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                <text>[Successful treatment of a geriatric COVID-19 patient with severe chest trauma : An interdisciplinary case report].</text>
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                <text>A Akil, M C Müller, S Ziegeler, N Dickgreber, S Fischer</text>
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                <text>The coronavirus disease 2019 (COVID-19) has spread rapidly worldwide and leads to high morbidity and mortality. Clinical experience regarding the surgical management in COVID-19 patients is limited. We report the interdisciplinary approach in a COVID-19 patient with severe thoracic trauma and pulmonary symptoms, who was admitted to the emergency unit after blunt chest trauma with dislocated serial rib fractures and concomitant hemothorax.</text>
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                <text>coronavirus, pneumonia, Hemothorax, Rib fracture, Rib osteosynthesis</text>
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                <text>10.1007/s00113-021-00962-3</text>
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                <text>Der Unfallchirurg</text>
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                <text>A Ammar, J-L Drapé, M-P Revel</text>
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                <text>10.1016/j.diii.2020.09.007</text>
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                <text>Diagnostic and interventional imaging</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Detection of coronaviruses in Pteropus &amp; Rousettus species of bats from different States of India</text>
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                <text>A B Sudeep, Devendra T Mourya, Pragya D Yadav, R. Balasubramanian, Abhimanyu Kumar, Nivedita Gupta, M D Gokhale, Dimpal A. Nyayanit, Sreelekshmy Mohandas, Anita Shete-Aich, Triparna Majumdar, Savita Patil, Prachi Pardeshi, Dilip Patil, Padinjaremattathil Thankappan Ullas, Hitesh Dighe, Pradeep Sawant, Basavaraj Mathapati, Sreekant Baradkar, Rutuja Kharde, Malvika Salve, Yash Joshi</text>
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                <text>Background &amp; objectives: Bats are considered to be the natural reservoir for many viruses, of which some are potential human pathogens. In India, an association of Pteropus medius bats with the Nipah virus was reported in the past. It is suspected that the recently emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) also has its association with bats. To assess the presence of CoVs in bats, we performed identification and characterization of bat CoV (BtCoV) in P. medius  and Rousettus species from representative States in India, collected during 2018 and 2019. Methods: Representative rectal swab (RS) and throat swab specimens of Pteropus and Rousettus spp. bats were screened for CoVs using a pan-CoV reverse transcription-polymerase chain reaction (RT-PCR) targeting the RNA-dependent RNA polymerase (RdRp) gene. A single-step RT-PCR was performed on the RNA extracted from the bat specimens. Next-generation sequencing (NGS) was performed on a few representative bat specimens that were tested positive. Phylogenetic analysis was carried out on the partial sequences of RdRp gene sequences retrieved from both the bat species and complete viral genomes recovered from Rousettus spp. Results: Bat samples from the seven States were screened, and the RS specimens of eight Rousettus spp. and 21 Pteropus spp. were found positive for CoV RdRp gene. Among these, by Sanger sequencing, partial RdRp sequences could be retrieved from three Rousettus and eight Pteropus bat specimens. Phylogenetic analysis of the partial RdRp region demonstrated distinct subclustering of the BtCoV sequences retrieved from these Rousettus and Pteropus spp. bats. NGS led to the recovery of four sequences covering approximately 94.3 per cent of the whole genome of the BtCoVs from Rousettus bats. Three BtCoV sequences had 93.69 per cent identity to CoV BtRt-BetaCoV/GX2018. The fourth BtCoV sequence was 96.8 per cent identical to BtCoV HKU9-1. Interpretation &amp; conclusions: This study was a step towards understanding the CoV circulation in Indian bats. Detection of potentially pathogenic CoVs in Indian bats stresses the need for enhanced screening for novel viruses in them. One Health approach with collaborative activities by the animal health and human health sectors in these surveillance activities shall be of use to public health. This would help in the development of diagnostic assays for novel viruses with outbreak potential and be useful in disease interventions. Proactive surveillance remains crucial for identifying the emerging novel viruses with epidemic potential and measures for risk mitigation.</text>
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                <text>2020</text>
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                <text>bats - coronavirus - india - next-generation sequencing - phylogenetic - reverse transcription-polymerase chain reaction</text>
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                <text>DOI: 10.4103/ijmr.IJMR_795_20</text>
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                <text>Indian Journal of Medical Research</text>
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            <name>Publisher</name>
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                <text>Wolters Kluwer Medknow Publications</text>
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                <text>Medicine</text>
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                <text>Low-dose ruxolitinib plus steroid in severe SARS-CoV-2 pneumonia.</text>
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                <text>A D'Alessio, P Del Poggio, F Bracchi, G Cesana, N Sertori, D Di Mauro, A Fargnoli, M Motta, C Giussani, P Moro, G Vitale, M Giacomini, G Borra</text>
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                <text>10.1038/s41375-020-01087-z</text>
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                <text>Leukemia</text>
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                <text>Health status of children with chronic liver disease during the SARS-CoV-2 outbreak: results from a multicentre study"."</text>
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                <text>A Di Giorgio, E Nicastro, S Arnaboldi, O Montini, F Di Stasio, L D'Antiga, P Gaio, L N Fovino, M Cananzi, M Pinon, P L Calvo, V Camelli</text>
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                <text>10.1016/j.clinre.2020.101610</text>
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                <text>Gaseous Nitric Oxide and Dinitrosyl Iron Complexes with Thiol-Containing Ligands as Potential Medicines that Can Relieve COVID-19.</text>
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                <text>A F Vanin, A V Pekshev, A B Vagapov, N A Sharapov, V L Lakomkin, A A Abramov, A A Timoshin, V I Kapelko</text>
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                <text>It is shown that the inhalation of gaseous nitric oxide (gNO) or sprayed aqueous solutions of binuclear dinitrosyl iron complexes with glutathione or N-acetyl-L-cysteine by animals or humans provokes no perceptible hypotensive effects. Potentially, these procedures may be useful in COVID-19 treatment. The NO level in complexes with hemoglobin in blood decreases as the gNO concentration in the gas flow produced by the Plazon system increases from 100 to 2100 ppm, so that at 2000 ppm more than one-half of the gas can be incorporated into dinitrosyl complexes formed in tissues of the lungs and respiratory tract. Thus, the effect of gNO inhalation may be similar to that observed after administration of solutions of dinitrosyl iron complexes, namely, to the presence of dinitrosyl iron complexes with thiol-containing ligands in lung and airway tissues. With regard to the hypothesis posited earlier that these complexes can suppress coronavirus replication as donors of nitrosonium cations (Biophysics 65, 818, 2020), it is not inconceivable that administration of gNO or chemically synthesized dinitrosyl iron complexes with thiol-containing ligands may help treat COVID-19. In tests on the authors of this paper as volunteers, the tolerance concentration of gNO inhaled within 15 min was approximately 2000 ppm. In tests on rats that inhaled sprayed aqueous solutions of dinitrosyl iron complexes, their tolerance dose was approximately 0.4 mmol/kg body weight.</text>
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                <text>covid-19, Keywords: nitric oxide, dinitrosyl iron complexes</text>
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                <text>10.1134/S0006350921010218</text>
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                <text>Biophysics</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Impact on elective ophthalmic surgery caused by the COVID-19 pandemic after the lockdown at the Clinical Institute of Ophthalmology of the Hospital Clinic de Barcelona.</text>
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                <text>A García Tirado, B Sánchez-Dalmau, A Adán</text>
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                <text>10.1016/j.oftal.2020.11.007</text>
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                <text>Archivos de la Sociedad Espanola de Oftalmologia</text>
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                <text>COVID-19 Tragic Pandemic: Concerns over Unintentional “Directed Accelerated Evolution” of Novel Coronavirus (SARS-CoV-2) and Introducing a Modified Treatment Method for ARDS</text>
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                <text>A Ghadimi Moghadam, M. Haghani, JJ Bevelacqua, A. Jafarzadeh, A Kaveh-Ahangar, S.M.J. Mortazavi, S A R Mortazavi</text>
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                <text>Global health authorities are trying to work out the current status of the novel coronavirus (COVID-19) outbreak and explore methods to reduce the rate of its transmission to healthy individuals. In this viewpoint we provide insights concerning how health care professionals can unintentionally shift the novel coronavirus type to more drug-resistant forms. It is worth noting that viruses usually have different sensitivities to physical and chemical damaging agents such antiviral drugs, UV and heat ranging from extremely sensitive (ES) to extremely resistant (ER) based on a bell-shaped curve. Given this consideration, the widespread infection of people with such ER viruses would be a real disaster. Here, we introduce a modified treatment method for COVID-19-associated pneumonia. In this proposed method, COVID-19 patients will receive a single dose of 100, 180 or 250 mSv X-ray radiation that is less than the maximum annual radiation dose of the residents of high background radiation areas of Ramsar that is up to 260 mSv. In contrast with antiviral drugs, a single dose of either 100, 180 or 250 mSv of low LET X-rays cannot exert a significant selective pressure on the novel coronavirus (SARS-CoV-2) and hence does not lead to directed accelerated evolution of these viruses. Moreover, Low Dose Radiation (LDR) has the capacity of modulating excessive inflammatory responses, regulating lymphocyte counts, and controling bacterial co-infections in patients with COVID-19.</text>
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                <text>2020</text>
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                <text>coronavirus, X-rays, respiratory distress syndrome, Radiation Dosage, selective pressure, directed evolution</text>
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                <text>DOI: 10.31661/jbpe.v0i0.2003-1085</text>
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                <text>Journal of Biomedical Physics and Engineering</text>
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                <text>Shiraz University of Medical Sciences</text>
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                <text>Medical physics. Medical radiology. Nuclear medicine</text>
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                <text>High flow oxygen therapy in the treatment of SARS-CoV-2 pneumonia.</text>
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                <text>A González-Castro, E Cuenca Fito, A Fernandez-Rodriguez, P Escudero Acha, J C Rodríguez Borregán, Y Peñasco</text>
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                <text>MRONJ and COVID-19 caution.</text>
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                <text>A Hasan, S Alraisi</text>
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