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                  <text>Coronavirus</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Frequent Respiratory Viral Infections in Children with Febrile Neutropenia - A Prospective Follow-Up Study.</text>
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                <text>Martina Söderman, Samuel Rhedin, Thomas Tolfvenstam, Maria Rotzén-Östlund, Jan Albert, Kristina Broliden, Anna Lindblom</text>
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                <text>OBJECTIVE:Febrile neutropenia is common in children undergoing chemotherapy for the treatment of malignancies. In the majority of cases, the cause of the fever is unknown. Although respiratory viruses are commonly associated with this condition, the etiologic significance of this finding remains unclear and is therefore the subject of this study. STUDY DESIGN:Nasopharyngeal aspirates were collected during 87 episodes of febrile neutropenia in children age 0-18 years, being treated at a children's oncology unit between January 2013 and June 2014. Real-time polymerase chain reaction was used to determine the presence of 16 respiratory viruses. Follow-up samples were collected from children who tested positive for one or more respiratory viruses. Rhinoviruses were genotyped by VP4/VP2 sequencing. Fisher's exact test and Mann-Whitney U test were used for group comparisons. RESULTS:At least one respiratory virus was detected in samples from 39 of 87 episodes of febrile neutropenia (45%), with rhinoviruses the most frequently detected. Follow-up samples were collected after a median of 28 days (range, 9-74 days) in 32 of the 39 virus-positive episodes. The respiratory viral infection had resolved in 25 episodes (78%). The same virus was detected at follow-up in one coronavirus and six rhinovirus episodes. Genotyping revealed a different rhinovirus species in two of the six rhinovirus infections. CONCLUSION:The frequency of respiratory viral infections in this group of patients suggests an etiologic role in febrile neutropenia. However, these findings must be confirmed in larger patient cohorts.</text>
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                <text>2016</text>
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                <text>DOI: 10.1371/journal.pone.0157398</text>
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                <text>PLoS ONE</text>
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                  <text>Dominio científico: Coronavirus</text>
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            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Frequent Travelers and Rate of Spread of Epidemics</text>
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                <text>T. Déirdre Hollingsworth, Neil M. Ferguson, Roy M. Anderson</text>
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            <description>An account of the resource</description>
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                <text>A small proportion of air travelers make disproportionately more journeys than the rest of travelers. They also tend to interact predominantly with other frequent travelers in hotels and airport lounges. This group has the potential to accelerate global spread of infectious respiratory diseases. Using an epidemiologic model, we simulated exportation of cases from severe acute respiratory syndrome–like and influenza-like epidemics in a population for which a small proportion travel more frequently than the rest. Our simulations show that frequent travelers accelerate international spread of epidemics only if they are infected early in an outbreak and the outbreak does not expand rapidly. If the epidemic growth rate is high, as is likely for pandemic influenza, heterogeneities in travel are frequently overwhelmed by the large number of infected persons in the majority population and the resulting high probability that some of these persons will take an international flight.</text>
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            <name>Date</name>
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                <text>2007</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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                <text>SARS, influenza, epidemics, mathematical model, international air travel, research</text>
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                <text>DOI: 10.3201/eid1309.070081</text>
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            <description>A related resource from which the described resource is derived</description>
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                <text>Emerging Infectious Diseases</text>
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                <text>Centers for Disease Control and Prevention</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Infectious and parasitic diseases, Medicine</text>
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            <description>A language of the resource</description>
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                <text>EN</text>
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              <description>A name given to the resource</description>
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                  <text>Agricultura sostenible</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Agricultura sostenible</text>
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            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Frijol silvestre en el Valle Central de Costa Rica: distribución ecológica y caracterización molecular.</text>
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            <description>An entity primarily responsible for making the resource</description>
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                <text>Rosa Inés González-Torres, Rodolfo Araya-Villalobos, Eliana Gaitán-Solís, Daniel G. Debouck</text>
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            <description>An account of the resource</description>
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                <text>Este  trabajo presenta una actualización sobre la distribución de las  formas silvestres de fríjol común en Costa Rica, su ecología y  su caracterización molecular. Ala fecha 22 poblaciones fueron  encontradas en cuatro cuencas alrededor del Valle Central, generalmente  en vegetaciones ruderales (frecuentemente bordes  de cafetales), con estatuto de conservación variable (desde  protegido a amenazado). Su caracterización molecular indica  su pertenencia al acervo genético mesoamericano. Varios marcadores  indican una variabilidad aumentada en las formas silvestres  y permiten inferir la presencia de un fenómeno de flujo  genético e introgresión desde materiales cultivados.</text>
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            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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                <text>2004</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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                <text>América Central, Biología de la Conservación, Phaseolus vulgaris, flujo de genes, genética de poblaciones</text>
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            <description>An unambiguous reference to the resource within a given context</description>
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                <text>10.15517/am.v15i2.11894</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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                <text>Agronomía Mesoamericana</text>
              </elementText>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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                <text>Universidad de Costa Rica</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Agriculture</text>
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            <description>A related resource</description>
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                <text>&lt;a href="https://revistas.ucr.ac.cr/index.php/agromeso/article/view/11894" target="_blank" rel="noreferrer noopener"&gt;https://revistas.ucr.ac.cr/index.php/agromeso/article/view/11894&lt;/a&gt;</text>
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              <name>Title</name>
              <description>A name given to the resource</description>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>From Anti-SARS-CoV-2 Immune Responses to COVID-19 via Molecular Mimicry</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="86016">
                <text>Darja Kanduc</text>
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            <description>An account of the resource</description>
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                <text>Aim: To define the autoimmune potential of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. Methods: Experimentally validated epitopes cataloged at the Immune Epitope DataBase (IEDB) and present in SARS-CoV-2 were analyzed for peptide sharing with the human proteome. Results: Immunoreactive epitopes present in SARS-CoV-2 were mostly composed of peptide sequences present in human proteins that—when altered, mutated, deficient or, however, improperly functioning—may associate with a wide range of disorders, from respiratory distress to multiple organ failure. Conclusions: This study represents a starting point or hint for future scientific–clinical investigations and suggests a range of possible protein targets of autoimmunity in SARS-CoV-2 infection. From an experimental perspective, the results warrant the testing of patients’ sera for autoantibodies against these protein targets. Clinically, the results warrant a stringent surveillance on the future pathologic sequelae of the current SARS-CoV-2 pandemic.</text>
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                <text>2020</text>
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                <text>cross reactivity, autoimmunity, Molecular Mimicry, peptide sharing, SARS-CoV-2 epitopes</text>
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                <text>10.3390/antib9030033</text>
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            <description>A related resource from which the described resource is derived</description>
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                <text>Epidemiology and Health</text>
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                <text>Korean Society of Epidemiology</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Immunologic diseases. Allergy</text>
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                <text>In cells, positive strand RNA viruses, such as Retroviridae, must selectively recognize their full-length RNA genome among abundant cellular RNAs to assemble and release particles. How viruses coordinate the intracellular trafficking of both RNA and protein components to the assembly sites of infectious particles at the cell surface remains a long-standing question. The mechanisms ensuring packaging of genomic RNA are essential for viral infectivity. Since RNA packaging impacts on several essential functions of retroviral replication such as RNA dimerization, translation and recombination events, there are many studies that require the determination of RNA packaging efficiency and/or RNA packaging ability. Studies of RNA encapsidation rely upon techniques for the identification and quantification of RNA species packaged by the virus. This review focuses on the different approaches available to monitor RNA packaging: Northern blot analysis, ribonuclease protection assay and quantitative reverse transcriptase-coupled polymerase chain reaction as well as the most recent RNA imaging and sequencing technologies. Advantages, disadvantages and limitations of these approaches will be discussed in order to help the investigator to choose the most appropriate technique. Although the review was written with the prototypic simple murine leukemia virus (MLV) and complex human immunodeficiency virus type 1 (HIV-1) in mind, the techniques were described in order to benefit to a larger community.</text>
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                <text>From degeneration to infection/inflammation, and from individual-centered to ecologic approaches to investigation of evolving patterns of diseases occurrences in populations Da degeneração à infecção e da abordagem centrada no indivíduo à investigação ecológica dos padrões de ocorrência de enfermidades nas populações</text>
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                <text>Variation in attributes of CHD cases over time suggests a temporal change in the source sub-population of cases. It is proposed that an early 20th century expansion of a CHD-prone sub-population, characterized by high-serum cholesterol phenotype and high case-fatality - and which contributed with most of the CHD cases and deaths during the 1960s - may have followed the 1918 Influenza Pandemic. The extinction of those birth-cohorts would have resulted in a relative increase in cases coming from a second source sub-population, characterized by insulin resistance and chronic expression of low grade inflammation markers, comparatively less vulnerable to acutely die from CHD. This re-interpretation of the CHD trend, and the abandonment of the idea of degeneration for inflammation/infection calls for a change in epidemiology. Besides exposures (diet, infection...), temporal variations in proportional representations of inherited and acquired phenotypes associated with individual resistance/vulnerability, would be important determinants of evolving patterns of diseases occurrences in populations.A variação registrada nos atributos dos casos de Doença Isquêmica do Coração (DIC) ao longo do tempo sugere variação temporal na subpopulação fonte dos casos. Propõe-se que tenha ocorrido, em associação com a Pandemia de Influenza de 1918, a expansão de uma subpopulação caracterizada por um fenótipo de hipercolesterolemia e alta propensão à mortalidade por DIC, que teria contribuído com a maior parte dos casos e dos óbitos por DIC registrados na década de 1960. A progressiva extinção daquelas coortes de nascimento teria resultado em crescimento relativo dos casos de DIC oriundos de uma segunda subpopulação, caracterizada por resistência à insulina e expressão de marcadores associados a inflamação crônica subclínica. Esta re-interpretação da tendência temporal da mortalidade por DIC, e o abandono da idéia de degeneração pela idéia de inflamação/infecção pede por uma mudança na epidemiologia. Além de exposições ambientais (dieta, infecção), variações temporais nas representações proporcionais de fenótipos associados à resistência e à vulnerabilidade individual seriam importantes determinantes dos padrões de ocorrência de doenças em populações.</text>
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            <description>The topic of the resource</description>
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                <text>Doença cardiovascular, Ecologic studies, Epidemia, Epidemic, Mortalidade, ecología humana, heart disease, influenza, mortality</text>
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                <text>10.1590/S1413-81232004000400007</text>
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                <text>Ciência &amp; Saúde Coletiva</text>
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                <text>Associação Brasileira de Pós-Graduação em Saúde Coletiva</text>
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                <text>Public aspects of medicine</text>
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                <text>&lt;a href="http://www.scielo.br/scielo.php?script=sci_arttext&amp;amp;pid=S1413-81232004000400007" target="_blank" rel="noreferrer noopener"&gt;http://www.scielo.br/scielo.php?script=sci_arttext&amp;amp;pid=S1413-81232004000400007&lt;/a&gt;</text>
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                <text>From dialogue to extensionist experience in the Territories of Sisal and Northern Piemonte of Itapicuru by FETRAF-BA</text>
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                <text>Jandeson Cardoso Silva, Cleilton Vasconcelos Moreira</text>
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                <text>This work is configured as an experience of family farming through dialogues and activities in rural communities in the territories of Sisal and Piemonte Norte de Itapicuru, through the Federation of Rural Workers in Family Agriculture in Bahia (FETRAF-BA) - Senhor do Bonfim Unit. The present work relates the experience in the communities and the municipalities of Senhor do Bonfim, Pindobaçu, Ponto Novo and Monte Santo, focusing on different areas of rural production, ranging from effective monitoring of technical assistance for agriculture, livestock, with a focus on environmental improvements and entrepreneurship to the process of organizing and carrying out social activities in communities. The report addresses the actions in a social context of popular communication and family farming, through extension activities and accompanied technical visits, during the supervised internship. The activities developed provided an understanding of the work dynamics of an organization focused on extension actions. Therefore, jointly, it was possible to understand the ways in which FETRAF-BA technicians approach and systematize ideas in communities. The result of this experience reflected in the practical understanding of extension techniques and the importance of approaching, dialoguing and building knowledge of extension activities for the improvement and organization of rural communities.</text>
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                <text>extensão universitária. comunidades rurais. agricultura familiar</text>
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                <text>Universidade Federal da Grande Dourados</text>
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                <text>General Works</text>
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                <text>From Donor to Patient: Collection, Preparation and Cryopreservation of Fecal Samples for Fecal Microbiota Transplantation</text>
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                <text>Carole Nicco, Armelle Paule, Peter Konturek, Marvin Edeas</text>
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