Canine Enteric Coronaviruses: Emerging Viral Pathogens with Distinct Recombinant Spike Proteins
subject: canine coronavirus, viral pathogenesis, spike protein, recombination
description: Canine enteric coronavirus (CCoV) is an alphacoronavirus infecting dogs that is closely related to enteric coronaviruses of cats and pigs. While CCoV has traditionally caused mild gastro-intestinal clinical signs, there are increasing reports of lethal CCoV infections in dogs, with evidence of both gastrointestinal and systemic viral dissemination. Consequently, CCoV is now considered to be an emerging infectious disease of dogs. In addition to the two known serotypes of CCoV, novel recombinant variants of CCoV have been found containing spike protein N-terminal domains (NTDs) that are closely related to those of feline and porcine strains. The increase in disease severity in dogs and the emergence of novel CCoVs can be attributed to the high level of recombination within the spike gene that can occur during infection by more than one CCoV type in the same host.
creator: Beth N. Licitra, Gerald E. Duhamel, Gary R. Whittaker
source: Viruses
publisher: MDPI AG
date: 2014
language: EN
identifier: DOI: 10.3390/v6083363
coverage: Microbiology