https://socictopen.socict.org/files/original/3fca539bcf5c3f4e1d58b2d635530cfc.pdf 48f11dff8d3cadbc5ef3d360793b54c1 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Second Episode of COVID-19 in Health Professionals: Report of Two Cases Creator An entity primarily responsible for making the resource de Brito CAA, Lima PMA, de Brito MCM, de Oliveira DB Description An account of the resource Carlos Alexandre Antunes de Brito,1,2 Petrus Moura Andrade Lima,3 Marina Coelho Moraes de Brito,2,4 Daniela Barbosa de Oliveira2 1Department of Internal Medicine, Center of Medical Sciences of Federal University, Recife, Pernambuco, Brazil; 2Department of Immunology, Autoimmune Research Institute, Recife, Pernambuco, Brazil; 3Department of Digestive Surgery, Institute of Integral Medicine Fernando Figueira (IMIP), Recife, Pernambuco, Brazil; 4Center of Medical Sciences, Federal University of Pernambuco, Recife, Pernambuco, BrazilCorrespondence: Carlos Alexandre Antunes de Brito Av. Professor Moraes Rego, s/n, Várzea, Department of Internal MedicineFederal University of Pernambuco, Recife 50670-910, Pernambuco, BrazilTel +55 (81) 2126.3699Email cbritoc@gmail.comAbstract: Although primary infection has been shown to prevent reinfection of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) in animal models, gaps in the understanding of the immune response to the virus have not been adequately addressed, and some cases of possible reinfection have been reported; however, the frequency, relevance and proof of these events have yet to be determined. We report cases of two doctors who had two episodes of COVID-19 with positive RT-PCR (reverse transcriptase polymerase chain reaction) test results, raising the probability of reinfection. Case 1 was a 40-year-old male physician who presented fever and respiratory symptoms on April 10, with a positive RT-PCR test for SARS-CoV-2, with complete improvement of symptoms in five days. After 44 days, the patient presented the same symptoms of the previous episode, associated with anosmia and dysgeusia. The results of a new RT-PCR test performed two days later were positive for SARS-CoV-2. Case 2 was a 44-year-old female physician who worked in a reference clinic for COVID-19 (coronavirus disease 2019) and had onset of symptoms indicative of the disease on April 30. The RT-PCR test was positive for SARS-CoV-2, with improvement of symptoms in six days. On May 24, the patient presented fever, cough, and sore throat accompanied by headache, asthenia, myalgia, and diarrhea, and in this new episode, anosmia and dysgeusia were also present. A new RT-PCR test from nasopharyngeal swabs was performed with a positive result. Our two patients described here and other patients with possible reinfection who are now being observed in clinical practice reinforce the need to expand the investigation. Then, if the risk of reinfection is confirmed, these findings will be relevant from a clinical-epidemiological perspective to define isolation strategies and develop vaccines.Keywords: COVID-19, SARS-CoV-2, reinfection, antibody Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource covid-19, antibody, SARS-CoV-2, Reinfection Source A related resource from which the described resource is derived Biotemas Publisher An entity responsible for making the resource available Universidade Federal de Santa Catarina Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine (General)