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Severe acute respiratory syndrome coronavirus envelope protein regulates cell stress response and apoptosis.
Severe acute respiratory syndrome virus (SARS-CoV) that lacks the envelope (E) gene (rSARS-CoV-ΔE) is attenuated in vivo. To identify factors that contribute to rSARS-CoV-ΔE attenuation, gene expression in cells infected by SARS-CoV with or without E…
Position: 5353 (21 views)
Potent and selective inhibition of pathogenic viruses by engineered ubiquitin variants.
The recent Middle East respiratory syndrome coronavirus (MERS-CoV), Ebola and Zika virus outbreaks exemplify the continued threat of (re-)emerging viruses to human health, and our inability to rapidly develop effective therapeutic countermeasures.…
Position: 4539 (22 views)
Evasion by stealth: inefficient immune activation underlies poor T cell response and severe disease in SARS-CoV-infected mice.
Severe Acute Respiratory Syndrome caused substantial morbidity and mortality during the 2002-2003 epidemic. Many of the features of the human disease are duplicated in BALB/c mice infected with a mouse-adapted version of the virus (MA15), which…
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The Role of Human Coronaviruses in Children Hospitalized for Acute Bronchiolitis, Acute Gastroenteritis, and Febrile Seizures: A 2-Year Prospective Study.
UNLABELLED:Human coronaviruses (HCoVs) are associated with a variety of clinical presentations in children, but their role in disease remains uncertain. The objective of our prospective study was to investigate HCoVs associations with various…
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Design and Construction of Chimeric VP8-S2 Antigen for Bovine Rotavirus and Bovine Coronavirus
Purpose: Bovine Rotavirus and Bovine Coronavirus are the most important causes of diarrhea in newborn calves and in some other species such as pigs and sheep. Rotavirus VP8 subunit is the major determinant of the viral infectivity and neutralization.…
Position: 2135 (27 views)
Lisansüstü Turizm Öğrencilerinin Akademik Güdülenme, Bilimsel Araştırma Özyeterlilik ve Araştırma Yapmaya Yönelik Kaygılarının Değerlendirilmesi
Araştırmanın amacı, lisansüstü düzeyde turizm eğitimi alan öğrencilerin bilimsel araştırmaözyeterliliği, araştırmaya yönelik kaygı ve akademik güdülenme düzeylerini belirlemek ve eğervarsa bu değişkenler arasındaki ilişkiyi ortaya koymaktır. Bu…
Position: 8656 (18 views)
Viral discovery and sequence recovery using DNA microarrays.
Because of the constant threat posed by emerging infectious diseases and the limitations of existing approaches used to identify new pathogens, there is a great demand for new technological methods for viral discovery. We describe herein a DNA…
Position: 11521 (16 views)
MyD88 is required for protection from lethal infection with a mouse-adapted SARS-CoV.
A novel human coronavirus, SARS-CoV, emerged suddenly in 2003, causing approximately 8000 human cases and more than 700 deaths worldwide. Since most animal models fail to faithfully recapitulate the clinical course of SARS-CoV in humans, the virus…
Position: 6290 (20 views)
Molecular basis of resistance to muramidase and cationic antimicrobial peptide activity of lysozyme in staphylococci.
It has been shown recently that modification of peptidoglycan by O-acetylation renders pathogenic staphylococci resistant to the muramidase activity of lysozyme. Here, we show that a Staphylococcus aureus double mutant defective in…
Position: 2811 (25 views)
Coronavirus non-structural protein 1 is a major pathogenicity factor: implications for the rational design of coronavirus vaccines.
Attenuated viral vaccines can be generated by targeting essential pathogenicity factors. We report here the rational design of an attenuated recombinant coronavirus vaccine based on a deletion in the coding sequence of the non-structural protein 1…
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