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              <name>Title</name>
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                  <text>Coronavirus</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Clinical characteristics of patients with 2019 coronavirus disease in a non-Wuhan area of Hubei Province, China: a retrospective study</text>
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                <text>Yuan Yan Tang, Xinying Zhao, Tao Xiong, Zhiping Huang, Baoping Yu, Aiying Yang, Xuanxuan Xu, Haisen Yin, Qin-Ming Hu</text>
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                <text>Abstract Background Since December 2019, the 2019 coronavirus disease (COVID-19) has expanded to cause a worldwide outbreak that more than 600,000 people infected and tens of thousands died. To date, the clinical characteristics of COVID-19 patients in the non-Wuhan areas of Hubei Province in China have not been described. Methods We retrospectively analyzed the clinical characteristics and treatment progress of 91 patients diagnosed with COVID-19 in Jingzhou Central Hospital. Results Of the 91 patients diagnosed with COVID-19, 30 cases (33.0%) were severe and two patients (2.2%) died. The severe disease group tended to be older (50.5 vs. 42.0 years; p = 0.049) and have more chronic disease (40% vs. 14.8%; p = 0.009) relative to mild disease group. Only 73.6% of the patients were quantitative polymerase chain reaction (qPCR)-positive on their first tests, while typical chest computed tomography images were obtained for each patient. The most common complaints were cough (n = 75; 82.4%), fever (n = 59; 64.8%), fatigue (n = 35; 38.5%), and diarrhea (n = 14; 15.4%). Non-respiratory injury was identified by elevated levels of aspartate aminotransferase (n = 18; 19.8%), creatinine (n = 5; 5.5%), and creatine kinase (n = 14; 15.4%) in laboratory tests. Twenty-eight cases (30.8%) suffered non-respiratory injury, including 50% of the critically ill patients and 21.3% of the mild patients. Conclusions Overall, the mortality rate of patients in Jingzhou was lower than that of Wuhan. Importantly, we found liver, kidney, digestive tract, and heart injuries in COVID-19 cases besides respiratory problems. Combining chest computed tomography images with the qPCR analysis of throat swab samples can improve the accuracy of COVID-19 diagnosis.</text>
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                <text>2020</text>
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                <text>Mortality, Respiratory failure, COVID-19, Disease characteristics, Non-respiratory injury</text>
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                <text>DOI: 10.1186/s12879-020-05010-w</text>
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                <text>BMC Infectious Diseases</text>
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                <text>BMC</text>
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                <text>Infectious and parasitic diseases</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Tackling the COVID-19 Pandemic: Managing the Cause, Spread, and Impact</text>
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                <text>Yudan Whulanza, Nandy Putra, Muhammad Arif Budiyanto, Paramita Atmodiwirjo, Yandi Andri Yatmo, Eny Kusrini, Mohammed Ali Berawi, Eko Adhi Setiawan, Akhmad Herman  Yuwono, Nyoman Suwartha, Muhammad  Suryanegara, Ruki Harwahyu, Yuri T.  Zagloel</text>
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                <text>&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;The outbreak of SARS-CoV-2 or COVID-19 is attacking societies in all regions. The speedand scale of the outbreak have been acceleratingfatalities and causing social and economic disruption. We need coordinatedand comprehensive actions on the national and international level in creating a sharedresponsibility and&amp;nbsp;&amp;nbsp;human solidarityto suppress thespread of the virus, empower resilience in society, and address the virus’ socio-economicimpact. Increasing the healthcare capacity for testing andtracing, implementing quarantine and physical distancing measures, restrictingmovement, andprioritizingthe most vulnerable groups – the elderly and/or chronically sick patients – shouldbe treated as ways to minimize the spread and impact of the virus. Furthermore, the social andeconomic dimensions of this crisis must be managed to enhance the resilienceof societies and countries. &amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;There have been&amp;nbsp;catastrophiclosses due to this pandemic, leading to fatalities and bringing instability to many social andeconomic urbanareas. The approaches to tackling this virus must be well-established. Making society safe in thispandemic&amp;nbsp;is everybody’s business.Governments, the private sector, academics, and professionals, as well as everycitizen, need to be engaged and play their role in building a resilient societyin terms of health, economic, and social resilience. Citizen empowerment iscrucial in mitigating the impacts of the pandemic, including the ability toadapt to shock, panic, and stress and to quickly respond to an unstableenvironment.</text>
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                <text>2020</text>
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                <text>DOI: 10.14716/ijtech.v11i2.4035</text>
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              <elementText elementTextId="30264">
                <text>International Journal of Technology</text>
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                <text>Universitas Indonesia</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Technology, Technology (General)</text>
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                <text>Analysis of the susceptibility of lung cancer patients to SARS-CoV-2 infection</text>
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              <elementText elementTextId="30251">
                <text>Yue Wu, Yu Gu, Jianguo Guo, Qi Kong, Zhiguang Xiang, Fei Geng</text>
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                <text>Abstract Recent studies have reported that COVID-19 patients with lung cancer have a higher risk of severe events than patients without cancer. In this study, we investigated the gene expression of angiotensin I-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) with prognosis in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC). Lung cancer patients in each age stage, subtype, and pathological stage are susceptible to SARS-CoV-2 infection, except for the primitive subtype of LUSC. LUAD patients are more susceptible to SARS-CoV-2 infection than LUSC patients. The findings are unanimous on tissue expression in gene and protein levels.</text>
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                <text>2020</text>
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                <text>lung cancer, ACE2, TMPRSS2, SARS-CoV-2, COVID-19</text>
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                <text>DOI: 10.1186/s12943-020-01209-2</text>
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                <text>Molecular Cancer</text>
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                <text>BMC</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Neoplasms. Tumors. Oncology. Including cancer and carcinogens</text>
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              <name>Title</name>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Considerations for Treating Corona Virus (Sars-Cov-2) Infection with Passive Immunotherapy</text>
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              <elementText elementTextId="30242">
                <text>Stephen Ash, Abraham  Karpas, Douglas Bainbridge</text>
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                <text>The corona viruses are transient RNA viruses; once an infected individual recovers he or she becomes virus-free and immune. One could expect that in SARS-Covid-19 also, infected individuals who recover will have developed some form of protective immunity. Very little is yet known about its development, when and for how long it might last, and though it is very likely to involve virus-neutralising antibodies, to what extent it might depend on the appearance of such antibodies. However in a recent report 10 very advanced corona patients were treated with a single 200 ml dose of plasma obtained from individuals recovered from the infection. There was impressive clinical improvement.</text>
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                <text>2020</text>
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                <text>immunotherapy, emergency, coronavirus, SARS-CoV-2, COVID-19</text>
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              <elementText elementTextId="30246">
                <text>DOI: 10.13128/Substantia-924</text>
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                <text>Substantia</text>
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              <elementText elementTextId="30248">
                <text>Firenze University Press</text>
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                <text>Chemistry, History (General) and history of Europe</text>
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                <text>Novel Coronavirus disease (COVID-19) in newborns and infants: what we know so far</text>
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                <text>Abstract Recently, an outbreak of viral pneumonitis in Wuhan, Hubei, China successively spread as a global pandemia, led to the identification of a novel betacoronavirus species, the 2019 novel coronavirus, successively designated 2019-nCoV then SARS-CoV-2). The SARS-CoV-2 causes a clinical syndrome designated coronavirus disease 2019 (COVID19) with a spectrum of manifestations ranging from mild upper respiratory tract infection to severe pneumonitis, acute respiratory distress syndrome (ARDS) and death. Few cases have been observed in children and adolescents who seem to have a more favorable clinical course than other age groups, and even fewer in newborn babies. This review provides an overview of the knowledge on SARS-CoV-2 epidemiology, transmission, the associated clinical presentation and outcomes in newborns and infants up to 6 months of life.</text>
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                <text>DOI: 10.1186/s13052-020-0820-x</text>
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                <text>Italian Journal of Pediatrics</text>
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                <text>BMC</text>
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                <text>Masomeh Bayani, Soheil Ebrahimpour, Mostafa Javanian, Jila Masrour-Roudsari</text>
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                <text>DOI: </text>
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                <text>Caspian Journal of Internal Medicine</text>
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                <text>Babol University of Medical Sciences</text>
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                <text>Internal medicine</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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                <text>COVID-19: where is the national ethical guidance?</text>
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            <name>Creator</name>
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              <elementText elementTextId="30217">
                <text>Richard Huxtable</text>
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            <name>Date</name>
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                <text>2020</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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                <text>coronavirus, COVID-19, Professional guidance, ethical guidance</text>
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            <name>Identifier</name>
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              <elementText elementTextId="30220">
                <text>DOI: 10.1186/s12910-020-00478-2</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="30221">
                <text>BMC Medical Ethics</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="30222">
                <text>BMC</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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              <elementText elementTextId="30223">
                <text>Medical philosophy. Medical ethics</text>
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              <name>Title</name>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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              <elementText elementTextId="30208">
                <text>Li Chen, Jianming Li, Jing Yuan, Ling Peng, Liang Yang, Ying-xia Liu, Xiao Jiang, Chuming Chen, Yinfeng Li, Peiyan Zhang, Zhao Cai, Meng-Li Cao, Weibo Wu, Fuxiang Wang, Shiyan Feng</text>
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                <text>Abstract Background The novel coronavirus disease 2019 (COVID-19) outbreak started in Wuhan, Hubei, China since Dec 2019 and cases of infection have been continuously reported in various countries. It is now clear that the SARS-COV-2 coronavirus is transmissible from human to human. Nucleic acid detection is considered as the gold standard for the diagnosis of COVID-19. In this case report, we describe our experience in detection of SARS-COV-2 from a confirmed patient using nucleic acid test of bronchoalveolar-lavage fluid (BALF) samples but not nasopharyngeal swabs. Case presentation We present a case of severely ill SARS-COV-2 infected 46-year-old man with fever, coughing and chest tightness. We performed viral detection using his BALF samples and imaging method (CT) for confirmation. The patient received combination of interferonalfa-1b and ribavirin, lopinavir and ritonavir for antiviral treatment at different stages. Other medication was also given to him in combination for anti-inflammation, intestinal microbial regulation, phlegm elimination, liver protection and pulmonary fibrosis prevention purposes. We provided oxygen supply to him using BIPAP ventilator and high-flow humidification oxygen therapy instrument to facilitate respiration. The patient was cured and discharged. Conclusion This case report described an effective supportive medication scheme to treat SARS-COV-2 infected patient and emphasized the necessity of detection of the viral genome using BALF samples and its significance in the diagnosis and prognosis of the disease.</text>
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                <text>2020</text>
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                <text>DOI: 10.1186/s12879-020-05045-z</text>
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                <text>BMC Infectious Diseases</text>
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                <text>BMC</text>
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                <text>Infectious and parasitic diseases</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Physical Activity During the Coronavirus (COVID-19) Pandemic: Prevention of a Decline in Metabolic and Immunological Functions</text>
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                <text>Johan Jakobsson, Ulf Ekelund, Maria Furberg, Christer Malm, Michael Svensson</text>
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                <text>Health, physical activity, Mortality, sedentary behavior, coronavirus, COVID-19</text>
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                <text>DOI: 10.3389/fspor.2020.00057</text>
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                <text>Frontiers in Sports and Active Living</text>
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                <text>Frontiers Media S.A.</text>
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                <text>Sports</text>
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                <text>Novel Coronavirus Disease 2019 Infection in Children: The Dark Side of a Worldwide Outbreak</text>
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                <text>Piero Valentini, Danilo Buonsenso, Giuseppe Zampino</text>
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                <text>In this pediatric perspectives article, we discuss current limits in the understanding of novel coronavirus infection. In our opinion, the burden of novel coronavirus infections is underestimated because not actively looked for. We discuss the basis of our observations and what this can generate, suggesting a different approach for the search of the virus in children.</text>
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          <element elementId="40">
            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="30193">
                <text>2020</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="30194">
                <text>Children, Public Health, coronavirus, SARS-CoV-2, COVID-19</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="43">
            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
            <elementTextContainer>
              <elementText elementTextId="30195">
                <text>DOI: 10.3389/fped.2020.00215</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="30196">
                <text>Frontiers in Pediatrics</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="30197">
                <text>Frontiers Media S.A.</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="30198">
                <text>Pediatrics</text>
              </elementText>
            </elementTextContainer>
          </element>
        </elementContainer>
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  </item>
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