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RANGE MIGRATION ALGORITHM IN THE PROCESSING CHAIN OF SIGNALS OF A GROUND-BASED SAR SENSOR
Synthetic aperture radar (SAR) system based on frequency modulated continuous wave (FM-CW) transmission is a viable option for producing high-resolution ground-based imaging radars. Compared with pulsed SAR systems, the combination of FM-CW…
Position: 7101 (19 views)
Mouse hepatitis coronavirus RNA replication depends on GBF1-mediated ARF1 activation.
Coronaviruses induce in infected cells the formation of double membrane vesicles, which are the sites of RNA replication. Not much is known about the formation of these vesicles, although recent observations indicate an important role for the…
Position: 11252 (16 views)
Arterivirus Nsp1 modulates the accumulation of minus-strand templates to control the relative abundance of viral mRNAs.
The gene expression of plus-strand RNA viruses with a polycistronic genome depends on translation and replication of the genomic mRNA, as well as synthesis of subgenomic (sg) mRNAs. Arteriviruses and coronaviruses, distantly related members of the…
Position: 8353 (18 views)
Mesodermal gene expression in the acoel Isodiametra pulchra indicates a low number of mesodermal cell types and the endomesodermal origin of the gonads.
Acoelomorphs are bilaterally symmetric small marine worms that lack a coelom and possess a digestive system with a single opening. Two alternative phylogenetic positions of this group within the animal tree are currently debated. In one view,…
Position: 6010 (20 views)
Reference-free validation of short read data.
BACKGROUND: High-throughput DNA sequencing techniques offer the ability to rapidly and cheaply sequence material such as whole genomes. However, the short-read data produced by these techniques can be biased or compromised at several stages in the…
Position: 5056 (21 views)
Liposome-coupled peptides induce long-lived memory CD8 T cells without CD4 T cells.
CD8(+) T cells provide broad immunity to viruses, because they are able to recognize all types of viral proteins. Therefore, the development of vaccines capable of inducing long-lived memory CD8(+) T cells is desired to prevent diseases, especially…
Position: 3615 (23 views)
The role of viral population diversity in adaptation of bovine coronavirus to new host environments.
The high mutation rate of RNA viruses enables a diverse genetic population of viral genotypes to exist within a single infected host. In-host genetic diversity could better position the virus population to respond and adapt to a diverse array of…
Position: 11252 (16 views)
Correction: Reversal of the Progression of Fatal Coronavirus Infection in Cats by a Broad-Spectrum Coronavirus Protease Inhibitor.
[This corrects the article DOI: 10.1371/journal.ppat.1005531.].
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Identification of the Mechanisms Causing Reversion to Virulence in an Attenuated SARS-CoV for the Design of a Genetically Stable Vaccine.
A SARS-CoV lacking the full-length E gene (SARS-CoV-∆E) was attenuated and an effective vaccine. Here, we show that this mutant virus regained fitness after serial passages in cell culture or in vivo, resulting in the partial duplication of the…
Position: 9804 (17 views)
Crystal structure of Middle East respiratory syndrome coronavirus helicase.
Middle East respiratory syndrome coronavirus (MERS-CoV) remains a threat to public health worldwide; however, effective vaccine or drug against CoVs remains unavailable. CoV helicase is one of the three evolutionary most conserved proteins in…
Position: 3615 (23 views)