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                  <text>Coronavirus</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Codiseño del curso TIACE en la formación inicial docente de educación preescolar ante la contingencia de la COVID-19</text>
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                <text>Brenda Luz Colorado Aguilar</text>
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                <text>El objetivo del presente estudio se centró en valorar el codiseño del curso, la Tecnología Informática Aplicada a los Centros Escolares (TIACE) en la formación inicial docente de la licenciatura en educación preescolar, ante la contingencia provocada por la COVID-19. La investigación de corte mixto y alcance descriptivo, se realizó en una escuela normal del estado de Veracruz, México. Se utilizó el cuestionario escala Likert aplicado a una muestra de 27 docentes en formación, así como  la aplicación de 12 entrevistas semiestructuradas para el estudio fenomenológico hermenéutico. Se obtuvieron resultados favorables del codiseño del curso en cuanto a las estrategias de organización y dinámica,  aspectos pedagógicos, de contenido y tecnológicos. Con respecto a los factores que intervinieron para dar continuidad con las clases ante la pandemia, surgieron aspectos  de estados de ánimo y contingencias familiares como factores a tomarse en cuenta en la  modalidad de aprendizaje en línea.</text>
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                <text>2020</text>
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            <description>The topic of the resource</description>
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                <text>covid-19, TIC, formación docente, codiseño</text>
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                <text>10.21556/edutec.2020.74.1815</text>
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                <text>Epidemiology and Health</text>
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                <text>Korean Society of Epidemiology</text>
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                <text>Theory and practice of education</text>
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                  <text>Coronavirus</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Codon Usage and Phenotypic Divergences of SARS-CoV-2 Genes</text>
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                <text>Alexandros G Georgakilas, Athanasia Pavlopoulou, Andrea Giansanti, Maddalena Dilucca, Sergio Forcelloni</text>
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                <text>Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which first occurred in Wuhan (China) in December of 2019, causes a severe acute respiratory illness with a high mortality rate, and has spread around the world. To gain an understanding of the evolution of the newly emerging SARS-CoV-2, we herein analyzed the codon usage pattern of SARS-CoV-2. For this purpose, we compared the codon usage of SARS-CoV-2 with that of other viruses belonging to the subfamily of Orthocoronavirinae. We found that SARS-CoV-2 has a high AU content that strongly influences its codon usage, which appears to be better adapted to the human host. We also studied the evolutionary pressures that influence the codon usage of five conserved coronavirus genes encoding the viral replicase, spike, envelope, membrane and nucleocapsid proteins. We found different patterns of both mutational bias and natural selection that affect the codon usage of these genes. Moreover, we show here that the two integral membrane proteins (matrix and envelope) tend to evolve slowly by accumulating nucleotide mutations on their corresponding genes. Conversely, genes encoding nucleocapsid (N), viral replicase and spike proteins (S), although they are regarded as are important targets for the development of vaccines and antiviral drugs, tend to evolve faster in comparison to the two genes mentioned above. Overall, our results suggest that the higher divergence observed for the latter three genes could represent a significant barrier in the development of antiviral therapeutics against SARS-CoV-2.</text>
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                <text>2020</text>
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                <text>Natural selection, host adaptation, coronaviruses, codon usage bias, mutational bias, SARS-CoV-2</text>
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                <text>DOI: 10.3390/v12050498</text>
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                <text>Viruses</text>
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                <text>MDPI AG</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Microbiology</text>
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                  <text>Agricultura sostenible</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Agricultura sostenible</text>
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            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Coffea arabica L. Resistant to Coffee Berry Borer (Hypothenemus hampei) Mediated by Expression of the Bacillus thuringiensis Cry10Aa Protein</text>
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            <name>Creator</name>
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                <text>Eliana Valencia-Lozano, Jose Luis Cabrera-Ponce, Juan C. Noa-Carrazana, Jorge E. Ibarra</text>
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                <text>Coffea spp. are tropical plants used for brewing beverages from roasted and grounded seeds, the favorite drink in the world. It is the most important commercial crop plant and the second most valuable international commodity after oil. Global coffee trade relies on two Coffea species: C. arabica L. (arabica coffee) comprising 60% and C. canephora (robusta) comprising the remaining 40%. Arabica coffee has lower productivity and better market price than robusta. Arabica coffee is threatened by disease (i.e., coffee leaf rust), pests [i.e., Hypothenemus hampei or coffee berry borer (CBB) and nematodes], and susceptibility to climate change (i.e., drought and aluminum toxicity). Plant biotechnology by means of tissue culture inducing somatic embryogenesis (SE) process, genetic transformation, and genome editing are tools that can help to solve, at least partially, these problems. This work is the continuation of a protocol developed for stable genetic transformation and successful plant regeneration of arabica coffee trees expressing the Bacillus thuringiensis (Bt) toxin Cry10Aa to induce CBB resistance. A highly SE line with a high rate of cell division and conversion to plants with 8-month plant regeneration period was produced. To validate this capability, gene expression analysis of master regulators of SE, such as BABY BOOM (BBM), FUS3, and LEC1, embryo development, such as EMB2757, and cell cycle progression, such as ETG1 and MCM4, were analyzed during induction and propagation of non-competent and highly competent embryogenic lines. The particle bombardment technique was used to generate stable transgenic lines after 3 months under selection using hygromycin as selectable marker, and 1 month in plant regeneration. Transgenic trees developed fruits after 2 years and demonstrated expression of the Bt toxin ranging from 3.25 to 13.88 μg/g fresh tissue. Bioassays with transgenic fruits on CBB first instar larvae and adults induced mortalities between 85 and 100% after 10 days. In addition, transgenic fruits showed a seed damage lower than 9% compared to 100% of control fruits and adult mortality. This is the first report on stable transformation and expression of the Cry10Aa protein in coffee plants with the potential to control CBB.</text>
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                <text>2021</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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                <text>Bacillus thuringiensis, Coffee Berry Borer, coffee transformation, cry10aa, somatic embryogenesis</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="210256">
                <text>10.3389/fpls.2021.765292</text>
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            <description>A related resource from which the described resource is derived</description>
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                <text>Frontiers in Plant Science</text>
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                <text>Frontiers Media S.A.</text>
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                <text>Plant culture</text>
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                <text>&lt;a href="https://www.frontiersin.org/articles/10.3389/fpls.2021.765292/full" target="_blank" rel="noreferrer noopener"&gt;https://www.frontiersin.org/articles/10.3389/fpls.2021.765292/full&lt;/a&gt;</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Cognitive Network Science Reconstructs How Experts, News Outlets and Social Media Perceived the COVID-19 Pandemic</text>
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                <text>Massimo Stella</text>
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                <text>This work uses cognitive network science to reconstruct how experts, influential news outlets and social media perceived and reported the news “COVID-19 is a pandemic”. In an exploratory corpus of 1 public speech, 10 influential news media articles on the same news and 37,500 trending tweets, the same pandemic declaration elicited a wide spectrum of perceptions retrieved by automatic language processing. While the WHO adopted a narrative strategy of mitigating the pandemic by raising public concern, some news media promoted fear for economic repercussions, while others channelled trust in contagion containment through semantic associations with science. In Italy, the first country to adopt a nationwide lockdown, social discourse perceived the pandemic with anger and fear, emotions of grief elaboration, but also with trust, a useful mechanism for coping with threats. Whereas news mostly elicited individual emotions, social media promoted much richer perceptions, where negative and positive emotional states coexisted, and where trust mainly originated from politics-related jargon rather than from science. This indicates that social media linked the pandemics to institutions and their intervention policies. Since both trust and fear strongly influence people’s risk-averse behaviour and mental/physical wellbeing, identifying evidence for these emotions is key under a global health crisis. Cognitive network science opens the way to unveiling the emotional framings of massively read news in automatic ways, with relevance for better understanding how information was framed and perceived by large audiences.</text>
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                <text>covid-19, emotions, text mining, Semantic networks, social media mining, computational cognitive science</text>
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                <text>10.3390/systems8040038</text>
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                <text>Epidemiology and Health</text>
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                <text>Korean Society of Epidemiology</text>
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                <text>Technology (General), Systems engineering</text>
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                <text>Cognitive Outcomes During COVID-19 Confinement Among Older People and Their Caregivers Using Technologies for Dementia: Protocol for an Observational Cohort Study</text>
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                <text>Goodman-Casanova, Jessica Marian, Dura-Perez, Elena, Guerrero-Pertiñez, Gloria, Barnestein-Fonseca, Pilar, Guzman-Parra, Jose, Vega-Nuñez, Amanda, Varela-Moreno, Esperanza, Cuesta-Vargas, Antonio, Mayoral-Cleries, Fermin</text>
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                <text>BackgroundThe COVID-19 pandemic has led to worldwide implementation of unprecedented restrictions to control its rapid spread and mitigate its impact. The Spanish government has enforced social distancing, quarantine, and home confinement measures. Such restrictions on activities of daily life and separation from loved ones may lead to social isolation and loneliness with health-related consequences among community-dwelling older adults with mild cognitive impairment or mild dementia and their caregivers. Additionally, inadequate access to health care and social support services may aggravate chronic conditions. Home-based technological interventions have emerged for combating social isolation and loneliness, while simultaneously preventing the risk of virus exposure.             ObjectiveThe aim of this cohort study is to explore, analyze, and determine the impact of social isolation on (1) cognition, quality of life, mood, technophilia, and perceived stress among community-dwelling older adults with mild cognitive impairment or mild dementia and on the caregiver burden; (2) access to and utilization of health and social care services; and (3) cognitive, social, and entertainment-related uses of information and communication technologies.             MethodsThis study will be conducted in Málaga (Andalucía, Spain). In total 200 dyads, consisting of a person with mild cognitive impairment or mild dementia and his/her informal caregiver, will be contacted by telephone. Potential respondents will be participants of the following clinical trials: support, monitoring, and reminder technology for mild dementia (n=100) and television-based assistive integrated service to support European adults living with mild dementia or mild cognitive impairment (n=100).             ResultsAs of May 2021, a total of 153 participants have been enrolled and assessed during COVID-19 confinement, of whom 67 have been assessed at 6 months of enrollment. Changes in the mean values of the variables will be analyzed relative to baseline findings of previous studies with those during and after confinement, using repeated-measures analysis of variance or the nonparametric Friedman test, as appropriate. The performance of multivariate analysis of covariance (ANCOVA) to introduce potential covariates will also be considered. Values of 95% CI will be used.             ConclusionsIf our hypothesis is accepted, these findings will demonstrate the negative impact of social isolation owing to COVID-19 confinement on cognition, quality of life, mood, and perceived stress among community-dwelling older adults with mild cognitive impairment and mild dementia, the impact on technophilia, caregiver burden, the access to and utilization of health and social care services, and the cognitive, social, and entertainment-related use of information and communication technologies during and after COVID-19 confinement.             Trial RegistrationClinicalTrials.gov NCT04385797; https://clinicaltrials.gov/ct2/show/NCT04385797             International Registered Report Identifier (IRRID)DERR1-10.2196/26431</text>
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                <text>Korean Society of Epidemiology</text>
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                <text>Medicine, Computer applications to medicine. Medical informatics</text>
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                <text>Chen Xu, Yanjun Xu, Song Xu, Qianhui Zhang, Xiaotong Liu, Yifan Shao, Xiaoxiao Xu, Li Peng, Min Li</text>
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                <text>The purpose of this study is to examine how the emotion regulation strategy, cognitive reappraisal, affects the association between perceived stress and anxiety symptoms in COVID-19 isolated people. Data for this cross-sectional study come from a community-based online survey of COVID-19 isolated people (N = 328), who are not infected with the 2019-nCoV virus. We applied correlation and moderating effect for data analysis and found that cognitive reappraisal negatively moderated the relationship between perceived stress and anxiety symptoms. These results give us a new perspective on understanding the relationship between anxiety symptoms and perceived stress by clarifying the protective function of cognitive reappraisal. It buffers the induced negative emotion when COVID-19 isolated people perceive overpressure, and thus instigates future research into targeted clinical interventions, which aim to cultivate cognitive reappraisal skills for those isolated people in the face of stressful events or crisis events.</text>
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                <text>emotion regulation, perceived stress, anxiety symptoms, cognitive reappraisal, COVID-19 isolated people</text>
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                <text>10.3389/fpsyt.2020.00858</text>
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                <text>Psychiatry</text>
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              <elementText elementTextId="14550">
                <text>Marcos Saavedra-Velasco, Christian Chiara-Chilet, Rafael Pichardo Rodríguez, Antonio Grandez-Urbina, Fiorella Inga-Berrospi</text>
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                <text>El impacto que ha originado la enfermedad por coronavirus 2019 (COVID-19) en diferentes partes del mundo, alcanza en la actualidad 597, 072 personas contagiadas y 27,364 fallecidas según los últimos reportes. En ese contexto, en nuestro país, una zona de relevancia epidemiológica es la amazonia peruana, debido a la distribución de enfermedades endémicas como las enfermedades metaxénicas (Dengue, Malaria entre otras), en donde el problema se incrementa debido a que la infección por COVID-19 puede llevar a falsos positivos en las pruebas de cribado para Dengue. Conllevando de esa forma a un retraso en el diagnóstico de la infección por COVID-19 y una mayor diseminación del virus, debido a que en la mayor parte de los casos de Dengue no se presentan signos de alarma y el tratamiento es ambulatorio. Este artículo busca emitir una opinión sobre la necesidad del abordaje de casos de coinfección entre Dengue y Covid-19 en zonas endémicas.</text>
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                <text>coronavirus, Dengue, epidemia, Salud Pública</text>
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                <text>DOI: 10.31053/1853.0605.v77.n1.28031</text>
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                <text>Revista de la Facultad de Ciencias Médicas de Córdoba</text>
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                <text>Universidad Nacional de Córdoba</text>
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                <text>Resumen  La sociedad precisa personas preparadas en distintas competencias para llevar a cabo tareas complejas. Además, las soluciones a los problemas de la sociedad actual requieren la cooperación de diferentes disciplinas ¿Podemos ayudar a los estudiantes universitarios a aprender a trabajar en equipos multidisciplinares? Realizar una auditoría energética es una labor compleja. Para analizar el comportamiento energético de un edificio es preciso manejar diversas variables en procesos dinámicos y cambiantes. Si no se cuenta con unos datos de partida precisos, los errores en las conclusiones pueden resultar significativos. Pero, por otro lado, también se puede caer en la pretensión de un exceso de precisión que hace inviable el trabajo de campo para la toma de datos y que aporta muy poco más a las conclusiones finales. Alumnos de informática y alumnos de arquitectura pueden aportar visiones complementarias para abordar con más éxito el problema del estudio de la eficiencia energética de los edificios.  Inicialmente, alumnos de Gado de Ingeniería de Sistemas Informáticos discuten con estudiantes de Grado en Fundamentos de Arquitectura las especificaciones del proyecto (variables a medir, características del edificio, estructura de los datos, etc.). Basándose en estas especificaciones, diseñan la infraestructura informática necesaria, fundamentalmente una red de sensores, un sistema de comunicación y un sistema de almacenamiento que permita el posterior análisis. Por su parte, los alumnos de arquitectura reciben los valiosos datos aportados. En primer lugar, tienen que aprender a manejar, analizar e interpretar la gran cantidad de datos recogidos. Además, obtienen un fundamento empírico que les permite obtener conclusiones validadas por los datos obtenidos. Además de manejar datos estadísticos y resultados que ofrecen las simulaciones, tienen acceso a los datos reales recogidos in situ, lo que permite afinar en las conclusiones. En el proceso ambos alumnos enriquecen su trabajo mutuamente. Los alumnos de arquitectura explicitan sus necesidades y los alumnos de informática vuelcan su esfuerzo en dar respuesta a las demandas de un problema real y de gran utilidad que les permite desarrollar competencias técnicas y transversales. Por último, la sociedad también sale beneficiada de este proceso de aprendizaje compartido. Más concretamente la Escuela de Minas de la Universidad Politécnica de Madrid ofrece un aula donde llevar a cabo la auditoría energética y recibe de manera desinteresada el fruto del aprendizaje.   Las conclusiones del estudio le permiten acometer medidas de mejora en el desempeño energético del aula. Obtiene una hoja de ruta que le permite acometer las inversiones que pueda realizar con unos criterios de rentabilidad acertados. Pero también la sociedad en general se ve beneficiada, dado que las medidas que la Escuela de Minas pueda acometer redundan en una reducción del consumo energético, lo que implica una reducción de las emisiones de CO2 y, por tanto, cierta mitigación del cambio climático, tan urgente en el momento actual. En el curso 2018-2019 una estudiante de arquitectura y dos de informática han realizado sus respectivos TFG y PFM en este contexto, obteniendo unos resultados satisfactorios, tanto en el aspecto técnico como de aprendizaje.  Society needs people with different skills to carry out complex tasks. In addition, solutions to the problems of today's society require the cooperation of different disciplines. Can we help university students to learn to work in multidisciplinary teams? Carrying out an energy audit is a complex task. In order to analyze the energy consumption of a building, it is necessary to manage several variables in dynamic and changing processes. In the absence of accurate initial data, the errors in conclusions can be significant. However, we can also fall into the trap of an excess of precision, which makes fieldwork for data collection unviable and which contributes very little more to the final conclusions. Computer science students and architecture students can provide complementary insights to address the problem of studying the energy efficiency of buildings more successfully.  Initially, students of Computer Science discuss with students in Architecture Fundamentals the specifications of the project (variables to be measured, characteristics of the building, data structure, etc.). Based on these specifications, they design the necessary IT infrastructure, basically a sensor network, a communication system and a storage system that allows subsequent analysis. On the other hand, the students in architecture receive the valuable data provided. First, they have to learn how to manage, analyze and interpret the large amount of data collected. In this way they have an empirical basis that allows them to draw conclusions validated by the data obtained. In addition to handling statistical data and results offered by the simulations, they have access to real data collected in situ, which allows them to fine-tune their conclusions. In the process, students of both fields mutually enrich their work. Architecture students explain their needs and computer science students focus their efforts on responding to the demands of a real and very useful problem that allows them to develop technical and transversal skills. Finally, society also benefits from this shared learning process. More specifically, the Escuela de Minas of the Universidad Politécnica de Madrid offers a classroom to carry out the energy audit and obtains the learning results in a disinterested way.   The conclusions of the study allow them to undertake measures to improve the energy performance of the classroom. They obtain a roadmap that allows them to undertake the investments they can make with the right profitability criteria. But society in general also benefits, since the measures that the Escuela de Minas may undertake result in a reduction in energy consumption, which implies a reduction in CO2 emissions and, therefore, some mitigation of climate change, so urgent at the present time. In the academic year 2018-2019 one architecture student and two computer science students have carried out their respective TFG and PFM in this context, obtaining satisfactory results, both in the technical and learning side.</text>
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