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                <text>Cláudio Jorge Moura de Castilho, Katielle Susane do Nascimento Silva</text>
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                <text>Este ensaio reflete sobre a atual crise pandémica da COVID-19 procurando problematizá-la a partir das desigualdades sociais na cidade do Recife, na região Nordeste do Brasil. O método é analítico-reflexivo a partir da espacialização da COVID-19, tendo como suporte teórico o desenvolvimento geográfico desigual no seio das sociedades capitalistas. Presumimos e chamamos à atenção para as desiguais suscetibilidades sociais e condições de resposta à crise pandémica por parte da população, as quais se ligam às injustiças presentes e (re)produzidas na cidade.</text>
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                <text>Biotemas</text>
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                <text>Injusticias epistémicas y crisis ambiental</text>
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                <text>El presente trabajo tiene como principal objetivo vincular la discusión en torno a las injusticias epistémicas que se ha ido desarrollando al interior de la epistemología social con una serie de problemáticas asociadas con la crisis ambiental contemporánea, en especial con sus aspectos más relacionados con el conocimiento. El término de injusticia epistémica fue originalmente acuñado por la filósofa Miranda Fricker y ha dado lugar a un fecundo campo de estudios que escudriña cómo las diversas posiciones sociales de los individuos que componen una sociedad los colocan en situaciones epistemológicamente asimétricas que puede generar dinámicas injustas como la de ignorar los testimonios de cierto estrato social. Sin embargo, este campo de estudios se ha concentrado excesivamente en las identidades de los individuos y ha dejado de lado dinámicas colectivas y aspectos contextuales como los relacionados con el medioambiente. Justamente la apuesta del presente texto consiste en superar estas limitaciones.</text>
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                <text>Narrativas, ecología queer, injusticia hermenéutica, injusticia testimonial, pensamiento ambiental</text>
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                <text>Iztapalapa</text>
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                <text>Universidad Autónoma Metropolitana Unidad Iztapalapa</text>
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                <text>Social sciences (General), Anthropology, Political science (General)</text>
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                <text>&lt;a href="https://revistaiztapalapa.izt.uam.mx/index.php/izt/article/view/1592" target="_blank" rel="noreferrer noopener"&gt;https://revistaiztapalapa.izt.uam.mx/index.php/izt/article/view/1592&lt;/a&gt;</text>
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                <text>T. Lützkendorf</text>
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                <text>Desde que aspectos tales como el cambio climático, la escasez de recursos o los problemas sociales en las megalópolis llegaron a los medios de comunicación, la sociedad se ha sensibilizado con las cuestiones relacionadas con el desarrollo sostenible. Esto también ha llevado a un intenso debate dentro del sector inmobiliario. En el pasado, el discurso sobre la sostenibilidad fue habitualmente centrado en la contribución y el papel de los diseñadores y de los industriales, fabricantes, promotores y constructores. El concepto algo abstracto de desarrollo sostenible, en el mejor de los casos, se había incluido formalmente dentro de los objetivos y metas corporativas. Mientras tanto, el importante papel de los inversores públicos y privados, los bancos, las compañías de seguros y las autoridades gubernamentales está siendo cada vez más reconocido; no sólo por la academia, sino también por el público en general, que ha presionado a las corporaciones para que tuvieran en cuenta las consecuencias de sus acciones y, por tanto, aspectos de desarrollo sostenible en la toma de decisiones.De acuerdo con tendencias actuales en Europa y las lecciones aprendidas en Alemania, este artículo reflexiona sobre la transformación de la propiedad y los mercados inmobiliarios y sostiene que los procesos de toma de decisión en inmuebles y construcciones deben ser sostenidos y apoyados por un conjunto de herramientas y métodos basados en la metodología de ACV y de CCV. Asimismo, se argumenta que las líneas que sigue el mercado para implementar los principios del desarrollo sostenible en el sector inmobiliario y en la industria de la construcción serán apoyadas por medidas gubernamentales y políticas fiscales que permitan alcanzar su transformación con eficacia y rapidez.</text>
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                <text>2010</text>
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                <text>instrumentos políticos, métodos de evaluación, normalización, perspectiva europea, sostenibilidad en la construcción, toma de decisiones</text>
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                <text>Informes de la Construccion</text>
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                <text>Consejo Superior de Investigaciones Científicas</text>
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                <text>Architecture, Building construction</text>
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                <text>&lt;a href="http://informesdelaconstruccion.revistas.csic.es/index.php/informesdelaconstruccion/article/view/804" target="_blank" rel="noreferrer noopener"&gt;http://informesdelaconstruccion.revistas.csic.es/index.php/informesdelaconstruccion/article/view/804&lt;/a&gt;</text>
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                <text>Arezoo Hosseini, Vida Hashemi, Navid Shomali, Faezeh Asghari, Tohid Gharibi, Morteza Akbari, Saber Gholizadeh, Abbas Jafari</text>
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                <text>Coronaviruses (CoVs) are a member of the Coronaviridae family with positive-sense single- stranded RNA. In recent years, the CoVs have become a global problem to public health. The immune responses (innate and adaptive immunity) are essential for elimination and clearance of CoVs infections, however, uncontrolled immune responses can result in aggravating acute lung injury and significant immunopathology. Gaining profound understanding about the interaction between CoVs and the innate and adaptive immune systems could be a critical step in the field of treatment. In this review, we present an update on the host innate and adaptive immune responses against SARS-CoV, MERS-CoV and newly appeared SARS-CoV-2.</text>
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                <text>Biomedicine &amp; pharmacotherapy = Biomedecine &amp; pharmacotherapie</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="22030">
                <text>Yu-Ting Cheng, Dominic  D. Skinner, Thomas E Lane</text>
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            </elementTextContainer>
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            <description>An account of the resource</description>
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                <text>Multiple sclerosis (MS) is a disease of the central nervous system (CNS) characterized by chronic neuroinflammation, axonal damage, and demyelination. Cellular components of the adaptive immune response are viewed as important in initiating formation of demyelinating lesions in MS patients. This notion is supported by preclinical animal models, genome-wide association studies (GWAS), as well as approved disease modifying therapies (DMTs) that suppress clinical relapse and are designed to impede infiltration of activated lymphocytes into the CNS. Nonetheless, emerging evidence demonstrates that the innate immune response e.g., neutrophils can amplify white matter damage through a variety of different mechanisms. Indeed, using a model of coronavirus-induced neurologic disease, we have demonstrated that sustained neutrophil infiltration into the CNS of infected animals correlates with increased demyelination. This brief review highlights recent evidence arguing that targeting the innate immune response may offer new therapeutic avenues for treatment of demyelinating disease including MS.</text>
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                <text>2018</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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                <text>virus, Innate Immunity, Neutrophils, demyelination, remyelination</text>
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                <text>DOI: 10.3390/jcm8010003</text>
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          <element elementId="48">
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            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="22035">
                <text>Journal of Clinical Medicine</text>
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            <name>Publisher</name>
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                <text>MDPI AG</text>
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                <text>Medicine</text>
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                <text>EN</text>
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              <name>Title</name>
              <description>A name given to the resource</description>
              <elementTextContainer>
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                  <text>Coronavirus</text>
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              </elementTextContainer>
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            <element elementId="41">
              <name>Description</name>
              <description>An account of the resource</description>
              <elementTextContainer>
                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
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            <elementTextContainer>
              <elementText elementTextId="62788">
                <text>Innate Immune Responses to Highly Pathogenic Coronaviruses and Other Significant Respiratory Viral Infections</text>
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            </elementTextContainer>
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          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="62789">
                <text>Zihai Li, Hanaa Ahmed-Hassan, Hanaa Ahmed-Hassan, Brianna Sisson, Rajni Kant Shukla, Yasasvi Wijewantha, Nicholas T. Funderburg, Don Hayes, Don Hayes, Thorsten Demberg, Namal P. M. Liyanage, Namal P. M. Liyanage, Namal P. M. Liyanage</text>
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          <element elementId="41">
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            <description>An account of the resource</description>
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                <text>The new pandemic virus SARS-CoV-2 emerged in China and spread around the world in &amp;lt;3 months, infecting millions of people, and causing countries to shut down public life and businesses. Nearly all nations were unprepared for this pandemic with healthcare systems stretched to their limits due to the lack of an effective vaccine and treatment. Infection with SARS-CoV-2 can lead to Coronavirus disease 2019 (COVID-19). COVID-19 is respiratory disease that can result in a cytokine storm with stark differences in morbidity and mortality between younger and older patient populations. Details regarding mechanisms of viral entry via the respiratory system and immune system correlates of protection or pathogenesis have not been fully elucidated. Here, we provide an overview of the innate immune responses in the lung to the coronaviruses MERS-CoV, SARS-CoV, and SARS-CoV-2. This review provides insight into key innate immune mechanisms that will aid in the development of therapeutics and preventive vaccines for SARS-CoV-2 infection.</text>
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            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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              <elementText elementTextId="62791">
                <text>2020</text>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="62792">
                <text>Coronavirus (CoV), covid-19, SARS-CoV-2, coronavirus (2019-nCoV) outbreak, innate immune responses</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
            <elementTextContainer>
              <elementText elementTextId="62793">
                <text>10.3389/fimmu.2020.01979</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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                <text>Epidemiology and Health</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="62795">
                <text>Korean Society of Epidemiology</text>
              </elementText>
            </elementTextContainer>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="62796">
                <text>Immunologic diseases. Allergy</text>
              </elementText>
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                  <text>Coronavirus</text>
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              <description>An account of the resource</description>
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                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
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            </element>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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    <elementSetContainer>
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        <name>Dublin Core</name>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Innate Immune Signaling and Proteolytic Pathways in the Resolution or Exacerbation of SARS-CoV-2 in Covid-19: Key Therapeutic Targets?</text>
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          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="32150">
                <text>Loïc Guillot, Jean-Michel Sallenave</text>
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          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="32151">
                <text>COVID-19 is caused by the Severe Acute Respiratory Syndrome (SARS) coronavirus (Cov)-2, an enveloped virus with a positive-polarity, single-stranded RNA genome. The initial outbreak of the pandemic began in December 2019, and it is affecting the human health of the global community. In common with previous pandemics (Influenza H1N1 and SARS-CoV) and the epidemics of Middle east respiratory syndrome (MERS)-CoV, CoVs target bronchial and alveolar epithelial cells. Virus protein ligands (e.g., haemagglutinin or trimeric spike glycoprotein for Influenza and CoV, respectively) interact with cellular receptors, such as (depending on the virus) either sialic acids, Dipeptidyl peptidase 4 (DPP4), or angiotensin-converting enzyme 2 (ACE2). Host proteases, e.g., cathepsins, furin, or members of the type II transmembrane serine proteases (TTSP) family, such as Transmembrane protease serine 2 (TMPRSS2), are involved in virus entry by proteolytically activating virus ligands. Also involved are Toll Like Receptor (TLR) family members, which upregulate anti-viral and pro-inflammatory mediators [interleukin (IL)-6 and IL-8 and type I and type III Interferons among others], through the activation of Nuclear Factor (NF)-kB. When these events (virus cellular entry and innate immune responses) are uncontrolled, a deleterious systemic response is sometimes encountered in infected patients, leading to the well-described “cytokine storm” and an ensuing multiple organ failure promoted by a downregulation of dendritic cell, macrophage, and T-cell function. We aim to describe how the lung and systemic host innate immune responses affect survival either positively, through downregulating initial viral load, or negatively, by triggering uncontrolled inflammation. An emphasis will be put on host cellular signaling pathways and proteases involved with a view on tackling these therapeutically.</text>
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              <elementText elementTextId="32152">
                <text>2020</text>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="32153">
                <text>protease, coronavirus, SARS-CoV-2, COVID-19, lung innate immunity</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="32154">
                <text>DOI: 10.3389/fimmu.2020.01229</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="32155">
                <text>Frontiers in Immunology</text>
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            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="32156">
                <text>Frontiers Media S.A.</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Immunologic diseases. Allergy</text>
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              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Agricultura sostenible</text>
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            <element elementId="41">
              <name>Description</name>
              <description>An account of the resource</description>
              <elementTextContainer>
                <elementText elementTextId="88122">
                  <text>Dominio científico: Agricultura sostenible</text>
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            </element>
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            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Innovación de un molino de agave cocido para la producción de mezcal</text>
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          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="167474">
                <text>Magdaleno Caballero Caballero, José Luis Montes Bernabé, María Eugenia Silva Rivera</text>
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          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
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              <elementText elementTextId="167475">
                <text>La agroindustria del sistema agave-mezcal es de gran importancia económica en Oaxaca ya que de ella dependen, directa e indirectamente más de 25000 familias, entre productores de agave, productores de mezcal, envasadores y comercializadores. En el proceso artesanal para la elaboración de mezcal se emplean 12,7 kg de agave verde para producir un litro de mezcal. Este trabajo seleccionó la fase de molienda que es una de las más importantes dentro del proceso de producción de mezcal, y su mejora no violenta las características organolépticas del producto, implementando la innovación de un molino artesanal de agave hidrolizado, al cambiar la tracción animal por tracción mecánica de la rueda de molienda, y el rediseño de la misma que da como resultado el incremento en su capacidad de procesamiento de 312 kg/h a 1101,36 kg/h, además de incrementar el porcentaje de producto totalmente molido de 55% a 98%. Esto se traduce en un incremento en la eficiencia en la producción al aumentar el rendimiento de 78,74 litros de mezcal a 102,36 litros, con el empleo de 1000 kg de agave verde, es decir se redujo de 12,7 kg a 9,76 kg de agave para la obtención de un litro de mezcal.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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                <text>2013</text>
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          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="167477">
                <text>Revista Ciencias Técnicas Agropecuarias</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="167478">
                <text>Universidad Agraria de La Habana</text>
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          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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              <elementText elementTextId="167479">
                <text>Agriculture, Environmental technology. Sanitary engineering</text>
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            <description>A related resource</description>
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                <text>&lt;a href="http://www.redalyc.org/articulo.oa?id=93231387008" target="_blank" rel="noreferrer noopener"&gt;http://www.redalyc.org/articulo.oa?id=93231387008&lt;/a&gt;</text>
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            <element elementId="50">
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                  <text>Agricultura sostenible</text>
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                  <text>Dominio científico: Agricultura sostenible</text>
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                <text>Innovación en la cadena agroindustrial de mezcal en tres municipios en Oaxaca, México</text>
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              <elementText elementTextId="208586">
                <text>Anastacio Espejel García, Ariadna Barrera Rodríguez, Adán Guillermo Ramírez García, Venancio Cuevas Reyes</text>
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            <description>An account of the resource</description>
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                <text>El mezcal es la bebida más emblemática y con mayor densidad cultural de México, la Denominación de Origen le confiere atributos específicos asociados al territorio. Tiene gran importancia económica y sociocultural. Oaxaca es la entidad con mayor diversidad de agaves silvestres y concentra la mayor producción. El objetivo de este trabajo es analizar la adopción de innovaciones en la cadena agave-mezcal. Se seleccionaron 41 palenques (agroindustrias) ubicados en tres municipios de Oaxaca. Se calculó la adopción y velocidad, se estimó la relación beneficio-costo de la actividad productiva. Para estimar la relación entre innovación y rentabilidad se realizó un análisis de conglomerados. Los mayores índices de innovación están relacionados a la producción y conservación de los recursos naturales (75%); el segundo estrato presentó un índice de innovación de 75%; el primer estrato registró una baja adopción. Dos componentes explican el 70% de la variabilidad (Kaiser, Meyer y Olkin, KMO: 0.74). En el componente 1 (53.6%) las innovaciones de mayor peso son: proveeduría, proceso, mercado, valoración de recursos naturales, administración y utilidad; en el componente 2 (16.8%) el volumen procesado y el rendimiento son las de mayor contribución. Los palenques con producción ancestral y mayor innovación presentan mayor rentabilidad.</text>
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