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                <text>MHC-II constrains the natural neutralizing antibody response to the SARS-CoV-2 spike RBM in humans.</text>
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                <text>Andrea Castro, Kivilcim Ozturk, Maurizio Zanetti, Hannah Carter</text>
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                <text>SARS-CoV-2 antibodies develop within two weeks of infection, but wane relatively rapidly post-infection, raising concerns about whether antibody responses will provide protection upon re-exposure. Here we revisit T-B cooperation as a prerequisite for effective and durable neutralizing antibody responses centered on a mutationally constrained RBM B cell epitope. T-B cooperation requires co-processing of B and T cell epitopes by the same B cell and is subject to MHC-II restriction. We evaluated MHC-II constraints relevant to the neutralizing antibody response to a mutationally-constrained B cell epitope in the receptor binding motif (RBM) of the spike protein. Examining common MHC-II alleles, we found that peptides surrounding this key B cell epitope are predicted to bind poorly, suggesting a lack MHC-II support in T-B cooperation, impacting generation of high-potency neutralizing antibodies in the general population. Additionally, we found that multiple microbial peptides had potential for RBM cross-reactivity, supporting previous exposures as a possible source of T cell memory.</text>
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                <text>10.1101/2020.12.26.424449</text>
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                <text>bioRxiv : the preprint server for biology</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Andrea Coelho  Lastória, Thais Angela Cavalheiro de Azevedo  Morandini, Francislaine Soledade  Carniel, José Faustino de Almeida  Santos</text>
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                <text>Neste trabalho investigamos a disciplina de Cartografia Escolar inserida num curso de Licenciatura em Pedagogia que passou da modalidade presencial para o ensino remoto no contexto da COVID-19. Como um estudo de caso analítico-descritivo com abordagem qualitativa, o objetivo da investigação foi diagnosticar os principais enfrentamentos da docente e dos seus estudantes. Os procedimentos teórico-metodológicos estão assentados em pesquisas sobre formação de professores e Cartografia para Crianças e Escolares no Brasil. Os dados foram colhidos por meio de questionário aplicado aos alunos que cursaram a disciplina. Os resultados apontam para limites impostos, principalmente, pela ausência de situações práticas presenciais e coletivas, pelas dificuldades com a utilização das novas ferramentas tecnológicas e, por outro lado, pela recondução da disciplina, tendo em vista a ampliação dos repertórios dos estudantes e a ressignificação de noções e conceitos cartográficos nas práticas escolares.</text>
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                <text>2020</text>
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                <text>covid-19, formação de professores, Cartograﬁa Escolar</text>
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                <text>10.35699/2237-5864.2020.24720</text>
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                <text>Revista Docência do Ensino Superior</text>
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                <text>UFMG</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Education</text>
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                  <text>Agricultura sostenible</text>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Agricultura sostenible</text>
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                <text>PALEOCLIMAS Y PALEOESCENARIOS EN LA PATAGONIA AUSTRAL Y EN TIERRA DEL FUEGO DURANTE EL CUATERNARIO</text>
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                <text>Andrea Coronato, Ana Maria Borromei, Jorge Rabassa</text>
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            <description>An account of the resource</description>
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                <text>Se presentan evidencias geomorfológicas y palinológicas indicadoras de paleoescenarios existentes en los últimos dos millones de años en el extremo sur de Patagonia y Tierra del Fuego. Estos procesos indican la ocurrencia de cambios climáticos no forzados por intervención humana en la atmósfera. Los períodos fríos habrían sido progresivamente menos intensos desde la Gran Glaciación Patagónica, ocurrida hace 1 millón de años. Durante el Holoceno y los tiempos históricos, las glaciaciones se restringieron a las zonas superiores a los 900 m s.n.m. y el deterioro climático no habría afectado significativamente al ecosistema bosque ubicado a menos de 400 m s.n.m. Un importante período cálido ocurrido en tiempos históricos fue registrado en las zonas de altura en Patagonia Norte y en las cercanías al nivel del mar en Tierra del Fuego</text>
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                <text>2007</text>
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                <text>Bioclimatologia, Cambios Climáticos, Patagonia Argentinca, climatologia</text>
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                <text>Boletín Geográfico</text>
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                <text>Departamento de Geografía, Facultad de Humanidades, Universidad Nacional del Comahue</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Geography. Anthropology. Recreation, Environmental sciences, Human ecology. Anthropogeography</text>
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                <text>&lt;a href="http://revele.uncoma.edu.ar/htdoc/revele/index.php/geografia/article/view/100/110" target="_blank" rel="noreferrer noopener"&gt;http://revele.uncoma.edu.ar/htdoc/revele/index.php/geografia/article/view/100/110&lt;/a&gt;</text>
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                  <text>Coronavirus</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Chloroquine for COVID-19: rationale, facts, hopes</text>
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            <description>An entity primarily responsible for making the resource</description>
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                <text>Andrea Cortegiani, Sharon Einav, Mariachiara Ippolito, Giulia Ingoglia</text>
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                <text>2020</text>
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                <text>Pneumonia, chloroquine, coronavirus, SARS-CoV-2, COVID-19</text>
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                <text>DOI: 10.1186/s13054-020-02932-4</text>
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            <description>A related resource from which the described resource is derived</description>
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                <text>Critical Care</text>
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                <text>BMC</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Medical emergencies. Critical care. Intensive care. First aid</text>
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                  <text>Coronavirus</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Global Psychological Implications of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and Coronavirus Disease-2019 (COVID-19). What Can Be Learned From Italy. Reflections, Perspectives, Opportunities</text>
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                <text>Andrea De Giorgio</text>
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                <text>On December 31, 2019, the Chinese authorities announced that in the city of Wuhan, Hubei Province, central-eastern China, a cluster of pneumonia cases of unknown etiology had developed. A new coronavirus (SARS-CoV-2) that causes serious problems like pneumonia and even death, has been discovered. This new disease (COVID-19) has spread also in Italy starting from the first recognized case on February 20. Beyond its biological implications, this coronavirus allows us many psychological reflections. A new virus is indeed a potentially serious problem for mankind, but it can also be an opportunity to bring the focus back to us, to observe what is happening, who we are and how we are reacting both as individuals and as a population. Even positive implication of this pandemic was discussed.</text>
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                <text>2020</text>
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                <text>In the Milan experience, Covid-19 emergency crucial issues were already hidden weaknesses of the city and its region: the limited capacity of transit transport, roads and public spaces, with crowding problems for both work and leisure. The challenge is to regenerate the competitive “human measure” of Milan, based on its unique relationship between public spaces and mobility, overcoming its health risk. The report raises a question on the established transit-oriented development approach, focusing on spaces “in between” and not only on nodes and networks. The traditional “invariants” welcome changes: the spatial structure of the public realm becomes a platform for ever-changing mobility and services, providing quality of life for communities, users and tourists. With this respect, streets represent by far the most strategic asset of the urban public realm. They can be reshaped in resilient infrastructure capable to respond to new forms of mobility based on a renewed Mobility-as-A-Service paradigm, as final result of different travel behaviors of the post pandemic scenario, among which an expected reduction of the overall “mobility consumption” (space) and new temporal urban rhythms (time). To this end, short-term and responsive planning becomes a crucial opportunity to enable rapidly deployed responses, through an extensive use of new analytical tools based on Open and Big data analytics and computer-based simulations.</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="40">
            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="36650">
                <text>2020</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="36651">
                <text>mobility, data analytics, public space, resilient infrastructure</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="43">
            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
            <elementTextContainer>
              <elementText elementTextId="36652">
                <text>DOI: 10.6092/1970-9870/6857</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="36653">
                <text>TeMA: Journal of Land Use, Mobility and Environment</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="36654">
                <text>Università di Napoli Federico II</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="36655">
                <text>Transportation engineering, Urbanization. City and country</text>
              </elementText>
            </elementTextContainer>
          </element>
        </elementContainer>
      </elementSet>
    </elementSetContainer>
  </item>
</itemContainer>
