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                <text>Ali Poormohammadi, Ghasem Azarian</text>
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                <text>Dear EditorIn recent days, coronavirus disease (COVID-19) as a viral infection caused by the SARS-Cov-2 virus has become a pandemic disease and has created critical conditions worldwide [1]. According to previous studies on pathogenic viruses associated with acute respiratory distress syndrome, each virus has a specific virulence dose, which it is about 2×103-3×103 viral particles for the influenza virus. Given the emergence of the SARSCov-2 virus and no complete information on its virulence dose, it is clear that its very low virulence dose can cause its rapid spread. Regarding the effectiveness of the use of simple cloth filter masks, it can be stated that these masks provide relative safety depending on their type and structure [2]. In this regard, Blachere et al., reported that in multi-stage sampling of influenza viruses, 46% of the viruscontaining particles are trapped in the first filter layer of the sampler with a diameter of 4 microns, 49% of the viral particles are trapped in the second layer filter with a diameter 1 to 4 microns and only 1% of viruses are trapped in the last layer filter with a diameter of about 1 micron [2-4]. Coughing, sneezing, speaking, and breathing create a cloud of particles in the air with varying diameters ranging from a few millimeters to</text>
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                <text>DOI: 10.29252/jech.7.2.69</text>
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                <text>Journal of Education and Community Health</text>
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                <text>Hamadan University of Medical Sciences</text>
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                <text>Mark Woolhouse, Francisca Mutapi, Geoffrey Banda, Felix Stein, Meghan Perry</text>
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                <text>DOI: 10.1136/bmjgh-2020-002786</text>
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                <text>SARS-CoV-2 Pathogenesis: Imbalance in the Renin-Angiotensin System Favors Lung Fibrosis</text>
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                <text>M. Victoria Delpino, Jorge Quarleri</text>
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                <text>fibrosis, ACE2, Ang-(1-7), renin-angiotensin system (RAS), SARS-CoV-2</text>
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                <text>DOI: 10.3389/fcimb.2020.00340</text>
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                <text>Cytokine Release Syndrome (CRS) and Nicotine in COVID-19 Patients: Trying to Calm the Storm</text>
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                <text>Juan D. Navarro-Lopez, Lydia Jiménez-Díaz, Jesus Gonzalez-Rubio, Alberto Nájera, Carmen Navarro-Lopez, Elena Lopez-Najera, Ana Lopez-Najera</text>
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                <text>SARS-CoV-2 is a new coronavirus that has caused a worldwide pandemic. It causes severe acute respiratory syndrome (COVID-19), which is fatal in many cases, and is characterized by a cytokine release syndrome (CRS). Great efforts are currently being made to block the signal transduction pathway of pro-inflammatory cytokines in order to control this “cytokine storm” and rescue severely affected patients. Consequently, possible treatments for cytokine-mediated hyperinflammation, preferably within approved safe therapies, are urgently being researched to reduce rising mortality. One approach to inhibit proinflammatory cytokine release is to activate the cholinergic anti-inflammatory pathway through nicotinic acetylcholine receptors (α7nAchR). Nicotine, an exogenous α7nAchR agonist, is clinically used in ulcerative colitis to counteract inflammation. We have found epidemiological evidence, based on recent clinical SARS-CoV-2 studies in China, that suggest that smokers are statistically less likely to be hospitalized. In conclusion, our hypothesis proposes that nicotine could constitute a novel potential CRS therapy in severe SARS-CoV-2 patients.</text>
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                <text>Nicotine, lung, cholinergic anti-inflammatory pathway, COVID-19, SARS-CoV-2 virus, Cytokine Release Syndrom (CRS)</text>
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                <text>DOI: 10.3389/fimmu.2020.01359</text>
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                <text>Frontiers in Immunology</text>
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                <text>Frontiers Media S.A.</text>
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                <text>Immunologic diseases. Allergy</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Should We Perform Old-for-Old Kidney Transplantation during the COVID-19 Pandemic? The Risk for Post-Operative Intensive Stay</text>
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                <text>Klemens Budde, Robert Öllinger, Frank Friedersdorff, Thorsten Schlomm, Philip Zeuschner, Michael Stöckle, Lutz Liefeldt, Urban Sester, Matthias Saar, Janine Mihm, Paul Ritschl, Ilias Zompolas, Nasrin El‑Bandar</text>
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                <text>Health care systems worldwide have been facing major challenges since the outbreak of the SARS-CoV-2 pandemic. Kidney transplantation (KT) has been tremendously affected due to limited personal protective equipment (PPE) and intensive care unit (ICU) capacities. To provide valid information on risk factors for ICU admission in a high-risk cohort of old kidney recipients from old donors in the Eurotransplant Senior Program (ESP), we retrospectively conducted a bi-centric analysis. Overall, 17 (16.2%) patients out of 105 KTs were admitted to the ICU. They had a lower BMI, and both coronary artery disease (CAD) and hypertensive nephropathy were more frequent. A risk model combining BMI, CAD and hypertensive nephropathy gained a sensitivity of 94.1% and a negative predictive value of 97.8%, rendering it a valuable search test, but with low specificity (51.1%). ICU admission also proved to be an excellent parameter identifying patients at risk for short patient and graft survivals. Patients admitted to the ICU had shorter patient (1-year 57% vs. 90%) and graft (5-year 49% vs. 77%) survival. To conclude, potential kidney recipients with a low BMI, CAD and hypertensive nephropathy should only be transplanted in the ESP in times of SARS-CoV-2 pandemic if the local health situation can provide sufficient ICU capacities.</text>
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                <text>DOI: 10.3390/jcm9061835</text>
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                <text>Journal of Clinical Medicine</text>
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                <text>Medicine</text>
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                <text>Bharath Srinivasaiah, Harsh Deora</text>
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                <text>DOI: 10.1055/s-0040-1713342</text>
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                <text>Journal of Neurosciences in Rural Practice</text>
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            <description>An entity responsible for making the resource available</description>
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                <text>Thieme Publishers</text>
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                <text>Neurosciences. Biological psychiatry. Neuropsychiatry</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Remdesivir—Bringing Hope for COVID-19 Treatment</text>
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            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="35849">
                <text>Naser F. Al-Tannak, Ladislav Novotny, Adel Alhunayan</text>
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                <text>At the beginning of 2020, the world was swept with a wave of a new coronavirus disease, named COVID-19 by the World Health Organization (WHO 2). The causative agent of this infection is the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The data available on one of the promising therapeutic agents—nucleotide analog remdesivir (Gilead Sciences number GS-5734)—were evaluated. These data were concerned with remdesivir activation from the prodrug to the active molecule—triphosphate containing 1′-cyano group and modified nucleobase. This triphosphate competes with the natural substrate adenosine triphosphate. Additionally, its mechanisms of action based on RNA and proofreading exonuclease inhibition, leading to the delayed RNA chain termination of infected cells, and basic pharmacological data were assessed. Additionally, the analytical determination of remdesivir and its metabolites in cells and body liquids and also some data from remdesivir use in other RNA infections—such as Ebola, Nipah virus infection, and Middle East Respiratory Syndrome (MERS)—were summarized. More recent and more detailed data on the clinical use of remdesivir in COVID-19 were reported, showing the intensive efforts of clinicians and scientists to develop a cure for this new disease. Remdesivir as such represents one of the more promising alternatives for COVID-19 therapy, however the current understanding of this disease and the possible ways of dealing with it requires further investigation.</text>
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                <text>2020</text>
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                <text>WHO, RNA dependent RNA polymerase, endonuclease, remdesivir, GS-5734, COVID-19</text>
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              <elementText elementTextId="35853">
                <text>DOI: 10.3390/scipharm88020029</text>
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              <elementText elementTextId="35854">
                <text>Scientia Pharmaceutica</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="35855">
                <text>Österreichische Apotheker-Verlagsgesellschaft m. b. H.</text>
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                <text>Pharmacy and materia medica</text>
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  <item itemId="3906" public="1" featured="0">
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              <name>Title</name>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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      <elementSet elementSetId="1">
        <name>Dublin Core</name>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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              <elementText elementTextId="35840">
                <text>New Strategy for COVID-19: An Evolutionary Role for RGD Motif in SARS-CoV-2 and Potential Inhibitors for Virus Infection</text>
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          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="35841">
                <text>Haixia Sun, Guohui Wan, Xian-Zhang Bu, Shijia Yan</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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                <text>2020</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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              <elementText elementTextId="35843">
                <text>Pandemic, drug screening, integrin, RGD, SARS-CoV-2, COVID-19</text>
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            <name>Identifier</name>
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              <elementText elementTextId="35844">
                <text>DOI: 10.3389/fphar.2020.00912</text>
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          <element elementId="48">
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            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="35845">
                <text>Frontiers in Pharmacology</text>
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            </elementTextContainer>
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          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="35846">
                <text>Frontiers Media S.A.</text>
              </elementText>
            </elementTextContainer>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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              <elementText elementTextId="35847">
                <text>Therapeutics. Pharmacology</text>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
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                <elementText elementTextId="1">
                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
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              </elementTextContainer>
            </element>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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      <elementSet elementSetId="1">
        <name>Dublin Core</name>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="35831">
                <text>COVID-19: Presumed Infection Routes and Psychological Impact on Staff in Administrative and Logistics Departments in a Designated Hospital in Wuhan, China</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="35832">
                <text>Xian-Tao Zeng, Xinghuan Wang, Lin Cai, Lisha Luo, Ying-Hui Jin, Zhenyu Pan</text>
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            <name>Description</name>
            <description>An account of the resource</description>
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              <elementText elementTextId="35833">
                <text>Objective: Our aim was to explore the presumed infection routes and psychological impact of COVID-19 on staff in administrative and logistics departments (ALDs).Methods: We gathered data from all 18 staff members with COVID-19 in ALDs in Zhongnan Hospital of Wuhan University, China. The baseline, job before diagnosis, presumed infection environment, use of protective equipment, and psychological status before and after diagnosis were collected and analyzed. A total of 18 uninfected staff members working alongside them in the same environment and 18 random matched infected doctors and nurses formed two control groups; the psychological impact of these three groups was then compared.Results: Of the 18 members of staff, 88.89% were infected due to the working environment (hospital), and nine had face-to-face conversations with doctors and nurses in their daily work. Many staff members did not take any protective measures in their routine work. Before they were diagnosed, 12 staff members were aware of the seriousness of the epidemic, and most of the staff maintained a neutral attitude to the COVID-19 outbreak. A total of 77.78% of the staff experienced psychological stress or emotional changes after diagnosis, which were mainly caused by family health and disease related issues. Most of them managed their emotions by self-control and video calls with their families. There was no significant difference in psychological impact among the three groups, but uninfected staff members were fully aware of the seriousness of the epidemic.Conclusions: Effective protective measures should be taken for staff members in ALDs. Psychological interventions are very important to help infected staff members in ALDs cope with psychological distress.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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              <elementText elementTextId="35834">
                <text>2020</text>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
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              <elementText elementTextId="35835">
                <text>nosocomial infection, Staff, psychological intervention, SARS-CoV-2, COVID-19, administrative and logistics departments</text>
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            <name>Identifier</name>
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              <elementText elementTextId="35836">
                <text>DOI: 10.3389/fpsyg.2020.01501</text>
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            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="35837">
                <text>Frontiers in Psychology</text>
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            </elementTextContainer>
          </element>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="35838">
                <text>Frontiers Media S.A.</text>
              </elementText>
            </elementTextContainer>
          </element>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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              <elementText elementTextId="35839">
                <text>Psychology</text>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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          <element elementId="50">
            <name>Title</name>
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              <elementText elementTextId="35822">
                <text>On the Analysis of New COVID-19 Cases in Pakistan Using an Exponentiated Version of the M Family of Distributions</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="35823">
                <text>Christophe Chesneau, Farrukh Jamal, Mohammed Elgarhy, Rashad  A. R. Bantan</text>
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            <description>An account of the resource</description>
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              <elementText elementTextId="35824">
                <text>This paper develops the exponentiated Mfamily of continuous distributions, aiming to provide new statistical models for data fitting purposes. It stands out from the other families, as it depends on two baseline distributions, with the use of ratio and power transforms in the definition of the main cumulative distribution function. Thanks to the joint action of the possibly different baseline distributions, flexible statistical models can be created, motivating a complete study in this regard. Thus, we discuss the theoretical properties of the new family, with emphasis on those of potential interest to the overall probability and statistics. Then, a new three-parameter lifetime distribution is derived, with the choices of the inverse exponential and exponential distributions as baselines. After pointing out the great flexibility of the related model, we apply it to analyze an actual dataset of current interest: the daily COVID-19 cases observed in Pakistan from 21 March to 29 May 2020 (inclusive). As notable results, we demonstrate that the proposed model is the best among the 15 top ranked models in the literature, including the inverse exponential and exponential models, several modern extensions of them depending on more parameters, and the “unexponentiated” version of the proposed model as well. As future perspectives, the proposed model can be of interest to analyze data on COVID-19 cases in other countries, for possible comparison studies.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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              <elementText elementTextId="35825">
                <text>2020</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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                <text>Entropy, Data analysis, parameter estimation, COVID-19 epidemic, families of continuous distributions, exponentiated family of continuous distributions</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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                <text>DOI: 10.3390/math8060953</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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                <text>Mathematics</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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                <text>MDPI AG</text>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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              <elementText elementTextId="35830">
                <text>Mathematics</text>
              </elementText>
            </elementTextContainer>
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