https://socictopen.socict.org/files/original/8be43c9befecb66fa6701763ef58267d.pdf 64fa61690012c766baf3df87b8ec8104 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Bacterial Outer Membrane Vesicles (OMVs)-Based Dual Vaccine for Influenza A H1N1 Virus and MERS-CoV Creator An entity primarily responsible for making the resource Mahmoud M. Shehata, Ahmed Mostafa, Lisa Teubner, Sara H. Mahmoud, Ahmed Kandeil, Rabeh El Shesheny, Thamer A. Boubak, Renate Frantz, Luigi La Pietra, Stephan Pleschka, Ahmed Osman, Ghazi Kayali, Trinad Chakraborty, Mohamed A. Ali, Mobarak Abu Mraheil Description An account of the resource Vaccination is the most functional medical intervention to prophylactically control severe diseases caused by human-to-human or animal-to-human transmissible viral pathogens. Annually, seasonal influenza epidemics attack human populations leading to 290−650 thousand deaths/year worldwide. Recently, a novel Middle East Respiratory Syndrome Coronavirus emerged. Together, those two viruses present a significant public health burden in areas where they circulate. Herein, we generated a bacterial outer membrane vesicles (OMVs)-based vaccine presenting the antigenic stable chimeric fusion protein of the H1-type haemagglutinin (HA) of the pandemic influenza A virus (H1N1) strain from 2009 (H1N1pdm09) and the receptor binding domain (RBD) of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) (OMVs-H1/RBD). Our results showed that the chimeric antigen could induce specific neutralizing antibodies against both strains leading to protection of immunized mice against H1N1pdm09 and efficient neutralization of MERS-CoV. This study demonstrate that OMVs-based vaccines presenting viral antigens provide a safe and reliable approach to protect against two different viral infections. Date A point or period of time associated with an event in the lifecycle of the resource 2019 Subject The topic of the resource OMVs, influenza vaccine, MERS-CoV, H1N1pdm Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/vaccines7020046 Source A related resource from which the described resource is derived Vaccines Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine Language A language of the resource EN