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                <text>Ying-Hui Jin, Lin Cai, Zhen-Shun  Cheng, Hong Cheng, Tong Deng, Yi-Pin Fan, Cheng Fang, Di Huang, Luqi Huang, Qiao Huang, Yong HAN, Bo Hu, Fen Hu, Bing-Hui Li, Yi-Rong Li, Ke Liang, Li-Kai Lin, Lisha Luo, Jing Ma, Lin-Lu Ma, Zhi-Yong Peng, Yunbao Pan, Zhenyu Pan, Xuequn Ren, Hui-Min Sun, Ying Wang, Yunyun Wang, Hong Weng, Chao-Jie Wei, Dongfang Wu, Jian Xia, Yong Xiong, Hai-bo Xu, Xiaomei Yao, Yufeng Yuan, Tai-Sheng Ye, Xiaochun Zhang, Ying Wen Zhang, Yingao Zhang, Huamin Zhang, Yan Zhao, Ming-Juan Zhao, Hao Zi, Xian-Tao Zeng, Yongyan Wang, Xinghuan Wang, , for the Zhongnan Hospital of Wuhan University Novel Coronavirus Management and Research Team, Evidence-Based Medicine Chapter of China International Exchange and Promotive Association for Medical and Health Care (CPAM)</text>
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                <text>Abstract In December 2019, a new type viral pneumonia cases occurred in Wuhan, Hubei Province; and then named “2019 novel coronavirus (2019-nCoV)” by the World Health Organization (WHO) on 12 January 2020. For it is a never been experienced respiratory disease before and with infection ability widely and quickly, it attracted the world’s attention but without treatment and control manual. For the request from frontline clinicians and public health professionals of 2019-nCoV infected pneumonia management, an evidence-based guideline urgently needs to be developed. Therefore, we drafted this guideline according to the rapid advice guidelines methodology and general rules of WHO guideline development; we also added the first-hand management data of Zhongnan Hospital of Wuhan University. This guideline includes the guideline methodology, epidemiological characteristics, disease screening and population prevention, diagnosis, treatment and control (including traditional Chinese Medicine), nosocomial infection prevention and control, and disease nursing of the 2019-nCoV. Moreover, we also provide a whole process of a successful treatment case of the severe 2019-nCoV infected pneumonia and experience and lessons of hospital rescue for 2019-nCoV infections. This rapid advice guideline is suitable for the first frontline doctors and nurses, managers of hospitals and healthcare sections, community residents, public health persons, relevant researchers, and all person who are interested in the 2019-nCoV.</text>
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                <text>DOI: 10.1186/s40779-020-0233-6</text>
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                <text>Ying-Hui Jin, Lin Cai, Zhen-Shun  Cheng, Hong Cheng, Tong Deng, Yi-Pin Fan, Cheng Fang, Di Huang, Luqi Huang, Qiao Huang, Yong HAN, Bo Hu, Fen Hu, Bing-Hui Li, Yi-Rong Li, Ke Liang, Li-Kai Lin, Lisha Luo, Jing Ma, Lin-Lu Ma, Zhi-Yong Peng, Yunbao Pan, Zhenyu Pan, Xuequn Ren, Hui-Min Sun, Ying Wang, Yunyun Wang, Hong Weng, Chao-Jie Wei, Dongfang Wei, Jian Xia, Yong Xiong, Hai-bo Xu, Xiaomei Yao, Tai-Sheng Ye, Yufeng Yuan, Xiaochun Zhang, Ying Wen Zhang, Yingao Zhang, Huamin Zhang, Yan Zhao, Ming-Juan Zhao, Hao Zi, Xian-Tao Zeng, Yongyan Wang, Xinghuan Wang, for the Zhongnan Hospital of Wuhan Unive Novel Coronavirus Management and Research Team, Evidence-Based Medicine Chapter, China International Exchange and Promoti for Medical and Health Care (CPAM)</text>
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                <text>10.11855/j.issn.0577-7402.2020.01.01</text>
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                <text>Medical Journal of Chinese People's Liberation Army</text>
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                <text>Editorial Board of Medical Journal of Chinese People's Liberation Army</text>
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                <text>Pei Huang, Hualei Wang, Zengguo Cao, Hong-li Jin, Hang Chi, Jincun Zhao, Beibei Yu, Feihu Yan, Xingxing Hu, Fangfang Wu, Cuicui Jiao, Pengfei Hou, Shengnan Xu, Yongkun Zhao, Na Feng, Jian-Zhong Wang, Weiyang Sun, Tiecheng Wang, Yuwei Gao, Songtao Yang, Xianzhu Xia</text>
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                <text>Middle East respiratory syndrome coronavirus (MERS-CoV) is a novel human coronavirus that can cause human respiratory disease. The development of a detection method for this virus that can lead to rapid and accurate diagnosis would be significant. In this study, we established a nucleic acid visualization technique that combines the reverse transcription loop-mediated isothermal amplification technique and a vertical flow visualization strip (RT-LAMP-VF) to detect the N gene of MERS-CoV. The RT-LAMP-VF assay was performed in a constant temperature water bath for 30 min, and the result was visible by the naked eye within 5 min. The RT-LAMP-VF assay was capable of detecting 2 × 101 copies/μl of synthesized RNA transcript and 1 × 101 copies/μl of MERS-CoV RNA. The method exhibits no cross-reactivities with multiple CoVs including SARS-related (SARSr)-CoV, HKU4, HKU1, OC43 and 229E, and thus exhibits high specificity. Compared to the real-time RT-PCR (rRT-PCR) method recommended by the World Health Organization (WHO), the RT-LAMP-VF assay is easy to handle, does not require expensive equipment and can rapidly complete detection within 35 min.</text>
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                <text>DOI: 10.3389/fmicb.2018.01101</text>
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                <text>Frontiers in Microbiology</text>
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                <text>Frontiers Media S.A.</text>
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                <text>A Rapid, Simple, Inexpensive, and Mobile Colorimetric Assay COVID-19-LAMP for Mass On-Site Screening of COVID-19</text>
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                <text>Franklin  Wang-Ngai Chow, Tony  Tat-Yin Chan, Anthony  Raymond Tam, Suhui Zhao, Weiming Yao, Joshua Fung, Flora  Ka-Kei Cheng, George  Chi-Shing Lo, Stella Chu, Kam  Leng Aw-Yong, James  Yat-Man Tang, Chi-Ching Tsang, Hayes  Kam-Hei Luk, Antonio  Cheuk-Pui Wong, Kenneth  Sze-Ming Li, Longchao Zhu, Zirong He, Emily  Wan Ting Tam, Tom  Wai-Hin Chung, Sally  Cheuk Ying Wong, Tak-Lun Que, Kitty  Sau-Chun Fung, David  Christopher Lung, Alan  Ka-Lun Wu, Ivan  Fan-Ngai Hung, Patrick  Chiu-Yat Woo, Susanna  Kar-Pui Lau</text>
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                <text>To control the COVID-19 pandemic and prevent its resurgence in areas preparing for a return of economic activities, a method for a rapid, simple, and inexpensive point-of-care diagnosis and mass screening is urgently needed. We developed and evaluated a one-step colorimetric reverse-transcriptional loop-mediated isothermal amplification assay (COVID-19-LAMP) for detection of SARS-CoV-2, using SARS-CoV-2 isolate and respiratory samples from patients with COVID-19 (n = 223) and other respiratory virus infections (n = 143). The assay involves simple equipment and techniques and low cost, without the need for expensive qPCR machines, and the result, indicated by color change, is easily interpreted by naked eyes. COVID-19-LAMP can detect SARS-CoV-2 RNA with detection limit of 42 copies/reaction. Of 223 respiratory samples positive for SARS-CoV-2 by qRT-PCR, 212 and 219 were positive by COVID-19-LAMP at 60 and 90 min (sensitivities of 95.07% and 98.21%) respectively, with the highest sensitivities among nasopharyngeal swabs (96.88% and 98.96%), compared to sputum/deep throat saliva samples (94.03% and 97.02%), and throat swab samples (93.33% and 98.33%). None of the 143 samples with other respiratory viruses were positive by COVID-19-LAMP, showing 100% specificity. Samples with higher viral load showed shorter detection time, some as early as 30 min. This inexpensive, highly sensitive and specific COVID-19-LAMP assay can be useful for rapid deployment as mobile diagnostic units to resource-limiting areas for point-of-care diagnosis, and for unlimited high-throughput mass screening at borders to reduce cross-regional transmission.</text>
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                <text>Biology (General), Chemistry</text>
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                <text>A Rare Case of Acute Mesenteric Ischemia in the Setting of COVID-19 Infection.</text>
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                <text>Neeharika Krothapalli, Jason Jacob</text>
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                <text>Severe respiratory syndrome coronavirus 2 (SARS-CoV-2) is well known for causing respiratory and other extrapulmonary manifestations. Patients infected with coronavirus disease 2019 (COVID-19) may demonstrate atypical presentations with gastrointestinal symptoms. Clinicians managing these patients should reserve a high index of suspicion for the rare complication of acute mesenteric ischemia (AMI). It is a challenging diagnosis that is often missed when presenting symptoms are subtle and nonspecific like nausea, emesis, or diarrhea. Outcomes are typically catastrophic and fatal as bowel ischemia progresses to necrosis but may be averted with timely diagnostic and therapeutic methods to swiftly restore blood flow.</text>
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                <text>2021</text>
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                <text>covid-19, gastrointestinal manifestations, acute mesenteric ischemia</text>
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                <text>10.7759/cureus.14174</text>
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                <text>Cureus</text>
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                <text>A Rare Case of Human Coronavirus 229E Associated with Acute Respiratory Distress Syndrome in a Healthy Adult</text>
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              <elementText elementTextId="27337">
                <text>Antonios Papadopoulos, Foula Vassilara, Aikaterini Spyridaki, George Pothitos, Athanassia Deliveliotou</text>
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            <description>An account of the resource</description>
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                <text>Human coronavirus 229E (HCoV-229E) is one of the first coronavirus strains being described. It is linked to common cold symptoms in healthy adults. Younger children and the elderly are considered vulnerable to developing lower respiratory tract infections (LRTIs). In particular, immunocompromised patients have been reported with severe and life-threatening LRTIs attributed to HCoV-229E. We report for the first time a case of LRTI and acute respiratory distress syndrome developed in a healthy adult with no comorbidities and HCoV-229E strain identified as the only causative agent. A 45-year-old female with a clear medical history presented with fever, cough, and headache. Respiratory tract infection was diagnosed, and empirical antibiotics were started. Within two days, she developed bilateral pleural effusions, diffuse consolidations, and ground glass opacities involving all lung fields. She needed immediate oxygen supply, while ABGs deteriorated and chest imaging and PaO2/FiO2 indicated ARDS. Early administration of systemic corticosteroids led to gradual clinical improvement. Multiplex PCR from nasal secretions was positive only for HCoV-229E and negative for multiple other pathogens. It remains to be elucidated how an immunocompetent adult developed a life-threatening LRTI caused by a “benign considered” coronavirus strain, the HCoV-229E.</text>
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                <text>2018</text>
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                <text>DOI: 10.1155/2018/6796839</text>
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                <text>Case Reports in Infectious Diseases</text>
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            <description>An entity responsible for making the resource available</description>
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                <text>Hindawi Limited</text>
              </elementText>
            </elementTextContainer>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Infectious and parasitic diseases</text>
              </elementText>
            </elementTextContainer>
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  <item itemId="8590" public="1" featured="0">
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              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
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        <name>Dublin Core</name>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>A Rare Case of SARS-CoV-2 Infection Associated With Pituitary Apoplexy Without Comorbidities.</text>
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            </elementTextContainer>
          </element>
          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="73243">
                <text>Dipayan Roy, Julián Benito-LeÓn, Ritwik Ghosh, Devlina Roy, Arpan Mandal, Aloke Dutta, Dinabandhu Naga</text>
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          <element elementId="41">
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            <description>An account of the resource</description>
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                <text>Pituitary apoplexy is a medical and surgical emergency caused by hemorrhage or infarction of the hypophysis, which typically occurs within a pituitary adenoma. It is usually characterized by severe (often thunderclap) headache, visual disturbances, cranial nerve impairments, and hormonal deficiencies. We herein report a case of a previously healthy woman with severe acute respiratory syndrome coronavirus 2 infection associated with pituitary apoplexy. The plausible pathophysiological mechanisms of pituitary apoplexy in infectious coronavirus disease 2019 are discussed.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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              <elementText elementTextId="73245">
                <text>2021</text>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="73246">
                <text>covid-19, SARS-CoV-2, Pituitary apoplexy</text>
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            </elementTextContainer>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
            <elementTextContainer>
              <elementText elementTextId="73247">
                <text>10.1210/jendso/bvaa203</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="73248">
                <text>Journal of the Endocrine Society</text>
              </elementText>
            </elementTextContainer>
          </element>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
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                <elementText elementTextId="1">
                  <text>Coronavirus</text>
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              </elementTextContainer>
            </element>
            <element elementId="41">
              <name>Description</name>
              <description>An account of the resource</description>
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                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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              <elementText elementTextId="1210">
                <text>A rational approach to estimating the surgical demand elasticity needed to guide manpower reallocation during contagious outbreaks.</text>
              </elementText>
            </elementTextContainer>
          </element>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="1211">
                <text>Hsiao-Mei Tsao, Ying-Chou Sun, Der-Ming Liou</text>
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            <name>Description</name>
            <description>An account of the resource</description>
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              <elementText elementTextId="1212">
                <text>Emerging infectious diseases continue to pose serious threats to global public health. So far, however, few published study has addressed the need for manpower reallocation needed in hospitals when such a serious contagious outbreak occurs.To quantify the demand elasticity of the major surgery types in order to guide future manpower reallocation during contagious outbreaks.Based on a nationwide research database in Taiwan, we extracted the monthly volumes of major surgery types for the period 1998-2003, which covered the SARS period, in order to carry out a time series analysis. The demand elasticity of each surgery type was then estimated by autoregressive integrated moving average (ARIMA) analysis.During the study period, the surgical volumes of most selected surgery types either increased or remained steady. We categorized these surgery types into low-, moderate- and high-elastic groups according to their demand elasticity. Appendectomy, 'open reduction of fracture with internal fixation' and 'free skin graft' were in the low demand elasticity group. Transurethral prostatectomy and extracorporeal shockwave lithotripsy (ESWL) were in the high demand elasticity group. The manpower of the departments carrying out the surgeries with low demand elasticity should be maintained during outbreaks. In contrast, departments in charge of surgeries mainly with high demand elasticity, like urology departments, may be in a position to have part of their staff reallocated.Taking advantage of the demand variation during the SARS period in 2003, we adopted the concept of demand elasticity and used a time series approach to figure out an effective index of demand elasticity for various types of surgery that could be used as a rational reference to carry out manpower reallocation during contagious outbreak situations.</text>
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                <text>2015</text>
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            <name>Identifier</name>
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              <elementText elementTextId="1214">
                <text>DOI: 10.1371/journal.pone.0122625</text>
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              <elementText elementTextId="1215">
                <text>PLoS ONE</text>
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            <description>An entity responsible for making the resource available</description>
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                <text>Public Library of Science (PLoS)</text>
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                <text>Science, Medicine</text>
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                <text>EN</text>
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        <src>https://socictopen.socict.org/files/original/fa96fb252a33042419025433d510077a.pdf</src>
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              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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            <element elementId="41">
              <name>Description</name>
              <description>An account of the resource</description>
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                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
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              </elementTextContainer>
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    <itemType itemTypeId="1">
      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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    <elementSetContainer>
      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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              <elementText elementTextId="56285">
                <text>A rational approach to manage surgical procedures in COVID Era – A perspective based on experience in a private referral hospital</text>
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            </elementTextContainer>
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          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="56286">
                <text>Rama Gupta, Bishav Mohan, Kamakshi Garg, Ashima Taneja, Satpal S Virk, Anju Grewal, Rajesh Mahajan</text>
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          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
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              <elementText elementTextId="56287">
                <text>Background and Aims: COVID-19 disease has imposed challenges in caring for non-Covid elective surgical patients. As elective surgeries become essential, we propose to evaluate our approach and outcomes of surgical procedures performed during the initial period of COVID-19 pandemic so as to provide a road-map for safer approach. Material and Methods: We retrospectively evaluated outcomes in patients who underwent essential elective and emergency surgeries during the 5-week period between April 18, 2020 and May 28, 2020. All patients were screened at the front desk on their arrival to identify possible exposure to SARS- CoV-2. Nasopharyngeal swab of patients requiring hospital admission was tested for COVID-19 by quantitative RT-PCR. Patients needing essential elective surgery were taken up for surgery if they tested negative for COVID-19. Emergency procedures were undertaken in a demarcated theatre for COVID after taking level-3 protection without delay. The clinical data was reviewed and analysed. Results: A total of 764 surgical procedures were conducted, of which 70.7% were elective essential surgeries, with 95.4% of these patients being discharged in stable healthy condition. Approximately 23% of the elective and 26% of the emergency surgeries was categorised in the surgical difficulty category III and majority of these were performed under general anesthesia. Postoperative mortality was 1.04%, but the overall mortality rate was approximately 2.5%. Only two patients (0.3%) tested positive for COVID-19 in our series. Conclusion: A robust preoperative screening and testing can enable safe scheduling of essential elective surgeries.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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                <text>2020</text>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
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                <text>covid-19, Elective surgical procedure, preoperative rt pcr testing</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="56290">
                <text>10.4103/joacp.JOACP_420_20</text>
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            </elementTextContainer>
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                <text>A Rational Decision-Making Process with Public Engagement for Designing Public Transport Services: A Real Case Application in Italy</text>
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                <text>Luca D’Acierno, Mariano Gallo, Armando Cartenì</text>
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                <text>The sustainable design of public transport services is a crucial issue that may affect the economy of local areas and the social inclusion of their inhabitants. Indeed, transport accessibility of households, businesses, and retail activities is one of the main drivers that influence location choices and sustainable development and where the public transport services may play a key (positive) role. Furthermore, the economic crisis of the 2009 and the current ones caused by the COVID-19 pandemic has further limited the funds available for public services, including the transport sector. In this critical context, sound design of public transport services assumes great importance, especially in light of financial constraints. Starting from these considerations, the aim of this paper has been to propose an innovative methodology for designing public transport services based on a rational decision-making process with stakeholder engagement, aiming to perform a sustainable development perspective. The proposed methodology combines technical aspects, social and political issues, equity perspectives, and it is aimed in obtaining a design solution that can be accepted by the whole community. The proposed theoretical design methodology has also been applied to a case study in order to verify its applicability to a real context, consisting of the design of the public transport plan of the province of Foggia in southern Italy. Applications results show that the sustainable design scenario is not only the best ones from a technical point of view, but also participated, equitable, and approved by both policymakers and stakeholders.</text>
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                <text>public engagement, sustainable mobility, Local public transport, transport quality, network and services design, equitable resource allocation</text>
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                <text>10.3390/su12166303</text>
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                <text>Biotemas</text>
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                <text>Universidade Federal de Santa Catarina</text>
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                <text>Environmental effects of industries and plants, Renewable energy sources, Environmental sciences</text>
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