Differential Tropism of SARS-CoV and SARS-CoV-2 in Bat Cells
SARS, severe acute respiratory syndrome, Viruses, SARS-CoV-2, severe acute respiratory syndrome coronavirus 2, coronavirus disease
Severe acute respiratory syndrome coronavirus 2 did not replicate efficiently in 13 bat cell lines, whereas severe acute respiratory syndrome coronavirus replicated efficiently in kidney cells of its ancestral host, the Rhinolophus sinicus bat, suggesting different evolutionary origins. Structural modeling showed that RBD/RsACE2 binding may contribute to the differential cellular tropism.
Susanna K.P. Lau, Antonio C.P. Wong, Hayes K.H. Luk, Kenneth S.M. Li, Joshua Fung, Zirong He, Flora K.K. Cheng, Tony T.Y. Chan, Stella Chu, Kam Leng Aw-Yong, Terrence C.K. Lau, Kitty S.C. Fung, Patrick C.Y. Woo
Centers for Disease Control and Prevention
Medicine, Infectious and parasitic diseases