153 10 20655 https://socictopen.socict.org/files/original/c70d6778de044892f063f11e1361f06a.pdf db53c42fc6260dfa58f72d05adff6553 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Amino-3,5-Dicyanopyridines Targeting the Adenosine Receptors. Ranging from Pan Ligands to Combined A1/A2B Partial Agonists Creator An entity primarily responsible for making the resource Daniela Catarzi, Flavia Varano, Katia Varani, Fabrizio Vincenzi, Silvia Pasquini, Diego Dal Ben, Rosaria Volpini, Vittoria Colotta Description An account of the resource The amino-3,5-dicyanopyridine derivatives belong to an intriguing series of adenosine receptor (AR) ligands that has been developed by both academic researchers and industry. Indeed, the studies carried out to date underline the versatility of the dicyanopyridine scaffold to obtain AR ligands with not only a wide range of affinities but also with diverse degrees of efficacies at the different ARs. These observations prompted us to investigate on the structure–activity relationships (SARs) of this series leading to important previously reported results. The present SAR study has helped to confirm the 1H-imidazol-2-yl group at R2 position as an important feature for producing potent AR agonists. Moreover, the nature of the R1 substituent highly affects not only affinity/activity at the hA1 and hA2B ARs but also selectivity versus the other subtypes. Potent hA1 and hA2B AR ligands were developed, and among them, the 2-amino-6-[(1H-imidazol-2-ylmethyl)sulfanyl]-4-[4-(prop-2-en-1-yloxy)phenyl]pyridine-3,5-dicarbonitrile (3) is active in the low nanomolar range at these subtypes and shows a good trend of selectivity versus both the hA2A and hA3 ARs. This combined hA1/hA2B partial agonist activity leads to a synergistic effect on glucose homeostasis and could potentially be beneficial in treating diabetes and related complications. Date A point or period of time associated with an event in the lifecycle of the resource 2019 Subject The topic of the resource G protein-coupled receptors, adenosine a_2b receptor ligands, adenosine a₁ receptor ligands, aminopyridine-3, 5-dicarbonitriles, ligand-adenosine receptor modeling studies Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/ph12040159 Source A related resource from which the described resource is derived Pharmaceuticals Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Pharmacy and materia medica Language A language of the resource EN https://socictopen.socict.org/files/original/c8ea30074bebbdec93f3ccd588ad64ec.pdf c547e9c7452267958978f46f839abe7a Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Aminoglycosides as potential inhibitors of SARS-CoV-2 main protease: an in silico drug repurposing study on FDA-approved antiviral and anti-infection agents. Creator An entity primarily responsible for making the resource Shafiul Haque, Mohammed S. Alqahtani, Ali S. Alqahtani, Qamar Zia, Anzarul Haque, Omar M. Almarfadi, Saeed Banawas, Keshav L. Ameta, Mohammad Z Ahmed Description An account of the resource The emergence and spread of SARS-CoV-2 throughout the world has created an enormous socioeconomic impact. Although there are several promising drug candidates in clinical trials, none is available clinically. Thus, the drug repurposing approach may help to overcome the current pandemic. The main protease (Mpro) of SARS-CoV-2 is crucial for cleaving nascent polypeptide chains. Here, FDA-approved antiviral and anti-infection drugs were screened by high-throughput virtual screening (HTVS) followed by re-docking with standard-precision (SP) and extra-precision (XP) molecular docking. The most potent drug's binding was further validated by free energy calculations (Prime/MM-GBSA) and molecular dynamics (MD) simulation. Out of 1397 potential drugs, 157 showed considerable affinity toward Mpro. After HTVS, SP, and XP molecular docking, four high-affinity lead drugs (Iodixanol, Amikacin, Troxerutin, and Rutin) with docking energies -10.629 to -11.776kcal/mol range were identified. Among them, Amikacin exhibited the lowest Prime/MM-GBSA energy (-73.800kcal/mol). It led us to evaluate other aminoglycosides (Neomycin, Paramomycin, Gentamycin, Streptomycin, and Tobramycin) against Mpro. All aminoglycosides were bound to the substrate-binding site of Mpro and interacted with crucial residues. Altogether, Amikacin was found to be the most potent inhibitor of Mpro. MD simulations of the Amikacin-Mpro complex suggested the formation of a complex stabilized by hydrogen bonds, salt bridges, and van der Waals interactions. Aminoglycosides may serve as a scaffold to design potent drug molecules against COVID-19. However, further validation by in vitro and in vivo studies is required before using aminoglycosides as an anti-COVID-19 agent. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource covid-19, SARS-CoV-2, Antibiotics, aminoglycosides, Docking and simulation Identifier An unambiguous reference to the resource within a given context 10.1016/j.jiph.2021.01.016 Source A related resource from which the described resource is derived Journal of infection and public health https://socictopen.socict.org/files/original/ad1577cce717725af2a3c88de08ccd38.pdf 5c014106ce01899a96eb0b97487a222e Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Agricultura sostenible Description An account of the resource Dominio científico: Agricultura sostenible Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Ampliación de la distribución de Lutzomyia longipalpis (Lutz & Neiva, 1912) (Diptera: Psychodidae) en el departamento de Caldas: potencial aumento del riesgo de leishmaniasis visceral Creator An entity primarily responsible for making the resource Luz Adriana Acosta, Karina Mondragon-Shem, Daniela Vergara, Andrés Velez-Mira, Horacio Cadena, Lina Maria Carrillo Description An account of the resource Introducción. Diversos estudios a nivel taxonómico y molecular sugieren que Lutzomyia longipalpis, principal vector de la leishmaniasis visceral en Latinoamérica, es un complejo de especies con ampliadistribución a lo largo del continente y con adaptaciones a diferentes hábitats. Objetivo. Realizar vigilancia entomológica en el área de influencia de la hidroeléctrica Miel I. Materiales y métodos. Se utilizaron trampas adhesivas en una intersección de 400 km, aproximadamente, para la captura de insectos, los cuales fueron identificados con la clave taxonómica de Youngy Duncan. Resultados. En este estudio se reporta la presencia de Lu. longipalpis en los municipios de Norcasia a una altitud de 392 msnm y en Marquetalia a 1.387 msnm; es el primer reporte a esta altura para esta especie en Colombia. Conclusiones. Se sugiere que la ampliación de la distribución geográfica y altitudinal de Lu. longipalpis en el país podría estar relacionada con la existencia del complejo de especies Lu. longipalpis, o a factores ambientales como el aumento de temperatura debido al cambio climático global que viene sucediendo en las últimas décadas. Esta última hipótesis sugeriría que se están creando nuevos hábitats propiciospara el establecimiento de Lu. longipalpis, lo cual genera un nuevo riesgo epidemiológico de posiblesnuevos focos de leishmaniasis visceral en el país.   doi: http://dx.doi.org/10.7705/biomedica.v33i2.762 Date A point or period of time associated with an event in the lifecycle of the resource 2013 Identifier An unambiguous reference to the resource within a given context 10.7705/biomedica.v33i2.762 Source A related resource from which the described resource is derived Biomédica: revista del Instituto Nacional de Salud Publisher An entity responsible for making the resource available Instituto Nacional de Salud Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine, Arctic medicine. Tropical medicine Relation A related resource <a href="http://www.revistabiomedica.org/index.php/biomedica/article/view/762" target="_blank" rel="noreferrer noopener">http://www.revistabiomedica.org/index.php/biomedica/article/view/762</a> https://socictopen.socict.org/files/original/a8c7776328f8163af032111af21c8fe5.pdf 509a702b6eed5dbc8ba815599887348a Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Agricultura sostenible Description An account of the resource Dominio científico: Agricultura sostenible Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Ampliación de la distribución geográfica de cacomixtle tropical, bassariscus sumichrasti (carnivora: procyonidae) en méxico Creator An entity primarily responsible for making the resource OSCAR VILLARREAL-EB, GERMÁN MENDOZA M, JULIO CAMACHORONQUILLO, FRANCISCO FRANCO-GUERRA, JORGE HERNÁNDEZHERNÁNDEZ, FERNANDO PLATA P Description An account of the resource El cacaomixtle tropical (Bassariscus sumichrasti: Saussure, 1860: Carnivora: Procyonidae) se distribuye desde el sureste de México hasta Panamá (COATESESTRADA y ESTRADA, 1986; EMMONS, 1999). Su hábitat son las selvas altas y medianas perennifolias, el bosque mesófilo de montaña y las áreas húmedas y densas de bosques de encino-pino, desde el nivel del mar hasta los 2.900 m. de altitud. La especie es simpátrica con el cacomixtle común (Bassariscus astutus: Lichtenstein, 1830) en algunas zonas de los estados de Guerrero, Veracruz y Oaxaca; se ha registrado en el sureste de México y en la Península de Yucatán (NAVA, 2005). La especie está incluida en el Apéndice III de CITES (Convention on International Trade in Endangered Species), en México está considerada como sujeta a protección especial por el Instituto Nacional de Ecología, en la norma oficial mexicana NOM-059-ECOL (DIARIO OFICIAL DE LA FEDERACIÓN, 2001) Date A point or period of time associated with an event in the lifecycle of the resource 2012 Subject The topic of the resource Bassariscus sumichrasti Identifier An unambiguous reference to the resource within a given context 10.24188/recia.v4.n1.2012.305 Source A related resource from which the described resource is derived Revista Colombiana de Ciencia Animal Recia Publisher An entity responsible for making the resource available Universidad de Sucre Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Agriculture (General), Agriculture, Animal culture Relation A related resource <a href="https://revistas.unisucre.edu.co/index.php/recia/article/view/305" target="_blank" rel="noreferrer noopener">https://revistas.unisucre.edu.co/index.php/recia/article/view/305</a> https://socictopen.socict.org/files/original/cec59d7f904959442d52d30ef6b19410.pdf 207f885d00c1d762bcecdcf07d320014 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Agricultura sostenible Description An account of the resource Dominio científico: Agricultura sostenible Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Ampliación del ámbito geográfico-altitudinal y uso de hábitats suburbanos por la mascarita pico grueso (Geothlypis poliocephala) Geographic-altitudinal range extension and suburban habitat use of the Grey-crowned Yellowthroat (Geothlypis poliocephala) Creator An entity primarily responsible for making the resource Ian MacGregor-Fors, Jorge E Schondube, Lorena Morales-Pérez, Javier Quesada Description An account of the resource Se presenta el primer registro de la mascarita pico grueso (Geothlypis poliocephala) para la región del Eje Neovolcánico Transversal, México. Los sitios donde registramos/capturamos esta especie se encuentran en los suburbios de la ciudad de Morelia, 427 m arriba del ámbito altitudinal descrito para la especie. Esto puede deberse a 2 factores: 1) la urbanización que genera hábitats propicios para la especie en su periferia, y 2 ) el incremento de la temperatura en la región en la que se encuentra la ciudad de Morelia. Ambos factores facilitan que esta especie de tierras bajas pueda habitar en áreas de mayor altitud. Así, nuestros registros sugieren que la mascarita pico grueso puede catalogarse como especie potencial a utilizar hábitats suburbanos cuando éstos son similares a los hábitats en los que se distribuye de manera natural.The first record of the Grey-crowned Yellowthroat (Geothlypis poliocephala) in the Transmexican Volcanic Belt biogeographic region (Mexico), within the Morelia city suburbs is presented. Sites were this parulid was sighted / captured were located 427 m higher than its described altitudinal range. This could be due to 2 factors: 1) urbanization generates suitable habitats for this species in periurban areas, and 2) temperature values have increased in the region where the city of Morelia is located. These factors allow that a lowland bird species can inhabit in more elevated areas. Thus, our records suggest that the Grey-crowned Yellowthroat can be catalogued as potential to use suburban environments when these are similar to those used by the species on its natural distribution area. Date A point or period of time associated with an event in the lifecycle of the resource 2008 Subject The topic of the resource Distribución geográfica, Ecología urbana, Geothlypis poliocephala, Grey-crowned Yellowthroat, Morelia, México, Urban ecology, altitudinal range, geographic range, mascarita pico grueso, ámbito altitudinal Source A related resource from which the described resource is derived Revista Mexicana de Biodiversidad Publisher An entity responsible for making the resource available Universidad Nacional Autónoma de México Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Biology (General) Relation A related resource <a href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S1870-34532008000200027" target="_blank" rel="noreferrer noopener">http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S1870-34532008000200027</a> https://socictopen.socict.org/files/original/35b72510ff0a04d569db6fa7e4f32954.pdf 7fa348d5e06c15e1ef7b8f62d017c85f Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Agricultura sostenible Description An account of the resource Dominio científico: Agricultura sostenible Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Ampliando la frontera agrícola de la papa (Solanum tubrosum L.) para disminuir los efectos del cambio climático Creator An entity primarily responsible for making the resource Gabriel Julio, Ismael Ruiz, Xavier Cuesta Description An account of the resource La mayoría de los cultivares tradicionales de papa no están adaptadas a las condiciones del cultivo provocadas por el cambio climático, que hacen disminuir drásticamente los rendimientos e incluso perder completamente la cosecha en muchos lugares desfavorecidos. En países en vías de desarrollo, como en Latinoamérica, esta situación afecta a la base alimentaria de las comunidades, y al sostenimiento económico y social; los agricultores optan por migrar en búsqueda de otros medios de subsistencia. Ante esta problemática, se estableció un consorcio de ocho instituciones reconocidas de siete países para identificar y desarrollar cultivares de papa adaptados al cambio climático y desarrollar metodologías y herramientas moleculares eficientes que aceleren este proceso. El proyecto logró cultivares con mejor adaptación a condiciones ambientales adversas en zonas productoras y zonas desfavorecidas. Se mejoró la competitividad del cultivo de la papa, que aumentó la superficie de su cultivo, y se diversificó la producción agraria, asegurando el suministro de alimentos en zonas deprimidas. Los agricultores cuentan con cultivares, con buena adaptación a los cambios en temperatura, precipitación, y mayor resistencia al tizón tardío (Phytphthora infestans). Los investigadores disponen de metodologías adecuadas para la evaluación de resistencias a estreses bióticos y abióticos y disponen de marcadores moleculares útiles para predecir el comportamiento agronómico y la adaptación. Date A point or period of time associated with an event in the lifecycle of the resource 2018 Subject The topic of the resource Competitividad|, agricultores, germoplasma, marcadores moleculares, reistencia Source A related resource from which the described resource is derived Universidad y Sociedad Publisher An entity responsible for making the resource available Universidad de Cienfuegos Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Special aspects of education, Social sciences (General) Relation A related resource <a href="https://rus.ucf.edu.cu/index.php/rus/article/view/760/861" target="_blank" rel="noreferrer noopener">https://rus.ucf.edu.cu/index.php/rus/article/view/760/861</a> https://socictopen.socict.org/files/original/7f266debb85bc4968fc41b53944e0bdf.pdf 7e5e7bdac8dc8ecc6e03ef8485587b5e Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Agricultura sostenible Description An account of the resource Dominio científico: Agricultura sostenible Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Ampliando procesos y espacios de aprendizaje en agroindustria con dinámica de sistemas Creator An entity primarily responsible for making the resource Juan Sebastian Angarita-Zapata, Carlos A. Vásquez Cardozo, Hugo H. Andrade-Sosa Description An account of the resource Se propone una estrategia de integración del modelado y simulación con dinámica de sistemas a la formación en agroindustria ofrecida por el Instituto de Proyección Regional y Educación a Distancia en la Universidad Industrial de Santander. El diseño y la aplicación la estrategia se realizaron mediante experiencias-experimento, con docentes y estudiantes, en la asignatura de Manejo de Nutrición Animal del programa agroindustrial. Tales experiencias giraron en torno al uso en clase de ambientes de aprendizaje para complementar el conocimiento teórico mediante experimentación simulada que permitiera acercarlo a experiencias reales en campo. A partir de las experiencias-experimento realizadas y de la estrategia planteada es posible concluir que los ambientes de aprendizaje permiten desarrollar capacidades de toma de decisiones apoyadas en escenarios de simulación muy cercanos a la realidad de campo. Date A point or period of time associated with an event in the lifecycle of the resource 2019 Subject The topic of the resource Agroindústria, Pensamiento sistémico, aprendizaje, dinámica de sistemas, modelado dinámico Identifier An unambiguous reference to the resource within a given context 10.19053/22160159.v10.n22.2019.6197 Source A related resource from which the described resource is derived Praxis & Saber Publisher An entity responsible for making the resource available Universidad Pedagógica y Tecnológica de Colombia Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Special aspects of education, Education Relation A related resource <a href="https://revistas.uptc.edu.co/index.php/praxis_saber/article/view/6197/7735" target="_blank" rel="noreferrer noopener">https://revistas.uptc.edu.co/index.php/praxis_saber/article/view/6197/7735</a> https://socictopen.socict.org/files/original/c154a140f847d1751ca4e64883f819f0.pdf 7decc439aab73547f603764adad13eaa Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Amplification of Emerging Viruses in a Bat Colony Creator An entity primarily responsible for making the resource Jan Felix Drexler, Victor Max Corman, Tom Wegner, Adriana Fumie Tateno, Rodrigo Melim Zerbinati, Florian Gloza-Rausch, Antje Seebens, Marcel A. Müller, Christian Drosten Description An account of the resource Bats host noteworthy viral pathogens, including coronaviruses, astroviruses, and adenoviruses. Knowledge on the ecology of reservoir-borne viruses is critical for preventive approaches against zoonotic epidemics. We studied a maternity colony of Myotis myotis bats in the attic of a private house in a suburban neighborhood in Rhineland-Palatinate, Germany, during 2008, 2009, and 2010. One coronavirus, 6 astroviruses, and 1 novel adenovirus were identified and monitored quantitatively. Strong and specific amplification of RNA viruses, but not of DNA viruses, occurred during colony formation and after parturition. The breeding success of the colony was significantly better in 2010 than in 2008, in spite of stronger amplification of coronaviruses and astroviruses in 2010, suggesting that these viruses had little pathogenic influence on bats. However, the general correlation of virus and bat population dynamics suggests that bats control infections similar to other mammals and that they may well experience epidemics of viruses under certain circumstances. Date A point or period of time associated with an event in the lifecycle of the resource 2011 Subject The topic of the resource Zoonoses, bats, coronavirus, astrovirus, adenovirus, Viruses Identifier An unambiguous reference to the resource within a given context DOI: 10.3201/eid1703.100526 Source A related resource from which the described resource is derived Emerging Infectious Diseases Publisher An entity responsible for making the resource available Centers for Disease Control and Prevention Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Infectious and parasitic diseases, Medicine Language A language of the resource EN https://socictopen.socict.org/files/original/3321a5b4fb1e6a225830c1cb7f7352a9.pdf 9e64c70a553ade942f33730fd7fb7cd8 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Amplifying the role of knowledge translation platforms in the COVID-19 pandemic response. Creator An entity primarily responsible for making the resource Racha Fadlallah, Lama Bou-Karroum, Fadi El-Jardali Description An account of the resource The COVID-19 pandemic presents the worst public health crisis in recent history. The response to the COVID-19 pandemic has been challenged by many factors, including scientific uncertainties, scarcity of relevant research, proliferation of misinformation and fake news, poor access to actionable evidence, time constraints, and weak collaborations among relevant stakeholders. Knowledge translation (KT) platforms, composed of organisations, initiatives and networks supporting evidence-informed policy-making, can play an important role in providing relevant and timely evidence to inform pandemic responses and bridge the gap between science, policy, practice and politics. In this Commentary, we highlight the emerging roles of KT platforms in light of the COVID-19 pandemic. We also reflect on the lessons learned from the efforts of a KT platform in a middle-income country to inform decision-making and practice during the COVID-19 pandemic. The lessons learned can be integrated into strengthening the role, structures and mandates of KT platforms as hubs for trustworthy evidence that can inform policies and practice during public health crises and in promoting their integration and institutionalisation within the policy-making processes. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource research, Data, Knowledge Translation, evidence, Evidence-informed policy-making, COVID-19 pandemic Identifier An unambiguous reference to the resource within a given context DOI: 10.1186/s12961-020-00576-y Source A related resource from which the described resource is derived Health Research Policy and Systems Publisher An entity responsible for making the resource available BMC https://socictopen.socict.org/files/original/acc1c57694eb1b3d2640555122ef03d1.pdf 34c1409ac9a8fd83515da765c36e733b Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Amylmetacresol/2,4-dichlorobenzyl alcohol, hexylresorcinol, or carrageenan lozenges as active treatments for sore throat Creator An entity primarily responsible for making the resource Morokutti-Kurz M, Graf C, Prieschl-Grassauer E Description An account of the resource Martina Morokutti-Kurz,&nbsp;Christine Graf,&nbsp;Eva Prieschl-Grassauer Marinomed Biotechnologie GmbH, Vienna, Austria Abstract: Up to 80% of sore throats are caused by viruses. Several over the counter products are available which provide symptomatic, not causal relief. For such lozenges, containing the antiseptics and local anesthetics amylmetacresol (AMC) and 2,4-dichlorobenzyl alcohol (DCBA) or hexylresorcinol (HR), recently an additional virucidal effect was published. Therefore, we tested a set of Strepsils&reg; lozenges, containing either HR (Max [#2]) or AMC/DCBA (Original [#3], Extra Strong [#4], Warm [#5], Orange and Vitamin C [#6], Sugar free Lemon [#7], Children/Strawberry [#8] and Soothing Honey and Lemon [#9]) for their antiviral efficiency against representatives of respiratory viruses known to cause sore throat: human rhinovirus (HRV) 1a, HRV8, influenza virus A H1N1n, Coxsackievirus A10, and human coronavirus (hCoV) OC43. The lozenges were tested head to head with Coldamaris&reg; lozenges (#1), which contain the patented antiviral iota-carrageenan. None of the tested AMC/DCBA or HR containing lozenges shows any antiviral effectiveness against HRV8 at the tested concentrations, whereas all are moderately active against HRV1a. Only lozenge #5 shows any activity against hCoV OC43 and Coxsackievirus A10 at the tested concentrations. Similarly, only lozenge #3 is moderately active against influenza A H1N1n virus. The data indicates that neither the isolated effect of the active ingredients nor the pH but rather one or more of the excipients of the specific formulations are responsible for the antiviral effect of some of the AMC/DCBA or HR containing lozenges. In contrast, carrageenan-containing lozenges are highly active against all viruses tested. In another experiment, we showed that binding and inactivation of virus particles by iota-carrageenan are fast and highly effective. During the residence time of the lozenge in the mouth, the viral titer is reduced by 85% and 91% for influenza A virus and hCoV OC43, respectively. Carrageenan-containing lozenges are, therefore, suitable as causative therapy against viral infections of the throat. Keywords: local anesthetics, polymer, antiviral, respiratory viruses Date A point or period of time associated with an event in the lifecycle of the resource 2017 Subject The topic of the resource Local anesthetics, polymer, antiviral, Respiratory viruses Identifier An unambiguous reference to the resource within a given context DOI: Source A related resource from which the described resource is derived International Journal of General Medicine Publisher An entity responsible for making the resource available Dove Medical Press Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine (General) Language A language of the resource EN