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                <text>Infoxicación en la comunicación del cambio climático. Mitigación y adaptación</text>
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                <text>Rogelio Fernández Reyes</text>
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                <text>El desarrollo tecnológico y científico en el último siglo ha generado una explosión en el volumen de conocimientos que fluyen a través de las nuevas tecnologías. Supone uno de los fenómenos más característicos del periodismo actual. Una de las consecuencias es la infoxicación que se puede llegar a producir por la sobrecarga de información. En el presente artículo se analiza la infoxicación en el cambio climático a través de un análisis de contenido del punto focal de un incremento de temperatura media mundial en torno a 2º C con respecto a los niveles preindustriales en El País. Las categorías que se analizan son: Protagonismo del punto focal (Se aborda de manera prioritaria o Se aborda de manera secundaria), Cómo se aborda (A propósito de lo que ocurre, A propósito de lo que se hace, A propósito de lo que se dice) y Respuestas (Mitigación, Adaptación). Como conclusiones observamos la presencia de infoxicación en la temática en torno al incremento de temperatura media mundial de 2º C en la predominancia del discurso de “lo que se dice” por encima de “lo que se hace” y de “lo que ocurre”; y la prevalencia del tratamiento de la adaptación sobre la mitigación. Como propuesta de desinfoxicación, desde un periodismo en transición, sugerimos apoyar el valor del punto focal de 350 ppm de CO2; la prevalencia de tratar “lo que se hace” y “lo que ocurre” sobre “lo que se dice”; y propiciar un equilibrio en el volumen de tratamiento de la adaptación y la mitigación.</text>
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                <text>2014</text>
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                <text>Ámbitos</text>
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                <text>Editorial Universidad de Sevilla</text>
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                <text>Communication. Mass media</text>
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                <text>&lt;a href="http://www.redalyc.org/articulo.oa?id=16832539010" target="_blank" rel="noreferrer noopener"&gt;http://www.redalyc.org/articulo.oa?id=16832539010&lt;/a&gt;</text>
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                  <text>Dominio científico: Agricultura sostenible</text>
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                <text>Inframedia: barreras infraestructurales y ecologÃ­as online en la Web 2.0</text>
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                <text>JosÃ© SÃ¡nchez LÃ³pez</text>
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                <text>Nuestra inteligencia colectiva y con ella nuestro posicionamiento â€œglocalâ€ dependen estrechamente de la operaciÃ³n a gran escala de los media existentes en las redes (motores de bÃºsqueda, redes sociales, Wikis etc.). El origen digital de tales medios, y su dependencia de las ciencias de la computaciÃ³n las hace adoptar formas distintivas en relaciÃ³n especÃ­fica con el diseÃ±o de software. Dada esta situaciÃ³n, es importante seÃ±alar la condiciÃ³n limitada, particular a nuestro contacto fenomenolÃ³gico y cognitivo con las infraestructuras de red que lo soportan.  El presente trabajo trata de resumir una investigaciÃ³n personal sobre la visualidad en las redes, que tiene por objetivo proveer de contexto teÃ³rico a una prÃ³xima experimentaciÃ³n artÃ­stica en el Ã¡mbito de los nuevos medios. Ã‰sta, Ã³rbita alrededor de una serie de cuestiones que surgen en relaciÃ³n con la nociÃ³n de â€œinterfaz cibernÃ©ticaâ€, entendida como la parte visible de todo un complejo infraestructural.  Se destacan cuatro principales focos de incidencia: 1. ValoraciÃ³n de la estructura en capas de abstracciÃ³n funcional, propias de la gestiÃ³n mediada: arquitectura, protocolos y algoritmos que componen la â€œvidaâ€ tecno-material de la red. 2. La doble acepciÃ³n de â€œcolectividadâ€ en las redes: la generaciÃ³n de contenidos por parte de usuarios, y su oscilaciÃ³n entre lo procomÃºn y la recolecciÃ³n de datos. 3. AtenciÃ³n al tÃ©rmino acuÃ±ado por James Bridle: â€œNew Aestheticsâ€, y la iniciativa de seÃ±alar la creciente autonomÃ­a de lo digital en su vocaciÃ³n de referir lo real desde sus propios tÃ©rminos. Circunstancia puesta en relaciÃ³n con las inquietudes de la sociologÃ­a contemporÃ¡nea por considerar la implicaciÃ³n de los agentes no-humanos en las dinÃ¡micas sociales propias de la ecologÃ­a on-line. 4. Impacto sobre casos concretos: prÃ¡cticas artÃ­sticas contemporÃ¡neas sujetas al contexto digital desde sus estrategias formales, sea en complicidad, o en actitud de resistencia en un ejercicio de contra-diseÃ±o.</text>
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                <text>2017</text>
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            <description>The topic of the resource</description>
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                <text>Esencialismo de interfaz visual, New Aesthetics, capas de abstracciÃ³n, interactividad, medios computacionales</text>
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                <text>10.4995/aniav.2017.7826</text>
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                <text>ANIAV</text>
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                <text>Universitat Politécnica de Valencia</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Fine Arts, Visual arts</text>
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            <description>A related resource</description>
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                <text>&lt;a href="https://polipapers.upv.es/index.php/aniav/article/view/7826" target="_blank" rel="noreferrer noopener"&gt;https://polipapers.upv.es/index.php/aniav/article/view/7826&lt;/a&gt;</text>
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                <text>INGENIERÍA ANALÍTICA A LA CONVIVENCIA PACÍFICA DE LA NATURALEZA, EL ÁTOMO Y EL HOMBRE</text>
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            <description>An account of the resource</description>
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                <text>La revoluci&amp;oacute;n cient&amp;iacute;fico-t&amp;eacute;cnica transforma a la ciencia en una fuerza productiva directa, convierte en realidad lo que no hace mucho pertenec&amp;iacute;a al mundo de lo fant&amp;aacute;stico. Pero la inmensa y creciente actividad del hombre reviste tambi&amp;eacute;n consecuencias negativas. Con alarma e inquietudobservamos que un r&amp;iacute;o, anta&amp;ntilde;o caudaloso, se sec&amp;oacute; de s&amp;uacute;bito; que el pinar suburbano dej&amp;oacute; de ser atractivo, que el ruido urbano se intensifica. El hombre y la naturaleza, dos palabras que saltan con frecuencia a las p&amp;aacute;ginas de diarios y libros, las pronuncian en la radio y la televisi&amp;oacute;n o simplemente en conversaciones. Y hay que se&amp;ntilde;alar que hasta hace poco el t&amp;eacute;rmino 'ecolog&amp;iacute;a' lo conoc&amp;iacute;a s&amp;oacute;lo un reducido grupo de especialistas. Preservar la naturaleza y adem&amp;aacute;s no reducir sino elevar su fecundidad a fin de que no s&amp;oacute;lo nosotros sino tambi&amp;eacute;n las generaciones venideras puedan disfrutar de sus riquezas, es una de las tareas m&amp;aacute;s importantes. Una tarea que no puede dejar a nadie indiferente. En este art&amp;iacute;culo se hace un an&amp;aacute;lisis ingenieril a la relaci&amp;oacute;n naturaleza, &amp;aacute;tomo y hombre, con el objeto de esclarecer y, de cierta forma colaborar, para que los seres humanos comprendan que es una simbiosis necesaria para el futuro de la humanidad.</text>
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                <text>Lámpsakos</text>
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                <text>Fundación Universitaria Luis Amigó</text>
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                <text>Engineering (General). Civil engineering (General), Technology</text>
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                <text>&lt;a href="http://www.funlam.edu.co/revistas/index.php/lampsakos/article/view/771" target="_blank" rel="noreferrer noopener"&gt;http://www.funlam.edu.co/revistas/index.php/lampsakos/article/view/771&lt;/a&gt;</text>
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                  <text>Agricultura sostenible</text>
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                  <text>Dominio científico: Agricultura sostenible</text>
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                <text>Ingeniería genética contra estrés abiótico en cultivos neotropicales: osmolitos, factores de transcripción y CRISPR/Cas9</text>
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                <text>Víctor M. Jiménez, Paula Carvajal-Campos</text>
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                <text>El neotrópico es sitio de origen de gran variedad de plantas que actualmente son cultivadas con éxito en diferentes regiones del mundo. Sin embargo, condiciones climáticas adversas, que se pueden ver acrecentadas por efectos del cambio climático antropogénico, pueden afectar su rendimiento y productividad debido a las situaciones de estrés abiótico que se pueden generar. Como alternativa para contrarrestar estos efectos, se ha experimentado con modificaciones genéticas, particularmente en genes relacionados con la producción de osmolitos y factores de transcripción que han llevado a que estas plantas, a nivel experimental, tengan mayor tolerancia a estrés oxidativo, altas y bajas temperaturas y fotoinhibición, sequía y salinidad, mediante la acumulación de osmoprotectores, la regulación en la expresión de genes y cambios en el fenotipo. En este trabajo se presentan y describen las estrategias metodológicas planteadas con estos fines y se complementan con ejemplos de trabajos realizados en cultivos de origen neotropical de importancia económica, como maíz, algodón, papa y tomate. Además, y debido a la novedad y potencial que ofrece la edición génica por medio del sistema CRISPR/Cas9, también se mencionan trabajos realizados en plantas con origen neotropical, enfocados en comprender e implementar mecanismos de tolerancia a sequía. Las metodologías aquí descritas podrían constituirse en opciones prácticas para mejorar la seguridad alimentaria con miras a contrarrestar las consecuencias negativas del cambio climático antropogénico.</text>
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                <text>Algodón, Cambio climático, Papa, maíz, tomate</text>
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                <text>Revista Colombiana de Biotecnología</text>
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                <text>Universidad Nacional de Colombia</text>
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                <text>Biotechnology</text>
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                <text>INGENIERÍA SOCIAL, COMUNICOLOGÍA E HISTORIA ORAL Contextos posibles para el desarrollo de un oficio emergente</text>
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                <text>Luis Jesús Galindo Cáceres</text>
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                <text>El texto está dividido en cuatro partes. En la primera se presenta un conjunto de observaciones sobre la ubicación que en laactualidad y en forma tradicional ha tenido el área de la Historia Oral en un fondo casi exclusivo del mundo de la Humanidades.En ese sentido, se presenta una tesis alternativa donde la Historia Oral puede relacionarse y reubicarse en un contexto másasociado a la trayectoria de la Ciencia y la Ingeniería. Partiendo de esa primera presentación, en la segunda parte se propone unanueva configuración para el desarrollo programático de los estudios en Historia Oral dentro de las propuestas de una IngenieríaSocial y de la Comunicología social, en diálogo con las llamadas Ciencias Sociales y las Humanidades, y las Ciencias Básicas ylas nuevas propuestas epistemológicas constructivistas, sistémicas, ecológicas y de la complejidad. En la tercera parte se proponedentro del programa posible de una Ingeniería Social de la Historia Oral, y de una Comunicología social de la Historia Oral, unapunte de programa donde la Oralidad es central para un proyecto de Ecología social y desarrollo sustentable. Termina el textocon la cuarta parte, una selección de referencias en una bibliografía sintética de apoyo a las tesis y comentarios presentados a lolargo del texto.</text>
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                <text>2010</text>
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                <text>Comunicología Humanidades, Ingeniería Social, ciência, história oral, ingeniería</text>
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            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="200452">
                <text>Universidad Nacional de La Plata</text>
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                <text>Communication. Mass media</text>
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                <text>&lt;a href="https://perio.unlp.edu.ar/ojs/index.php/question/article/view/896" target="_blank" rel="noreferrer noopener"&gt;https://perio.unlp.edu.ar/ojs/index.php/question/article/view/896&lt;/a&gt;</text>
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            <description>A name given to the resource</description>
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                <text>Ingeniería sostenible: nuevos objetivos en los proyectos de construcción Sustainable engineering: new objectives for construction projects</text>
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            <description>An entity primarily responsible for making the resource</description>
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                <text>Fernando Rodríguez, Gonzalo Fernández</text>
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            <description>An account of the resource</description>
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                <text>Los impactos sobre los servicios de los ecosistemas debidos a la actividad humana son un hecho. Los Objetivos de Desarrollo del Milenio (MDGs), las propuestas de mitigación y adaptación del Grupo ínter gubernamental de expertos sobre Cambio Climático (IPCC) en sus sucesivos informes, así como las propuestas por parte de Millenium Ecosystem Assessment (MA) no pueden pasar desapercibidos para los proyectos en general y para los proyectos de construcción en particular. La cantidad de residuos generados por el sector así como la cantidad de recursos consumidos (energía, materias primas) en todo el ciclo de vida (construcción, explotación, mantenimiento y deconstrucción) contribuyen decididamente al aumento de la huella ecológica humana. Los objetivos y requisitos para la Dirección Integrada de Proyectos de Ingeniería Civil tienen que cambiar. El fin ya no es sólo la consecución del triple objetivo (plazo, coste y calidad) y de las prestaciones establecidas por el promotor. Ahora existen nuevos objetivos y requisitos de sostenibilidad en los proyectos de construcción. Se analizan las herramientas y técnicas realizadas en el campo de la construcción para lograr la consecución de una construcción más sostenible y se propone un marco metodológico de gestión sostenible dentro de los estándares de Dirección Integrada de Proyectos.Impacts on ecosystem services, due to human activity, are already a fact. The objectives of Millennium Development Goals (MDGs), the alleviation and adjustment proposals from the Intergovernmental Panel on Climate Change (IPCC) in their consecutive reports, as well as the proposals by the Millennium Ecosystem Assessment (MA) cannot go unnoticed for general projects and for particular construction projects. The amount of waste material generated by the sector, as well as the amount of resources consumed (energy, raw materials) by the whole life cycle (construction, exploitation, maintenance and deconstruction) definitely contributes to increase the human ecological footprint. The goals and requirements for the Integrated Project Management must change. The objective is no longer the achievement of a triple goal (time, costs and quality) and the performance established by the developer. Nowadays there are new sustain ability goals and requirements for construction projects. Tools and development techniques are analyzed in the construction field, in order to get a construction achievement in a more sustainable way; and a methodological framework for sustainable management according to standards of Integrated Project Management is proposed.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="203711">
                <text>2010</text>
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            </elementTextContainer>
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            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="203712">
                <text>Construcción sostenible, Sustainable construction, civil engineering, gestión de proyectos, ingeniería civil, project management, sostenibilidad, sustainability</text>
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          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="203713">
                <text>Revista de Ingeniería de Construcción</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="203714">
                <text>Pontificia Universidad Católica de Chile</text>
              </elementText>
            </elementTextContainer>
          </element>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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              <elementText elementTextId="203715">
                <text>Building construction</text>
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            <name>Relation</name>
            <description>A related resource</description>
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              <elementText elementTextId="203716">
                <text>&lt;a href="http://www.scielo.cl/scielo.php?script=sci_arttext&amp;amp;pid=S0718-50732010000200001" target="_blank" rel="noreferrer noopener"&gt;http://www.scielo.cl/scielo.php?script=sci_arttext&amp;amp;pid=S0718-50732010000200001&lt;/a&gt;</text>
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                  <text>Agricultura sostenible</text>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Agricultura sostenible</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Ingresos monetarios y riqueza familiar en asentamientos ambientalmente diferenciados en la Amazonia: un análisis comparativo en Anapu (Pará, Brasil)</text>
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            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="238846">
                <text>Mara Cristina de Lima Costa, Roberto  Porro</text>
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            <name>Description</name>
            <description>An account of the resource</description>
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              <elementText elementTextId="238847">
                <text>El artículo examina la composición de los ingresos monetarios y el patrimonio familiar de hogares ubicados en 2 tipos de asentamientos de reforma agraria: convencional (PA) y ambientalmente diferenciado (Proyecto de Desarrollo Sostenible, PDS). El estudio cuantitativo se realizó mediante aplicación de diagnósticos en 2 PAs y 2 PDS ubicados en Anapu, estado de Pará. Los resultados indican diferencias entre las dos modalidades de asentamiento, especialmente en los niveles de capitalización y estrategias productivas. Los PDS presentan un promedio anual de ingresos monetarios de R$ 27.807, significativamente inferior al de los PAs (R$ 47.815). El resultado es similar para el valor promedio del patrimonio familiar: R$ 363.797 en PAs y R$ 172.680 en PDS. La falta de inversión estatal en infraestructura y en ayudas a la producción ha contribuido al abandono de muchas parcelas por parte de sus propietarios, situación más frecuente en los PDS, por su menor nivel de capitalización, corroborando que esta modalidad presenta dificultades para promover el desarrollo sostenible.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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              <elementText elementTextId="238848">
                <text>2021</text>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
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              <elementText elementTextId="238849">
                <text>agricultura familiar; medios de vida; reforma agraria; transamazónica</text>
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            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="238850">
                <text>Revista de Estudios Brasileños</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="238851">
                <text>Universidad de Salamanca</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>History of scholarship and learning. The humanities, Social sciences (General), Law in general. Comparative and uniform law. Jurisprudence</text>
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                <text>&lt;a href="https://revistas.usal.es/index.php/2386-4540/article/view/26096" target="_blank" rel="noreferrer noopener"&gt;https://revistas.usal.es/index.php/2386-4540/article/view/26096&lt;/a&gt;</text>
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              <description>A name given to the resource</description>
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                  <text>Agricultura sostenible</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Agricultura sostenible</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Inheritance and Gender Identity Among Brazilian Farming Families</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="146602">
                <text>Maria José Carneiro</text>
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            <name>Description</name>
            <description>An account of the resource</description>
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                <text>To understand the rules by which family estates are transmitted among farming families,particularly in the case of land and taking into account gender differences, it is necessary toidentify the distinct roles reserved to men and women in the dynamics of social reproduction. Theunderstanding of these distinct logics requires the investigation of the different meanings that theterritorial patrimony itself has in each social and cultural context.Although inheritance is based on the notion of shared blood, common law rules do not recognizethe same rights for all children. It is precisely these differences that we will deal with in this article,particularly in respect to those differences derived from gender identity. We will be seeking tounderstand the logic of different forms of transmitting inheritances and their relationship with thesocial reproduction of farming families in two different regions: in southern Brazil (state of RioGrande do Sul), among descendants of Italian colonists, and in the mountainous region of thestate of Rio de Janeiro, among descendants of Swiss and German colonists.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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              <elementText elementTextId="146604">
                <text>2001</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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                <text>Agricultura Familiar, herança, identidades de género, reprodução social</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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                <text>Revista Estudos Feministas</text>
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            <name>Publisher</name>
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                <text>Universidade Federal de Santa Catarina</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Women. Feminism</text>
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            <name>Relation</name>
            <description>A related resource</description>
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              <elementText elementTextId="146609">
                <text>&lt;a href="https://periodicos.ufsc.br/index.php/ref/article/view/9671" target="_blank" rel="noreferrer noopener"&gt;https://periodicos.ufsc.br/index.php/ref/article/view/9671&lt;/a&gt;</text>
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        <src>https://socictopen.socict.org/files/original/b66b2601e3c608024cc623c8ea73ac99.pdf</src>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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      <elementSet elementSetId="1">
        <name>Dublin Core</name>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Inhibition of acid sphingomyelinase by ambroxol prevents SARS-CoV-2 entry into epithelial cells.</text>
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          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="58278">
                <text>Barbara Gripp, Katrin Anne Becker, Alexander Carpinteiro, Markus Hoffmann, Stefan Pöhlmann, Nicolas Hoertel, Michael J Edwards, Markus Kamler, Johannes Kornhuber, Erich Gulbins</text>
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          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
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              <elementText elementTextId="58279">
                <text>The acid sphingomyelinase/ceramide system has been shown to be important for cellular infection with at least some viruses, for instance rhinovirus or SARS-CoV-2. Functional inhibition of the acid sphingomyelinase using tricyclic antidepressants prevented infection of epithelial cells, for instance with SARS-CoV-2. The structure of ambroxol, i.e. trans-4-[(2,4-dibromanilin-6-yl)-methyamino]-cyclohexanol, a mucolytic drug applied by inhalation, suggests that the drug might inhibit the acid sphingomyelinase, and thereby infection with SARS-CoV-2. To test this, we used spike protein pseudotyped viral particles (pp-VSV-SARS-CoV-2 spike), a bona fide system for mimicking SARS-CoV-2 entry into cells. Viral uptake and formation of ceramide localization were determined by fluorescence microscopy, activity of the acid sphingomyelinase by consumption of [14C]sphingomyelin and ceramide was quantified by a kinase method. We found that entry of pp-VSV-SARS-CoV-2 spike required activation of acid sphingomyelinase and release of ceramide, events that were all prevented by pretreatment with ambroxol. We also obtained nasal epithelial cells from human volunteers prior to and after inhalation of ambroxol. Inhalation of ambroxol reduced acid sphingomyelinase activity in nasal epithelial cells, and prevented pp-VSV-SARS-CoV-2 spike-induced acid sphingomyelinase activation, ceramide release, and entry of pp-VSV-SARS-CoV-2 spike ex vivo. The addition of purified acid sphingomyelinase or C16 ceramide restored entry of pp-VSV-SARS-CoV-2 spike into ambroxol-treated epithelial cells. We propose that ambroxol might be suitable for clinical studies to prevent COVID-19.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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              <elementText elementTextId="58280">
                <text>2021</text>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="58281">
                <text>infection, SARS-CoV-2, ambroxol, acid sphingomyelinase, ceramide, human nasal epithelial cells</text>
              </elementText>
            </elementTextContainer>
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          <element elementId="43">
            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
            <elementTextContainer>
              <elementText elementTextId="58282">
                <text>10.1016/j.jbc.2021.100701</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="58283">
                <text>The Journal of biological chemistry</text>
              </elementText>
            </elementTextContainer>
          </element>
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    </elementSetContainer>
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  <item itemId="998" public="1" featured="0">
    <fileContainer>
      <file fileId="998">
        <src>https://socictopen.socict.org/files/original/3606825afc45419ebc08446385760246.pdf</src>
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      <elementSetContainer>
        <elementSet elementSetId="1">
          <name>Dublin Core</name>
          <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
          <elementContainer>
            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
              <elementTextContainer>
                <elementText elementTextId="1">
                  <text>Coronavirus</text>
                </elementText>
              </elementTextContainer>
            </element>
            <element elementId="41">
              <name>Description</name>
              <description>An account of the resource</description>
              <elementTextContainer>
                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
                </elementText>
              </elementTextContainer>
            </element>
          </elementContainer>
        </elementSet>
      </elementSetContainer>
    </collection>
    <itemType itemTypeId="1">
      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
    </itemType>
    <elementSetContainer>
      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
        <elementContainer>
          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="9475">
                <text>Inhibition of cytokine gene expression and induction of chemokine genes in non-lymphatic cells infected with SARS coronavirus</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="9476">
                <text>Weber Friedemann, Spiegel Martin</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="9477">
                <text>Abstract Background SARS coronavirus (SARS-CoV) is the etiologic agent of the severe acute respiratory syndrome. SARS-CoV mainly infects tissues of non-lymphatic origin, and the cytokine profile of those cells can determine the course of disease. Here, we investigated the cytokine response of two human non-lymphatic cell lines, Caco-2 and HEK 293, which are fully permissive for SARS-CoV. Results A comparison with established cytokine-inducing viruses revealed that SARS-CoV only weakly triggered a cytokine response. In particular, SARS-CoV did not activate significant transcription of the interferons IFN-α, IFN-β, IFN-λ1, IFN-λ2/3, as well as of the interferon-induced antiviral genes ISG56 and MxA, the chemokine RANTES and the interleukine IL-6. Interestingly, however, SARS-CoV strongly induced the chemokines IP-10 and IL-8 in the colon carcinoma cell line Caco-2, but not in the embryonic kidney cell line 293. Conclusion Our data indicate that SARS-CoV suppresses the antiviral cytokine system of non-immune cells to a large extent, thus buying time for dissemination in the host. However, synthesis of IP-10 and IL-8, which are established markers for acute-stage SARS, escapes the virus-induced silencing at least in some cell types. Therefore, the progressive infiltration of immune cells into the infected lungs observed in SARS patients could be due to the production of these chemokines by the infected tissue cells.</text>
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          <element elementId="40">
            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="9478">
                <text>2006</text>
              </elementText>
            </elementTextContainer>
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          <element elementId="43">
            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="9479">
                <text>DOI: 10.1186/1743-422X-3-17</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="9480">
                <text>Virology Journal</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="9481">
                <text>BMC</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="9482">
                <text>Infectious and parasitic diseases</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="44">
            <name>Language</name>
            <description>A language of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="9483">
                <text>EN</text>
              </elementText>
            </elementTextContainer>
          </element>
        </elementContainer>
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  </item>
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