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                <text>Antonio Filippini, Alessio D’Alessio</text>
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                <text>Caveolae are flask-shaped invaginations of the plasma membrane found in numerous cell types and are particularly abundant in endothelial cells and adipocytes. The lipid composition of caveolae largely matches that of lipid rafts microdomains that are particularly enriched in cholesterol, sphingomyelin, glycosphingolipids, and saturated fatty acids. Unlike lipid rafts, whose existence remains quite elusive in living cells, caveolae can be clearly distinguished by electron microscope. Despite their similar composition and the sharing of some functions, lipid rafts appear more heterogeneous in terms of size and are more dynamic than caveolae. Following the discovery of caveolin-1, the first molecular marker as well as the unique scaffolding protein of caveolae, we have witnessed a remarkable increase in studies aimed at investigating the role of these organelles in cell functions and human disease. The goal of this review is to discuss the most recent studies related to the role of caveolae and caveolins in endothelial cells. We first recapitulate the major embryological processes leading to the formation of the vascular tree. We next discuss the contribution of caveolins and cavins to membrane biogenesis and cell response to extracellular stimuli. We also address how caveolae and caveolins control endothelial cell metabolism, a central mechanism involved in migration proliferation and angiogenesis. Finally, as regards the emergency caused by COVID-19, we propose to study the caveolar platform as a potential target to block virus entry into endothelial cells.</text>
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                <text>10.3390/biom10091218</text>
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                <text>Could the Inhibition of Endo-Lysosomal Two-Pore Channels (TPCs) by the Natural Flavonoid Naringenin Represent an Option to Fight SARS-CoV-2 Infection?</text>
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                <text>Antonio Filippini, Fioretta Palombi, Armando Carpaneto, Antonella D'Amore</text>
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                <text>Frontiers Media S.A.</text>
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              <description>A name given to the resource</description>
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                  <text>Agricultura sostenible</text>
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            <element elementId="41">
              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Agricultura sostenible</text>
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                <text>FLORA DA SERRA DO MEL RN NA VILA ALAGOAS</text>
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            <name>Creator</name>
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                <text>Antonio Flauvio Cezar, Francisco Aires Sizenando Filho, Luciene Xavier de Mesquita, Yvana Christine da Silva Costa</text>
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            <description>An account of the resource</description>
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                <text>Realizou-se um Estudo Florístico e Fitossociológico em dois Ambientes de Caatinga, onde o primeiro Ambiente caracterizava se por uma área de preservação ambiental (Ambiente I) e uma segunda área antropizada, usada para pastoreio e retirada de madeira para fins energéticos (Ambiente II). Foram demarcadas 12 parcelas de 10 m x 20 m em cada Ambiente. Foram encontradas 13 espécies, e 8 famílias, no Ambiente I, enquanto que no Ambiente II constatou-se a ocorrência de 5 espécies pertencentes a 8 famílias. Os parâmetros florísticos e fitossociológicos avaliados foram densidade, dominância, freqüência e índice de valor de importância e de cobertura. Em ordem decrescente, Catanduba (Piptadenia moniliformis Benth.) e João mole (Pisonia tomentosa C.), destacando-se por apresentarem IVI e IVC elevados nos dois Ambientes.</text>
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                <text>2006</text>
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                <text>Revista Verde de Agroecologia e Desenvolvimento Sustentável</text>
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                <text>Grupo Verde de Agroecologia e Abelhas (GVAA)</text>
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                <text>Agriculture (General), Geography. Anthropology. Recreation, Environmental sciences</text>
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                <text>&lt;a href="https://www.gvaa.com.br/revista/index.php/RVADS/article/view/20" target="_blank" rel="noreferrer noopener"&gt;https://www.gvaa.com.br/revista/index.php/RVADS/article/view/20&lt;/a&gt;</text>
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                <text>Morfodinámica del litoral caribe y amenazas naturales</text>
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                <text>Antonio Florez, Kim G. Robertson</text>
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                <text>La mayoría de los modelados de los litorales (formas y formaciones superficiales), se relacionan con los cambios del nivel del mar, a su vez ligados a los cambios climáticos del cuaternario. La máxima de la transgresión holocénica ocurrió entre 6000 y 2500 años A.P y a ella corresponden algunos niveles de terrazas y marismas (no funcionales). Los últimos 2500 años han mostrado una relativa estabilidad del nivel del medio del mar, aunque con fluctuaciones menores. En este trabajo se estudió la morfogénesis del litoral caribe y especialmente el retroceso de la línea de costa debido al evento transgresivo menor de los últimos 150 años, durante el cual se estima un ascenso del nivel del medio del mar de aproximadamente 20cm, como consecuencia del calentamiento. La erosión y retroceso de la línea de costa está afectando los asentamientos humanos ubicados en el litoral, tanto en sus obras de infraestructura como en sus actividades. El estudio muestra que la tendencia es hada el aumento del problema, con los consiguientes impactos sodo-ambientales.</text>
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                <text>Abstract Background Verticillium wilt of olive (VWO) is caused by the soilborne fungal pathogen Verticillium dahliae. One of the best VWO management measures is the use of tolerant/resistant olive cultivars. Knowledge on the olive-associated microbiome and its potential relationship with tolerance to biotic constraints is almost null. The aims of this work are (1) to describe the structure, functionality, and co-occurrence interactions of the belowground (root endosphere and rhizosphere) microbial communities of two olive cultivars qualified as tolerant (Frantoio) and susceptible (Picual) to VWO, and (2) to assess whether these communities contribute to their differential disease susceptibility level. Results Minor differences in alpha and beta diversities of root-associated microbiota were detected between olive cultivars regardless of whether they were inoculated or not with the defoliating pathotype of V. dahliae. Nevertheless, significant differences were found in taxonomic composition of non-inoculated plants’ communities, “Frantoio” showing a higher abundance of beneficial genera in contrast to “Picual” that exhibited major abundance of potential deleterious genera. Upon inoculation with V. dahliae, significant changes at taxonomic level were found mostly in Picual plants. Relevant topological alterations were observed in microbial communities’ co-occurrence interactions after inoculation, both at structural and functional level, and in the positive/negative edges ratio. In the root endosphere, Frantoio communities switched to highly connected and low modularized networks, while Picual communities showed a sharply different behavior. In the rhizosphere, V. dahliae only irrupted in the microbial networks of Picual plants. Conclusions The belowground microbial communities of the two olive cultivars are very similar and pathogen introduction did not provoke significant alterations in their structure and functionality. However, notable differences were found in their networks in response to the inoculation. This phenomenon was more evident in the root endosphere communities. Thus, a correlation between modifications in the microbial networks of this microhabitat and susceptibility/tolerance to a soilborne pathogen was found. Moreover, V. dahliae irruption in the Picual microbial networks suggests a stronger impact on the belowground microbial communities of this cultivar upon inoculation. Our results suggest that changes in the co-occurrence interactions may explain, at least partially, the differential VWO susceptibility of the tested olive cultivars. Video abstract.</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="40">
            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="152032">
                <text>2020</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="152033">
                <text>Microbial functional community, Microbial structural community, Olea europaea, Rhizosphere, Verticillium dahliae, root endosphere</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="43">
            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
            <elementTextContainer>
              <elementText elementTextId="152034">
                <text>10.1186/s40168-020-0787-2</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="152035">
                <text>Microbiome</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="152036">
                <text>BMC</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="152037">
                <text>Microbial ecology</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="46">
            <name>Relation</name>
            <description>A related resource</description>
            <elementTextContainer>
              <elementText elementTextId="152038">
                <text>&lt;a href="https://doi.org/10.1186/s40168-020-0787-2" target="_blank" rel="noreferrer noopener"&gt;https://doi.org/10.1186/s40168-020-0787-2&lt;/a&gt;</text>
              </elementText>
            </elementTextContainer>
          </element>
        </elementContainer>
      </elementSet>
    </elementSetContainer>
  </item>
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