Arthropod Ectoparasites Have Potential to Bind SARS-CoV-2 via ACE
subject: spike protein, covid-19, Parasite, SARS-CoV-2, ACE2, structural bioinformatics
description: Coronavirus-like organisms have been previously identified in Arthropod ectoparasites (such as ticks and unfed cat flea). Yet, the question regarding the possible role of these arthropods as SARS-CoV-2 passive/biological transmission vectors is still poorly explored. In this study, we performed in silico structural and binding energy calculations to assess the risks associated with possible ectoparasite transmission. We found sufficient similarity between ectoparasite ACE and human ACE2 protein sequences to build good quality 3D-models of the SARS-CoV-2 Spike:ACE complex to assess the impacts of ectoparasite mutations on complex stability. For several species (e.g., water flea, deer tick, body louse), our analyses showed no significant destabilisation of the SARS-CoV-2 Spike:ACE complex, suggesting these species would bind the viral Spike protein. Our structural analyses also provide structural rationale for interactions between the viral Spike and the ectoparasite ACE proteins. Although we do not have experimental evidence of infection in these ectoparasites, the predicted stability of the complex suggests this is possible, raising concerns of a possible role in passive transmission of the virus to their human hosts.
creator: Margarita Villar, José de la Fuente, Christian Gortázar, Su Datt Lam, Paul Ashford, Sandra Díaz-Sánchez, Christine Orengo
source: Epidemiology and Health
publisher: Korean Society of Epidemiology
date: 2021
coverage: Microbiology