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                <text>Co-infection of chlamydia pneumoniae and mycoplasma pneumoniae with SARS-CoV-2 is associated with more severe features.</text>
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                <text>Sergio Bove, Maria Antonia De Francesco, Claudio Poiesi, Franco Gargiulo, Carlo Bonfanti, Patrizia Pollara, Simona Fiorentini, Francesca Caccuri, Valentina Carta, Lucia Mangeri, Simone Pellizzeri, Damiano Rizzoni, Paolo Malerba, Massimo Salvetti, Maria Lorenza Muiesan, Federico Alberici, Francesco Scolari, Andrea Pilotto, Alessandro Padovani, Michela Bezzi, Raffaella Chiappini, Chiara Ricci, Maurizio Castellano, Marialma Berlendis, Giulia Savio, Giovanni Montani, Maurizio Ronconi, Emanuele Focà, Lina Tomasoni, Francesco Castelli, Angelo Rossini, Riccardo Inciardi, Marco Metra, Arnaldo Caruso</text>
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                <text>10.1016/j.jinf.2021.01.009</text>
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                <text>The Journal of infection</text>
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                <text>Co-infection with SARS-CoV-2 and Influenza A Virus in Patient with Pneumonia, China.</text>
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                <text>Xu Huang, Ying Cai, Fan Wang, Li Zhao, Xin Yu, Yongjun Li, Teng Xu, Xiaojing WU, Quanguo Li, Qingyuan Zhan, Binghuai Lu, Si-Chao Gu</text>
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                <text>We report co-infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza A virus in a patient with pneumonia in China. The case highlights possible co-detection of known respiratory viruses. We noted low sensitivity of upper respiratory specimens for SARS-CoV-2, which could further complicate recognition of the full extent of disease.</text>
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                <text>2020</text>
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                <text>influenza, co-infection, China, Pneumonia, Viruses, Zoonoses, influenza A, CO detection, SARS-CoV-2, COVID-19, Severe Acute Respiratory Syndrome Coronavirus 2, 2019 novel coronavirus disease</text>
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                <text>DOI: 10.3201/eid2606.200299</text>
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                <text>Emerging Infectious Diseases</text>
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                <text>Centers for Disease Control and Prevention</text>
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                <text>Co-infection, SARS-CoV-2 and influenza: an evolving puzzle.</text>
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                <text>Sara Covin, George W Rutherford</text>
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                <text>2020</text>
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                <text>covid-19, SARS-CoV-2, influenza A, respiratory distress, influenza B</text>
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            <name>Identifier</name>
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                <text>10.1093/cid/ciaa1810</text>
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            <name>Source</name>
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              <elementText elementTextId="70417">
                <text>Clinical infectious diseases : an official publication of the Infectious Diseases Society of America</text>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
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                <text>CO-RADS versus CT-SS scores in predicting severe COVID-19 patients: retrospective comparative study</text>
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                <text>Niveen E. Zayed, Manar A. Bessar, Samah Lutfy</text>
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                <text>Abstract Background The role of CT in assessing and plotting viral pulmonary affection land marking is its potential among other investigation tools, and the aim of the study was to compare the ability of two different CT-based scoring systems in discriminating severe COVID-19 disease. Results Retrospective comparative study included 142 confirmed COVID-19 patients by real-time polymerase chain reaction (RT-PCR) test, with different degrees of disease (mild to severe), the data of patients collected from medical records, and patients with their first CT chest read for calculating CO-RADS and severity scoring system (CT-SS) score. The patients with severe COVID-19 disease were significantly older and had different comorbidities. The level of C-reactive protein, ESR, ferritin, and LDH were significantly higher in severe disease, P &lt; 0.001. The ability of CT chest and its score bases (CT-SS and CO-RADS) were accurate in differentiation between mild/moderate and severe disease; AUC were 89% and 97%, respectively. The cutoff value of less than 7.5 and 4.5 for CT-SS and CO-RADS, respectively, can rule out severe COVID-19 by 90% and 97%, respectively. Conclusions CT chest play a segregate role in COVID-19 disease, add on an advantage in clinical data in triage, and highlight the decision of hospital admission.</text>
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                <text>2021</text>
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                <text>covid-19, Chest CT, CO-RADS, CTSS</text>
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            <name>Identifier</name>
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              <elementText elementTextId="67452">
                <text>10.1186/s43168-021-00060-3</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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                <text>The Egyptian Journal of Bronchology</text>
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                <text>SpringerOpen</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Diseases of the respiratory system, Medical emergencies. Critical care. Intensive care. First aid</text>
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                  <text>Agricultura sostenible</text>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Agricultura sostenible</text>
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                <text>CO2 como refrigerante: del pasado al futuro CO2 as refrigerant: from the past to future</text>
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                <text>Juan Manuel Belman Flores, V. Pérez-García</text>
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            <description>An account of the resource</description>
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                <text>En años recientes y debido a la problemática que ha originado el calentamiento mundial, en el campo de la refrigeración y climatización se ha incrementado el interés por utilizar refrigerantes naturales e hidrocarburos con bajo potencial de calentamiento mundial, este es el caso de la utilización del CO2 como fluido frigorígeno que ha sido visto como una alter­nativa adecuada a los actuales refrigerantes en la comunidad científica. Hoy en día, el CO2 cada vez está retomando presencia en el campo de la refrigeración y climatización a nivel internacional, así pues, el presente trabajo tiene la finalidad de dar a conocer su potencial como refrigerante natural, las causas por las cuales este fluido fue relevado momentánea­mente por refrigerantes clorofluorocarbonados y su renacer en pleno siglo XXI. Además, se plantea su aplicación en la generación de frío en nuestro país mediante la tecnología de compresión de vapor basado en ciclo transcrítico.  In recent years, and due to problems resulting from global warming, interest has grown in the fields of refrigeration and air conditioning, specifically regarding the use of natural refrigerants and hydrocarbons with low potential for global warming. Such is the case of the use of CO2 as a cold fluid, which has been considered in the scientific community as an adequate alternative to common refrigerants. Nowadays, the use of CO2 in the areas of refrigeration and air conditioning has been recognized at international levels. Therefore, this work aims to show its potential as a natural refrigerant, the causes why this fluid was temporarily replaced by chlorofluorocarbon refrigerants, and its reappearance in the XXI century. It also proposes the use of CO2 in air conditioning in our country by using vapor compression technology, based on the transcritical cycle.</text>
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                <text>2013</text>
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                <text>Dióxido de carbono, calentamiento global, ciclo transcrítico, refrigeración</text>
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                <text>Acta Universitaria</text>
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                <text>Universidad de Guanajuato</text>
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                <text>Social Sciences, Science (General)</text>
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                <text>&lt;a href="http://www.actauniversitaria.ugto.mx/index.php/acta/article/view/426" target="_blank" rel="noreferrer noopener"&gt;http://www.actauniversitaria.ugto.mx/index.php/acta/article/view/426&lt;/a&gt;</text>
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                <text>Coagulation Disorders in COVID-19: Role of Toll-like Receptors</text>
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                <text>Biswas I, Khan GA</text>
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                <text>Indranil Biswas,1 Gausal A Khan2 1Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA; 2Department of Physiology &amp;amp; Physiotherapy, College of Medicine, Nursing and Health Sciences, Fiji National University, Suva, Fiji IslandsCorrespondence: Gausal A KhanDepartment of Physiology &amp;amp; Physiotherapy, College of Medicine, Nursing and Health Sciences, Fiji National University, Suva, Fiji IslandsEmail gausalk@gmail.comAbstract: Coronavirus disease 2019 (COVID-19) has spread rapidly throughout the world. The range of the disease is broad but among hospitalized patients with COVID-19 are coagulation disorders, pneumonia, respiratory failure, and acute respiratory distress syndrome (ARDS). The excess production of early response proinflammatory cytokines results in what has been described as a cytokine storm, leading to an increased risk of thrombosis, inflammations, vascular hyperpermeability, multi-organ failure, and eventually death over time. As the pandemic is spreading and the whole picture is not yet clear, we highlight the importance of coagulation disorders in COVID-19 infected subjects and summarize it. COVID-19 infection could induce coagulation disorders leading to clot formation as well as pulmonary embolism with detrimental effects in patient recovery and survival. Coagulation and inflammation are closely related. In this review, we try to establish an association between virus infections associated with innate immune activation, inflammation and coagulation activation.Keywords: COVID-19, coagulation disorders, TLR3, tissue factor</text>
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                <text>2020</text>
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                <text>covid-19, coagulation disorders, TLR3, Tissue factor</text>
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                <text>Universidade Federal de Santa Catarina</text>
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                <text>Pathology</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Coagulation Inhibitors in COVID-19 Leading to Compressive Airway Hematoma.</text>
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                <text>Amr Mohamed</text>
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                <text>We are focusing on three things for every patient in the hospital with COVID-19, namely dexamethasone, remdesivir and enhanced anticoagulation protocols as this had shown improved mortality. However, the bleeding risk in these patients has not been taken into consideration. In our ICU setting at Rochester General hospital, we have seen too many cases with gastrointestinal bleeding and hemoptysis in COVID-19 patients. In this case, we report bleeding related to central access removal related to coagulation inhibitors that lead to airway compression. The aim of this case is to keep bleeding tendency of COVID-19 patients on the radar and to delineate that it has clear severe consequences just as clotting.</text>
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                <text>2021</text>
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                <text>covid-19, covid coagulopathy</text>
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                <text>10.7759/cureus.12580</text>
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                <text>Cureus</text>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Coagulopathy of hospitalised COVID-19: A Pragmatic Randomised Controlled Trial of Therapeutic Anticoagulation versus Standard Care as a Rapid Response to the COVID-19 Pandemic (RAPID COVID COAG – RAPID Trial): A structured summary of a study protocol for a randomised controlled trial</text>
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                <text>Michelle Sholzberg, Grace H. Tang, Elnara Negri, Hassan Rahhal, Lisa Baumann Kreuziger, Carlos E. Pompilio, Paula James, Michael Fralick, Musaad AlHamzah, Faris Alomran, Eric Tseng, Gloria Lim, David Lillicrap, Marc Carrier, Fionnuala Ní Áinle, Andrew Beckett, Bruno R. da Costa, Kevin Thorpe, Saskia Middeldorp, Agnes Lee, Mary Cushman, Peter Jüni</text>
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                <text>Abstract Objectives To determine the effect of therapeutic anticoagulation, with low molecular weight heparin (LMWH) or unfractionated heparin (UFH, high dose nomogram), compared to standard care in hospitalized patients admitted for COVID-19 with an elevated D-dimer on the composite outcome of intensive care unit (ICU) admission, non-invasive positive pressure ventilation, invasive mechanical ventilation or death up to 28 days. Trial design Open-label, parallel, 1:1, phase 3, 2-arm randomized controlled trial Participants The study population includes hospitalized adults admitted for COVID-19 prior to the development of critical illness. Excluded individuals are those where the bleeding risk or risk of transfusion would generally be considered unacceptable, those already therapeutically anticoagulated and those who have already have any component of the primary composite outcome. Participants are recruited from hospital sites in Brazil, Canada, Ireland, Saudi Arabia, United Arab Emirates, and the United States of America. The inclusion criteria are: 1) Laboratory confirmed COVID-19 (diagnosis of SARS-CoV-2 via reverse transcriptase polymerase chain reaction as per the World Health Organization protocol or by nucleic acid based isothermal amplification) prior to hospital admission OR within first 5 days (i.e. 120 hours) after hospital admission; 2) Admitted to hospital for COVID-19; 3) One D-dimer value above the upper limit of normal (ULN) (within 5 days (i.e. 120 hours) of hospital admission) AND EITHER: a. D-Dimer ≥2 times ULN OR b. D-Dimer above ULN and Oxygen saturation ≤ 93% on room air; 4) &gt; 18 years of age; 5) Informed consent from the patient (or legally authorized substitute decision maker). The exclusion criteria are: 1) pregnancy; 2) hemoglobin 65 versus ≤65 years) using a 1:1 computer-generated random allocation sequence with variable block sizes. Randomization will occur within the first 5 days (i.e. 120 hours) of participant hospital admission. However, it is recommended that randomization occurs as early as possible after hospital admission. Central randomization using an interactive web response system will ensure allocation concealment. Blinding (masking) No blinding involved. This is an open-label trial. Numbers to be randomised (sample size) 462 patients (231 per group) are needed to detect a 15% risk difference, from 50% in the control group to 35% in the experimental group, with power of 90% at a two-sided alpha of 0.05. Trial Status Protocol Version Number 1.4. Recruitment began on May 11th, 2020. Recruitment is expected to be completed March 2022. Recruitment is ongoing. Trial registration ClinicalTrials.gov Identifier: NCT04362085 Date of Trial Registration: April 24, 2020 Full protocol The full protocol is attached as an additional file, accessible from the Trials website (Additional file 1). In the interest of expediting dissemination of this material, the familiar formatting has been eliminated; this Letter serves as a summary of the key elements of the full protocol.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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                <text>2021</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="75518">
                <text>covid-19, heparin, Anti coagulation, coagulopathy, Randomised controlled trial, and protocol</text>
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          <element elementId="43">
            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="75519">
                <text>10.1186/s13063-021-05076-0</text>
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            <description>A related resource from which the described resource is derived</description>
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                <text>Epidemiology and Health</text>
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            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="75521">
                <text>Korean Society of Epidemiology</text>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Medicine (General)</text>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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              </elementTextContainer>
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            <element elementId="41">
              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
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        <name>Dublin Core</name>
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            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Coagulopathy of Patients with COVID-19 is Associated with Infectious and Inflammatory Markers</text>
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              <elementText elementTextId="53059">
                <text>Long X, Zhang Z, Zou W, Ling J, Li D, Jing L, Yu S, Zou X, Bian Y, Wu W, Li S, Fang M</text>
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            <description>An account of the resource</description>
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                <text>Xin Long,1,* Zhanguo Zhang,1,* Wenbin Zou,2,* Jianmin Ling,3 Donghui Li,3 Liang Jing,3 Shanshan Yu,3 Xiaojing Zou,3 Yi Bian,3 Wenjuan Wu,4 Shusheng Li,3 Minghao Fang3 1Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People&amp;rsquo;s Republic of China; 2Department of Thoracic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People&amp;rsquo;s Republic of China; 3Department of Intensive Care Unit, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People&amp;rsquo;s Republic of China; 4Department of Intensive Care Unit, Jinyintan Hospital, Wuhan 430023, People&amp;rsquo;s Republic of China*These authors contributed equally to this workCorrespondence: Minghao Fang Tel +86 15071157405Email fangmh@tjh.tjmu.edu.cnBackground: SARS-CoV-2 infection activates coagulation and stimulates innate immune system. Little is known about coagulopathy and response of inflammation and infection in ICU patients with COVID-19. Derangement of coagulation and markers of infection and inflammation induced by SARS-CoV-2 infection, as well as their correlations were elucidated.Methods: One hundred eight ICU patients with COVID-19 (28 survivors and 80 non-survivors) in Tongji hospital and Wuhan Jinyintan hospital, in Wuhan, China were included. Coagulation parameters, infectious and inflammatory markers were dynamically analysed. The correlation between coagulopathy of patients and infectious and inflammatory markers was verified.Results: SARS-CoV-2-associated coagulopathy occurred in most cases of critical illness. Raised values of d-dimer and FDP were measured in all patients, especially in non-survivors, who had longer PT, APTT, INR, as well as TT, and lower PTA and AT compared to survivors. SIC and DIC mostly occurred in non-survivors. CRP, ESR, serum ferritin, IL-8, and IL-2R increased in all patients, and were much higher in non-survivors who had significantly higher levels of IL-6 and IL-10. D-dimer was positively associated with CRP, serum ferritin (p = 0.02), PCT (p &amp;lt; 0.001), and IL-2R (p = 0.007). SIC scores were positively correlated with CRP (p = 0.006), PCT (p = 0.0007), IL-1&amp;beta; (p = 0.048), and IL-6 (p = 0.009). DIC scores were positively associated with CRP (p &amp;lt; 0.0001), ESR (p = 0.02), PCT (p &amp;lt; 0.0001), serum ferritin (p &amp;lt; 0.0001), IL-10 (p = 0.02), and IL-2R (p = 0.0005).Conclusion: Prothrombotic state, SIC, and DIC are the characteristics of coagulation in ICU patients with COVID-19. CRP, ESR, serum ferritin, IL-8, IL-2R, IL-6, and PCT were stimulated by SARS-CoV-2 infection. CRP, PCT, serum ferritin, and IL-2R indicate the coagulopathy severity of patients with COVID-19.Keywords: SARS-CoV-2, COVID-19, coagulopathy, markers of infection and inflammation, correlation</text>
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                <text>covid-19, SARS-CoV-2, coagulopathy, correlation, markers of infection and inflammation</text>
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                <text>Universidade Federal de Santa Catarina</text>
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                  <text>Agricultura sostenible</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Agricultura sostenible</text>
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      <name>Text</name>
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        <name>Dublin Core</name>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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              <elementText elementTextId="240153">
                <text>COASTAL MORPHO- DYNAMICS OF THE NORTH-WESTERN ONEZHSKY PENINSULA, WHITE SEA IN THE HOLOCENE. KONYUKHOV BAY</text>
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            <name>Creator</name>
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              <elementText elementTextId="240154">
                <text>Dmitry Subetto, Maksim Potakhin, Tatyana Repkina, Natalia Zaretskaya, Mergen Kungaa, Anna Novikova, Pyotr Leontiev</text>
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            <name>Description</name>
            <description>An account of the resource</description>
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              <elementText elementTextId="240155">
                <text>Data from geomorphological surveys of the Konyukhov Bay coast (north-western part of Onezhsky Peninsula), radiocarbon dating of organogenic sediments, echo sounding of water areas of the bay and lakes (water lines at 15.8-26.1 m a. s. l.) performed during thevoyage of the research vessel 'Ecolog' in July 2014 were used to reconstruct the history of the landform development in the Holocene. The morphodynamics of the coast is considered as a result of interactions between coastal processes and the underlying litho- genic structure against the background of postglacial movements and climate change. Two geomorphological levels were distinguished and dated, which differ in the scope of transformation of ice-marginal formations of the Neva stage of the last glaciation by the sea and correspond to the main stages of post-glacial development of the relief: 1) paleo- straits and bays in depressions between moraine ridges at altitudes of 17.5-30 m a. s. l., filled in during the post-glacial transgression; the basinal stage of their development ended no later than 8540 ± 50 - 7610 ± 70 14C (~9500-8400 cal.) BP; 2) marine terraces at altitudes below 15-17 m a. s. l., formed in the middle-late Holocene in the environments similar to modern ones. The abrasion coastline (14-17.5 m) formed during the sea level stabilization stage with its high wave activity, which took place during the Tapes transgression, was revealed. Bays at the upper level, with a threshold runoff below ~ 17.5 m a. s. l., were at that time re-filled with sea water. The relative uplift rate of the Konyukhov Bay coast was estimated according to the ages of the lower horizon of lacustrine and palus- trine sediments at 2-2.2 mm/year.</text>
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            <name>Date</name>
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              <elementText elementTextId="240156">
                <text>2017</text>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
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              <elementText elementTextId="240157">
                <text>Holocene, Vertical movements, White Sea, chronology, coast, morainic kettle hole lakes, morphodynamics, sea level</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="240158">
                <text>10.17076/bg717</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="240159">
                <text>Transactions of the Karelian Research Centre of the Russian Academy of Sciences</text>
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          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="240160">
                <text>Karelian Research Centre of the Russian Academy of Sciences</text>
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          </element>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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              <elementText elementTextId="240161">
                <text>Science</text>
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          <element elementId="46">
            <name>Relation</name>
            <description>A related resource</description>
            <elementTextContainer>
              <elementText elementTextId="240162">
                <text>&lt;a href="http://journals.krc.karelia.ru/index.php/biogeo/article/view/717" target="_blank" rel="noreferrer noopener"&gt;http://journals.krc.karelia.ru/index.php/biogeo/article/view/717&lt;/a&gt;</text>
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