146 10 20655 https://socictopen.socict.org/files/original/2b8bf34c71c113544b0d42060bedc065.pdf 7bb2b005c22ead7600503925174362ff Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource All hands on deck: early graduation of senior medical students in the COVID-19 pandemic Creator An entity primarily responsible for making the resource Laith Alexander, James Ashcroft, Matthew H. V. Byrne, Jonathan Wan Description An account of the resource During the COVID-19 pandemic, early graduation of senior medical students simultaneously offers useful clinical experience in preparation for junior doctor posts, whilst helping address staffing shortages due to illness or self-isolation. Having recently graduated early from medical school, we offer our reflections on the obstacles and opportunities associated with working in an uncharted clinical environment. We are not the only ones on a steep learning curve at this time: this pandemic will challenge and provide learning for staff of all levels. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource covid-19, medical students, graduation, junior doctors Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine, Special aspects of education https://socictopen.socict.org/files/original/d179046a9e1d5af0d2830b300c3135a9.pdf a442fbb50ff0ccdd77f2c28fac62e8a2 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource All India difficult airway association (AIDAA) consensus guidelines for airway management in the operating room during the COVID-19 pandemic Creator An entity primarily responsible for making the resource Rakesh Garg, Jigeeshu Vasishtha Divatia, Pankaj Kundra, Sabyasachi Das, Syed Moied Ahmed, Sheila Nainan Myatra, Amit Shah, Apeksh Patwa, Jeson Rajan Doctor, Sumalatha Radhakrishna Shetty Description An account of the resource Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) which causes coronavirus disease (COVID-19) is a highly contagious virus. The closed environment of the operation room (OR) with aerosol generating airway management procedures increases the risk of transmission of infection among the anaesthesiologists and other OR personnel. Wearing complete, fluid impermeable personal protective equipment (PPE) for airway related procedures is recommended. Team preparation, clear methods of communication and appropriate donning and doffing of PPEs are essential to prevent spread of the infection. Optimal pre oxygenation, rapid sequence induction and video laryngoscope aided tracheal intubation (TI) are recommended. Supraglottic airways (SGA) and surgical cricothyroidotomy should be preferred for airway rescue. High flow nasal oxygen, face mask ventilation, nebulisation, small bore cannula cricothyroidotomy with jet ventilation should be avoided. Tracheal extubation should be conducted with the same levels of precaution as TI. The All India Difficult Airway Association (AIDAA) aims to provide consensus guidelines for safe airway management in the OR, while attempting to prevent transmission of infection to the OR personnel during the COVID-19 pandemic. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource coronavirus, Pandemic, airway, personal protective equipment, Operation Room, SARS-CoV-2, COVID-19 Identifier An unambiguous reference to the resource within a given context DOI: 10.4103/ija.IJA_498_20 Source A related resource from which the described resource is derived Indian Journal of Anaesthesia Publisher An entity responsible for making the resource available Wolters Kluwer Medknow Publications Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Anesthesiology https://socictopen.socict.org/files/original/0f6240079d14654d5e12a3fcf4f40a4e.pdf a442fbb50ff0ccdd77f2c28fac62e8a2 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource All India difficult airway association (AIDAA) consensus guidelines for airway management in the operating room during the COVID-19 pandemic Creator An entity primarily responsible for making the resource Apeksh Patwa, Amit Shah, Rakesh Garg, Jigeeshu Vasishtha Divatia, Pankaj Kundra, Jeson Rajan Doctor, Sumalatha Radhakrishna Shetty, Syed Moied Ahmed, Sabyasachi Das, Sheila Nainan Myatra Description An account of the resource Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) which causes coronavirus disease (COVID-19) is a highly contagious virus. The closed environment of the operation room (OR) with aerosol generating airway management procedures increases the risk of transmission of infection among the anaesthesiologists and other OR personnel. Wearing complete, fluid impermeable personal protective equipment (PPE) for airway related procedures is recommended. Team preparation, clear methods of communication and appropriate donning and doffing of PPEs are essential to prevent spread of the infection. Optimal pre oxygenation, rapid sequence induction and video laryngoscope aided tracheal intubation (TI) are recommended. Supraglottic airways (SGA) and surgical cricothyroidotomy should be preferred for airway rescue. High flow nasal oxygen, face mask ventilation, nebulisation, small bore cannula cricothyroidotomy with jet ventilation should be avoided. Tracheal extubation should be conducted with the same levels of precaution as TI. The All India Difficult Airway Association (AIDAA) aims to provide consensus guidelines for safe airway management in the OR, while attempting to prevent transmission of infection to the OR personnel during the COVID-19 pandemic. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource coronavirus, covid-19, Pandemic, Personal protective equipment, SARS-CoV-2, airway, Operation room Identifier An unambiguous reference to the resource within a given context 10.4103/ija.IJA_498_20 Source A related resource from which the described resource is derived Biotemas Publisher An entity responsible for making the resource available Universidade Federal de Santa Catarina Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Anesthesiology https://socictopen.socict.org/files/original/1e6f3489d7e4b50d38ffe35bf7c83a94.pdf 2af3fd83cb839c1a0ba8810c03281bd4 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource All India Ophthalmological Society – Indian Journal of Ophthalmology consensus statement on preferred practices during the COVID-19 pandemic Creator An entity primarily responsible for making the resource Jagat Ram, Santosh G Honavar, S Natarajan, Namrata Sharma, Rohit Shetty, Sabyasachi Sengupta, Atul Kumar, Kim Ramasamy, Kasturi Bhattacharjee, Ashvin Agarwal, Rohit Khanna, Elesh Jain, Girish S Rao, Mahipal S Sachdev, Tatyarao P Lahane, Writing Committee on behalf of the All India Ophthalmological Society - Indian Journal of Ophthalmology Expert Group for COVID-19 Practice Guidelines Description An account of the resource The COVID-19 pandemic has taken tragic proportions and has disrupted lives globally. In the wake of governmental lockdowns, ophthalmologists need practical and actionable guidelines based on advisories from national health departments on how to conduct their duties during nationwide lockdowns and after these are lifted. In this paper, we present a preferred practice pattern (PPP) based on consensus discussions between leading ophthalmologists and health care professionals in India including representatives from major governmental and private institutions as well as the All India Ophthalmological Society leadership. In this document, the expert panel clearly defines the range of activities for Indian ophthalmologists during the ongoing lockdown phase and precautions to be taken once the lockdown is lifted. Guidelines for triage, governmental guidelines for use of personal protective equipment from ophthalmologists' point of view, precautions to be taken in the OPD and operating room as well as care of various ophthalmic equipment have been described in detail. These guidelines will be applicable to all practice settings including tertiary institutions, corporate and group practices and individual eye clinics and should help Indian ophthalmologists in performing their professional responsibilities without being foci of disease transmission. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource Guidelines, Ophthalmology, consensus, Pandemic, precautions, COVID-19, lockdown, preferred practice Identifier An unambiguous reference to the resource within a given context DOI: 10.4103/ijo.IJO_871_20 Source A related resource from which the described resource is derived Indian Journal of Ophthalmology Publisher An entity responsible for making the resource available Wolters Kluwer Medknow Publications Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Ophthalmology https://socictopen.socict.org/files/original/899f3488ec2c07b122efb620126d54f5.pdf 13e2bffe962d65ee0567889d8685f864 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource All STEM-Ed up: Gaps and Silences around Ecological Education in Australia Creator An entity primarily responsible for making the resource Annette Gough Description An account of the resource Similar to much of the world, the Australian Government has a vision for society to be engaged in and enriched by science which has, as its prime focus, building skills and capabilities in Science, Technology, Engineering and Mathematics (STEM). Simultaneously, the Government’s policies and projects, including in education, ignore intergovernmental environmental initiatives, such as the Intergovernmental Panel on Climate Change (IPCC) and the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services (IPBES). This article critically analyses the Australian Government’s STEM and climate change education policies and programs, including Citizen Science activities, through an ecological education lens and finds many, and growing, gaps and silences in these areas. It compares the Australian situation with STEM and ecological education-related developments in several other countries. In the context of significant global changes such as the COVID-19 pandemic, this article argues that it is time for the Australian education agenda to take the Government’s international responsibilities seriously, include meaningful engagement with climate change and biodiversity related topics through ecological education in the school curriculum, and discusses what a reimagined school science curriculum could look like. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource climate change, sustainable development goals, stem, Environmental Education, ecological education, goals for schooling Identifier An unambiguous reference to the resource within a given context 10.3390/su13073801 Source A related resource from which the described resource is derived Biotemas Publisher An entity responsible for making the resource available Universidade Federal de Santa Catarina Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Environmental effects of industries and plants, Renewable energy sources, Environmental sciences https://socictopen.socict.org/files/original/8202dbbdb163012bcab784a0659d595d.pdf f3cb24ecb5e7eb0b9ac8d40da7c11b94 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Allelic Variation in the Toll-Like Receptor Adaptor Protein Ticam2 Contributes to SARS-Coronavirus Pathogenesis in Mice Creator An entity primarily responsible for making the resource Lisa E Gralinski, Vineet D. Menachery, Andrew P. Morgan, Allison L. Totura, Anne Beall, Jacob Kocher, Jessica Plante, D. Corinne Harrison-Shostak, Alexandra Schäfer, Fernando Pardo-Manuel de Villena, Martin T. Ferris, Ralph S. Baric Description An account of the resource Host genetic variation is known to contribute to differential pathogenesis following infection. Mouse models allow direct assessment of host genetic factors responsible for susceptibility to Severe Acute Respiratory Syndrome coronavirus (SARS-CoV). Based on an assessment of early stage lines from the Collaborative Cross mouse multi-parent population, we identified two lines showing highly divergent susceptibilities to SARS-CoV: the resistant CC003/Unc and the susceptible CC053/Unc. We generated 264 F2 mice between these strains, and infected them with SARS-CoV. Weight loss, pulmonary hemorrhage, and viral load were all highly correlated disease phenotypes. We identified a quantitative trait locus of major effect on chromosome 18 (27.1–58.6 Mb) which affected weight loss, viral titer and hemorrhage. Additionally, each of these three phenotypes had distinct quantitative trait loci [Chr 9 (weight loss), Chrs 7 and 12 (virus titer), and Chr 15 (hemorrhage)]. We identified Ticam2, an adaptor protein in the TLR signaling pathways, as a candidate driving differential disease at the Chr 18 locus. Ticam2−/− mice were highly susceptible to SARS-CoV infection, exhibiting increased weight loss and more pulmonary hemorrhage than control mice. These results indicate a critical role for Ticam2 in SARS-CoV disease, and highlight the importance of host genetic variation in disease responses. Date A point or period of time associated with an event in the lifecycle of the resource 2017 Subject The topic of the resource SARS-CoV, Collaborative Cross, F2, Ticam2, host susceptibility genes, Multiparent Advanced Generation Inter-Cross (MAGIC), multiparental populations, MPP Identifier An unambiguous reference to the resource within a given context DOI: 10.1534/g3.117.041434 Source A related resource from which the described resource is derived G3: Genes, Genomes, Genetics Publisher An entity responsible for making the resource available Genetics Society of America Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Genetics Language A language of the resource EN https://socictopen.socict.org/files/original/5aeeedf68992aac3d92256694d38aa9c.pdf ab50de5589b1b7191e5a910a7e8e9812 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Agricultura sostenible Description An account of the resource Dominio científico: Agricultura sostenible Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Allelopathic effects of orange (Citrus sinensis L.) peel essential oil Efeitos alelopáticos do óleo essencial da casca da laranja (Citrus sinensis L.) Creator An entity primarily responsible for making the resource Jose Pedro Nepomuceno Ribeiro, Maria Inês Salgueiro Lima Description An account of the resource Crop weeds are the main problem in agriculture, causing a worldwide annual loss of about US$95 billion. The principal method for control is the use of synthetic herbicides. The continued use of these products increases crop costs, reduces crop quality, and leaves toxic residues in the environment, which are a threat to human and livestock health. Therefore, there is a demand for environmentally friendly methods of weed control. The use of allelopathic compounds from crop residues is an alternative. Orange is one of the biggest crops in the world, and its cultivation generates large amounts of residues. There is strong evidence of bioactivity in orange peel essential oil. Therefore, the objective in this work was to verify the allelopathic proprieties of this oil. We extracted the oil from the peels of recently discarded oranges using water vapor flow with a Clevenger extractor, and tested it against the growth of Euphorbia heterophylla L. and Ipomoea grandifolia (Dammer) O'Donell seedlings when placed in contact with the oil vapor. The results were both quantitative and qualitative in the inhibition of the seedlings.Plantas daninhas são o principal problema da agricultura no mundo, causando anualmente um prejuízo de U$95 bilhões. A principal forma de combate às plantas daninhas são os herbicidas sintéticos. Entretanto, o uso continuado desses produtos encarece a produção, reduz a qualidade dos alimentos, deixa resíduos tóxicos no ambiente e ameaça a saúde humana e animal. Existe assim, uma demanda por técnicas menos agressivas de controle. O uso de compostos alelopáticos de descartes de culturas para esse fim é uma alternativa. A laranja é uma das maiores culturas do mundo, e gera grandes quantidades de resíduos. Existem evidências da bioatividade no óleo essencial da casca da laranja. Nesse trabalho, nosso objetivo foi verificar a existência de propriedades alelopáticas desse óleo. Para isto, extraímos o óleo por arraste de vapor de água utilizando o aparelho de Clevenger, e colocamos os produtos volatilizáveis do óleo essencial em contato com plântulas de Euphorbia heterophylla L. e Ipomoea grandifolia (Dammer) O'Donell. O resultado foi inibição tanto quantitativa quanto qualitativa das plântulas Date A point or period of time associated with an event in the lifecycle of the resource 2012 Subject The topic of the resource Agricultura orgânica, Controle de pragas, Crop residues, Limonene, alelopatia, allelopathy, descartes de cultivos, limoneno, organic agriculture, plantas invasoras de culturas, weed controly, weeds Identifier An unambiguous reference to the resource within a given context 10.1590/S0102-33062012000100025 Source A related resource from which the described resource is derived Acta Botânica Brasílica Publisher An entity responsible for making the resource available Sociedade Botânica do Brasil Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Botany Relation A related resource <a href="http://www.scielo.br/scielo.php?script=sci_arttext&amp;pid=S0102-33062012000100025" target="_blank" rel="noreferrer noopener">http://www.scielo.br/scielo.php?script=sci_arttext&amp;pid=S0102-33062012000100025</a> https://socictopen.socict.org/files/original/c3b9017c7c10af408862a2070d025b55.pdf dbc283f3b6cd554a619ba61462005be3 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Allergic Reactions and Anaphylaxis to LNP-Based COVID-19 Vaccines. Creator An entity primarily responsible for making the resource S Moein Moghimi Date A point or period of time associated with an event in the lifecycle of the resource 2021 Identifier An unambiguous reference to the resource within a given context 10.1016/j.ymthe.2021.01.030 Source A related resource from which the described resource is derived Molecular therapy : the journal of the American Society of Gene Therapy https://socictopen.socict.org/files/original/592d6eced0beeddcfa0b42b467b3ef62.pdf 6e0fdcd698b5b2c3a36161af43691d4b Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Agricultura sostenible Description An account of the resource Dominio científico: Agricultura sostenible Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Allium pyrenaicum Costa and Vayr. (Liliaceae) en el Valle del Roncal (Pirineo Occidental, Navarra) : Propuesta para su protección legal / Creator An entity primarily responsible for making the resource Lorda López, M. Description An account of the resource Allium pyrenaicum (Liliaceae) se cita por primera vez para Navarra (Pirineo Occidental) ; se trata de una planta endémica del Pirineo, con área disyunta en Cataluña, al Este, y en Aragón-Navarra, al Oeste. Además de los datos corológicos, en esta nota se estima el tamaño de la población y se comentan su hábitat, posibles riesgos y grado de protección. Tambien se aporta in mapa de distribución del taxón y fotografía de este ajo silvestre. Date A point or period of time associated with an event in the lifecycle of the resource 2009 Subject The topic of the resource Allium pyrenaicum; Liliaceae; distribución; ecología; riesgos; protección; Pirineo Occidental; Navarra Source A related resource from which the described resource is derived Munibe Ciencias Naturales Publisher An entity responsible for making the resource available Sociedad de Ciencias Aranzadi Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Science Relation A related resource <a href="http://www.aranzadi.eus/fileadmin/docs/Munibe/2009035045CN.pdf" target="_blank" rel="noreferrer noopener">http://www.aranzadi.eus/fileadmin/docs/Munibe/2009035045CN.pdf</a> https://socictopen.socict.org/files/original/06736b2863175c780527157e6cf30ce7.pdf 401b24a3685109034cb87004bc80e0da Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Allo-priming as a universal anti-viral vaccine: protecting elderly from current COVID-19 and any future unknown viral outbreak Creator An entity primarily responsible for making the resource Reuven Or, Michael Har-Noy Description An account of the resource Abstract Background We present the rationale for a novel allo-priming approach to serve the elderly as a universal anti-virus vaccine, as well serving to remodel the aging immune system in order to reverse immunosenescence and inflammaging. This approach has the potential to protect the most vulnerable from disease and provide society an incalculable economic benefit. Allo-priming healthy elderly adults is proposed to provide universal protection from progression of any type of viral infection, including protection against progression of the current outbreak of COVID-19 infection, and any future variants of the causative SARS-CoV-2 virus or the next ‘Disease X’. Allo-priming is an alternative approach for the COVID-19 pandemic that provides a back-up in case vaccination strategies to elicit neutralizing antibody protection fails or fails to protect the vulnerable elderly population. The allo-priming is performed using activated, intentionally mismatched, ex vivo differentiated and expanded living Th1-like cells (AlloStim®) derived from healthy donors currently in clinical use as an experimental cancer vaccine. Multiple intradermal injections of AlloStim® creates a dominate titer of allo-specific Th1/CTL memory cells in circulation, replacing the dominance of exhausted memory cells of the aged immune system. Upon viral encounter, by-stander activation of the allo-specific memory cells causes an immediate release of IFN-ϒ, leading to development of an “anti-viral state”, by-stander activation of innate cellular effector cells and activation of cross-reactive allo-specific CTL. In this manner, the non-specific activation of allo-specific Th1/CTL initiates a cascade of spatial and temporal immune events which act to limit the early viral titer. The release of endogenous heat shock proteins (HSP) and DAMP from lysed viral-infected cells, in the context of IFN-ϒ, creates of conditions for in situ vaccination leading to viral-specific Th1/CTL immunity. These viral-specific Th1/CTL provide sterilizing immunity and memory for protection from disease recurrence, while increasing the pool of Th1/CTL in circulation capable of responding to the next viral encounter. Conclusion Allo-priming has potential to provide universal protection from viral disease and is a strategy to reverse immunosenescence and counter-regulate chronic inflammation (inflammaging). Allo-priming can be used as an adjuvant for anti-viral vaccines and as a counter-measure for unknown biological threats and bio-economic terrorism. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource immunotherapy, cell therapy, vaccine, immunosenescence, Inflammaging, COVID-19 Identifier An unambiguous reference to the resource within a given context DOI: 10.1186/s12967-020-02363-3 Source A related resource from which the described resource is derived Journal of Translational Medicine Publisher An entity responsible for making the resource available BMC Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine