A SARS-CoV-2 antibody curbs viral nucleocapsid protein-induced complement hyperactivation
While SARS-CoV-2 S protein targeting monoclonal antibodies (mAbs) are well studied, little is known about N protein-targeting mAbs. Here, Kang et al. provide the crystal structure of the N protein RNA binding domain with a mAb derived from a convalescent patient and show that it compromises the N protein-induced complement hyperactivation.
Guan-Min Jiang, Xiaoxue Chen, Sisi Kang, Mei Yang, Suhua He, Yueming Wang, Yao-Qing Chen, Zhongsi Hong, Jing Liu, Qiuyue Chen, Ziliang Zhou, Zhechong Zhou, Zhaoxia Huang, Xi Huang, Huanhuan He, Weihong Zheng, Hua-Xin Liao, Fei Xiao, Hong Shan, Shoudeng Chen