The Coronavirus E Protein: Assembly and Beyond
subject: envelope protein, coronavirus assembly, ion channel, Golgi complex, membrane protein topology
description: The coronavirus E protein is a small membrane protein that has an important role in the assembly of virions. Recent studies have indicated that the E protein has functions during infection beyond assembly, including in virus egress and in the host stress response. Additionally, the E protein has ion channel activity, interacts with host proteins, and may have multiple membrane topologies. The goal of this review is to highlight the properties and functions of the E protein, and speculate on how they may be related.
creator: Travis R. Ruch, Carolyn E. Machamer
source: Viruses
publisher: MDPI AG
date: 2012
language: EN
identifier: DOI: 10.3390/v4030363
coverage: Microbiology