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                  <text>Coronavirus</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Zn(2+) inhibits coronavirus and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these viruses in cell culture.</text>
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                <text>Aartjan J. W. te Velthuis, Sjoerd H E van den Worm, Amy C. Sims, Ralph S. Baric, Eric J. Snijder, Martijn J van Hemert</text>
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                <text>Increasing the intracellular Zn(2+) concentration with zinc-ionophores like pyrithione (PT) can efficiently impair the replication of a variety of RNA viruses, including poliovirus and influenza virus. For some viruses this effect has been attributed to interference with viral polyprotein processing. In this study we demonstrate that the combination of Zn(2+) and PT at low concentrations (2 µM Zn(2+) and 2 µM PT) inhibits the replication of SARS-coronavirus (SARS-CoV) and equine arteritis virus (EAV) in cell culture. The RNA synthesis of these two distantly related nidoviruses is catalyzed by an RNA-dependent RNA polymerase (RdRp), which is the core enzyme of their multiprotein replication and transcription complex (RTC). Using an activity assay for RTCs isolated from cells infected with SARS-CoV or EAV--thus eliminating the need for PT to transport Zn(2+) across the plasma membrane--we show that Zn(2+) efficiently inhibits the RNA-synthesizing activity of the RTCs of both viruses. Enzymatic studies using recombinant RdRps (SARS-CoV nsp12 and EAV nsp9) purified from E. coli subsequently revealed that Zn(2+) directly inhibited the in vitro activity of both nidovirus polymerases. More specifically, Zn(2+) was found to block the initiation step of EAV RNA synthesis, whereas in the case of the SARS-CoV RdRp elongation was inhibited and template binding reduced. By chelating Zn(2+) with MgEDTA, the inhibitory effect of the divalent cation could be reversed, which provides a novel experimental tool for in vitro studies of the molecular details of nidovirus replication and transcription.</text>
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                <text>2010</text>
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                <text>DOI: 10.1371/journal.ppat.1001176</text>
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                <text>PLoS Pathogens</text>
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                <text>Public Library of Science (PLoS)</text>
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                <text>Biology (General), Immunologic diseases. Allergy</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Medical and Paramedical Care of Patients With Cerebellar Ataxia During the COVID-19 Outbreak: Seven Practical Recommendations of the COVID 19 Cerebellum Task Force</text>
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                <text>Aasef G. Shaikh, Elan D Louis, Michael Strupp, Hiroshi Mitoma, Mario Manto, Frank Van Overwalle, Bing-Wen Soong, Jeremy D. Schmahmann, Marios Hadjivassiliou, Nicolas Dupré, Marco Molinari</text>
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                <text>The severe acute respiratory syndrome coronavirus 2 (SARS-CoV2), the cause of the current pandemic coronavirus disease 2019 (COVID-19), primarily targets the respiratory system. Some patients also experience neurological signs and symptoms ranging from anosmia, ageusia, headache, nausea, and vomiting to confusion, encephalitis, and stroke. Approximately 36% of those with severe COVID-19 experience neurological complications. The virus may enter the central nervous system through the olfactory nerve in the nasal cavity and damage neurons in the brainstem nuclei involved in the regulation of respiration. Patients with cerebellar ataxia (CA) are particularly vulnerable to severe outcome if they contract COVID-19 because of the complexity of their disease, the presence of comorbidities, and their use of immunosuppressive therapies. Most CA patients burdened by progressive neurologic deficits have substantially impaired mobility and other essential functions, for which they rely heavily on ambulatory services, including rehabilitation and psychosocial care. Cessation of these interventions because of isolation restrictions places the CA patient population at risk of further deterioration. This international panel of ataxia experts provides recommendations for neurologists caring for patients with CA, emphasizing a pro-active approach designed to maintain their autonomy and well-being: continue long-term medications, promote rehabilitation efforts, utilize the technology of virtual visits for regular contact with healthcare providers, and pay attention to emotional and psychosocial health. Neurologists should play an active role in decision-making in those CA cases requiring escalation to intensive care and resuscitation. Multi-disciplinary collaboration between care teams is always important, and never more so than in the context of the current pandemic.</text>
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                <text>2020</text>
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                <text>ataxia, Cerebellum, Therapies, SARS-CoV-2, COVID-19</text>
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                <text>DOI: 10.3389/fneur.2020.00516</text>
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                <text>Frontiers in Neurology</text>
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                <text>Frontiers Media S.A.</text>
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                <text>Neurology. Diseases of the nervous system</text>
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                <text>MERS-CoV: Understanding the Latest Human Coronavirus Threat</text>
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            <description>An entity primarily responsible for making the resource</description>
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                <text>Aasiyah Chafekar, Burtram C. Fielding</text>
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            <description>An account of the resource</description>
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                <text>Human coronaviruses cause both upper and lower respiratory tract infections in humans. In 2012, a sixth human coronavirus (hCoV) was isolated from a patient presenting with severe respiratory illness. The 60-year-old man died as a result of renal and respiratory failure after admission to a hospital in Jeddah, Saudi Arabia. The aetiological agent was eventually identified as a coronavirus and designated Middle East respiratory syndrome coronavirus (MERS-CoV). MERS-CoV has now been reported in more than 27 countries across the Middle East, Europe, North Africa and Asia. As of July 2017, 2040 MERS-CoV laboratory confirmed cases, resulting in 712 deaths, were reported globally, with a majority of these cases from the Arabian Peninsula. This review summarises the current understanding of MERS-CoV, with special reference to the (i) genome structure; (ii) clinical features; (iii) diagnosis of infection; and (iv) treatment and vaccine development.</text>
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                <text>2018</text>
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                <text>human coronavirus, MERS-CoV, clinical features, Upper respiratory tract infections, lower respiratory tract infections, Respiratory viruses</text>
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                <text>DOI: 10.3390/v10020093</text>
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                <text>Viruses</text>
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                <text>MDPI AG</text>
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                <text>Microbiology</text>
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            <description>A language of the resource</description>
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                  <text>Coronavirus</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Technoeconomic Modeling of Plant-Based Griffithsin Manufacturing</text>
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                <text>Aatif Alam, Linda Jiang, Gregory A. Kittleson, Kenneth D. Steadman, Somen Nandi, Joshua L Fuqua, Kenneth E. Palmer, Daniel Tusé, Karen A. McDonald</text>
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                <text>Griffithsin is a marine algal lectin that exhibits broad-spectrum antiviral activity by binding oligomannose glycans on viral envelope glycoproteins, including those found in HIV-1, HSV-2, SARS, HCV and other enveloped viruses. An efficient, scalable and cost-effective manufacturing process for Griffithsin is essential for the adoption of this drug in human antiviral prophylaxis and therapy, particularly in cost-sensitive indications such as topical microbicides for HIV-1 prevention. The production of certain classes of recombinant biologics in plants can offer scalability, cost and environmental impact advantages over traditional biomanufacturing platforms. Previously, we showed the technical viability of producing recombinant Griffithsin in plants. In this study, we conducted a technoeconomic analysis (TEA) of plant-produced Griffithsin manufactured at commercial launch volumes for use in HIV microbicides. Data derived from multiple non-sequential manufacturing batches conducted at pilot scale and existing facility designs were used to build a technoeconomic model using SuperPro Designer® modeling software. With an assumed commercial launch volume of 20 kg Griffithsin/year for 6.7 million doses of Griffithsin microbicide at 3 mg/dose, a transient vector expression yield of 0.52 g Griffithsin/kg leaf biomass, recovery efficiency of 70%, and purity of &amp;gt;99%, we calculated a manufacturing cost for the drug substance of $0.32/dose and estimated a bulk product cost of $0.38/dose assuming a 20% net fee for a contract manufacturing organization (CMO). This is the first report modeling the manufacturing economics of Griffithsin. The process analyzed is readily scalable and subject to efficiency improvements and could provide the needed market volumes of the lectin within an acceptable range of costs, even for cost-constrained products such as microbicides. The manufacturing process was also assessed for environmental, health and safety impact and found to have a highly favorable environmental output index with negligible risks to health and safety. The results of this study help validate the plant-based manufacturing platform and should assist in selecting preferred indications for Griffithsin as a novel drug.</text>
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                <text>2018</text>
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                <text>biomanufacturing, economics, Griffithsin, microbicide, antiviral, cost</text>
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                <text>DOI: 10.3389/fbioe.2018.00102</text>
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                <text>Frontiers in Bioengineering and Biotechnology</text>
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                <text>Frontiers Media S.A.</text>
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                <text>Biotechnology</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Knowledge, Attitude, and Precautionary Measures Towards COVID-19 Among Medical Visitors at the University of Gondar Comprehensive Specialized Hospital Northwest Ethiopia</text>
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                <text>Abate H, Mekonnen CK</text>
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                <text>Hailemichael Abate, Chilot Kassa Mekonnen Department of Medical Nursing, College of Health Science, Gondar, EthiopiaCorrespondence: Hailemichael Abate Email haie206k@gmail.comBackground: Novel coronavirus disease 2019 (COVID-19) is an emerging respiratory disease caused by severe acute respiratory syndrome coronavirus. It was designated a public health emergency of international concern on January 30, 2020. COVID-19 has no effective treatment; nonetheless, early recognition of the disease and applying prevention strategies will help to mitigate the virus propagation.Objective: This study aimed to assess the knowledge, attitude, and precautionary measures of medical center visitors at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia.Methods: An institutional-based cross-sectional study was conducted from July 15 to August 15, 2020. A consecutive sampling technique was used to select the study participants. Data were collected by using a pre-tested structured, self-administered questionnaire. Data were analyzed using SPSS version 20. To explain the study variables, frequency tables, figures, and percentages were used. Bivariable and multivariable logistic regressions were used to see the association between independent and dependent variables.Results: The prevalence of poor knowledge, attitude, and precautionary measures was 42.2%, 39%, and 41.6%, respectively. Being female (AOR=2.79, 95% CI=1.752&amp;ndash; 4.44), divorced (AOR=0.29, 95% CI=0.09&amp;ndash; 0.88), and residing in a rural location (AOR=1.93, 95% CI=1.07&amp;ndash; 3.26) were significantly associated with poor knowledge. Being female (AOR=95%, CI=1.21&amp;ndash; 2.98), a farmer (AOR=4.13, 95% CI=1.60&amp;ndash; 10.63), residing in a rural location (AOR=2.53, 95% CI=1.31&amp;ndash; 4.88), poor knowledge (AOR=2.38, 95% CI=1.52&amp;ndash; 3.72), and negative attitude (AOR=3.25, 95% CI=2.07&amp;ndash; 5.09) were significantly associated with poor precautionary measures. Increasing income in one unit of Ethiopian birr (ETB) (AOR=0.26, 95% CI=0.031&amp;ndash; 0.051) was significantly associated with negative attitude.Conclusion: The finding of this study showed that more than one-third of the participants had poor knowledge, attitude, and precautionary measures towards COVID-19 disease. A comprehensive health education program concerning knowledge, attitude, and precautionary measures toward COVID-19 ought to be strengthened.Keywords: coronavirus, COVID-19, attitude, knowledge, precautionary measures</text>
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                <text>2020</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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                <text>coronavirus, covid-19, Knowledge, attitude, precautionary measures</text>
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            </elementTextContainer>
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            <description>A related resource from which the described resource is derived</description>
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                <text>Biotemas</text>
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                <text>Universidade Federal de Santa Catarina</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Infectious and parasitic diseases</text>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
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                <text>Nursing Surge Capacity Strategies for Management of Critically Ill Adults with COVID-19</text>
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                <text>Abbas Al Mutair, Anas Amr, Zainab Ambani, Khulud  Al Salman, Deborah Schwebius</text>
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            <description>An account of the resource</description>
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                <text>Background: There is a vital need to develop strategies to improve nursing surge capacity for caring of patients with coronavirus (COVID-19) in critical care settings. COVID-19 has spread rapidly, affecting thousands of patients and hundreds of territories. Hospitals, through anticipation and planning, can serve patients and staff by developing strategies to cope with the complications that a surge of COVID-19 places on the provision of adequate intensive care unit (ICU) nursing staff—both in numbers and in training. Aims: The aim is to provide an evidence-based starting point from which to build expanding staffing models dealing with these additional demands. Design/Method: In order to address and develop nursing surge capacity strategies, a five-member expert panel was formed. Multiple questions directed towards nursing surge capacity strategies were posed by the assembled expert panel. Literature review was conducted through accessing various databases including MEDLINE, CINAHL, Cochrane Central, and EMBASE. All studies were appraised by at least two reviewers independently using the Joanna Briggs Institute JBI Critical Appraisal Tools. Results: The expert panel has issued strategies and recommendation statements. These proposals, supported by evidence-based resources in regard to nursing staff augmentation strategies, have had prior success when implemented during the COVID-19 pandemic. Conclusion: The proposed guidelines are intended to provide a basis for the provision of best practice nursing care during times of diminished intensive care unit (ICU) nursing staff capacity and resources due to a surge in critically ill patients. The recommendations and strategies issued are intended to specifically support critical care nurses incorporating COVID-19 patients. As new knowledge evidence becomes available, updates can be issued and strategies, guidelines and/or policies revised. Relevance to Clinical Practice: Through discussion and condensing research, healthcare professionals can create a starting point from which to synergistically develop strategies to combat crises that a pandemic like COVID-19 produces.</text>
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            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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                <text>2020</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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                <text>covid-19, coronavirus 2019, ICU surge capacity, nursing surge capacity and strategies</text>
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            <description>An unambiguous reference to the resource within a given context</description>
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                <text>10.3390/nursrep10010004</text>
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                <text>Nursing Reports</text>
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                <text>MDPI AG</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Nursing</text>
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                  <text>Agricultura sostenible</text>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Agricultura sostenible</text>
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                <text>Ciertos espacios de ocupación. La relación agroindustria-protestantismo en la formación de una región fronteriza entre México y Estados Unidos</text>
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                <text>Abbdel Camargo Martínez</text>
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            <name>Description</name>
            <description>An account of the resource</description>
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                <text>En este documento se propone analizar la interrelación de dos dinámicas de ocupación territorial basada en el expansionismo estadounidense en una región agroindustrial del noroeste de México. Por medio de una perspectiva longitudinal este documento plantea cómo han actuado los procesos de colonización a través del desarrollo económico y la instauración de un modelo religioso de tipo protestante en el modelo productivo y en el poblamiento regional de una de las zonas agroexportadoras más importantes del noroeste del país. A pesar de limitaciones en el método, el trabajo sobresale al vincular dinámicas complejas de la globalización que usualmente son analizadas por separado. El trabajo muestra el desarrollo de un sentido colonial en la dinámica de ocupación territorial de empresas vinculadas a la agroindustria y al desarrollo de un campo religioso protestante en este territorio fronterizo; al mismo tiempo se identifica la disputa por la tenencia de una identidad regional que no ha estado exenta de conflictos entre los pobladores.</text>
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            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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                <text>2018</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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                <text>Ocupación, Protestantismo, economia, frontera, poblamiento, región</text>
              </elementText>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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                <text>10.21670/ref.1817017</text>
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            <description>A related resource from which the described resource is derived</description>
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                <text>Estudios Fronterizos</text>
              </elementText>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="169557">
                <text>Universidad Autonoma de Baja California</text>
              </elementText>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Social Sciences, Social sciences (General)</text>
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                <text>&lt;a href="http://ref.uabc.mx/ojs/index.php/ref/article/view/723" target="_blank" rel="noreferrer noopener"&gt;http://ref.uabc.mx/ojs/index.php/ref/article/view/723&lt;/a&gt;</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>The Phenomenon of Moving to Online/Distance Delivery as a Result of COVID-19: Exploring Initial Perceptions of Higher Education Faculty at a Rural Midwestern University</text>
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                <text>Abby Cameron-Standerford, Katherine Menard, Christi Edge, Bethney Bergh, Ashley Shayter, Kristen Smith, Laura VandenAvond</text>
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                <text>The purpose of this study was to explore the initial perceptions and experiences of faculty whose classes were moved to an online/distance delivery as a result of the COVID-19 pandemic. Using mixed methods online survey methodology, the researchers sought to describe faculty perceptions relative to their response to moving all university courses online within the timeframe allotted by university leadership. Building upon this groups’ previous research, which focused on the relationships among care and rigor in the online teaching/learning environment, the researchers designed survey questions to further explore these concepts during a time of chaos. The survey addressed faculty perceptions and lived experiences related to supporting this transition, previous experiences with online teaching, the role of rigor and care in course design and implementation, and opportunities for demonstrating care toward colleagues. Information gleaned from the study will help to inform university leadership, instructional design support personnel, and faculty. As the long-term economic, social, and academic effects are realized across the world, the researchers anticipate significant changes in higher education.</text>
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                <text>2020</text>
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                <text>online learning, emergency remote teaching, emotional intelligence, care, rigor</text>
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                <text>10.3389/feduc.2020.583881</text>
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                <text>Epidemiology and Health</text>
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                <text>Korean Society of Epidemiology</text>
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        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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              <elementText elementTextId="68456">
                <text>Nursing Students' Perceptions, Knowledge, and Preventive Behaviors Toward COVID-19: A Multi-University Study</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="68457">
                <text>Abdalkarem F. Alsharari, Hamdan Mohammad Albaqawi, Nahed Alquwez, Ejercito Balay-odao, Junel Bryan Bajet, Hawa Alabdulaziz, Fatmah Alsolami, Regie B. Tumala, Hanan M. M. Tork, Ebaa Marwan Felemban, Jonas Preposi Cruz</text>
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            <name>Description</name>
            <description>An account of the resource</description>
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                <text>Background: Knowledge, perception, and preventive behavior should be considered in the planning of effective educational interventions for the coronavirus disease of 2019 (COVID-19) pandemic and in increasing awareness about the health risks brought about by this disease. This research aimed to assess knowledge, perceptions, and preventive behavior toward the COVID-19 infection among student nurses.Methods: The study has quantitative, descriptive, and cross-sectional design. A convenience sample of 1,226 student nurses from seven universities in Saudi Arabia was surveyed from March 22 to April 4, 2020. A four-part online survey on demographic characteristics, perceptions, knowledge, and preventive behavior of Saudi student nurses was carried out.Results: Nearly all students were aware of the outbreak (99.2%), and most of them received information on COVID-19 primarily from social media (71.0%). Over three-fourths of the students were confident that the government (89.1%) and Ministry of Health (MOH) (86.5%) were doing a good job responding to the COVID-19 outbreak in the country. The overall average score in the knowledge questionnaire was 9.85 (SD = 1.62, range = 0–12), which is equivalent to 82.1%. The majority of the students always performed most of the preventive behavior identified in the survey, except “washing hands with soap and water for at least 20 s after blowing my nose, coughing, or sneezing” (39.2%) and “daily cleaning and disinfecting frequently touched surfaces” (41.6%). Being female, being in the fourth year, and gaining good perceived knowledge were associated with high actual COVID-19 knowledge. University, gender, age, academic level, and perceived COVID-19 knowledge were the associated factors.Conclusions: The findings of this study have provided baseline information on the current state of Saudi nursing students' perceptions, knowledge, and preventive behavior toward COVID-19 as the crisis is happening. The findings revealed some areas that should be focused on by nursing education, as well as health agencies, to ensure that the students have adequate knowledge and correct preventive behavior.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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              <elementText elementTextId="68459">
                <text>2020</text>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="68460">
                <text>covid-19, Knowledge, Perception, Preventive behavior, Saudi Arabia (KSA), Nursing – education</text>
              </elementText>
            </elementTextContainer>
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          <element elementId="43">
            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
            <elementTextContainer>
              <elementText elementTextId="68461">
                <text>10.3389/fpubh.2020.573390</text>
              </elementText>
            </elementTextContainer>
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          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="68462">
                <text>Epidemiology and Health</text>
              </elementText>
            </elementTextContainer>
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          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="68463">
                <text>Korean Society of Epidemiology</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="68464">
                <text>Public aspects of medicine</text>
              </elementText>
            </elementTextContainer>
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        <src>https://socictopen.socict.org/files/original/f1bd06c8593d9378a5903ea270546b5d.pdf</src>
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          <name>Dublin Core</name>
          <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
          <elementContainer>
            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
              <elementTextContainer>
                <elementText elementTextId="1">
                  <text>Coronavirus</text>
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              </elementTextContainer>
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              <name>Description</name>
              <description>An account of the resource</description>
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                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
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              </elementTextContainer>
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      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
        <elementContainer>
          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="82558">
                <text>Prediction of Epidemic Peak and Infected Cases for COVID-19 Disease in Malaysia, 2020</text>
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          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="82559">
                <text>Abdallah Alsayed, Raja Kamil, Hayder Sadir, Hasan Sari</text>
              </elementText>
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          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
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              <elementText elementTextId="82560">
                <text>The coronavirus COVID-19 has recently started to spread rapidly in Malaysia. The number of total infected cases has increased to 3662 on 05 April 2020, leading to the country being placed under lockdown. As the main public concern is whether the current situation will continue for the next few months, this study aims to predict the epidemic peak using the Susceptible–Exposed–Infectious–Recovered (SEIR) model, with incorporation of the mortality cases. The infection rate was estimated using the Genetic Algorithm (GA), while the Adaptive Neuro-Fuzzy Inference System (ANFIS) model was used to provide short-time forecasting of the number of infected cases. The results show that the estimated infection rate is 0.228 ± 0.013, while the basic reproductive number is 2.28 ± 0.13. The epidemic peak of COVID-19 in Malaysia could be reached on 26 July 2020, with an uncertain period of 30 days (12 July–11 August). Possible interventions by the government to reduce the infection rate by 25% over two or three months would delay the epidemic peak by 30 and 46 days, respectively. The forecasting results using the ANFIS model show a low Normalized Root Mean Square Error (NRMSE) of 0.041; a low Mean Absolute Percentage Error (MAPE) of 2.45%; and a high coefficient of determination (R2) of 0.9964. The results also show that an intervention has a great effect on delaying the epidemic peak and a longer intervention period would reduce the epidemic size at the peak. The study provides important information for public health providers and the government to control the COVID-19 epidemic.</text>
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          <element elementId="40">
            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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              <elementText elementTextId="82561">
                <text>2020</text>
              </elementText>
            </elementTextContainer>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="82562">
                <text>covid-19, SEIR model, Infection rate, Basic reproductive number, ANFIS, epidemic peak</text>
              </elementText>
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          <element elementId="43">
            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
            <elementTextContainer>
              <elementText elementTextId="82563">
                <text>10.3390/ijerph17114076</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="82564">
                <text>Epidemiology and Health</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="82565">
                <text>Korean Society of Epidemiology</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="82566">
                <text>Medicine</text>
              </elementText>
            </elementTextContainer>
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