https://socictopen.socict.org/files/original/5f4d7885c88af7a16a79f3c4123d978b.pdf f7bbef160a0a997442cd0ea1a57bea60 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource ACE2 Receptor in the skin and Cutaneous Manifestations of SARS-Cov-2: A Review of the Literature Creator An entity primarily responsible for making the resource Pho, Denita Meiliani Description An account of the resource A B S T R A C T Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is a newly discovered coronavirus that causes Coronavirus Disease 2019 (COVID-19). The interaction of SARS-CoV-2 transmembrane spike (S) glycoprotein with the human angiotensin-converting enzyme-2 (hACE2) is the primary method of virus entry to the cell. ACE2 is a transmembrane enzyme involved in the renin-angiotensin- aldosterone system. This enzyme plays pivotal roles in blood pressure regulations and also electrolyte homeostasis. The expression of ACE2 in various skin cells has been demonstrated in previous studies. Keratinocytes in the epidermis show an exceptionally high expression of ACE2. In addition to human skin, ACE2 is also found in animals’ tissues and were exceptionally high in cats and dogs’ skin and eyes. This finding suggests their obscure role in COVID-19 transmission. Cutaneous symptoms of COVID-19 in humans exist as the consequence of ACE2 presence in the skin. The possible mechanisms of COVID-19 clinical manifestations in the skin are upregulated innate immune human response, hypercoagulable state, and non- structural proteins in SARS-CoV-2. These processes are presented as different dermatologic manifestations, which are maculopapular rash, papulovesicular rash, and livedo reticularis. This review aims to link the theoretical framework and published findings to establish the connection between ACE2 expression in skin and cutaneous manifestations of COVID-19. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource covid-19, SARS-CoV-2, ACE2, hace2 Identifier An unambiguous reference to the resource within a given context 10.32539/bsm.v5i1.209 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Therapeutics. Pharmacology, Neurology. Diseases of the nervous system