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                  <text>Dominio científico: Coronavirus</text>
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                <text>Angioedema, endothelium, ACE2, and bradykinin - interrelationships in COVID-19: a case report</text>
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                <text>Francisco Kleyton Zacarias Florêncio, Maiza de Oliveira Tenório, Aluísio Roberto Andrade Macedo Júnior, Sandro Gonçalves de Lima</text>
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                <text>COVID-19 is a new disease, whose several atypical clinical manifestations began to be observed with the evolution of the pandemic, and have been investigated to understand the pathophysiology of the disease. In this article, the objective is to describe a case of angioedema in COVID-19, considered an atypical manifestation, and rarely described in the literature. The case is of a 55-year-old patient who sought medical attention for a complaint of intermittent fever for four days. On the seventh day, he manifested angioedema in the left zygomatic projection and the right subpalpebral region. The patient had no history of angioedema earlier in life. The following day, he presented a regression of the angioedema concerning the previous day. After this period, the patient progressed well and became asymptomatic. The RT-PCR laboratory test performed on the first days of manifesting symptoms was positive for SARS-CoV-2. We correlate the onset of angioedema with the possible endotheliitis present in the disease, which has been evidenced by the observation of severe endothelial injury associated with the intracellular presence of the virus in several histopathological studies of patients with COVID-19. Also, possible deregulation of the Kininogen-Kallikrein-Kinin System (KKKS) could explain this manifestation, as SARS-CoV-2 binds to the ACE2 receptor, which is responsible for degrading kinins, such as bradykinin.</text>
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                <text>pandemics, endothelium, angioedema, Coranavirus Infections, Bradkynin</text>
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                <text>Epidemiology and Health</text>
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                <text>Korean Society of Epidemiology</text>
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                <text>Angiotensin converting enzyme 2 (ACE2), COVID-19 and cardiac injury: what cardiologist should know</text>
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                <text>Sidhi Laksono, Budhi Setianto, Steven Philip Surya</text>
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                <text>Coronavirus disease 2019 (COVID-19) has already stated as a pandemic by the World Health Organization (WHO). Until now, Indonesia has also infected with this severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. All medical staffs join hand by hand to overcome this pandemic, not only pulmonologist but also cardiologist. Early reports from China showed that cardiovascular comorbidities add more mortality than without comorbid. Cardiac implication of this infection is cardiac injury. Viral pathology and pathophysiology that induced cardiac injury is still debatable and not well understood. Angiotensin-converting enzyme 2 (ACE2) has emerged as a key regulator of renin-angiotensin system in cardiovascular disease. ACE2 has been postulated as one of the pathophysiology of COVID-19 and cardiac injury.</text>
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                <text>covid-19, SARS-CoV-2, ACE2, pathophysiology, cardiac injury</text>
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                <text>10.19106/JMedSciSI005203202009</text>
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                <text>Journal of the Medical Sciences</text>
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                <text>Universitas Gadjah Mada</text>
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                <text>Angiotensin II and COVID-19. Secrets of interactions</text>
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                <text>A. O. Konradi, A. O. Nedoshivin</text>
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                <text>The article describes current data on the relationship of renin-angiotensin system and related drugs with the risk of COVID-19 infection and its outcomes. Analysis of the latest publications did not reveal association of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers with any risk of an unfavorable outcomes, and there was no data for withdrawal of these drugs.</text>
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                <text>covid-19, angiotensin-converting enzyme 2, angiotensin converting enzyme inhibitors</text>
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                <text>10.15829/1560-4071-2020-3861</text>
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                <text>Российский кардиологический журнал</text>
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                <text>«FIRMA «SILICEA» LLC </text>
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                <text>Diseases of the circulatory (Cardiovascular) system</text>
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                <text>Angiotensin II infusion in COVID-19-associated vasodilatory shock: a case series</text>
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                <text>Rinaldo Bellomo, Giovanni Landoni, Ary Serpa Neto, Alberto Zangrillo, Luigi Beretta, Federica Morselli, the COVID-BioB Study Group</text>
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                <text>DOI: 10.1186/s13054-020-02928-0</text>
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                <text>Catherine G Derington, Jordana B Cohen, April F Mohanty, Tom H Greene, James Cook, Jian Ying, Guo Wei, Jennifer S Herrick, Vanessa W Stevens, Barbara E Jones, Libo Wang, Alexander R Zheutlin, Andrew M South, Thomas C Hanff, Steven M Smith, Rhonda M Cooper-DeHoff, Jordan B King, G Caleb Alexander, Dan R Berlowitz, Faraz S Ahmad, M Jason Penrod, Rachel Hess, Molly B Conroy, James C Fang, Michael A Rubin, Srinivasan Beddhu, Alfred K Cheung, Weiming Xian, William S Weintraub, Adam P Bress</text>
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                <text>BackgroundAngiotensin II receptor blockers (ARBs) and angiotensin-converting enzyme inhibitors (ACEIs) may positively or negatively impact outcomes in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We investigated the association of ARB or ACEI use with coronavirus disease 2019 (COVID-19)-related outcomes in US Veterans with treated hypertension using an active comparator design, appropriate covariate adjustment, and negative control analyses.Methods and findingsIn this retrospective cohort study of Veterans with treated hypertension in the Veterans Health Administration (01/19/2020-08/28/2020), we compared users of (A) ARB/ACEI vs. non-ARB/ACEI (excluding Veterans with compelling indications to reduce confounding by indication) and (B) ARB vs. ACEI among (1) SARS-CoV-2+ outpatients and (2) COVID-19 hospitalized inpatients. The primary outcome was all-cause hospitalization or mortality (outpatients) and all-cause mortality (inpatients). We estimated hazard ratios (HR) using propensity score-weighted Cox regression. Baseline characteristics were well-balanced between exposure groups after weighting. Among outpatients, there were 5.0 and 6.0 primary outcomes per 100 person-months for ARB/ACEI (n = 2,482) vs. non-ARB/ACEI (n = 2,487) users (HR 0.85, 95% confidence interval [CI] 0.73-0.99, median follow-up 87 days). Among outpatients who were ARB (n = 4,877) vs. ACEI (n = 8,704) users, there were 13.2 and 14.8 primary outcomes per 100 person-months (HR 0.91, 95%CI 0.86-0.97, median follow-up 85 days). Among inpatients who were ARB/ACEI (n = 210) vs. non-ARB/ACEI (n = 275) users, there were 3.4 and 2.0 all-cause deaths per 100 person months (HR 1.25, 95%CI 0.30-5.13, median follow-up 30 days). Among inpatients, ARB (n = 1,164) and ACEI (n = 2,014) users had 21.0 vs. 17.7 all-cause deaths, per 100 person-months (HR 1.13, 95%CI 0.93-1.38, median follow-up 30 days).ConclusionsThis observational analysis supports continued ARB or ACEI use for patients already using these medications before SARS-CoV-2 infection. The novel beneficial association observed among outpatients between users of ARBs vs. ACEIs on hospitalization or mortality should be confirmed with randomized trials.</text>
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                <text>2021</text>
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            <name>Identifier</name>
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              <elementText elementTextId="57972">
                <text>10.1371/journal.pone.0248080</text>
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                <text>Epidemiology and Health</text>
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                <text>Korean Society of Epidemiology</text>
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            <element elementId="50">
              <name>Title</name>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
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                <text>Angiotensin-Converting Enzyme 2 as a Possible Correlation between COVID-19 and Periodontal Disease</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="85411">
                <text>Vincenzo Quinzi, Enrico Marchetti, Giuseppe Marzo, Stefano Mummolo, Leonardo Mancini</text>
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                <text>SARS-CoV-2 propagation in the world has led to rapid growth and an acceleration in the discoveries and publications of various interests. The main focus of a consistent number of studies has been the role of angiotensin-converting enzyme 2 (ACE2) in binding the virus and its role in expression of the inflammatory response after transmission. ACE2 is an enzyme involved in the renin–angiotensin system (RAS), whose key role is to regulate and counter angiotensin-converting enzyme (ACE), reducing the amount of angiotensin II and increasing angiotensin 1–7 (Ang1–7), making it a promising drug target for treating cardiovascular diseases. The classical RAS axis, formed by ACE, angiotensin II (Ang II), and angiotensin receptor type 1 (AT1), activates several cell functions and molecular signalling pathways related to tissue injury and inflammation. In contrast, the RAS axis composed of ACE2, Ang1–7, and Mas receptor (MasR) exerts the opposite effect concerning the inflammatory response and tissue fibrosis. Recent studies have shown the presence of the RAS system in periodontal sites where osteoblasts, fibroblasts, and osteoclasts are involved in bone remodelling, suggesting that the role of ACE2 might have a fundamental function in the under- or overexpression of cytokines such as interleukin-6 (IL-6), interleukin-7 (IL-7), tumour necrosis factor alpha (TNF-α), interleukin-2 (IL-2), interleukin-1 beta (IL-1β), monocyte chemoattractant protein-1 (MCP-1), and transforming growth factor-beta (TGF-β), associated with a periodontal disorder, mainly during coinfection with SARS-CoV-2, where ACE2 is underexpressed and cannot form the ACE2–Ang1–7–MasR axis. This renders the patient unresponsive to an inflammatory process, facilitating periodontal loss.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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              <elementText elementTextId="85413">
                <text>2020</text>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
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              <elementText elementTextId="85414">
                <text>Cytokines, inflammation, covid-19, ACE2, periodontitis</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="85415">
                <text>10.3390/app10186224</text>
              </elementText>
            </elementTextContainer>
          </element>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="85416">
                <text>Epidemiology and Health</text>
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          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="85417">
                <text>Korean Society of Epidemiology</text>
              </elementText>
            </elementTextContainer>
          </element>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Biology (General), Chemistry, Engineering (General). Civil engineering (General), Technology, Physics</text>
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                  <text>Coronavirus</text>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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        <name>Dublin Core</name>
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          <element elementId="50">
            <name>Title</name>
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              <elementText elementTextId="76413">
                <text>Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers: potential allies in the COVID-19 pandemic instead of a threat?</text>
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          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="76414">
                <text>Fedor Simko, Tomas Baka</text>
              </elementText>
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          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
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              <elementText elementTextId="76415">
                <text>Angiotensin-converting enzyme 2 (ACE2) is the leading player of the protective renin-angiotensin system (RAS) pathway but also the entry receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). RAS inhibitors seemed to interfere with the ACE2 receptor, and their safety was addressed in COVID-19 patients. Pedrosa et al. (Clin. Sci. (Lond.) (2021), 135, 465-481) showed in rats that captopril and candesartan up-regulated ACE2 expression and the protective RAS pathway in lung tissue. In culture of pneumocytes, the captopril/candesartan-induced ACE2 up-regulation was associated with inhibition of ADAM17 activity, counterbalancing increased ACE2 expression, which was associated with reduced SARS-CoV-2 spike protein entry. If confirmed in humans, these results could become the pathophysiological background for justifying RAS inhibitors as cornerstone cardiovascular protectives even during COVID-19 pandemic.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="76416">
                <text>2021</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="76417">
                <text>covid-19, ACE2, ADAM17, angiotensin-converting enzyme inhibitor, angiotensin II type 1 receptor blocker</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="43">
            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
            <elementTextContainer>
              <elementText elementTextId="76418">
                <text>10.1042/CS20210182</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="76419">
                <text>Clinical science (London, England : 1979)</text>
              </elementText>
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        <src>https://socictopen.socict.org/files/original/5d5c9d3bbb9aa958be5d3618e0f8400f.pdf</src>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
              <elementTextContainer>
                <elementText elementTextId="88121">
                  <text>Agricultura sostenible</text>
                </elementText>
              </elementTextContainer>
            </element>
            <element elementId="41">
              <name>Description</name>
              <description>An account of the resource</description>
              <elementTextContainer>
                <elementText elementTextId="88122">
                  <text>Dominio científico: Agricultura sostenible</text>
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              </elementTextContainer>
            </element>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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              <elementText elementTextId="220314">
                <text>ANILLOS ANUALES Y CLIMA EN RHIZOPHORA MANGLE L. DE LA BAHÍA DE CISPATÁ, COLOMBIA ANNUAL GROWTH RINGS AND CLIMATE IN RHIZOPHORA MANGLE L. FROM THE CISPATÁ BAY, COLOMBIA</text>
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          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="220315">
                <text>Jorge Andrés Ramírez Correa, Eliana Cristina Molina Grajales, Manuel Bernal Escobar</text>
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          </element>
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            <description>An account of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="220316">
                <text>Por su localización en el ecotono tierra-mar Rhizophora mangle es un organismo con gran sensibilidad al cambio climático. La existencia de anillos anuales climáticamente sensibles en esta especie revela un enorme potencial para la dendroclimatologia tropical. Aunque se ha documentado la existencia de anillos anuales en el género Rhizophora delimitados por cambios en la densidad de poros, aquí se demuestra mediante el uso de la tomografía computarizada que los anillos en R. mangle también están definidos por cambios de densidad de la madera. La comparación entre el número de máximos de densidad de madera (DM) y de poros (DP) en secciones trasversales con la edad de los árboles, reveló la anualidad de los anillos de crecimiento de R. mangle. A mayor precipitación mayor DP y menor DM; y viceversa. La DM y la DP se interpretan como rasgos adaptativos que le permiten a R. mangle adaptarse a los pulsos anuales en salinidad relacionados con las descargas de los ríos en la bahía de Cispatá.Because of its location in the land-sea ecotone Rhizophora mangle is an organism with great sensitivity to climate change. The existence of climate sensitive annual rings in this specie highlights its potential relevance for tropical dendroclimatology. Even though had been previously established the existence of annual rings, delimited by changes in pore-density, in Rhizophora genus, using computed tomographies, is also possible demonstrate, that the rings in R. mangle can also be defined by changes in wood density. Comparing wood density maxima (DM) and pore density maxima (PD) in tree cross-sections reveal the annual nature of R. mangle tree-rings. With increased rainfall PD increases and DM decreases, and vice versa. PD and DM are interpreted as adaptive traits that allow R. mangle to adapt to the conditions produced by annual pulses in salinity in the bay of Cispatá related to high and low discharges of the rivers.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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              <elementText elementTextId="220317">
                <text>2010</text>
              </elementText>
            </elementTextContainer>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="220318">
                <text>Computer tomography, Densitometry, Mangrove, dendroclimatology, dendroclimatología, densidad de madera, densidad de poros, densitometría, manglar, pore density, salinidad y crecimiento, salinity and growth, tomografía computarizada, wood density</text>
              </elementText>
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          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="220319">
                <text>Revista Facultad Nacional de Agronomía Medellín</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="220320">
                <text>Universidad Nacional de Colombia, Sede Medellín</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Agriculture (General), Agriculture</text>
              </elementText>
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            <description>A related resource</description>
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                <text>&lt;a href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;amp;pid=S0304-28472010000200017" target="_blank" rel="noreferrer noopener"&gt;http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;amp;pid=S0304-28472010000200017&lt;/a&gt;</text>
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                <text>Anima olea. El arte en la interpretación del paisaje del olivar como patrimonio natural y cultural</text>
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                <text>Carmen Andreu-Lara</text>
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            <description>An account of the resource</description>
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                <text>El olivar es el cultivo mediterráneo por excelencia, donde destaca tanto por su extensión como por su importancia milenaria. La cultura que se le asocia hunde sus raíces en los primeros procesos de domesticación agraria y ha tenido un papel fundamental en la ecología, la economía, la historia y la belleza del Mediterráneo y sus paisajes.Este artículo tiene como objetivo fundamental abordar desde una perspectiva artística, interdisciplinar y transdiciplinar los valores del paisaje del olivar andaluz, analizando algunas de las formas objetivas que ha adoptado en distintas áreas del territorio y profundizando en las percepciones y las emociones que estas suscitan. Partimos del estudio interdisciplinar de los valores de los paisajes de olivar para destacar su riqueza antropológica y estética, como patrimonio natural y cultural, sin olvidar algunos de los principales problemas ambientales que está suponiendo para estos las exigencias crecientes del mercado que lleva en numerosas ocasiones a la adopción de insumos y manejos insostenibles en el tratamiento del olivo en menoscabo de la riqueza de estos paisajes. Damos un paso metodológico más desarrollando trabajos de carácter transdisciplinar que abordan el paisaje del olivar creando relatos más allá del contexto disciplinar de los participantes.    </text>
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                <text>Arte, Paisaje, hermenéutica, olivar mediterráneo</text>
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                <text>10.33776/erebea.v9i0.3786</text>
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                <text>Universidad de Huelva</text>
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                <text>History of scholarship and learning. The humanities</text>
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                <text>Uddab Poudel, Deepak Subedi, Saurav Pantha, Santosh Dhakal</text>
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                <text>Coronaviruses are a group of enveloped, single-stranded, positive-sense RNA viruses which are broadly classified into Alpha, Beta, Gamma, and Delta coronaviruses genera based on the viral genome. Coronavirus was not thought to be a significant problem in humans until the outbreak of Severe Acute Respiratory Syndrome (SARS) in 2002 but infection in animals including pigs, cats, dogs and poultry has been problematic for long. The outbreak of Coronavirus Disease 2019 (COVID-19) in December 2019 in Wuhan, China drew special attention towards this virus once again. The intermediate host of this novel coronavirus, Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is yet to be determined, but it has a very close genomic relationship with the bat coronavirus (BatCoV), RaTG13 strain, and the pangolin coronaviruses. As veterinary medicine has long term experience dealing with coronaviruses, this could be helpful in better understanding to detect the origin of SARS-CoV-2 and drive human medicine towards the development of vaccines and antiviral drugs through the collaborative and transdisciplinary approach of One Health.</text>
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                <text>Tripoli University</text>
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                <text>Zoology</text>
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