https://socictopen.socict.org/files/original/41edf52a51934d0a4a36a3127a976a19.pdf e558a2c95f5de35cccef5ae2a32bf89a Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Biochemical and Computational Approach of Selected Phytocompounds from <i>Tinospora crispa</i> in the Management of COVID-19 Creator An entity primarily responsible for making the resource Jesus Simal-Gandara, Ahmed Rakib, Saad Ahmed Sami, Talha Bin Emran, Arkajyoti Paul, Abu Montakim Tareq, Md. Nazim Uddin Chy, Sumit Kumar Baral, Mohuya Majumder, Mohammad Nurul Amin, Asif Shahriar, Md. Zia Uddin, Mycal Dutta, Trina Ekawati Tallei Description An account of the resource A pandemic caused by the novel coronavirus (SARS-CoV-2 or COVID-19) began in December 2019 in Wuhan, China, and the number of newly reported cases continues to increase. More than 19.7 million cases have been reported globally and about 728,000 have died as of this writing (10 August 2020). Recently, it has been confirmed that the SARS-CoV-2 main protease (Mpro) enzyme is responsible not only for viral reproduction but also impedes host immune responses. The Mpro provides a highly favorable pharmacological target for the discovery and design of inhibitors. Currently, no specific therapies are available, and investigations into the treatment of COVID-19 are lacking. Therefore, herein, we analyzed the bioactive phytocompounds isolated by gas chromatography–mass spectroscopy (GC-MS) from Tinospora crispa as potential COVID-19 Mpro inhibitors, using molecular docking study. Our analyses unveiled that the top nine hits might serve as potential anti-SARS-CoV-2 lead molecules, with three of them exerting biological activity and warranting further optimization and drug development to combat COVID-19. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource covid-19, SARS-CoV-2, Natural products, phytochemicals, secondary metabolites, <i>Tinospora crispa</i> Identifier An unambiguous reference to the resource within a given context 10.3390/molecules25173936 Source A related resource from which the described resource is derived Biotemas Publisher An entity responsible for making the resource available Universidade Federal de Santa Catarina Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Organic chemistry