pure and Applied Microbiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Microbiology